An Enhancer Mutant of Arabidopsis salt overly sensitive 3 Mediates both Ion Homeostasis and the Oxidative Stress Response

Zhu, Jianhua,Fu, Xinmiao,Koo, Yoon Duck,Zhu, Jian-Kang,Jenney Jr., Francis E.,Adams, Michael W. W.,Zhu, Yanmei,Shi, Huazhong,Yun, Dae-Jin,Hasegawa, Paul M.,Bressan, Ray A. American Society for Microbiology 2007 Molecular and cellular biology Vol.27 No.14

<B>ABSTRACT</B><P>The myristoylated calcium sensor SOS3 and its interacting protein kinase, SOS2, play critical regulatory roles in salt tolerance. Mutations in either of these proteins render <I>Arabidopsis thaliana</I> plants hypersensitive to salt stress. We report here the isolation and characterization of a mutant called <I>enh1-1</I> that enhances the salt sensitivity of <I>sos3-1</I> and also causes increased salt sensitivity by itself. <I>ENH1</I> encodes a chloroplast-localized protein with a PDZ domain at the N-terminal region and a rubredoxin domain in the C-terminal part. Rubredoxins are known to be involved in the reduction of superoxide in some anaerobic bacteria. The <I>enh1-1</I> mutation causes enhanced accumulation of reactive oxygen species (ROS), particularly under salt stress. ROS also accumulate to higher levels in <I>sos2-1</I> but not in <I>sos3-1</I> mutants. The <I>enh1-1</I> mutation does not enhance <I>sos2-1</I> phenotypes. Also, <I>enh1-1</I> and <I>sos2-1</I> mutants, but not <I>sos3-1</I> mutants, show increased sensitivity to oxidative stress. These results indicate that ENH1 functions in the detoxification of reactive oxygen species resulting from salt stress by participating in a new salt tolerance pathway that may involve SOS2 but not SOS3.</P>

FDG PET-CT in Non-small Cell Lung Cancer: Relationship between Primary Tumor FDG Uptake and Extensional or Metastatic Potential

Zhu, Shou-Hui,Zhang, Yong,Yu, Yong-Hua,Fu, Zheng,Kong, Lei,Han, Da-Li,Fu, Lei,Yu, Jin-Ming,Li, Jia Asian Pacific Journal of Cancer Prevention 2013 Asian Pacific journal of cancer prevention Vol.14 No.5

Objective: To explore the relationships between primary tumor $^{18}F$-FDG uptake measured as the SUVmax and local extension, and nodal or distant organ metastasis in patients with NSCLC on pretreatment PET-CT. Methods: 93 patients with NSCLC who underwent $^{18}F$-FDG PET-CT scans before the treatment were included in the study. Primary tumor SUVmax was calculated; clinical stages, presence of local extension, nodal and distant organ metastases were recorded. The patients with SUVmax${\geq}2.5$ were divided into low and high SUVmax groups by using the median SUVmax. The low SUVmax group consisted of 45 patients with SUVmax<10.5, the high SUVmax group consisted of 46 patients with SUVmax${\geq}10.5$. Their data were compared statistically. Results: 91 cases with SUVmax${\geq}2.5$ were included for analysis. The mean SUVmax in patients without any metastasis was $7.42{\pm}2.91$ and this was significantly lower than that ($12.18{\pm}4.94$) in patients with nodal and/or distant organ metastasis (P=0.000). In the low SUV group, 19 patients had local extension, 22 had nodal metastasis, and 9 had distant organ metastasis. In the high SUV group, 31 patients had local extension, 37 had nodal metastasis, and 18 had distant organ metastases. There was a significant difference in local extension (P =0.016), distant organ metastasis (P =0.046), and most significant difference in nodal metastasis rate (P =0.002) between the two groups. In addition, there was a moderate correlation between SUVmax and tumor size (r = 0.642, P<0.001), tumor stage (r = 0.546, P<0.001), node stage (r = 0.388, P<0.001), and overall stage (r = 0.445, P= 0.000). Conclusion: Higher primary tumor SUVmax predicts higher extensional or metastatic potential in patients with NSCLC. Patients with higher SUVmax may need a close follow-up and more reasonable individual treatment because of their higher extensional and metastatic potential.

