Comparison of Two Kinds of Method in Forest Growth Estimation

( Hang Nan Yu ),이우균,남기준 한국임학회 2013 산림과학 공동학술대회 논문집 Vol.2013 No.-

The Relationship of Job Stress, Toughness and Burnout among Emergency Room Nurses in South Korea

Hang Nan Cho,Soo Jin Kim 한국간호과학회 2011 한국간호과학회 학술대회 Vol.2011 No.10

Prognostic Factors in Adult Patients with Solid Cancers and Bone Marrow Metastases

Hung, Yu-Shin,Chou, Wen-Chi,Chen, Tai-Di,Chen, Tse-Ching,Wang, Po-Nan,Chang, Hung,Hsu, Hung-Chih,Shen, Wen-Chi,Cheng, Wei-Hong,Chen, Jen-Shi Asian Pacific Journal of Cancer Prevention 2014 Asian Pacific journal of cancer prevention Vol.15 No.1

Background: Solid cancers with bone marrow metastases are rare but lethal. This study aimed to identify clinical factors predictive of survival in adult patients with solid cancers and bone marrow metastases. Methods: A total of 83 patients were enrolled consecutively between January 1, 2000 and December 31, 2012. Bone marrow metastases were confirmed by biopsies. Patient clinical features and laboratory data were analyzed for associations. Results: The median age of the patients was 54 years (range, 23-88 years), and 58% were male. The 3 most common primary tumor locations were the stomach (32 patients, 39%), prostate (16 patients, 19%), and lungs (12 patients, 15%). The median overall survival was 49 days (range, 3-1423 days). Patients with Eastern Cooperative Oncology Group performance status 1, cancers of prostate origin, platelet counts over 50,000/ml, and undergoing antitumor therapies had a significantly better prognosis in the multivariate analysis. The median survival times were 173 and 33 days for patients with 2-3 more favorable parameters (n=24) and those with 0-1 (n=69), respectively (hazard ratio 0.30; 95% CI 0.17-0.52, p<0.001). Conclusions: Solid cancers with bone marrow metastases are dismal and incurable diseases. Understanding prognostic factors to these diseases helps medical personnel to provide appropriate treatments and better inform patients about outcomes. Antitumor therapies may improve outcomes in selected patient cohorts.

Desertification monitoring using vegetation temperature condition index

( Hang Nan Yu ),이우균,이종열,최솔이 한국임학회 2013 산림과학 공동학술대회 논문집 Vol.2013 No.-

교대근무 여자간호사 이직의도 구조모형: 상급종합병원을 중심으로

조행난(Hang Nan Cho),소향숙(Hyang Sook So),장애리(Aeri Jang) 한국산학기술학회 2021 한국산학기술학회논문지 Vol.22 No.3

본 연구는 이직인과모델 기반 상급종합병원 교대근무 여자간호사의 이직의도 구조방정식 모형구축을 위한 연구이다. 자료수집은 2015년 11월 11일부터 12월 20일까지 진행되었으며, 총 283명의 자료가 최종분석에 포함되었다. 연구결과 최종 수정모형에 대한 적합도는 권장수준에 비교적 충족하였으며, 최종 수정모형의 19개 가설 중 12개의 가설이 지지되었다. 또한 외부취업 기회, 간호전문직관, 간호조직문화(관계지향, 혁신지향), 직무스트레스, 직무만족, 조직몰입, 소진은 상급종합병원 교대근무 간호사의 이직의도를 47.8% 설명하는 것으로 확인되었다. 세부적으로 이직의도에는 소진(+), 조직몰입(-)이 통계적으로 유의한 직접효과를 나타냈으며, 간호전문직관, 관계지향 간호조직문화와 직무스트레스는 통계적으로 유의한 간접효과를 나타냈다. 이에 본 연구결과를 기반하여 상급종합병원 교대근무 여자간호사의 이직의도 감소를 위해 소진을 감소시키고, 조직몰입과, 직무만족을 높이는 것이 필요하다고 판단되며, 이를 위해 관계지향적 간호조직문화와 간호전문직관을 강화하는 방안 요구된다. 따라서 병원인력관리 차원에서 탄력적으로 근무시간을 조정할 수 있도록 하고, 상호 존중하는 관계중심의 조직문화를 형성하며, 간호전문직관을 강화하는 교육 및 정책적 지원, 그리고 자긍심을 가지고 일할 수 있는 병원의 제도적 장치가 이루어져야 할 것이다. This study uses a structural equation model for the turnover intention of female nurses performing shift work at a tertiary hospital. Data collection was conducted from November 11 to December 20, 2015, and 283 samples were included in the final analysis. As a result, 12 of the 19 hypotheses of the final model were supported. It was confirmed that external employment opportunities, nursing professional value, nursing organizational culture, job stress, job satisfaction, organizational commitment, and burn out accounted for 47.8% of the turnover intention. Burn out(+) and organizational commitment(-)had direct effects on turnover intentions, and nursing professional, relationship-oriented nursing organizational culture, and job stress showed indirect effects. Therefore, in order to reduce the turnover intention of female nurses working in shifts at tertiary hospitals, it is necessary to prevent burnout, increase organizational commitment, and job satisfaction. For this purpose, measures to strengthen relation-oriented nursing organizational culture and nursing professional intuition are required. In terms of hospital manpower management, the institutional arrangements of hospitals that enable flexible working hours adjustment, mutually respectful relationship-centered organizational culture, education, and policy support to reinforce nursing professional intuition, and the institutional system of hospitals to work with pride should be implemented.

