http://chineseinput.net/에서 pinyin(병음)방식으로 중국어를 변환할 수 있습니다.
변환된 중국어를 복사하여 사용하시면 됩니다.
Helicobacter pylori promotes hepatic fibrosis in the animal model
Goo, Moon-Jung,Ki, Mi-Ran,Lee, Hye-Rim,Yang, Hai-Jie,Yuan, Dong-Wei,Hong, Il-Hwa,Park, Jin-Kyu,Hong, Kyung-Sook,Han, Jung-Youn,Hwang, Ok-Kyung,Kim, Dong-Hwan,Do, Sun-Hee,Cohn, Ronald D,Jeong, Kyu-Shik Springer Science and Business Media LLC 2009 Laboratory investigation Vol.89 No.11
<P>Helicobacter pylori infection has been reported to be very common in patients with chronic liver diseases, including cirrhosis. To elucidate the pathological effect of H. pylori infection on the progression of hepatic fibrosis, C57BL/6 mice and Sprague-Dawley rats were orally inoculated with H. pylori, and hepatic fibrosis was induced with carbon tetrachloride (CCl(4)) administration. We observed the histopathological changes and the presence of H. pylori genes by PCR in the liver. Significant increase in the fibrotic score as well as in serum alanine aminotransferase and aspartate aminotransferase levels was shown in the CCl(4)+H. pylori group compared with that in the CCl(4)-treated group. Compared with the CCl(4)-treated group, alpha-smooth muscle actin and transforming growth factor-beta1 were enhanced; however, senescence marker protein-30, a multifunctional protein protecting hepatocytes against oxidative stress and apoptosis, was suppressed in the CCl(4)+H. pylori group. The 16S rRNA (400 bp) was demonstrated by PCR for H. pylori genes from genomic DNA extracted from the liver, and H. pylori-infected mice showed 93.8% (15 of 16) seropositivity by contrast with seronegativity in all H. pylori-noninfected mice. In addition, immunohistochemical study against H. pylori showed positive antigen fragments in the liver of the infected groups. Consequently, our data suggest that H. pylori infection could be an important contributing infectious factor to the development of liver cirrhosis.</P>
Multiple urogenital abnormalities in a Persian cat
Goo, Moon-Jung,Williams, Bruce H.,Hong, Il-Hwa,Park, Jin-Kyu,Yang, Hai-Jie,Yuan, Dong-Wei,Lee, Hye-Rim,Hong, Kyung-Sook,Ki, Mi-Ran,Jeong, Kyu-Shik Elsevier 2009 JOURNAL OF FELINE MEDICINE AND SURGERY Vol.11 No.2
<P>A 1.5-year-old female Persian cat was presented for inappetence and azotemia. Ultrasonography and urography revealed multiple abnormalities involving the genitourinary tract, including agenesis of the right kidney and ureter. Gross examination of the abnormal uterus revealed segmental aplasia of right caudal uterine horn causing cranial distension with fluid, a normal left uterine horn, and both normal ovaries. Microscopically, endometrial glands of the right uterine horn were markedly decreased in number. The right uterine horn was hemorrhagic suggesting estrus. This is the first report of this combination of urinary and uterus abnormalities in the veterinary literature.</P>
Goo, Hyun Woo,Yang, Dong Hyun,Park, In-Sook,Ko, Jae Kon,Kim, Young Hwee,Seo, Dong-Man,Yun, Tae-Jin,Park, Jeong-Jun RADIOLOGICAL SOCIETY OF NORTH AMERICA INC 2007 Journal of Magnetic Resonance Imaging Vol.25 No.4
