관상용 블랙테트라(Gymnocorymbus ternetzi)에 있어서 trichlorfon의 급성 및 아급성 독성

장예승, 허강준 충북대학교 동물의학연구소 2008 Journal of Biomedical and Translational Research Vol.9 No.3

본문참고

Dual source CT 장비의 high pitch(flash) mode를 이용한 하지동맥검사의 유용성 분석

강헌효(Heon Hyo Gang),손성실(Seong Sil Son),김준혁(Junh Yeok Kim),박찬혁(Chan Hyeok Park),이예나(Ye Na Lee),김경환(Kyeong Whan Kim),신명호(Myeong Ho Sin),김민재(Min Jae Kim),강동원(Dong Won Gang) 대한CT영상기술학회 2012 대한CT영상기술학회지 Vol.14 No.2

목적 Dual source CT 장비의 high pitch mode를 이용하여 넓은 영역의 검사를 요하는 하지동맥검사에 적용 가능여부와 스캔시간의 감소에 따른 환자의 움직임의 최소화와 피폭선량 감소의 효과에 대해 알아보고자 한다. 대상 및 방법 2011년 10월 1일부터 2012년 2월 29일까지 본원에 방문하여 기존의 하지동맥검사방법으로 검사한 후 추적검사 시 high pitch mode로 검사한 50명의 환자를 대상으로 MDCT 128 row dual source; Somatom Definition Flash(Siemens medical system: Germany) 장비를 사용하여 검사하였다. 검사방법은 기존의 검사방법에 high pitch mode 적용여부를 알아보기 위해 AAPM 팬텀을 이용하여 기존의 검사법과 high pitch mode로 각각 스캔 후 Noise, Uniormity, Sparial resolution의 팬텀영상의 화질을 비교하였다. 또한 기존의 영상방법으로 얻은 영상과 high pitch mode로 얻은 영상에서 Aorta, both femoral artery, both distal artery에 각각 ROI를 그려 SD값을 비교하였다. 통계분석은 SPSS version 12.0 for window의 독립표본 T-test 검정방법을 사용하였다. 환자의 선량비교를 위해 CT 장비에서 제공하는 DLP(dose length product)와 유효선량(effective dose) 이용하여 비교하였으며 유효선량은 DLP값에 검사부위별로 국제적으로 정해져 있는 부위별 환산지수 conversion factor를 곱하여 계산하였다. 결과 AAPM 팬텀영상에서 산출된 Noise, Uniormity, Spatial resolution에 대해서는 기존 검사법과 high pitch mode를 적용한 검사는 크게 차이가 없으며 환자를 대상으로 검사한 영상에서도 SD값을 비교한 T 검정결과 유의수준 0.05(신뢰구간 95%)에서 유의확률이 각각 Aorta(low: 0.096, high: 0.099), Rt.FA(low: 0.265, high: 0.265), Lt.FA(low: 0.195, high: 0.196) Rt.Dis(low: 0.575, high: 0.575), Lt.Dis(low: 0.286, high: 0.287)로 유의적 차이가 없었다. 또한 선량면에서 기존의 검사방법에 비해 high pitch mode 검사방법은 27.8%의 선량감소 효과가 있었다. 결론 Dual source MDCT의 high pitch mode 하지동맥 검사방법은 기존의 하자동맥검사에 적용가능하며 넓은 영역의 검사를 요하는 하지동액검사에 있어 빠른 검사시간으로 환자의 움직임을 최소화하며 피폭선량을 경감시킬 수 있는 유용한 검사라 사료된다. I. Purpose It is to find out movement minimization caused by the fast scan time, effectiveness of dose reduction and the possibility of application on lower extremity angiography examination which needs long range scans in using high pitch mode of Dual source CT. II. Meterial and Methods It is studied with 50 patients who visited Pusan National Uni. Yangsan Hospital(PNUYH) for lower extremity angiography examination from 2011, 1 Oct to 2012, 30 Jan. MDCT 128 row dual source; somatom definition flash (Siemens medical system: Germany) was used as an equipment and high pitch mode is applied. The quality of phantom images which is divided into three sections; noise, Uniformity, Spatial resolution was compared after each scan in the general test method and the high pitch mode. It is to know that the general scan mode can be replaced with the high pitch mode. Each. Ra (region of importance) was drawn in aorta, both femoral artery, both distal artery images acquired in the general scan mode and the high pitch mode then SD (standard deviation) values were compared. Independent sample T-test of SPSS version 12.0 for window was used in statistical analysis. DLP (dale length product) and effective dose provided from the CT equipment were compared for patient’s dose comparison. Effective dose was calculated from multiplying DLP by the international standard conversion factor. III. Result There are no differences of Noise, Uniformity and Spatial resolution from AAPM phantom between the high pitch mode examination and common examinations. The T experiment results from SD figures that are compared with in clinical conditions also have no differences. Significant probabilities in 0.05 significance level(95% confidence interval) are Aorta(low: 0.096, high: 0.099), Rt.FA(low: 0.265, high: 0.265), Lt.FA(low: 0.195, high: 0.196), Rt.Dis(low: 0.575, high: 0.575), Lt,Dis(low: 0.286, high: 0.287) each. The high pitch mode examination method dropped radiation dose of 27.8% as compared with the general scan mode. IV. Conclusions The high pitch mode of dual source MDCT can be applied to a general mode on the lower extremity angiography. It is regarded as a useful method that is able to have dose reduction and minimize a movement of patients due to the fast scan In the case of the lower extremity angiography examination witch needs long area scan.

