신이식 환자에서 자발적으로 발생한 저구연산뇨증 연관성 요관 결석로

나정구,공성민,이동규,김성민,장윤정,김성록,이유지 이화여자대학교 의과학연구소 2015 EMJ (Ewha medical journal) Vol.38 No.3

Urolithiasis is an uncommon complication in renal transplantation. We report a case of hypocitraturia-related ureteral steinstrasse which was spontaneously formed in a renal transplant recipient. The patient who underwent renal transplantation was admitted with acute pyelonephritis. Hydronephrosis in the transplanted kidney and multiple stones (steinstrasse) in the distal ureter were incidentally found on computed tomography scanning. After a failed attempt of ureteroscopic removal of stones, the patient underwent open ureterolithotomy and ureteroureterostomy. On stone analysis, carbonate apatite was confirmed. Urinary citric acid levels were decreased to 127.6 mg/day. Potassium citrate was administered to prevent stone recurrence by increasing urinary citrate excretion. No recurrence of stones was shown six months later. Urolithiasis in renal transplant recipients requires a high index of suspicion. Hypocitraturia can increase the risk for urolithiasis. Rapid recognition by careful surveillance, prompt removal of stones, and precautionary efforts to prevent recurrence are needed.

귀인 훈련이 경도 정신지체아동의 무력감과 학업성취 및 태도에 미치는 효과

여광응,구유미,이정현,김선미 한국특수교육문제연구소 2001 특수교육저널 : 이론과 실천 Vol.2 No.1

이 연구의 목적은 경도 정신지체아동의 학습된 무력감을 감소시키기 위하여 체계적인 귀인훈련를 적용함으로써 학업성취능력과 학습태도 개선에 미치는 영향을 밝히는데 있다. 연구대상은 개인용 지능검사 결과 IQ 60-75사이이고 초등학교 특수학급에서 시간제 특수교육을 받고 있는 이동 3 명으로서 신체 및 언어장애와 같은 심한 장애가 없는 아동이다. 연구결과, 귀인훈련이 오랜 학교학습상황에서 겪게 된 학습의 실패상황에서 실패원인을 「능력」에 귀인하는 아동을 「노력」 에 귀인하도록 힘으로써 아동의 「학습된 무력감」 를 감소시키는데 효과적임이 밝려졌다. 즉,뺄셈학습과제의 수행속도가 귀인훈련 후 빨라졌으며 과제에 대한 흥미도 많이 증가하였다. 또한 귀인훈련이 경도 정신지체 아동의 학습태도를 개선하였다. 귀인훈련 후 아동의 실패과제에 대한 지속시간이 많이 늘어났으며, 아울러 실패과제에 대한 불안행동이 많이 감소하였고, 주의집중이 향상되며 학습태도가 바람직히게 변화된 것으로 나타났다. 이 결과는 귀인훈련을 통해 경도 정신지체아동의 학업성취도와 학습태도에 긍정적인 변화를 가져올 수 있음이 확인되었다. The purpose of the present study is to investigate how systematic atributional training affects leaming achievements and leaming attitudes for the children with mild mental retardation through decreasing their feelings of learned helplessness. For the study, three children with mental retardation, whose 1Qs range from 60 to 75, were selected from those who were enrolled at special classes of elementary schools. They do not have physical handicapped and language problems. The procedure applied to this study focused on the changes the reason for the learning failure from "their ability" to "their lack of effort".