Sulforaphane Inhibits TNF-α-Induced Adhesion Molecule Expression Through the Rho A/ROCK/NF-κB Signaling Pathway

Chi-Nan Hung,Hui-Pei Huang,Chau-Jong Wang,Kai-Li Liu,Chong-Kuei Lii 한국식품영양과학회 2014 Journal of medicinal food Vol.17 No.10

Endothelial dysfunction is an early indicator of cardiovascular diseases. Increased stimulation of tumor necrosis factor-a (TNF-a) triggers the inflammatory mediator secretion of endothelial cells, leading to atherosclerotic risk. In this study, we investigated whether sulforaphane (SFN) affected the expression of intracellular adhesion molecule-1 (ICAM-1) in TNF-a-induced ECV 304 endothelial cells. Our data showed that SFN attenuated TNF-a-induced expression of ICAM-1 in ECV 304 cells. Pretreatment of ECV 304 cells with SFN inhibited dose-dependently the secretion of proinflammatory cytokines, such as interleukin (IL)-1b, IL-6, and IL-8. SFN inhibited TNF-a-induced nuclear factor-jB (NF-jB) DNA binding activity. Furthermore, SFN decreased TNF-a-mediated phosphorylation of IjB kinase (IKK) and IjBa, Rho A, ROCK, ERK1/2, and plasminogen activator inhibitor-1 (PAI-1) levels. Collectively, SFN inhibited the NF-jB DNA binding activity and downregulated the TNF-a-mediated induction of ICAM-1 in endothelial cells by inhibiting the Rho A/ROCK/NF-jB signaling pathway, suggesting the beneficial effects of SFN on suppression of inflammation within the atherosclerotic lesion.

간호사의 도덕적 고뇌 정도에 대한 이직의도의 차이

조행난(Hang Nan Cho),안민정(Minjeong An),소향숙(Hyang Sook So) 한국콘텐츠학회 2015 한국콘텐츠학회논문지 Vol.15 No.5

본 연구는 일 대학병원 간호사의 도덕적 고뇌 정도에 따른 이직의도 차이를 파악하기 위한 조사연구이다. 연구대상은 G시에 소재한 일 대학병원 간호사 129명이었고, 자료수집은 2014년 7월1일부터 8월8일까지 도덕적 고뇌와 이직의도에 대해 구조화된 설문지를 사용하여 이루어졌다. 수집된 자료는 SPSS 20.0 프로그램을 사용하여 분석하였다. 본 연구결과, 도덕적 고뇌는 3.18점이었고, 이직의도는 3.20점이었다. 도덕적 고뇌가 높은 간호사 그룹이 낮은 간호사 그룹에 비해 이직의도가 높았다(t = -2.11, p = .037). 영역별로는 인지적 영역(t = -3.29, p = .001)과 정서적 영역(t = -3.93, p < .001)의 고뇌가 높은 그룹이 낮은 그룹보다 이직의도가 높게 나타났고, 상황적 영역에서는 두 그룹 간 차이가 없었다(t= -1.66, p = .-099). 이 결과는 간호사가 단순히 도덕적 고뇌가 높은 상황을 만날 때 이직을 고려하기 보다는, 그러한 상황에서 간호사가 시간 부족, 감독자의 반대 및 여러 제도와 환경에 대한 부정적 인지와 정서로 인해 고뇌가 증가되어 이직의 도가 증가함을 의미한다. 그러므로, 간호 실무에서 인지적 및 정서적 영역의 도덕적 고뇌 정도를 줄이기 위해 제도 개선, 윤리교육 프로그램 강화 및 도덕적 고뇌 관리 프로그램을 개발하여 간호사에게 적용하는 것이 필요하다. The purpose of this study was to examine the degree of moral distress and turnover intention in nurses. Participants were 129 nurses working at a university hospital. Data were collected using a structured questionnaire survey from July 1 to August 8, 2014. Total mean score of moral distress was 3.18 and that of turnover intention was 3.20. There was a statistically significant differences on turnover intention between the group with high moral distress and the group with low moral distress (t = -2.11, p = .037). Further researches are needed to develop and provide ethics education program and moral distress management program to reduce the degree of moral distress of nurses in nursing practice.

