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Clinicopathological features of the intraductal papillary neoplasms of the intrahepatic bile duct
Gi-Woong Jang,Shin Hwang,Yong-Joo Lee,Ki-Hun Kim,Kwang-Min Park,Chul-Soo Ahn,Deok-Bog Moon,Tae-Yong Ha,Gi-Won Song,Dong-Hwan Jung,Gil-Chun Park,Sung-Gyu Lee 한국간담췌외과학회 2012 한국간담췌외과학회지 Vol.16 No.4
Backgrounds/Aims: This study is intended to investigate the clinicopathological features of the intraductal papillary neoplasms of the intrahepatic bile duct (IPNB), especially focused on malignant changes. Methods: From the institutional database of liver resection cases (Asan Medical Center, University of Ulsan College of Medicine), 18 patients who met the definition of IPNB were selected. They had undergone liver resection between February 2002 and October 2006; thus, the follow-up period was more than 5 years. Results: Of the 18 patients, 11 patients were male. Their mean age was 61.3±6.7 years. There were no differences between the non-malignant and malignant lesions, in the comparison of the CEA levels (5.6±2.7 vs.12.6±31.1 ng/ml, p=0.439) and the CA19-9 levels (29.2±34.7 vs.31.9±30.2 ng/ml, p=0.871). The common radiologic findings were: intraductal growing mass in 10; bile duct dilatation in 6; and saccular duct dilatation in 2. Left and right hepatectomies were performed in 15 and 3, respectively. Five patients showed benign lesions of IPNB, and 13 patients revealed malignant lesions of intraductal papillary adnocarcinoma or cholangiocarcinoma. All 4 patients with benign lesions survived for a mean period of 53 months without recurrence. In 13 patients with the malignant lesions, 1-year, 3-year, and 5-year survival rates were 100%, 84.6%, and 59.2%, respectively. Conclusions: We concluded that intrahepatic IPNB is a rare type of biliary neoplasm which includes a histological spectrum, ranging from benign disease to invasive malignancy. The long-term survival was anticipated after complete curative resection. (Korean J Hepatobiliary Pancreat Surg 2012;16:138-141)
Jang Ju-hong,Lee Jeong Woong,Cho Min Ji,Hwang Byungtae,Kwon Min-Gi,Kim Dong-Hwan,Lee Nam-Kyung,Lee Jangwook,Park Young-Jun,Yang Yong Ryoul,Kim Jinchul,Kim Yong-Hoon,An Tae Hyeon,오경진,Bae Kwang-Hee,Park 생화학분자생물학회 2022 Experimental and molecular medicine Vol.54 No.-
Obesity is a growing global epidemic that can cause serious adverse health consequences, including insulin resistance (IR) and nonalcoholic fatty liver disease (NAFLD). Obesity development can be attributed to energy imbalance and metabolic inflexibility. Here, we demonstrated that lack of Kelch-like protein 3 (KLHL3) mitigated the development of obesity, IR, and NAFLD by increasing energy expenditure. KLHL3 mutations in humans cause Gordon’s hypertension syndrome; however, the role of KLHL3 in obesity was previously unknown. We examined differences in obesity-related parameters between control and Klhl3−/− mice. A significant decrease in body weight concomitant with fat mass loss and improved IR and NAFLD were observed in Klhl3−/− mice fed a high-fat (HF) diet and aged. KLHL3 deficiency inhibited obesity, IR, and NAFLD by increasing energy expenditure with augmentation of O2 consumption and CO2 production. Delivering dominant-negative (DN) Klhl3 using adeno-associated virus into mice, thereby dominantly expressing DN-KLHL3 in the liver, ameliorated diet-induced obesity, IR, and NAFLD. Finally, adenoviral overexpression of DN-KLHL3, but not wild-type KLHL3, in hepatocytes revealed an energetic phenotype with an increase in the oxygen consumption rate. The present findings demonstrate a novel function of KLHL3 mutation in extrarenal tissues, such as the liver, and may provide a therapeutic target against obesity and obesity-related diseases.