<B>Purpose</B><P>To evaluate the usefulness of time-resolved three-dimensional (3D) magnetic resonance angiography (MRA) using diluted contrast agent (CA) in patients who had undergone a Fontan operation or bidirectional cavopulmonary connection (BCPC).</P><B>Materials and Methods</B><P>Time-resolved 3D MRA (10 dynamic data sets, two seconds per dynamic data set) using parallel imaging and keyhole data sampling was performed on 15 patients (median age = 10 years, range = 1–20 years) who had undergone a Fontan operation (N = 11) or BCPC (N = 4). Diluted gadolinium (Gd) contrast agent (CA) was intravenously injected into the arm and/or leg veins. The flow dynamics and morphology of pulmonary circulation, and lung perfusion were assessed.</P><B>Results</B><P>Preferential or balanced pulmonary blood flow from each systemic vein was visualized on time-resolved 3D MRA in all patients. In addition, occlusion/stenosis of the central thoracic vein (N = 4) and pulmonary artery (N = 6), systemic venous (N = 5) and arterial (N = 6) collaterals, and lung perfusion defect (N = 4) were identified. Persistent hepatic venous plexus, pulmonary arteriovenous malformation, and axillary arteriovenous fistula were delineated in three patients, respectively.</P><B>Conclusion</B><P>Time-resolved 3D MRA with diluted CA is useful for evaluating patients who have undergone a Fontan operation or BCPC because it can reveal the flow dynamics and morphology of pulmonary circulation, and lung perfusion status. J. Magn. Reson. Imaging 2007. © 2007 Wiley-Liss, Inc.</P>
Yang, Chul-Su,Yuk, Jae-Min,Ko, Sung-Ryong,Cho, Byung-Goo,Sohn, Hyun-Joo,Kim, Young-Sook,Wee, Jae-Joon,Do, Jae-Ho,Jo, Eun-Kyeong The Korean Society of Ginseng 2008 Journal of Ginseng Research Vol.32 No.4
In the previous studies, we isolated the compound K rich fractions (CKRF) and showed that CKRF inhibited Toll-like receptor (TLR) 4- or TLR9-induced inflammatory signaling. To extend our previous studies,1) we investigated the molecular mechanisms of CKRF in the TLR4-associated signaling via nuclear factor (NF)-${\kappa}B$, and in vivo role of CKRF for induction of tolerance in lipopolysaccharide (LPS)-induced septic shock. In murine bone marrow-dervied macrophages, CKRF significantly inhibited the induction of mRNA expression of proinflammatory mediators such as tumor necrosis factor-${\alpha}$, interleukin-6, cyclooxygenase-2, and inducible nitric oxide synthase. In addition, CKRF significantly attenuated the transcriptional activities of TLR4/LPS-induced NF-${\kappa}B$. Nuclear translocation of NF-${\kappa}B$ in response to LPS stimulation was significantly abrogated by pre-treatment with CKRF. Furthermore, CKRF inhibited the recruitment of p65 to the interferon-sensitive response element flanking region in response to LPS. Finally, oral administration of CKRF significantly protected mice from Gram-negative bacterial LPS-induced lethal shock and inhibited systemic inflammatory cytokine levels. Together, these results demonstrate that CKRF modulates the TLR4-dependent NF-${\kappa}B$ activation, and suggest a therapeutic role for Gram-negative septic shock.
항생물질 생산 토양 Actinomycetes 균주 선별과 항생물질 생산특성 조사
구양모(Yang Mo Goo),이윤영(Youn Young Lee),정연숙(Youn Sook Chung),이영복(Young Bok Lee),조영애(Young Ae Joe),조희영(Hee Yeong Cho),고영선(Young Sun Koh),이창훈(Chang Hoon Lee) 대한약학회 1991 약학회지 Vol.35 No.3
Selective culture of actinomycetes from soil microbes and their antibiotic producing characters by agar-disk method were examined. Some of the organisms which produced antibiotics on agar disk did not produce antibiotics in liquid culture. Further examination indicated that production of antibiotic was dependent on the composition of medium. Many streptomycestes produced antibacterial substances in tryptic soy broth but others produced antifungal antibiotics in V-8 broth. Production of antibacterial substances by Streptomyces sp. was also dependent on the medium composition.
