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Kim, Gwi Ran,Cho, Soo-Na,Kim, Hyung-Seok,Yu, Seon Young,Choi, Sin Young,Ryu, Yuhee,Lin, Ming Quan,Jin, Li,Kee, Hae Jin,Jeong, Myung Ho Wolters Kluwer Health, Inc. All rights reserved. 2016 Journal of Hypertension Vol.34 No.11
<P>Objective:Histone deacetylase (HDAC) inhibitors have been reported to improve essential and secondary hypertension. However, the specific HDAC that might serve as a therapeutic target and the associated upstream and downstream molecules involved in regulating hypertension remain unknown. Our study was aimed at investigating whether a selective inhibitor of class II HDAC (MC1568) modulates hypertension, elucidating the underlying mechanism.Methods:Hypertension was established by administering angiotensin II (Ang II) to mice before treatment with MC1568. SBP was measured.Results:Treatment with MC1568 reduced elevated SBP; attenuated arterial remodeling in the kidney's small arteries and thoracic aorta; and inhibited cell cycle regulatory gene expression, vascular smooth muscle cell (VSMC) proliferation, DNA synthesis, and VSMC hypertrophy in vivo and in vitro. Ang II enhanced the expression of phosphorylated HDAC4 and GATA-binding factor 6 (GATA6) proteins, which were specifically localized in the cytoplasm of cells in the arteries of kidneys and in aortas. Forced expression and knockdown of HDAC4 increased and decreased, respectively, the proliferation and expression of cell cycle genes in VSMCs. GATA6, a newly described binding partner of HDAC4, markedly enhanced the size and number of VSMCs. Calcium(2+)/calmodulin-dependent kinase II (CaMKII), but not HDAC4, translocated from the nucleus to the cytoplasm in response to Ang II. CaMKII and protein kinase D1 were associated with VSMC hypertrophy and hyperplasia via direct interaction with HDAC4. MC1568 treatment weakened the association between HDAC4 and CaMKII.Conclusion:These results suggest that class II HDAC inhibition attenuates hypertension by negatively regulating VSMC hypertrophy and hyperplasia via the CaMKII/protein kinase D1/HDAC4/GATA6 pathway.</P>
Kyong-Jin Min,A-Min Kwak,E-Eun Jeong,Hae-lin Yu,Mi-Rae Shin,Hee-Wan Kang 한국버섯학회 2017 버섯 Vol.21 No.1
This study aimed to investigate antioxidant activity of various extracts from fruiting bodies and mycelia of two Phellinus linteus strains and P. baumii. The Phellinus strains have cultivated on oak and mulberry logs. The fruiting bodies species were harvested from each Phellinus strain and used in this study. The tested items include: 2, 2’-azinobis[3-ethylbenzthiazoline]-6-sulfonic acid (ABTS), free radical scavenging assay and determination of total phenolics contents (TPC), ferric reducing antioxidant power assay (FRAP), and DPPH (1, 1-diphenyl-2- picrylhydrazyl) radical-scavenging activities. Different extractions with 60% Ethyl alcohol, 70% methyl alcohol and heat water were done on the mycellial and fruiting bodies samples of the mushroom species. The methyl alcohol extraction from fruiting body of P. linteus KACC93057P displayed the highest antioxidant activity on ABTS, FRAP, and DPPH assays. The ethyl acetate fraction was concentrated and subjected to an ODS column chromatography, followed by Sephadex LH-20 column chromatography. Finally six compounds 1-6 were detected by preparative reversed-phase HPLC.
