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Han-Yang Ye,Zhan-Yuan Li,Yu Zheng,Yan Chen,Zhi-Hong Zhou,Jian Jin 대한약학회 2016 Archives of Pharmacal Research Vol.39 No.7
The present study was undertaken to investigate whether chlorogenic acid (CGA) could protect kidney function against oxidative stress in the diabetic nephropathy (DN) rats. The treatment with CGA could decrease significantly the levels of blood glucose, blood urea nitrogen and serum creatinine in DN rats. Moreover, CGA significantly increased the activity of superoxide dismutase, glutathione peroxidase, and catalase. Moreover, the level of lipid peroxidation malondialdehyde was reduced markedly after CGA administration. Immunohistochemical analysis also showed that CGA downregulated significantly cyclooxygenase-2 protein expression in renal tissue, which is considered as one of the major pathogeneses of oxidative stress. Furthermore, we demonstrated that CGA could block the expression of activating transcription factor-6, C/EBP homology protein and the phosphorylation of eukaryotic initiation factor 2α and double stranded RNAactivated protein kinase-like endoplasmic reticulum kinase. In addition, we attempted to detect the presence of diabetic renal tissues apoptosis-related proteins. Our data provided evidence to support this fact that CGA attenuated oxidative stress in streptozocin-induced DN rats. Its molecular mechanism may inhibit the endoplasmic reticulum-stress response in DN.
0.18 μm CMOS 공정을 이용한 실리콘 뉴런 회로 설계
한예지(Ye-Ji Han),지성현(Sung-Hyun Ji),양희성(Hee-Sung Yang),이수현(Soo-Hyun Lee),송한정(Han-Jung Song) 한국지능시스템학회 2014 한국지능시스템학회논문지 Vol.24 No.5
생물학적 신경 세포의 모델링을 위한 펄스타입 실리콘 뉴런 회로를 0.18 μm CMOS 공정을 이용하여 반도체 집적회로로 설계하였다. 제안하는 뉴런 회로는 입력 전류신호를 위한 커패시터 입력단과, 출력 전압신호 생성을 위한 증폭단 및 펄스신호 초기화를 위한 MOS 스위치로 구성된다. 전압신호 입력을 전류신호 출력으로 변환하는 기능의 시냅스 회로는 몇 개의 PMOS와 NMOS 트렌지스터로 이루어지는 범프회로를 사용한다. 제안하는 뉴런 모델의 검증을 위하여, 2개의 뉴런과 시냅스가 직렬연결된 뉴런체인을 구성하여 SPICE 모의실험을 실시하였다. 모의실험 결과, 뉴런신호의 생성과 시냅스 전달특성의 정상적인 동작을 확인하였다. Using 0.18 μm CMOS process silicon neuron circuit of the pulse type for modeling biological neurons, were designed in the semiconductor integrated circuit. Neuron circuiSt providing is formed by MOS switch for initializing the input terminal of the capacitor to the input current signal, a pulse signal and an amplifier stage for generating an output voltage signal. Synapse circuit that can convert the current signal output of the input voltage signal, using a bump circuit consisting of NMOS transistors and PMOS few. Configure a chain of neurons for verification of the neuron model that provides synaptic neurons and two are connected in series, were performed SPICE simulation. Result of simulation, it was confirmed the normal operation of the synaptic transmission characteristics of the signal generation of nerve cells.
Young-onset type 2 diabetes in South Korea: a review of the current status and unmet need
( Ye Seul Yang ),( Kyungdo Han ),( Tae Seo Sohn ),( Nam Hoon Kim ) 대한내과학회 2021 The Korean Journal of Internal Medicine Vol.36 No.5
The prevalence of young-onset (diagnosis at age < 40 years) type 2 diabetes mellitus (T2DM) is increasing globally. Young-onset T2DM has a common pathophysiology of glucose dysregulation as in late-onset T2DM. However, it presents a greater association with obesity and a more rapid decline in β-cell function than late-onset T2DM. Accumulating evidence indicates that disease progression in young-onset T2DM is rapid, resulting in early and frequent development of microvascular and macrovascular complications, as well as premature death. Improper management and low adherence to medical therapy are important issues in young-onset T2DM. This review discusses the epidemiology, disease entity, and clinical issues associated with young-onset T2DM. We also present the prevalence and clinical characteristics of patients with young-onset T2DM in South Korea.