( In Sook Kang ),( Joowon Suh ),( Mi-ni Lee ),( Chaeyoung Lee ),( Jing Jin ),( Changjin Lee ),( Young Il Yang ),( Yangsoo Jang ),( Goo Taeg Oh ) 생화학분자생물학회 2020 BMB Reports Vol.53 No.2
Cardiac regeneration with adult stem-cell (ASC) therapy is a promising field to address advanced cardiovascular diseases. In addition, extracellular vesicles (EVs) from ASCs have been implicated in acting as paracrine factors to improve cardiac functions in ASC therapy. In our work, we isolated human cardiac mesenchymal stromal cells (h-CMSCs) by means of three-dimensional organ culture (3D culture) during ex vivo expansion of cardiac tissue, to compare the functional efficacy with human bone-marrow derived mesenchymal stem cells (h-BM-MSCs), one of the actively studied ASCs. We characterized the h-CMSCs as CD90<sup>low</sup>, c-kit<sup>negative</sup>, CD105<sup>positive</sup> phenotype and these cells express NANOG, SOX2, and GATA4. To identify the more effective type of EVs for angiogenesis among the different sources of ASCs, we isolated EVs which were derived from CMSCs with either normoxic or hypoxic condition and BM-MSCs. Our in vitro tube-formation results demonstrated that the angiogenic effects of EVs from hypoxia-treated CMSCs (CMSC-Hpx EVs) were greater than the well-known effects of EVs from BM-MSCs (BM-MSC EVs), and these were even comparable to human vascular endothelial growth factor (hVEGF), a potent angiogenic factor. Therefore, we present here that CD90<sup>low</sup>c-kit<sup>negative</sup>CD105<sup>positive</sup> CMSCs under hypoxic conditions secrete functionally superior EVs for in vitro angiogenesis. Our findings will allow more insights on understanding myocardial repair. [BMB Reports 2020; 53(2): 118-123]
복막 중피 세포에서 IL-1β 자극에 의한 MCP-1과 RANTES의 생성
송인숙,이상구,박정식,양원석,김순배,윤견일 대한신장학회 2000 Kidney Research and Clinical Practice Vol.19 No.5
Human peritoneal mesothelial cells may have a great potential to secrete chemokines, growth factors, adhesion molecules, and various cytokines stimulated with proinflammatory cytokines during peritoneal infection. In the course of peritonitis, rapid neutrophil cell influx and subsequent monocytic cell influx can be observed. It has been demonstrated that human peritoneal mesothelial cells secrete a C-X-C chemokine, IL-8, which contributes to the recruitment of neutrophil influx during peritoneal infection. However, the production and role of C-C chemokines have not been fully defined in human peritoneal mesothelial cells. This study was performed to evaluate the production of MCP-1 and RANTES and their influence on the chemotaxis of monocytes when human peritoneal mesothelial cells were stimulated with IL-1β. Mesothelial cells obtained by enzymatic digestion of pieces of human omentum and stimulated with a various doses and times of IL-1β. The expression of MCP-1 and RANTES mRNA was measured by Northern bloassay and the expression of their proteins was analyzed by ELISA. To evaluate their function, monocytes chemotaxis assay was performed using a 48-well chemotactic chamber. Cultured human peritoneal mesothelial cells appeared to be polygonal at confluence using phase contrast microscope. Indirect immunofluorescent staining demonstrated that the mesothelial cells reacted positively with anti-cytokeratin antibody and anti-vimentin antibody. The expression of MCP-1 and RANTES mRNA increased in response to IL-1β in time and dose dependent manner. The protein levels of MCP-1 and RANTES with stimulation of 1.0ng/mL of IL-1β for 24 hours were higher than those without(30.0±2.22 vs 3.55±0.74ng/105cells and 1.53±0.41 vs 0.11±0.02ng/105cells respectively, p$lt;0.05, n=6). Chemotaxis assay showed that the supernatants from human peritoneal mesothelial cells with stimulation of IL-1β for 24 hours had significantly higher chemotaxis of monocytes than those without(71±3.4% vs 50±2.9%, p$lt;0.05, n=6). Coincubation of sup with stimulation and antibodies to MCP-1 or RANTES(20μL/mL, lOμL/mL, respectively) resulted in a significant inhibition of chemotaxis of monocytes by 33% and 12%(47±3.1% and 62±3.0% respectively, p$lt;0.05, n=6). Human peritoneal mesothelial cells are capable of the expression of MCP-1 and RANTES mRNA and the production of their proteins in response to IL-1β. Functionally, mesothelial cells derived Mand RANTES may contribute to the recruitment of monocytes and amplify the inflammatory process. Thus, human peritoneal mesothelial cells play an important role during peritoneal infection.
