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Phuc Nguyen Thien,Giang Nguyen Thi Huong,An Vu Nguyen Thien Truong,Nam Nguyen Thanh Hoai,Anh Ly Duc,Nguyen Huynh Cam,An Hoang,Phong Mai Thanh,Hieu Nguyen Huu 한국탄소학회 2023 Carbon Letters Vol.33 No.2
In this study, graphene oxide (GO) was synthesized by the improved Hummers’ method. The degree of oxidation from graphite (Gi) to GO was determined through interlayer spacing calculated from X–ray diffraction. Besides, the effect of KMnO4:Gi ratios (X1), H2SO4 volume (X2), oxidation temperature (X3), oxidation time of stage 1 (X4), and oxidation time of stage 2 (X5) was screened by the Plackett–Burman model. The simultaneous impact of three factors that influenced the degree of oxidation (X1, X2, and X3) was studied by the Box–Behnken experimental model of response surface methodology to achieve suitable conditions for the GO synthesis process. The characterization of GO product was investigated via the modern analytical methods: X-ray diffraction, Raman spectroscopy, Fourier transform infrared spectroscopy, UV–Vis spectroscopy, field emission scanning electron microscopy, transmission electron microscopy, and atomic force microscopy. In addition, the study was also carried out on a pilot scale for orientation in industrial application with the yield of 14 g/batch.
Oleuropein induces apoptosis in colorectal tumor spheres via mitochondrial fission
김다연,Park Sangmi,윤지수,Jang Woong Bi,비누스,Van Le Thi Hong,Giang Ly Thanh Truong,최재우,Lim Hye ji,권상모 대한독성 유전단백체 학회 2023 Molecular & cellular toxicology Vol.19 No.2
Background 5-Fluorouracil (5-FU) has been used as a standard chemotherapeutic agent for colorectal cancer (CRC). However, chemo-resistant cancer cells can survive under chemotherapeutic regimens, resulting in cancer recurrence. Thus, a novel approach is required to overcome chemo-resistance in CRC. Objective Recently, oleuropein (OLP), an extract derived from olive leaves, has shown anticancer eff ects and induces apoptosis in cancer cells; however, the role of OLP in 5-FU-resistant cells remains to be elucidated. Therefore, we have assessed the anticancer eff ect of OLP on tumor spheres and 5-FU-resistant cells, but also synergistic eff ect in combination of OLP and 5-FU. Results Our fi ndings revealed that OLP had a marked suppressive eff ect on tumor sphere formation capacity. Annexin V-PI staining data showed that OLP-induced apoptosis occurred in a dose-dependent manner. Mitochondrial fragmentation and mitochondrial superoxide production were observed following treatment with OLP. OLP treatment drastically suppressed the metastatic potential, including cell migration ability and anchorage-independent growth capability. In addition, combination treatment with 5-FU and OLP revealed a synergistic eff ect on cell viability in DLD-1 cells and 5-FU-resistant cells. Conclusion These fi ndings showed the suppressive eff ects of OLP against the colorectal tumor spheres and 5-FU-resistant cells. In addition, these results off er the new insights into novel therapeutic strategies for combining 5-FU and OLP in patients with chemo-resistant CRC.
endothelial progenitor cells via regulation of the AKT signaling pathway
Jian Zhang,Thi Hong Van Le,Vinoth Kumar Rethineswaran,Yeon-Ju Kim,Woong Bi Jang,Seung Taek Ji,Thanh Truong Giang Ly,Jong Seong Ha,Jisoo Yun,Jae Hun Cheong,Jinsup Jung,Sang-Mo Kwon 대한생리학회-대한약리학회 2021 The Korean Journal of Physiology & Pharmacology Vol.25 No.5
Cardiovascular disease (CVD) and its complications are the leading cause of morbidity and mortality in the world. Because of the side effects and incomplete recovery from current therapy, stem cell therapy emerges as a potential therapy for CVD treatment, and endothelial progenitor cell (EPC) is one of the key stem cells used for therapeutic applications. The effect of this therapy required the expansion of EPC function. To enhance the EPC activation, proliferation, and angiogenesis using dronedarone hydrochloride (DH) is the purpose of this study. DH received approval for atrial fibrillation treatment and its cardiovascular protective effects were already reported. In this study, DH significantly increased EPC proliferation, tube formation, migration, and maintained EPCs surface marker expression. In addition, DH treatment up-regulated the phosphorylation of AKT and reduced the reactive oxygen species production. In summary, the cell priming by DH considerably improved the functional activity of EPCs, and the use of which might be a novel strategy for CVD treatment.