P288 : The effect of PPARa activator containing moisturizer in patients with facial erythema

( Ye Seul Kim ),( Han Eul Lee ),( Gang Mo Lee ),( Je Min An ),( Young Lip Park ),( Moon Kyun Cho ),( Jong Kyung Youm ),( Sang Hoon Lee ) 대한피부과학회 2013 대한피부과학회 학술발표대회집 Vol.65 No.2

Background: Atopic dermatitis, seborrheic dermatitis, irritant or allergic contact dermatitis, rosacea, and acne are skin diseases that cause repeated facial erythema. Topical steroids are used to treat these dermatologic condition and long term use of topical steroids can cause complication such as skin atrophy, telangiectasia, and steroid induced acneiform eruption. PPARα is known to regulate keratinocyte differentiation and proliferation, and also participates in wound healing and skin inflammation. Objectives: This study is about the effect of PPARα activator containing moisturizers in patients with facial erythema by improving anti-inflammatory action and skin barrier function. Methods: 32 patients were included in this study and they were applied with PPARα activator containing moisturizers in one side of the face, and the other side with moisturizers not containing PPARα activator. They were applied twice a day two days a week and the study was double blinded, body-split study. The patients were checked of skin hydration, TEWL, and erythema the first day of hospital visit and 2 weeks after the study. Clinical photo analysis was done for checking erythema index and the result was assessed with doctor and patient survey. Results: Patients applied with PPARα activator containing moisturizer showed significant decrease of erythema measurement using mexameter, and decreased erythema index from photo analysis. No significant difference was noted in skin hydration and TEWL. Conclusion: We confirmed the effect and safety of PPARα activator containing moisturizers and anticipate it as a useful treatment for patients with facial erythema.