장영운(Jang Young Woon),최연웅(Choi Yun Woong),조기성(Cho Gi Sung) 대한공간정보학회 2009 한국공간정보학회 학술대회 Vol.2009 No.4
지형정보에 대한 3차원 재현 및 지리정보의 제공에 관한 연구는 최근 진행되는 여러 분야에 걸쳐 진행되어 왔다. 지형정보의 효율적인 제공을 위해서는 현재까지 구축된 정보들을 체계적으로 수정ㆍ갱신함은 몰론이며, 이후에 변경된 최신의 지형정보를 신속하고 경제적으로 취득할 필요성이 있다. 특히 최근에 많은 연구와 활용이 진행되고 있는 LiDAR 시스템은 지형정보에 제공이 가능한 3차원 공간데이터를 손쉽고 조밀하게 취득할 수 있는 이점이 있다. 3차원의 공간을 표현하기 위한 자료로써 LiDAR의 3차원 자료는 매우 적합하지만, 자료를 변환없이 그대로 사용할 경우 3차원으로 구성된 점 자료의 특성상 화면을 통한 2차원의 형태로 나타내기 위해서는 많은 연산 처리가 필요하기 때문에 높은 사양의 처리 프로세서가 필요하다. 이에 비해 기본적으로 2차원 형태로 구성된 격자구조자료는 간단한 구조와 처리속도로 인하여 벡터구조에 비하여 저가의 장비에서도 가능한 장점이 있다. 본 연구에서는 LiDAR 자료를 3차원 자료로 제공할 경우 처리속도를 고려하여 2차원 격자 형태의 자료로 재구성하되 세밀한 표현을 위한 데이터 용량을 고려하여 트리구조를 응용한 압축자료로 변환하는 기법을 제시하고자 한다.
카메라와 초음파센서 융합에 의한 이동로봇의 주행 알고리즘
장기동 ( Gi Dong Jang ),박상건 ( Sang Keon Park ),한성민 ( Sung Min Han ),이강웅 ( Kang Woong Lee ) 한국항행학회 2011 韓國航行學會論文誌 Vol.15 No.5
본 논문에서는 단일 카메라와 초음파센서 데이터를 융합하는 이동 로봇 주행제어 알고리즘을 제안하였다. 이진화 영상처리를 위한 임계값을 영상 정보와 초음파센서 정보를 이용하는 퍼지추론기법으로 설정하였다. 임계값을 상황에 따라 가변하면 조도가 낮은 환경에서도 장애물 인식이 향상된다. 카메라 영상 정보와 초음파 센서 정보를 융합하여 장애물에 대한 격자지도를 생성하고 원궤적 경로기법으로 장애물을 회피하도록 한다. 제안된 알고리즘의 성능을 입증하기 위하여 조도가 낮은 실내와 좁은 복도에서 Pioneer 2-DX 이동로봇의 주행제어에 적용하였다. In this paper, we propose a mobile robot navigation algorithm using data fusion of a monocular camera and ultrasonic sensors. Threshold values for binary image processing are generated by a fuzzy inference method using image data and data of ultrasonic sensors. Threshold value variations improve obstacle detection for mobile robot to move to the goal under poor illumination environments. Obstacles detected by data fusion of camera and ultrasonic sensors are expressed on the grid map and avoided using the circular planning algorithm. The performance of the proposed method is evaluated by experiments on the Pioneer 2-DX mobile robot in the indoor room with poor lights and a narrow corridor.
The Effect of Different Resistance Training on Fitness and Blood Lactate
( Hyun-gi Kim ),( Dong-hee Kim ),( Dong-soo Park ),( Dae-yeol Kim ),( Seon-woong Jang ) 한국체육학회 2016 국제스포츠과학 학술대회 Vol.2016 No.1
Purpose: The purpose of this study was to investigate the effect of 12 weeks of complex training and weight training on fitness related skills and blood lactate concentration in college soccer players. Method: Total of 21 college soccer players were participated in this study and were randomly divided into one of three groups (complex training group (n = 7, CT), weight training group (n = 7, WT) or control group (n = 7, CON). The subjects in CT and WT groups performed complex exercise and weight exercise, respectively (60 minutes per session and 3 times per week for 12 weeks). During training sessions, the subjects in CON group performed normal soccer exercise program. Before and after training period, fitness related skills (strength, power, muscle endurance and estimated aerobic capacity) and blood lactate concentration were measured. Baseline comparisons among three groups for all variables were evaluated by one-way analysis of variance (ANOVA). Two-way repeated measures ANOVA with post-hoc testing was utilized. Result: In the results, abdominal strength in WT group was significantly increased, but not in CT and CON groups. The record of 1000m running (estimated aerobic capacity) in CT group was significantly decreased but not in WT and CON groups. Lactate resistance, however, was not changed for all groups. Conclusion: These results indicated that other several fitness related skills in CT group slightly tended to be increased, but not in WT and CON groups. Thus, complex training may be appropriated for soccer players compared to weight training and no additional training. It may be improved when additional training is utilized with higher intensity or longer training period.