Study of the Correlation Between the Doped-Oxygen Species and the Supercapacitive Performance of TiC–CDC Carbon-Based Material

Yu Gu,Ruijun Zhang,Wenyu Wu,Bin Guo,Ping Wang,Huaxin Ma 성균관대학교(자연과학캠퍼스) 성균나노과학기술원 2019 NANO Vol.14 No.11

O-doping has proved to be one of the most promising approaches to further enhance the supercapacitive performance of carbon materials. However, it is presently not clear how the type of doped-O species affects the capacitive performance. In this paper, an attempt has been made to probe into the possible correlation between the type of doped-O species and the corresponding capacitive performance. Three O species (C=O, C–O and O–C=O) have been introduced onto TiC-derived carbon (TiC–CDC) by using a facile room-temperature oxidation strategy with three typical oxidizing agents (H2O2, HNO3 and (NH4)-2S2O8), respectively. The results have shown that as the content of the C=O species increases, both the specific capacitance and the capacitance retention for the oxidized TiC–CDC samples become higher, showing a positively correlative performance. This work suggests that optimizing the type of doped-O species will be great potential for obtaining the optimal electrochemical performances for the O-doped carbon materials.

Systematic Evaluation and Meta-Analysis of the Effect of Gynostemma pentaphyllum on Clinical Indexes of Hyperlipidemia

Yu-Long Gu,Xiang-Lan Piao 한국생약학회 2023 Natural Product Sciences Vol.29 No.4

The purpose of this study was to explore the clinical efficacy and safety of Gynostemma pentaphyllum (G. pentaphyllum) in the treatment of hyperlipidemia, and to provide systematic evaluation basis for clinical application. CNKI, Wanfang Data, VIP, Web of science, PubMed, Embase and Cochrane Library were searched for randomized controlled trials (RCTs) about G. pentaphyllum in the treatment of hyperlipidemia. Review Manager 5.4 were used for statistical analysis. Through reading topics, abstracts, and full texts, 27 papers with 2311 cases involved that met the inclusion and exclusion criteria were finally included for the analysis. In terms of curative effect, the effect of G. pentaphyllum alone in increasing high density lipoprotein (HDL) index was better than that of conventional treatment, and the effect of reducing total cholesterol (TC), triglyceride (TG) and low density lipoprotein (LDL) was similar to that of conventional treatment. There was a synergistic effect between G. pentaphyllum and conventional drugs, and the combination of G. pentaphyllum and conventional drugs was superior to conventional treatment in reducing TG and increasing HDL. G. pentaphyllum can also decrease the levels of serum glutamic pyruvic transaminase and glutamic oxaloacetic transaminase in the treatment of hyperlipidemia, indicating a certain protective function of the liver. In terms of safety, there were fewer cases of adverse reactions in the G. pentaphyllum treatment group, and the adverse reaction events reported in the literature was mild. According to the results of meta-analysis, G. pentaphyllum was effective in the treatment of hyperlipidemia, and it has the potential to be combined with traditional drugs, has a certain liver protection function, and was superior to traditional drugs in the treatment of hyperlipidemia.

Cytotoxic Effect of Oyster Mushroom Pleurotus ostreatus on Human Androgen-Independent Prostate Cancer PC-3 Cells

Yu-Huan Gu,Gowsala Sivam 한국식품영양과학회 2006 Journal of medicinal food Vol.9 No.2

Twenty species of edible mushrooms and three purified mushroom polysaccharides were screened for their an-titumor potential on human androgen-independent cancer PC-3 cells. A water-soluble extract (POE) prepared from the freshoyster mushroom Pleurotus ostreatusproduced the most significant cytotoxicity on PC-3 cells among the mushroom speciestested. At the same time, POE induced a rapid apoptosis on PC-3 cells detected with annexin V-fluorescein isothiocyanateflow cytometry when the cells were exposed to POE (150 .g/mL) for 2 hours. Induced apoptosis was also confirmed by DNAfragment terminal deoxynucleotidyl transferase-mediated X-dUTP nick end labeling staining while POE (200 .g/mL) wasadded to PC-3 cells for 6 hours. Both cytotoxicity and induced apoptosis mediated by POE in PC-3 cells are dose-dependent.Interestingly, PC-3 cells appeared to be more sensitive to POE in anchorage-independent growth condition. Tumor colony-forming efficiency was dramatically reduced to 4.5% or 0.5% in POE (60 or 120 .g/mL)-supplemented soft agar mediumcompared with that of POE-free medium (defined as 100%). Temperature in POE processing plays a decisive role for the cy-totoxic activity. Bioactivity of POE was eliminated by exposure to high temperature (80°C) for 2 hours; however, it remained