CYCLIN-DEPENDENT KINASE8 Differentially Regulates Plant Immunity to Fungal Pathogens through Kinase-Dependent and -Independent Functions in <i>Arabidopsis</i>

Zhu, Yingfang,Schluttenhoffer, Craig M.,Wang, Pengcheng,Fu, Fuyou,Thimmapuram, Jyothi,Zhu, Jian-Kang,Lee, Sang Yeol,Yun, Dae-Jin,Mengiste, Tesfaye American Society of Plant Biologists 2014 The Plant cell Vol.26 No.10

<P>This work explores the intriguing roles of Mediator subunit CYCLIN-DEPENDENT KINASE8 (CDK8) in plant immune responses to fungal infection. CDK8 regulates jasmonate-responsive gene expression and cuticle development via interactions with MEDIATOR COMPLEX SUBUNIT25 and transcription factor WIN1, respectively, while other interactions suggest evolutionary conservation of the Mediator kinase module.</P><P>CYCLIN-DEPENDENT KINASE8 (CDK8) is a widely studied component of eukaryotic Mediator complexes. However, the biological and molecular functions of plant CDK8 are not well understood. Here, we provide evidence for regulatory functions of <I>Arabidopsis thaliana</I> CDK8 in defense and demonstrate its functional and molecular interactions with other Mediator and non-Mediator subunits. The <I>cdk8</I> mutant exhibits enhanced resistance to <I>Botrytis cinerea</I> but susceptibility to <I>Alternaria brassicicola</I>. The contributions of CDK8 to the transcriptional activation of defensin gene <I>PDF1.2</I> and its interaction with MEDIATOR COMPLEX SUBUNIT25 (MED25) implicate CDK8 in jasmonate-mediated defense. Moreover, CDK8 associates with the promoter of <I>AGMATINE COUMAROYLTRANSFERASE</I> to promote its transcription and regulate the biosynthesis of the defense-active secondary metabolites hydroxycinnamic acid amides. CDK8 also interacts with the transcription factor WAX INDUCER1, implying its additional role in cuticle development. In addition, overlapping functions of CDK8 with MED12 and MED13 and interactions between CDK8 and C-type cyclins suggest the conserved configuration of the plant Mediator kinase module. In summary, while CDK8’s positive transcriptional regulation of target genes and its phosphorylation activities underpin its defense functions, the impaired defense responses in the mutant are masked by its altered cuticle, resulting in specific resistance to <I>B. cinerea</I>.</P>

Limonoids from the roots of Trichilia sinensis and their cytotoxicities

Zhu-Nian Wang,Wen-Li Mei,Hui-Qin Chen,Jun Wang,Zhu-Nian Wang,Hao Fu Dai 대한약학회 2018 Archives of Pharmacal Research Vol.41 No.12

Six new compounds (1–4, 8, 10), along with six known limonoids (5–7, 9, 11, 12), were isolated from the roots of Trichilia sinensis. Their structures were elucidated on the basis of extensive spectroscopic methods including 1H NMR, 13C NMR, DEPT, HSQC, HMBC, 1H–1H COSY and ROESY experiments, as well as by comparison with the literature. All the compounds were evaluated for cytotoxicities against K562, SGC-7901 and BEL-7402 cell lines. Compounds 2, 7, 10, 11, and 12 showed weak inhibitory activity to the selected cell lines.

Subcellular Characterization of Porcine Oocytes with Different Glucose-6-phosphate Dehydrogenase Activities

Fu, Bo,Ren, Liang,Liu, Di,Ma, Jian-Zhang,An, Tie-Zhu,Yang, Xiu-Qin,Ma, Hong,Zhang, Dong-Jie,Guo, Zhen-Hua,Guo, Yun-Yun,Zhu, Meng,Bai, Jing Asian Australasian Association of Animal Productio 2015 Animal Bioscience Vol.28 No.12