장웅비,지승택,박지혜,Kim Yeon-Ju,Kang Songhwa,김다연,이나경,김진수,Lim Hye Ji,최재우,LE THI HONG VAN,LY THANH TRUONG GIANG,비누스,김동환,하종성,윤지수,Baek Sang Hong,권상모 한국조직공학과 재생의학회 2020 조직공학과 재생의학 Vol.17 No.3
BACKGROUND: Despite promising advances in stem cell-based therapy, the treatment of ischemic cardiovascular diseases remains a big challenge due to both the insufficient in vivo viability of transplanted cells and poor angiogenic potential of stem cells. The goal of this study was to develop therapeutic human cardiac progenitor cells (hCPCs) for ischemic cardiovascular diseases with a novel M13 peptide carrier. METHOD: In this study, an engineered M13 peptide carrier was successfully generated using a QuikChange Kit. The cellular function of M13 peptide carrier-treated hCPCs was assessed using a tube formation assay and scratch wound healing assay. The in vivo engraftment and cell survival bioactivities of transplanted cells were demonstrated by immunohistochemistry after hCPC transplantation into a myocardial infarction animal model. RESULTS: The engineered M13RGD?SDKP peptide carrier, which expressed RGD peptide on PIII site and SDKP peptide on PVIII site, did not affect morphologic change and proliferation ability in hCPCs. In contrast, hCPCs treated with M13RGD?SDKP showed enhanced angiogenic capacity, including tube formation and migration capacity. Moreover, transplanted hCPCs with M13RGD?SDKP were engrafted into the ischemic region and promoted in vivo cell survival. CONCLUSION: Our present data provides a promising protocol for CPC-based cell therapy via short-term cell priming of hCPCs with engineered M13RGD?SDKP before cell transplantation for treatment of cardiovascular disease.
Quan T. Lai,Vu Anh Tuan,Dinh Kim Dieu,Alexander B. Orfinger,Ngo Minh Ly,Nguyen Thanh Ha,Trinh Truong Giang 한국해양과학기술원 2022 Ocean science journal Vol.57 No.4
This study aimed to analyze the sex ratio, spawning seasons, length at first maturity, length distribution, length–weight relationship, and relative condition factor of Cultellus maximus (Gmelin, 1791) in Southern Vietnam. A total of 1037 individuals of C. maximus were collected at 3 sampling sites from June, 2019 to June, 2020. The sex ratio was found to be female biased in Can Gio and male biased in Phu Tan and Ngoc Hien. The clam spawns throughout the year, peaking at Q2 and Q3 during the rainy season. Pooled length at first maturity was 10.12 cm (9.65–10.49 cm CI 95%, P-value < 2.2·10–16). The length–weight relationship indicates positive allometric growth. This study suggests that imposing a minimum harvest size limit on C. maximus using the length at first maturity as reference and with harvest seasons in Q1 in Ngoc Hien and Can Gio and Q2 or Q3 in Phu Tan would be ideal for consumption of this species.
Park Ji Hye,Kim Hyeok,Moon Hyung Ryong,박봉우,Park Jae-Hyun,Sim Woo-Sup,Kim Jin-Ju,Lim Hye Ji,Kim Yeon-Ju,지승택,장웅비,Rethineswaran Vinoth Kumar,Van Le Thi Hong,Giang Ly Thanh Truong,Yun Jisoo,Ha Jong Seong 생화학분자생물학회 2021 Experimental and molecular medicine Vol.53 No.-
Stem cell-based therapies with clinical applications require millions of cells. Therefore, repeated subculture is essential for cellular expansion, which is often complicated by replicative senescence. Cellular senescence contributes to reduced stem cell regenerative potential as it inhibits stem cell proliferation and differentiation as well as the activation of the senescence-associated secretory phenotype (SASP). In this study, we employed MHY-1685, a novel mammalian target of rapamycin (mTOR) inhibitor, and examined its long-term priming effect on the activities of senile human cardiac stem cells (hCSCs) and the functional benefits of primed hCSCs after transplantation. In vitro experiments showed that the MHY-1685‒primed hCSCs exhibited higher viability in response to oxidative stress and an enhanced proliferation potential compared to that of the unprimed senile hCSCs. Interestingly, priming MHY-1685 enhanced the expression of stemness-related markers in senile hCSCs and provided the differentiation potential of hCSCs into vascular lineages. In vivo experiment with echocardiography showed that transplantation of MHY-1685‒primed hCSCs improved cardiac function than that of the unprimed senile hCSCs at 4 weeks post-MI. In addition, hearts transplanted with MHY-1685-primed hCSCs exhibited significantly lower cardiac fibrosis and higher capillary density than that of the unprimed senile hCSCs. In confocal fluorescence imaging, MHY-1685‒primed hCSCs survived for longer durations than that of the unprimed senile hCSCs and had a higher potential to differentiate into endothelial cells (ECs) within the infarcted hearts. These findings suggest that MHY-1685 can rejuvenate senile hCSCs by modulating autophagy and that as a senescence inhibitor, MHY-1685 can provide opportunities to improve hCSC-based myocardial regeneration.