( A Reum Han ),( Tae Kwon Moon ),( Im Kyeung Kang ),( Dae Bong Yu ),( Yechan Kim ),( Cheolhwan Byon ),( Sujeong Park ),( Hae Lin Kim ),( Kyoung Jin Lee ),( Heuiran Lee ),( Ha-na Woo ),( Seong Who Kim 생화학분자생물학회 2024 BMB Reports Vol.57 No.6
Adult hippocampal neurogenesis plays a pivotal role in maintaining cognitive brain function. However, this process diminishes with age, particularly in patients with neurodegenerative disorders. While small, non-coding microRNAs (miRNAs) are crucial for hippocampal neural stem (HCN) cell maintenance, their involvement in neurodegenerative disorders remains unclear. This study aimed to elucidate the mechanisms through which miRNAs regulate HCN cell death and their potential involvement in neurodegenerative disorders. We performed a comprehensive microarray-based analysis to investigate changes in miRNA expression in insulin-deprived HCN cells as an in vitro model for cognitive impairment. miR-150-3p, miR-323-5p, and miR-370-3p, which increased significantly over time following insulin withdrawal, induced pronounced mitochondrial fission and dysfunction, ultimately leading to HCN cell death. These miRNAs collectively targeted the mitochondrial fusion protein OPA1, with miR-150-3p also targeting MFN2. Data-driven analyses of the hippocampi and brains of human subjects revealed significant reductions in OPA1 and MFN2 in patients with Alzheimer’s disease (AD). Our results indicate that miR-150-3p, miR-323-5p, and miR-370-3p contribute to deficits in hippocampal neurogenesis by modulating mitochondrial dynamics. Our findings provide novel insight into the intricate connections between miRNA and mitochondrial dynamics, shedding light on their potential involvement in conditions characterized by deficits in hippocampal neurogenesis, such as AD. [BMB Reports 2024; 57(6): 281-286]
김영운,권정환,권혜린,김동욱,서은해,양정원,이광우,정유지,정원주,이경순,Kim, Young-un,Kwon, Jung-hwan,Kwon, Hea-lin,Kim, Dong-wook,Seo, Eun-hae,Yang, Jung-won,Lee, Kwang-woo,Jeong, Yu-ji,Jeong, Won-joo,Lee, Kyung-soon 대한물리치료과학회 2015 대한물리치료과학회지 Vol.22 No.2
Background : The purpose of this study was to investigate the effects of taping on the neck rotation angle in the elderly. Methods : The twenty-eight elderly aged over 60 and twenty-seven college students participated in the study. In both groups, neck rotation angles were measured through CROM before and after taping. SPSS 18.0 was used for data analysis. Results : The results indicated that both groups showed significant increases in the neck rotation angles of the affected side after taping. However, there was no significant difference in the rotation angle of both neck regions after taping. The variation of the student group was higher than that of the elderly group after taping. Conclusion : We think that taping can be effective in balancing the neck muscles of both sides and in increasing the rotation angle of the neck.
Chondroitin Sulfate-Based Biomineralizing Surface Hydrogels for Bone Tissue Engineering
Kim, Hwan D.,Lee, Eunjee A.,An, Young-Hyeon,Kim, Seunghyun L.,Lee, Seunghun S.,Yu, Seung Jung,Jang, Hae Lin,Nam, Ki Tae,Im, Sung Gap,Hwang, Nathaniel S. American Chemical Society 2017 ACS APPLIED MATERIALS & INTERFACES Vol.9 No.26
<P>Chondroitin sulfate (CS) is the major component of glycosaminoglycan in :connective tissue. In this study, we fabricated methacrylated PEGDA/CS-based hydrogels with varying CS concentration (0, 1, 5, and 10%) and investigated them as biomineralizing three-dimensional scaffolds for charged ion binding and depositions. Due to its negative charge from the sulfate group, CS exhibited an osteogenically favorable microenvironment by binding charged ions such as calcium and phosphate. Particularly, ion binding and distribution within negatively charged hydrogel was dependent on CS concentration. Furthermore, CS dependent biomineralizing microenvironment induced osteogenic differentiation of human tonsil-derived mesenchymal stem cells in vitro. Finally, when we transplanted PEGDA/CS-based hydrogel into a critical sized cranial defect model for 8 weeks, 10% CS hydrogel induced effective bone formation with highest bone mineral density. This PEGDA/CS-based biomineralizing hydrogel platform can be utilized for in situ bone formation in addition to being an investigational tool for in vivo bone mineralization and resorption mechanisms.</P>