Butyrolactones Derivatives from the Fermentation Products of an Endophytic Fungus Aspergillus versicolor

Ye, Yan-Qing,Xia, Cong-Fang,Yang, Juan-Xia,Yang, Yu-Chun,Qin, Ying,Gao, Xue-Mei,Du, Gang,Li, Xue-Mei,Hu, Qiu-Fen Korean Chemical Society 2014 Bulletin of the Korean Chemical Society Vol.35 No.10

Two new butyrolactones, asperphenol A (1) and B (2), together with four known butyrolactones (3-6) were isolated from the fermentation products of an endophytic fungus Aspergillus versicolor. Their structures were elucidated by spectroscopic methods including extensive 1D- and 2D-NMR techniques. Compounds 1-6 were also tested for their anti-tobacco mosaic virus (anti-TMV) activities. The results showed that compound 2 exhibited high anti-TMV activity with inhibition rate of 46.7%. The other compounds also exhibited potential anti-TMV activities with inhibition rates in the range of 21.8-28.4%.

Fine-Mapping of a Major Quantitative Trait Locus q2ID1 for Rice Stem Diameter

( Ye-ji Lee ),( Yeisoo Yu ),( Hyeonso Ji ),( Gang-sub Lee ),( Nam-in Hyung ),( Keunpyo Lee ),( Tae-ho Kim ) 한국육종학회 2021 Plant Breeding and Biotechnology Vol.9 No.4

Rice culm is an important trait for determining rice lodging yield, and stem diameter has been suggested as a yield-related trait; however, studies for the genetic basis of its phenotypic variation are still required. In this study, we used 160 recombination inbred lines derived from a cross of two different rice varieties [‘Milyang23’ (Tongil rice) and ‘Giho’ (japonica)] for quantitative trait locus (QTL) mapping with nine stem traits. The analysis showed that QTLs for the diameters of the first, second, third and fourth internode traits were independently separated in the top of chromosome 1, whereas four lengths of internodes were estimated as being related to the semidwarf1 (sd1) gene. A major-effect QTL (q2ID1) was identified that the overlapped region of our previous mapping with a large genomic region. Therefore, we performed high-resolution genetic mapping for fine-mapping of q2ID1 to a ~140 kb region between Ind1_1 and Ind1_2 of genetic markers, with candidate genes predicted using a reference genome. We ultimately identified nine of the 15 candidate genes with specific gene functions and analyzed the sequence variations between two parents. These results offer valuable gene and/or genetic information on stem diameter to improve lodging resistance and yield.

Study on the Flavor Contribution of Phospholipids and Triglycerides to Pork

Ye-Chuan Huang,Hong-Jun Li,Zhi-Fei He,Ting Wang,Gang Qin 한국식품과학회 2010 Food Science and Biotechnology Vol.19 No.5

For investigating the flavor contribution of phospholipids and triglycerides to pork, the longissimus muscle of Rongchang (RC) and PIC (bred by PIC Company of England) pig were selectively removed of intramuscular triglycerides or total intramuscular lipids. After cooking, the flavor of different samples was compared by sensory evaluation, gas chromatographymass spectrometry (GC-MS), and electronic nose. The results showed that removing triglycerides had little effect on the aroma of the cooked meat, but when total intramuscular lipids were removed a remarkable difference was observed. The control samples covaried strongly with some lipid-derived products, and the petroleum ether defatted samples also positively related to these compounds,but to a lesser extent, both of them negatively covaried with chloroform-methanol extracted samples which associated with some Maillard reaction products. Moreover the flavor difference between 2 breeds would decrease when triglycerides were removed, and reduce further when phospholipids and triglycerides were removed simultaneously. These results suggested that intramuscular lipids especially phospholipids contributed significantly to pork flavor, the flavor difference between 2 breeds resulted mainly from different intramuscular lipids content and composition.