Mixed Osteosarcoma with Metastatic Alveolar Carcinomatous Appearance in Canine Mammary Gland Tumor
Moon-Jung Goo(구문정),Il-Hwa Hong(홍일화),Jin-Kyu Park(박진규),Hai-Jie Yang(양해걸),Dong-Wei Yuan(위엔동웨이),Mi-Ran Ki,(기미란),Hye-Rim Lee(이혜림),Kyung-Sook Hong(홍경숙),Jung-Youn Han(한정연),Ok-Kyung Hwang(황옥경),Tae-Hwan Kim,( 한국생명과학회 2007 생명과학회지 Vol.17 No.12
본 증례는 개의 유선에서 발생한 골형성성의 악성 혼합 유선 종양으로 샘포의 암종성 변화를 동반하고 있다. 종양은 12년령 암캐의 좌측 5번째 유선에서 절제되었으며 직경 2~2.5㎝의 단단한 mass로 절단 시 경도가 높은 골성의 구조를 가지고 있었다. 현미경학적 관찰 시, 골유사 물질이 미네랄 침착되고 있었으며 다수의 골형성 세포와 일부 파골세포가 골생성 종양 기질 전반에 걸쳐서 관찰되었다. 이러한 골유사 병변은 높은 밀집도를 보이는 근상피 세포와 연접하고 있었으며 이러한 세포들은 수 개의 유사분열상을 나타내고 있었다. 이와 더불어, 유선세관과 샘포의 암종성 변화를 보이는 세포들이 인접 기질로 침습하고 있는 모습이 관찰되었고 이것 역시 증가된 근상피 세포들로 둘러싸여 있었다. 본 증례에서 볼 수 있는 이러한 세포들의 출현은 동시 발생된 악성 종양의 형태를 제시할 수 있으며 종양의 기원은 상피 유래의 암종성 조직과 중간엽 유래의 육종성 연골 및 골 조직으로 구별할 수 있겠다. We describe here a case of malignant mixed osteogenic tumor of the mammary gland with alveolar carcinomatous appreance. A firm, 2 to 2.5cm (in diameter) mass under the 5th nipple, showing the structure of extraosseous osteogenic sarcoma, was removed from the left 5th mammary gland of 12-year-old female dog. When investigated under the microscope, the osteoid material undergoing mineralization was surrounded by numerous scattered osteoblasts and a few osteoclastic cells throughout the osteoid tumorous stroma. The osteoid lesions were continuous with hypercellular myoepithelial cells of a very immature character with several mitotic figures. In addition, there were also carcinomatous tubules and alveoli, with invading cells into peripheral stroma, surrounded by myoepithelial cells in the mammary gland. In these lesions, emanating cords of tumor cells appear to be continuous with the myoepithelial cell layer of a duct. The presence of all these cell types suggests the existence of a common malignant origin, the stem cell being differentiated into epithelial carcinomatous and mesenchymal sarcomatous chondral and osteogenic tissues.