A Comprehensive Review of Emerging Computational Methods for Gene Identification

Yu, Ning,Yu, Zeng,Li, Bing,Gu, Feng,Pan, Yi Korea Information Processing Society 2016 Journal of information processing systems Vol.12 No.1

Gene identification is at the center of genomic studies. Although the first phase of the Encyclopedia of DNA Elements (ENCODE) project has been claimed to be complete, the annotation of the functional elements is far from being so. Computational methods in gene identification continue to play important roles in this area and other relevant issues. So far, a lot of work has been performed on this area, and a plethora of computational methods and avenues have been developed. Many review papers have summarized these methods and other related work. However, most of them focus on the methodologies from a particular aspect or perspective. Different from these existing bodies of research, this paper aims to comprehensively summarize the mainstream computational methods in gene identification and tries to provide a short but concise technical reference for future studies. Moreover, this review sheds light on the emerging trends and cutting-edge techniques that are believed to be capable of leading the research on this field in the future.

Sirolimus and Non-melanoma Skin Cancer Prevention after Kidney Transplantation: A Meta-analysis

Gu, Yu-Hong,Du, Jia-Xin,Ma, Man-Ling Asian Pacific Journal of Cancer Prevention 2012 Asian Pacific journal of cancer prevention Vol.13 No.9

Background: Whether sirolimus is useful in the prevention of non-melanoma skin cancer (NMSC) remains unclear and we therefore performed this meta-analysis of randomized controlled trials to test the hypothesis that Sirolimus-based immunosuppression is associated with a decrease in NMSC. Methods: The main outcomes were NMSC, squamous-cell carcinoma and basal-cell carcinoma. The pooled risk ratio (RR) with its 95% confidence interval (95%CI) were used to assess the effects. Results: 5 randomized trials involving a total of 1499 patients receiving kidney transplantation were included. Patients undergoing Sirolimus-based immunosuppression had much lower risk of NMSC (RR = 0.49, 95%CI 0.32-0.76, P = 0.001). Subgroup analyses by tumor type showed that Sirolimus-based immunosuppression significantly decreased risk of both squamous-cell carcinoma (RR = 0.58, 95%CI 0.43-0.78, P < 0.001) and basal-cell carcinoma (RR = 0.56, 95%CI 0.37-0.85, P = 0.006). The quality of evidence was high for NMSC, and moderate for squamous-cell carcinoma and basal-cell carcinoma. No evidence of publication bias was observed. Conclusion: High quality evidence suggests that Sirolimus-based immunosuppression decreases risk of non-melanoma skin cancer, and Sirolimus has an antitumoral effect among kidney-transplant recipients.

In situ doping control and electrical transport investigation of single and arrayed CdS nanopillars

Gu, Leilei,Liu, Xi,Kwon, Kyungmook,La, Chih-Chung,Lee, Min Hyung,Yu, Kyoungsik,Chueh, Yu-Lun,Fan, Zhiyong The Royal Society of Chemistry 2013 Nanoscale Vol.5 No.16

<P>Highly aligned intrinsic and indium doped CdS nanopillar arrays were fabricated via a template assisted Solid Source Chemical Vapor Deposition method (SSCVD). The prepared nanopillar arrays were well aligned, dense and uniform in diameter and length. Their geometry can be well defined by the design of the templates. These unique properties make them promising candidates for future photonic and optoelectronic devices. The structure of the prepared nanopillars has been studied by high resolution transmission electron microscopy and their different growth orientation as compared to those grown in free space has been observed and interpreted by the template induced change of the liquid-solid interfacial energy and the surface tension at the edge of the circular interface. To investigate electrical property of CdS nanopillars, vertical nanopillar array devices and horizontal individual nanopillar field-effect transistors have been fabricated and characterized. The measurements showed that the location of the indium doping source significantly affected carrier concentration, conductivity and field-effect mobility of the prepared CdS nanopillars. Particularly, it was found that conductivity could be improved by 4 orders of magnitude and field-effect mobility could be enhanced up to 50 cm(2) V(-1) s(-1) via proper doping control. These results enable further applications of CdS nanopillars in nano-optoelectronic applications such as photodetection and photovoltaics in the future.</P>

