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( Ga Won Song ),( Sun Young Shin ),( Kyu Hyun Han ),( Suk Pyo Shin ),( Seong Gyu Hwang ),( Kyu Sung Rim ),( Hana Park ) 대한내과학회 2014 대한내과학회 추계학술발표논문집 Vol.2014 No.1
Background/Aim: Transarterial chemoembolization (TACE) is one of the locolesional treatment modalities for hepatocellular carcinoma (HCC). However, disease progression after TACE is often developed. The aim of our study was to determine the predictors of progression after TACE in patients with HCC. Method: We retrospectively reviewed a total of 374 patients who had diagnosed as HCC and performed the fi rst TACE in our institution, Bundang CHA hospital, from 2004 January to 2013 September. Tumor response was estimated as CR (complete response), PR (partial response), SD (stable disease) and PD (progressive disease) based on the results of computed tomography 4 weeks after TACE with modifi ed RECIST criteria.Results: Among a total 374 patients, 13 patients(3.5%) had experienced previous TACE, and 361 patients(96.5%) were TACE naive. Most patients(n=370, 98.9%) had liver cirrhosis, 289 patients(77.3%) were classifi ed as Child-Pugh class A and 85 patients( 22.2%) as Child-Pugh class B. After 4 weeks after TACE, tumor response was as follows: CR 146(39.0%), PR 124(3.2%), SD 16(4.3%) and PD 88(23.5%). In patients with PD, there was a signifi cantly greater portion of TACE experienced patients compared to those with CR, PR, and SD(8.0 vs. 2.1%, p=0.016). The mean size of largest tumor and total sum of tumor sizes were signifi cantly greater in patients with PD(6.4 vs. 3.6 cm of largest tumor size, p<0.001; 7.0 vs 4.1 cm of total sum of tumor sizes, p=0.001, respectively). In multivariate analysis, previous TACE experience[Odds ratio (OR) 8.746, p=0.002] and a total sum of tumor sizes( = 3cm; OR 4.022, p=0.016, = 10cm; OR 9.153, p=0.008) were predictors of progression after TACE.Conclusion: Progression of HCC after TACE is associated with history of previous TACE experience and the total sum of tumor sizes. * Ga Won Song and Sun Young Shin contributed equally.
A Demand Analysis of the Theme Park Using An Ordered Logit Model
Song, Ga-Young(송가영),Kim, Eui-June(김의준),Yoon, Min-Kyoung(윤민경) 한국지역개발학회 2009 韓國地域開發學會誌 Vol.21 No.1
본 연구에서는 국내 테마파크 방문자들의 인구통계학적 특징에 따른 테마파크의 수요를 분석하였다. 본 연구에서는 테마파크의 수요예측을 위해 순위 자료 분석에 적합한 순서형 로짓 모형 (Ordered Logit Model)을 사용하였다. 분석결과 테마파크 방문자가 주 5일 근무형태를 가질 경우 테마파크 방문을 결정하는데 긍정적인 영향을 끼쳤으며, 테마파크를 자주 방문할 경우 가까운 곳을 선호하였다. 방문자의 직업(소득)차이보다는 직업의 유무가 테마파크 방문에 영향을 끼쳤다. 이는 테마파크의 방문을 결정하는데 이용자간의 소득 격차보다 소득의 안정성이 더 중요하다는 것을 보여준다. 방문자의 연령변수를 살펴보면 나이가 어릴수록 자주 테마파크를 방문하겠다는 의견이 많은 것을 알 수 있다. 이런 확률의 증가는 20대까지만 나타났으며, 30대 초반 이후로는 급격한 감소현상을 보였다. 테마파크의 방문 결정은 근무형태, 직장, 결혼, 자녀출산 등 이용자의 개인적 특징과 테마파크와 거주지의 접근성 정도에 의해 결정되었다.