The Effects of Environmental Toxins on Allergic Inflammation

San-Nan Yang,Chong-Chao Hsieh,Hsuan-Fu Kuo,Min-Sheng Lee,Ming-Yii Huang,Chang-Hung Kuo,Chih-Hsing Hung 대한천식알레르기학회 2014 Allergy, Asthma & Immunology Research Vol.6 No.6

The prevalence of asthma and allergic disease has increased worldwide over the last few decades. Many common environmental factors are associated with this increase. Several theories have been proposed to account for this trend, especially those concerning the impact of environmental toxicants. The development of the immune system, particularly in the prenatal period, has far-reaching consequences for health during early childhood, and throughout adult life. One underlying mechanism for the increased levels of allergic responses, secondary to exposure, appears to be an imbalance in the T-helper function caused by exposure to the toxicants. Exposure to environmental endocrine-disrupting chemicals can result in dramatic changes in cytokine production, the activity of the immune system, the overall Th1 and Th2 balance, and in mediators of type 1 hypersensitivity mediators, such as IgE. Passive exposure to tobacco smoke is a common risk factor for wheezing and asthma in children. People living in urban areas and close to roads with a high volume of traffic, and high levels of diesel exhaust fumes, have the highest exposure to environmental compounds, and these people are strongly linked with type 1 hypersensitivity disorders and enhanced Th2 responses. These data are consistent with epidemiological research that has consistently detected increased incidences of allergies and asthma in people living in these locations. During recent decades more than 100,000 new chemicals have been used in common consumer products and are released into the everyday environment. Therefore, in this review, we discuss the environmental effects on allergies of indoor and outside exposure.

향요법이 노인의 수면증진에 미치는 효과: 국내학술지 논문에 대한 체계적 문헌 고찰

조행난(Cho Hang Nan),황윤영(Hwang Yoon Young),안민정(An Minjeong) 전남대학교 간호과학연구소 2019 Nursing and Health Issues(NHI) Vol.24 No.1

Purpose: The purpose of this review was to evaluate the effectiveness of aromatherapy for sleep improvement in older adults and summarize the available evidence. Methods: A systematic review was conducted in accordance with the Preferred Reporting Items for Systematic Reviews and Meta-Analyses statement. Peer-reviewed journal articles were searched using the following databases: RISS, KISS, NDSL, and KMbase. The studies selected were assessed for methodological quality using the Quality Assessment Tool for Quantitative Studies. Results: Of 16 studies, 14 found aromatherapy to be a therapeutic intervention for sleep improvement in older adults. This review provides valid evidence that aromatherapy with lavender oil is effective in managing old adults’ sleep problems. Conclusion: The review findings can assist health care providers and researchers who assist older adults with sleep issues living either in community settings or institutions.

Efficacy and Safety of 12 Weeks of Daclatasvir, Asunaprevir Plus Ribavirin for the Treatment of HCV Genotype 1b Infection without Baseline NS5A Resistance-Associated Variants (DARING)-Interim Report

( Ming-lung Yu ),( Chao-hung Hung ),( Yi-hsiang Huang ),( Cheng-yuan Peng ),( Chun-yen Lin ),( Pin-nan Cheng ),( Rong-nan Chien ),( Shih-jer Hsu ),( Chen-hua Liu ),( Jee-fu Huang ),( Chung-feng Huang 대한간학회 2018 춘·추계 학술대회 (KASL) Vol.2018 No.1

Aims: The current study aims to elucidate the treatment efficacy (defined as undetectable HCV RNA throughout 12 weeks of post-treatment follow-up, SVR12) and safety DCV/ASV plus ribavirin for 12 weeks in HCV-1b patients without NS5A RAS. Methods: This is a single-arm, open-label phase 2 study. Seventy directly acting antivirals (DAA)-naïve HCV-1b patients without L31/Y93 RAS are planned to receive daclatasvir (60 mg/ day) and asunaprevir (100 mg twice daily) plus weight-based ribavirin (1000-1200 mg/day) for 12 weeks. After treatment they were followed up for 12 weeks. Results: As of 31 Oct 2017, 58 eligible patients are allocated to treatment, with a mean age of 59.3 years and female predominance (67.2%, 39/58). The mean HCV RNA was 5.87+0.77 log10 IU/mL; 23 patients (39.7 %) had significant hepatic fibrosis (>F2). In the modified intention-to-treat analysis, the rate of undetectable HCV at week 1, week 2, week 4, week 8 and endof- treatment was 25 % (14/56), 84.8 % (39/46), 100 % (46/46), 100 % (38/38) and 100 % (27/27), respectively. Undetectable HCV RNA were observed in all of the patients with HCV RNA assessable 4 weeks (SVR4, 18/18) and 12 weeks (SVR12, 12/12) post treatment. None of the 18 patients who completed the 12-week treatment experienced relapse during post-treatment follow-up. The most common adverse event was fatigue (78.3 %), followed by pruritus (65.2 %) and dizziness (52.2 %), of which were considered as ribavirin related. None of the participating subjects withdrew treatment or follow-up throughout the trial peroid. Three serious adverse events were reported which included urosepsis, appendicitis and left ureteral stone. All were unrelated to the investigating drugs. Conclusions: 12 weeks of DCV/ASV plus ribavirin was highly effective and safe in HCV-1b patients without NS5A RAS in the interim analysis. The satisfactory results would be anticipated in the full patient set.