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왜모자반 (Sargassum yezoense)에서 분리한 화합물의 α-glucosidase 및 산화스트레스 억제효과
이은하,함정엽,안홍열,김민철,김철영,판철호,엄병헌,정상훈 한국생약학회 2009 생약학회지 Vol.40 No.2
We examined ethanol extracts prepared from the Korean marine algae belonging to the Sargassaceae family for their inhibitory effects on α-glucosidase activity and free radicals in vitro. Among five marine algae, the extracts of Sargassum yezoense were found to possess strongly α-glucosidase inhibition and free radicals scavenging activities. Two compounds were isolated via bioactivity guided isolation and tested for their effects on α-glucosidase, DPPH, ABTS + and Photochem® analysis. Their chemical structures were elucidated by spectral analysis and direct comparison with authentic compounds; their structures were identified as sargaquinoic acid (1) and sargahydroquinoic acid (2). The inhibitory effects of compound 1 and 2 (IC50 value: 14.2 and 12.8 µM, respectively) on α-glucosidase were more potent that of deoxynojirimycin as a positive control (IC50 value: 18.0 µM). All compounds displayed antioxidative activity which was measured by DPPH, ABTS + and Photoche ® apparatus.
이다혜,함정엽,강기성,이해정 대한화학회 2016 Bulletin of the Korean Chemical Society Vol.37 No.12
Cyaniding 3-O-glucoside is a flavonoid compound isolated from the fruits of the Lonicera caerulea. In the present study, we investigated the effects of L. caerulea extract and its active component cyaniding 3-O-glucoside on insulin release in INS-1 cells. L. caerulea extract and cyanidin 3-O-glucoside activated the secretion of insulin that lead to diminished glucose production in INS-1 cells. Cyanidin 3-O-glucoside also enhanced the phosphorylation of insulin receptor, insulin receptor substrate 1, and phosphoinositide 3-kinase protein expressions in INS-1 cells. These results suggest that cyanidin 3-O-glucoside is an active component of L. caerulea that enhances insulin production and activates insulin signaling.