( Ga Young Lee ),( Hyung-jun Kim ),( Myung Jin Song ),( Yeon Wook Kim ),( Byung Soo Kwon ),( Sung Yoon Lim ),( Yeon-Joo Lee ),( Jong Sun Park ),( Ho Il Yoon ),( Jae Ho Lee ),( Choon-taek Lee ),( Young 대한결핵 및 호흡기학회 2021 대한결핵 및 호흡기학회 추계학술대회 초록집 Vol.129 No.-
Background As cases of pneumothorax have been reported in coronavirus disease 2019 (COVID-19) patients, it is suspected as a complication of COVID-19. However, it has not been proven whether COVID-19 is associated with causing pneumothorax by comparing non-COVID-19 pneumonia under mechanical ventilation (MV). The purpose of this study was to evaluate the impacts of COVID-19 on pneumothorax development in mechanically ventilated patients. Methods A retrospective cohort study was performed in an intensive care unit (ICU) at tertiary, academic hospital, from February 2020 to March 2021. Occurrence of pneumothorax between COVID-19 and non-COVID-19 pneumonia group was assessed including their baseline clinical characteristics. Risk factors of pneumothorax and association with COVID-19 were analyzed by logistic regression model. Results Of the 135 patients, 48 (35.5%) patients were diagnosed with COVID-19. In COVID-19 patients, 30 (63.5%) were male, median age was 66.5 years and 10 (20.8%) developed pneumothorax, which occurred only 4 (4.6%) in non-COVID-19 (P=0.008). Compared to non-COVID-19, COVID-19 patients had lower P/F ratio at ICU admission (84.1 [69.8;126.1] vs. 144 [104.2;217.2], P=0.001) and higher MV settings [positive end expiratory pressure (PEEP) 10.0 [10.0;12.0] vs. 8.0 [6.0;10.0], P=0.001, pressure above PEEP 16.6 ± 5.2, 17.0 ± 4.0, P=0.068]. Co-morbidities tended to be more various in non-COVID19 patients. In the univariate analysis for the risk factors of pneumothorax, PEEP (OR 1.26, P<0.01,) and COVID-19 (OR 5.46, P=0.001) were significantly associated with the development of pneumothorax, where only COVID-19 (OR 14.0, P=0.030) was an exclusive risk factors in the multivariate analysis. Conclusions In patients with pneumonia who underwent MV, COVID-19 could be a decisive risk factor on the occurrence of pneumothorax.
( Ga Young Lee ),( Sukki Cho ),( Jin-haeng Chung ),( Hyung-jun Kim ),( Myung Jin Song ),( Byung Soo Kwon ),( Sung Yoon Lim ),( Yeon-joo Lee ),( Jong Sun Park ),( Young-jae Cho ),( Ho Il Yoon ),( Jae H 대한결핵 및 호흡기학회 2021 대한결핵 및 호흡기학회 추계학술대회 초록집 Vol.129 No.-
Background Spread through air spaces (STAS) is a recently determined pathologic phenomenon of lung cancers with significant impact on prognosis. However, the possible influence of mechanical forces caused by diagnostic interventions on the occurrence of STAS has not yet been explored. The purpose of this study was to evaluate the association of diagnostic lung biopsy on the risk of STAS, and its prognostic impact in resected stage I NSCLC. Methods We performed a retrospective review of 2,238 patients who underwent surgery for stage I NSCLC, from January 2011 to December 2019 in Seoul National University Bundang Hospital. The risk factors for STAS was assessed by logistic regression. In addition, the association between previous diagnostic lung biopsy and incidence of recurrence, lung cancer-related mortality were assessed stratified by STAS positivity with Multivariate Cox’s regression analyses and the Kaplan-Meier method. Results Of the 2,238 patients analyzed, 677(30.2%) patients had positive STAS. Lung cancer with STAS tended to be solid tumors with greater tumor size and T stage. In the univariate logistic regression analysis for the risk of STAS, previous percutaneous needle biopsy (OR=1.81, P<0.001), bronchoscopic biopsy (OR=1.42, P<0.030), bronchoscopic washing and BAL(OR=1.41, P<0.005) were all significantly associated with the risk for STAS. However, in the multivariate analysis, only solid type(OR=2.54,P<0.001) and tumor size (OR=1.76, P<0.001) remained significant for STAS positivity. Multivariate Cox proportional hazards models showed that after adjustments for previous diagnostic procedures, STAS was a significant risk factor for cancer recurrence(OR=1.62, P=0.005). In addition, for STAS positive patients, sublobar resection remained a significant risk factor for recurrence(OR=2.93, P<0.001) and lung cancer related mortality(OR= 9.58, P<0.001) after adjustments for previous diagnostic procedures. Conclusions Previous lung biopsy and intervention in stage I NSCLC are not associated with the development of STAS, and do not affect the prognosis of NSCLC related to STAS.