Applicative Value of Serum CA19-9, CEA, CA125 and CA242 in Diagnosis and Prognosis for Patients with Pancreatic Cancer Treated by Concurrent Chemoradiotherapy

Gu, Yu-Lei,Lan, Chao,Pei, Hui,Yang, Shuang-Ning,Liu, Yan-Fen,Xiao, Li-Li Asian Pacific Journal of Cancer Prevention 2015 Asian Pacific journal of cancer prevention Vol.16 No.15

Objective: To evaluate the application value of serum CA19-9, CEA, CA125 and CA242 in diagnosis and prognosis of pancreatic cancer cases treated with concurrent chemotherapy. Materials and Methods: 52 patients with pancreatic cancer, 40 with benign pancreatic diseases and 40 healthy people were selected. The electrochemiluminescence immunoassay method was used for detecting levels of CA19-9, CEA and CA125, and a CanAg CA242 enzyme linked immunoassay kit for assessing the level of CA242. The Kaplan-Meier method was used for analyzing the prognostic factors of patients with pancreatic cancer. The Cox proportional hazard model was applied for analyzing the hazard ratio (HR) and 95% confidential interval (CI) for survival time of patients with pancreatic cancer. Results: The levels of serum CA19-9, CEA, CA125 and CA242 in patients with pancreatic cancer were significantly higher than those in patients with benign pancreatic diseases and healthy people (P<0.001). The sensitivity of CA19-9 was the highest among these, followed by CA242, CA125 and CEA. The specificity of CA242 is the highest, followed by CA125, CEA and CA19-9. The sensitivity and specificity of joint detection of serum CA19-9, CEA, CA125and CA242 were 90.4% and 93.8%, obviously higher than single detection of those markers in diagnosis of pancreatic cancer. The median survival time of 52 patients with pancreatic cancer was 10 months (95% CI7.389~12.611).. Patients with the increasing level of serum CA19-9, CEA, CA125, CA242 had shorter survival times (P=0.047. 0.043, 0.0041, 0.029). COX regression analysis showed that CA19-9 was an independent prognostic factor for patients with pancreatic cancer (P=0.001, 95%CI 2.591~38.243). Conclusions: The detection of serum tumor markers (CA19.9, CEA, CA125 and CA242) is conducive to the early diagnosis of pancreatic cancer and joint detection of tumor markers helps improve the diagnostic efficiency. Moreover, CA19-9 is an independent prognostic factor for patients with pancreatic cancer.

Deep Learning in Genomic and Medical Image Data Analysis: Challenges and Approaches

Yu, Ning,Yu, Zeng,Gu, Feng,Li, Tianrui,Tian, Xinmin,Pan, Yi Korea Information Processing Society 2017 Journal of information processing systems Vol.13 No.2

Artificial intelligence, especially deep learning technology, is penetrating the majority of research areas, including the field of bioinformatics. However, deep learning has some limitations, such as the complexity of parameter tuning, architecture design, and so forth. In this study, we analyze these issues and challenges in regards to its applications in bioinformatics, particularly genomic analysis and medical image analytics, and give the corresponding approaches and solutions. Although these solutions are mostly rule of thumb, they can effectively handle the issues connected to training learning machines. As such, we explore the tendency of deep learning technology by examining several directions, such as automation, scalability, individuality, mobility, integration, and intelligence warehousing.