Up-dating of new dCAPS markers for mapping yield-related traits using MGRIL

Ye-Ji Lee,Hyun-Ju Lee,In-Seon Jeong,Seon-Hwa Bae,Hyeon-So Ji,Gang-Seob Lee,Ung-Han Yoon,Jang-Ho Hahn,Tae-Ho Kim 한국육종학회 2015 한국육종학회 심포지엄 Vol.2015 No.07

The next-generation sequencing(NGS) technology is being used for more effective genetic mapping. In previous study, we obtained 60x coverage of sequence from Milyang23 and Gihobyeo on average comparing with Nipponbare reference genome. Also, we developed new derived cleaved amplified polymorphic sequence(dCAPS) markers based on the single nucleotide polymorphisms(SNPs) in coding region sequence(CDS) between these varieties. Totally, 1,726,798 SNPs between Milyang23 and Gihobyeo were detected. Among them, 146 SNP were selected for making dCAPS markers and located on genetic map with previously reported 219 PCR-based DNA markers. The map was applied to the detection of quantitative trait loci(QTLs) for stem internode diameters, culm length and panicle length within MGRIL population, and six QTLs with relatively high LOD score were found at three chromosomes; culm length and stem diameter including the first internode diameter, third and fourth internode diameter. This study showed that the NGS allowed the rapid discovery of a large number of SNPs for dCAPS marker. So, we tried to find out more single nucleotide polymorphisms(SNPs) which were located on the whole genome sequence, such as un-translated region(UTR), intron, Inter-region and coding region sequence(CDS) between Milyang23 and Gihobyeo varieties. And we collected phenotypic information about culm length, panicle length, four stem internode diameters and panicle number in rice MGRIL population for QTLs. Furthermore, results of QTL analysis described above will shows relevance of molecular markers in mapping genes for useful breeding.

Mapping QTLs for Root Morphological Traits in Brassica rapa Based on AFLP and RAPD Markers

Gang Lu,Jiashu Cao,Wanzhi Ye,Xun Xiang,Hang Chen 한국원예학회 2006 한국원예학회 기타간행물 Vol.- No.-

Hsa-miR-181a-5p Expression and Effects on Cell Proliferation in Gastric Cancer

Chen, Gang,Shen, Zhi-Li,Wang, Ling,Lv, Chun-Ye,Huang, Xin-En,Zhou, Rong-Ping Asian Pacific Journal of Cancer Prevention 2013 Asian Pacific journal of cancer prevention Vol.14 No.6

Purpose: MicroRNAs (miRNAs) are small endogenous, non-coding, single-stranded RNAs (approximately 22 nt). Accumulating evidence has shown that aberrant miRNA expression is pronounced and correlated with gastric cancer genesis and progression. Materials and Methods: Expression levels of miR-181a-5p in GC tissues and cell lines were assessed by qRT-PCR and tested for correlation with clinical features. In addition, effects of miR-181a-5p on GC cell growth were investigated. Results: Our findings indicate that miR-181a-5p is upregulated in GC, in correlation with lymph node invasion, nerve invasion and vascular invasion (P<0.05). Enforced expression of miR-181a -5p promoted cell proliferation ability. Conclusions: This study suggested that increased miR-181a-5p is related to GC progression. MiR-181a-5p may represent a potential therapeutic target for GC.

만성 B형 간염 환자에서 Pegylated 인터페론 알파2a 치료 중 발생한 원형 탈모

김예슬 ( Ye Seul Kim ),이강모 ( Gang Mo Lee ),배유인 ( You In Bae ),박영립 ( Young Lip Park ),이상훈 ( Sang Hoon Lee ) 대한피부과학회 2014 大韓皮膚科學會誌 Vol.52 No.1

Recent studies recommend pegylated interferon alpha2a as the first choice treatment for chronic hepatitis B, especially when the patient is negative for HBeAg. Pegylated interferon alpha is known to show variable side effects including skin symptoms, with alopecia as the most common dermatologic side effect experienced for 10% up to 36%. pcc) Most alopecia cases related to pegylated interferon alpha were presented with telogen effluvium pattern, but alopecia areata cases are reported rarely. In this case, typically localized alopecia areata was presented with pegylated interferon alpha2a treatment in hepatitis B patient, and the course of alopecia areata seemed to be related with administration and discontinuation of pegylated interferon alpha2a. (Korean J Dermatol 2014;52(1):40∼43)