Ultrathin metamaterial-based perfect absorbers for VHF and THz bands
Ye Seul Yun,SangHyeon Kim,Han-Youl Ryu,Min-Su Park,V. D. Lam,J.G. Yang,Y. P. Lee 한국물리학회 2016 Current Applied Physics Vol.16 No.9
An ultrathin and angularly stable metamaterial perfect absorber (MPA) is demonstrated for VHF-band using four connected split-square resonators structure and low-cost fabrication process. The total incoming energy of electromagnetic wave (at 250 MHz) is consumed inside the efficient thickness, which is 240 times smaller than the absorption wavelength of MPA. Our MPA works well for a very wide range of incident angle up to 45 of electromagnetic wave and exhibits the polarization-independent behavior. Furthermore, by scaling the initial design and integrating a ferroelectric material (strontium titanate), a thermo-tunable ultrathin MPA is realized in the THz region. At room temperature (300 K), the thickness of THz MPA reaches roundly 1/300 of the working wavelength. In addition, a fractional frequency shift of 49% at the absorption over 90% can be controlled in the varied temperature range from 150 to 400 K. Our results presents good candidates for potential devices operating from the radio to the THz range.
Yang, Seung Won,Lee, Seung‐,Min,Choi, Eun Young,Lee, Kyung Hye,Kim, Soo Hyuk,Shin, Min‐,Jeong,Han, Ye Sun,Kang, Seok‐,Min,Chung, Ji Hyung Wiley Subscription Services, Inc., A Wiley Company 2011 Journal of cellular biochemistry Vol.112 No.9
<P><B>Abstract</B></P><P>Cell‐penetrating peptides (CPPs), including TAT‐CPP, have been used to deliver exogenous proteins into living cells. Although a number of proteins fused to TAT‐CPP can be delivered into various cells, little is known about the proteolytic cleavage of TAT‐fusion proteins in cells. In this study, we demonstrate that a small heat shock protein (sHSP), alphaB‐crystallin (αB‐crystallin), delivered by TAT‐CPP is susceptible to proteolytic cleavage by matrix metalloproteinase‐1 (MMP‐1) in cardiac myoblast H9c2 cells. Recombinant TAT‐αB‐crystallin was efficiently transduced into H9c2 cells. For a few hours following protein transduction, generation of a 14‐kDa fragment, a cleavage band of TAT‐αB‐crystallin, increased in a time‐dependent manner. This fragment was observed only in detergent‐insoluble fractions. Interestingly, treatment with MMP inhibitors blocked the cleavage of TAT‐αB‐crystallin. In test tubes, recombinant MMP‐1 processed TAT‐αB‐crystallin to generate the major cleavage fragment 14‐kDa, as observed in the cells treated with TAT‐αB‐crystallin. The N‐terminal sequences of the 14‐kDa fragment were identified as Leu‐Arg‐Ala‐Pro‐Ser‐Trp‐Phe, indicating that this fragment is generated by cleavage at Phe54‐Leu55 of αB‐crystallin. The MMP‐1‐selective inhibitor abolished the production of 14‐kDa fragments in cells. In addition, the cleaved fragment of TAT‐αB‐crystallin was significantly reduced in cells transfected with MMP‐1 siRNA. Moreover, the enzymatic activity of MMP‐1 was markedly increased in TAT‐αB‐crystallin‐treated cells. TAT‐αB‐crystallin has a cytoprotective effect on H9c2 cells under hypoxic insult, moreover, MMP‐1‐selective inhibitor treatment led to even increased cell viability. These results suggest that MMP‐1 is responsible for proteolytic cleavage of TAT‐αB‐crystallin during its intracellular transduction in H9c2 cells. J. Cell. Biochem. 112: 2454–2462, 2011. © 2011 Wiley‐Liss, Inc.</P>