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Zhang Wentao,Zheng Zongtai,Wang Keyi,Mao Weipu,Li Xue,Wang Guangchun,Zhang Yuanyuan,Huang Jianhua,Zhang Ning,Wu Pengfei,Liu Ji,Zhang Haimin,Che Jianping,Peng Bo,Zheng Junhua,Li Wei,Yao Xudong 생화학분자생물학회 2023 Experimental and molecular medicine Vol.55 No.-
Accumulating studies have confirmed that PIWI-interacting RNAs (piRNAs) are considered epigenetic effectors in cancer. We performed piRNA microarray expression analysis on renal cell carcinoma (RCC) tumor tissues and paired normal tissues and performed a series of in vivo and in vitro experiments to explore piRNAs associated with RCC progression and investigate their functional mechanisms. We found that piR-1742 was highly expressed in RCC tumors and that patients with high piR-1742 expression had a poor prognosis. Inhibition of piR-1742 significantly reduced tumor growth in RCC xenograft and organoid models. Mechanistically, piRNA-1742 regulates the stability of USP8 mRNA by binding directly to hnRNPU, which acts as a deubiquitinating enzyme that inhibits the ubiquitination of MUC12 and promotes the development of malignant RCC. Subsequently, nanotherapeutic systems loaded with piRNA-1742 inhibitors were found to effectively inhibit the metastasis and growth of RCC in vivo. Therefore, this study highlights the functional importance of piRNA-related ubiquitination in RCC and demonstrates the development of a related nanotherapeutic system, possibly contributing to the development of therapeutic approaches for RCC.
Effects of chlorantraniliprole on detoxification enzymes activities in Locusta migratoria L.
Guangchun Cao,Miao Jia,Xia Zhao,Lei Wang,Xiongbing Tu,Guangjun Wang,Xiangqun Nong,Zehua Zhang 한국응용곤충학회 2017 Journal of Asia-Pacific Entomology Vol.20 No.3
The broad insecticide chlorantraniliprole causes death by activating the ryanodine receptor, and its effects on detoxification enzymes limit its proper rotation and mixed use with other pesticides. Therefore, we studied the changes in detoxification enzymes activities of Locusta migratoria L. nymphs induced by chlorantraniliprole. When nymphs of locust were treated with chlorantraniliprole only on the first day, the LC50 was 4.8 μg mL−1, and the activities of esterases (ESTs) and glutathione S-transferases (GSTs) increased, but the activity of multifunction oxidases (MFOs) increased only at 3 day after treatment, although the activities fluctuated over 7 days after treatment. When the nymphs of locust were treated for 7 days, the LC50 was 2.3–3.1 μg mL−1, and similarly the activities of ESTs and GSTs increased while that of MFOs decreased significantly in a concentrationdependent manner. Synergism of triphenylphosphate, piperonyl butoxide, and diethyl maleate with chlorantraniliprole toxicity confirmed the correlation between chlorantraniliprole and changes in ESTs, GSTs, and MFOs activities. Herein, we improved the knowledge about the effects of chlorantraniliprole on these detoxification enzymes of L. migratória. These results clarified the effects of chlorantraniliprole on the activities of ESTs, GSTs, and MFOs in L. migratoria, and will provide insight into its proper rotation and mixed use with other pesticides.
Xunbing Huang,Huihui Wu,Xiongbing Tu,Zhuoran Zhang,Hongtian Su,Yongming Shi,Guang-Jun Wang,Guangchun Cao,Xiangqun Nong,Zehua Zhang 한국응용곤충학회 2016 Journal of Asia-Pacific Entomology Vol.19 No.1
Outbreaks of grasshoppers (Orthoptera: Acrididae) often cause serious ecological damage. Recently, there has been interest in using natural enemies of grasshopper for their biological control. This study examined the biology and predation on grasshoppers by Eremias argus, a common lizard in Inner Mongolia. Its developmental duration and life history are consistent with adaptation to grasshopper phenology. The diet structure of E. argus included grasshoppers, beetles, ants, leafhoppers, moths, bees and spiders. A positive correlation between E. argus population numbers and grasshopper population numbers was highly significant. We built models describing the functional response and intraspecific competition for E. argus adults. The functional feeding response of E. argus on grasshopper was classed as Holling type III. The maximum number of grasshoppers consumed by female and male adults were 11.2 and 7.0 individuals per day, respectively. Predatory ability was strongest in female adults, with the second and third instars of Oedaleus asiaticus preferred. The predation ratios(E) of E. argus on grasshoppers declinedwith increasing lizard density, especially for female adult E. argus. E. argus could play an important role in grasshopper control and maintaining a population of E. argus in the grassland ecosystemcould effectively control low-density grasshopper populations on grassland. Suggestions on how E. argus could fit into an IPM programme for biological control of grasshopper are discussed.