http://chineseinput.net/에서 pinyin(병음)방식으로 중국어를 변환할 수 있습니다.
변환된 중국어를 복사하여 사용하시면 됩니다.
LEE, WOOJUNG,HAM, JUNGYEOB,KWON, HAK CHEOL,YOON, GOO,BAE, GYU-UN,KIM, YONG KEE,KIM, SU-NAM UNKNOWN 2015 INTERNATIONAL JOURNAL OF MOLECULAR MEDICINE Vol.36 No.2
<P>In the present study, the anti-diabetic effects of amorphastilbol (APH) from Amorpha fruticosa (AF) were evaluated in high-fat-diet (HFD) mice. HFD-induced blood glucose and insulin levels are significantly reduced in AF extract or APH treatment groups. HFD-induced weight gain was reduced by AF treatment, which is accompanied by reduction of fat mass and adipocyte size and number in white adipose tissues. Furthermore, total cholesterol and low-density lipoprotein-cholesterol levels are decreased in AF- or APH-treated mice. In addition, AF and APH are able to improve insulin sensitivity through inhibition of protein tyrosine phosphatase 1B, a negative regulator of the insulin-signaling pathway. Taken together, the data suggest that AF has beneficial effects on glucose and lipid metabolism and its pharmacological effects are driven, in part, by its active component, APH. Therefore, AF and APH can be used as potential therapeutic agents against type 2 diabetes and associated metabolic disorders, including obesity, by enhancing glucose and lipid metabolism.</P>
Heat-processed Panax ginseng and diabetic renal damage: active components and action mechanism
Kang, Ki Sung,Ham, Jungyeob,Kim, Young-Joo,Park, Jeong Hill,Cho, Eun-Ju,Yamabe, Noriko The Korean Society of Ginseng 2013 Journal of Ginseng Research Vol.37 No.4
Diabetic nephropathy is one of the serious complications in patients with either type 1 or 2 diabetes mellitus but current treatments remain unsatisfactory. Results of clinical research studies demonstrate that Panax ginseng can help adjust blood pressure and reduce blood sugar and may be advantageous in the treatment of tuberculosis and kidney damage in people with diabetes. The heat-processing method to strengthen the efficacy of P. ginseng has been well-defined based on a long history of ethnopharmacological evidence. The protective effects of P. ginseng on pathological conditions and renal damage associated with diabetic nephropathy in the animal models were markedly improved by heat-processing. The concentrations of less-polar ginsenosides (20(S)-Rg3, 20(R)-Rg3, Rg5, and Rk1) and maltol in P. ginseng were significantly increased in a heat-processing temperature-dependent manner. Based on researches in animal models of diabetes, ginsenoside 20(S)-Rg3 and maltol were evaluated to have therapeutic potential against diabetic renal damage. These effects were achieved through the inhibition of inflammatory pathway activated by oxidative stress and advanced glycation endproducts. These findings indicate that ginsenoside 20(S)-Rg3 and maltol are important bioactive constituents of heat-processed ginseng in the control of pathological conditions associated with diabetic nephropathy.
Heat-processed Panax ginseng and diabetic renal damage
Ki Sung Kang,Jungyeob Ham,Young-Joo Kim,Jeong Hill Park,Eun-Ju Cho,Noriko Yamabe 고려인삼학회 2013 Journal of Ginseng Research Vol.37 No.4
Diabetic nephropathy is one of the serious complications in patients with either type 1 or 2 diabetes mellitus but current treatments remain unsatisfactory. Results of clinical research studies demonstrate that Panax ginseng can help adjust blood pressure and reduce blood sugar and may be advantageous in the treatment of tuberculosis and kidney damage in people with diabetes. The heat-processing method to strengthen the efficacy of P. ginseng has been well-defined based on a long history of ethnopharmacological evidence. The protective effects of P. ginseng on pathological conditions and renal damage associated with diabetic nephropathy in the animal models were markedly improved by heat-processing. The concentrations of less-polar ginsenosides (20(S)-Rg3, 20(R)-Rg3, Rg5, and Rk1) and maltol in P. ginseng were significantly increased in a heat-processing temperature-dependent manner. Based on researches in animal models of diabetes, ginsenoside 20(S)-Rg3 and maltol were evaluated to have therapeutic potential against diabetic renal damage. These effects were achieved through the inhibition of inflammatory pathway activated by oxidative stress and advanced glycation endproducts. These findings indicate that ginsenoside 20(S)-Rg3 and maltol are important bioactive constituents of heat-processed ginseng in the control of pathological conditions associated with diabetic nephropathy.
Choi, Eun Ju,Kwon, Hak Cheol,Ham, Jungyeob,Yang, Hyun Ok Springer Science and Business Media LLC 2009 The Journal of Antibiotics Vol.62 No.11
<P>Two new antibacterial phenazines were isolated from the culture broth of Brevibacterium sp. KMD 003 obtained from a marine purple vase sponge of the genus Callyspongia, collected in Kyeongpo, Gangwondo, Korea. The structures of these compounds were determined to be 6-hydroxymethyl-1-phenazine-carboxamide (1) and 1,6-phenazinedimethanol (2) through analyses of HR-EI-MS and NMR data. Compounds 1 and 2 showed antibacterial activities against Enterococcus hirae and Micrococcus luteus with 5 muM MIC values.The Journal of Antibiotics advance online publication, 2 October 2009; doi:10.1038/ja.2009.92.</P>
Nocatriones A and B, Photoprotective Tetracenediones from a Marine-Derived <i>Nocardiopsis</i> sp.
Kim, Min Cheol,Hwang, Eunson,Kim, Taejung,Ham, Jungyeob,Kim, Sun Yeou,Kwon, Hak Cheol American Chemical Society and American Society of 2014 Journal of natural products Vol.77 No.10
<P>Two new tetracenedione derivatives, nocatriones A (<B>1</B>) and B (<B>2</B>), were discovered from the culture broth of a marine actinomycete, <I>Nocardiopsis</I> sp. KMF-002, which was isolated from the tissue of an unidentified dark purple marine sponge. The structures of <B>1</B> and <B>2</B>, which are tetracenediones containing α-pyrone substituents, were determined to be 3,8,10,11-tetrahydroxy-2-(4-hydroxy-2-oxo-2<I>H</I>-pyran-6-yl)-1-methyltetracene-5,12-dione (<B>1</B>) and 3,8,10,12-tetrahydroxy-2-(4-hydroxy-2-oxo-2<I>H</I>-pyran-6-yl)-1-methyltetracene-6,11-dione (<B>2</B>). Ultraviolet B (UVB)-irradiated cells treated with 10 μM nocatrione A (<B>1</B>) significantly decreased the level of MMP-1, a protein that degrades collagen and other extracelluar matrix components that comprise dermal tissue, when compared to untreated cells. These results support that nocatriones A (<B>1</B>) and B (<B>2</B>) may show antiphotoaging activity in UVB-irradiated models.</P><P><B>Graphic Abstract</B> <IMG SRC='http://pubs.acs.org/appl/literatum/publisher/achs/journals/content/jnprdf/2014/jnprdf.2014.77.issue-10/np5006086/production/images/medium/np-2014-006086_0006.gif'></P><P><A href='http://pubs.acs.org/doi/suppl/10.1021/np5006086'>ACS Electronic Supporting Info</A></P>