Song, Mi-Young,Kim, Sang Hoon,Ryoo, Ga-Hee,Kim, Mi-Kyung,Cha, Hye-Na,Park, So-Young,Hwang, Hong Pil,Yu, Hee Chul,Bae, Eun Ju,Park, Byung-Hyun Nature Publishing Group UK 2019 Experimental and molecular medicine Vol.51 No.5
<▼1><P>Adipose tissue inflammation is a reproducible feature of obesity and obesity-linked insulin resistance. Although sirtuin 6 (Sirt6) deficiency has previously been implicated in diet-induced obesity and systemic insulin resistance, the adipocyte-specific role of Sirt6 in the regulation of adipose tissue inflammation and systemic metabolic dysfunction in mice fed normal chow and in humans remains elusive. Here, using <I>Adipoq-Cre</I>-mediated adipocyte-specific Sirt6 knockout (aS6KO) mice, we explored whether adipocyte Sirt6 inhibits adipose tissue inflammation and its underlying mechanism. aS6KO mice fed normal chow gained more body weight and fat mass than wild-type mice and exhibited glucose intolerance and systemic insulin resistance. Measurement of plasma and tissue cytokines and flow cytometric analysis of adipose stromal vascular cells indicated a decrease in alternatively activated M2 macrophages in the adipose tissue of aS6KO mice. Mechanistically, Sirt6 regulated the expression of the canonical type 2 cytokine IL-4 by adipocytes in a cell autonomous manner, which in turn affects M2 macrophage polarization. Consistent with animal experimental data, the degree of obesity and insulin resistance demonstrated by the body mass index, fasting blood glucose and HbA1c correlated negatively with the expression of Sirt6 in human visceral fat tissues. Collectively, these results suggest that adipocyte Sirt6 regulates body weight gain and insulin sensitivity independent of diet, and the increased IL-4 production by Sirt6 and resultant M2 polarization of adipose tissue macrophages may attenuate proinflammatory responses in adipose tissue.</P></▼1><▼2><P><B>Obesity and diabetes: A control protein in fat</B></P><P>A protein in adipose tissue (composed of fat cells) helps protect against inflammation and the development of resistance to insulin that develops in obesity and can lead to type 2 diabetes. Researchers in South Korea, led by Eun Ju Bae at Woosuk University, Wanju, and Byung-Hyun Park at Chonbuk National University, Jeonju, investigated the role of Sirt6 in mice and in human adipose tissue. Deleting the mouse gene that codes for Sirt6 in adipocytes promoted the impaired response to insulin and associated increase in blood glucose levels that are two key aspects of diabetes. Changes in biochemical signaling pathways controlling immune cells called macrophages were implicated in these effects and suggest an anti-inflammatory role for Sirt6. Analysis of human adipose tissue supported these findings. The research will help understand how obesity promotes type 2 diabetes.</P></▼2>
( Ga-young Song ),( Sung-hoon Jung ),( Seo-yeon Ahn ),( Mihee Kim ),( Jae-sook Ahn ),( Je-jung Lee ),( Hyeoung-joon Kim ),( Jang Bae Moon ),( Su Woong Yoo ),( Seong Young Kwon ),( Jung-joon Min ),( He 대한내과학회 2024 The Korean Journal of Internal Medicine Vol.39 No.2
Background/Aims: The prognostic significance of <sup>18</sup>F-fluorodeoxyglucose (FDG)-positron emission tomography-computed tomography (PET/CT) in peripheral T-cell lymphomas (PTCLs) are controversial. We explored the prognostic impact of sequential <sup>18</sup>F-FDG PET/CT during frontline chemotherapy of patients with PTCLs. Methods: In total, 143 patients with newly diagnosed PTCLs were included. Sequential <sup>18</sup>F-FDG PET/CTs were performed at the time of diagnosis, during chemotherapy, and at the end of chemotherapy. The baseline total metabolic tumor volume (TMTV) was calculated using the the standard uptake value with a threshold method of 2.5. Results: A baseline TMTV of 457.0 ㎤ was used to categorize patients into high and low TMTV groups. Patients with a high TMTV had shorter progression-free survival (PFS) and overall survival (OS) than those with a low TMTV (PFS, 9.8 vs. 26.5 mo, p = 0.043; OS, 18.9 vs. 71.2 mo, p = 0.004). The interim <sup>18</sup>F-FDG PET/CT response score was recorded as 1, 2-3, and 4-5 according to the Deauville criteria. The PFS and OS showed significant differences according to the interim <sup>18</sup>F-FDG PET/CT response score (PFS, 120.7 vs. 34.1 vs. 5.1 mo, p < 0.001; OS, not reached vs. 61.1 mo vs. 12.1 mo, p < 0.001). Conclusions: The interim PET/CT response based on visual assessment predicts disease progression and survival outcome in PTCLs. A high baseline TMTV is associated with a poor response to anthracycline-based chemotherapy in PTCLs. However, TMTV was not an independent predictor for PFS in the multivariate analysis.