The in vitro maturation (IVM) efficiency of porcine embryos is still low because of poor oocyte quality. Although brilliant cresyl blue positive (BCB+) oocytes with low glucose-6-phosphate dehydrogenase (G6PDH) activity have shown superior quality than BCB negative (-) oocytes with high G6PDH activity, the use of a BCB staining test before IVM is still controversial. This study aimed to shed more light on the subcellular characteristics of porcine oocytes after selection using BCB staining. We assessed germinal vesicle chromatin configuration, cortical granule (CG) migration, mitochondrial distribution, the levels of acetylated lysine 9 of histone H3 (AcH3K9) and nuclear apoptosis features to investigate the correlation between G6PDH activity and these developmentally related features. A pattern of chromatin surrounding the nucleoli was seen in 53.0% of BCB+ oocytes and 77.6% of BCB+ oocytes showed peripherally distributed CGs. After IVM, 48.7% of BCB+ oocytes had a diffused mitochondrial distribution pattern. However, there were no significant differences in the levels of AcH3K9 in the nuclei of blastocysts derived from BCB+ and BCB- oocytes; at the same time, we observed a similar incidence of apoptosis in the BCB+ and control groups. Although this study indicated that G6PDH activity in porcine oocytes was correlated with several subcellular characteristics such as germinal vesicle chromatin configuration, CG migration and mitochondrial distribution, other features such as AcH3K9 level and nuclear apoptotic features were not associated with G6PDH activity and did not validate the BCB staining test. In using this test for selecting porcine oocytes, subcellular characteristics such as the AcH3K9 level and apoptotic nuclear features should also be considered. Adding histone deacetylase inhibitors or apoptosis inhibitors into the culture medium used might improve the efficiency of IVM of BCB+ oocytes.

On the “Dualism” of Civil Procedure Defects and the Way to Cure

Zhu, Fu-Yong 한중법학회 2020 中國法硏究 Vol.41 No.-

민사절차하자는 민사소송절차 정의의 형평성에 대한 일종의 파괴이다. 재판 권과 소권이 함께 작용하는 영역에서 당사자 절차하자 구제 권리의 충분성은 재판권을 보장하는 권리 해결 절차의 결함, 민사소송활동규범의 효과적인 작동 을 촉진하는데 중요하고 필요하다. 많은 요인들에 기초하여, 중국은 '중대한 절 차상의 하자'에 대해 일원화된 입법 규정과 이론 연구로 인해 다수의 법원이 경미한 절차상의 하자에 대해 간단한 처리를 하거나 묵살함으로써 당사자들의 절차적 이익을 크게 감소시킴으로써 당사자들의 의구심과 우려를 해소하기 어 렵다. 이를 위해서는, 절차 하자의 유형을 경미한 절차하자와 중대한 절차하자 로 유형화하고, 서로 다른 구제 경로를 설계하는 것이 필요하다. 대화 교류 체 계를 확립하고, 논쟁범위와 권리구제절차의 운영을 명확히 하여, 그에 따라 절 차무효, 절차유효, 절차자동조정효과를 발생하였다. 중대한 절차하자에 대해서 는 당사자의 의지를 나타내고 법원의 감독을 핵심으로 하는 구제 체계를 확립 하고, 재심사유를 세분화하며, 당사자에게 절차적 선택권을 부여하고, 쌍방향 구속 체계를 확립하고, 절차하자를 강화할 수 있도록 하였다. The defect of civil procedure is a kind of destruction to the balance of justice in civil procedure. In the field of the joint effect of judicial power and litigation right, the adequacy of the party’s procedural defect remedy right is particularly necessary to protect the judicial power to heal procedural defects and promote the effective operation of civil litigation activities. Due to the unitary tendency of the theoretical and practical circles on the types of procedural defects, the “dualization” of procedural defects has only formal significance, it is difficult to resolve the parties’ doubts and dissatisfaction, and it really affects judicial justice and legal authority. Based on whether procedural flaws have a substantial impact on the judgment results, the procedural flaws are classified as “dual” of minor procedural flaws and major procedural flaws, and different treatment paths are designed: For minor procedural flaws, the right of party opposition is established Centered relief mechanism: Establish a dialogue mechanism, clarify the scope of dissent, and the operation of the procedure of right relief, resulting in the effects of invalid procedures, effective procedures, and self-healing procedures. For major procedural defects, the establishment of the party’s will be established and the court will review. The level of supervision is the core relief mechanism, detailing the reasons for returning to retrial, giving the parties the right to choose a procedure, establishing a two-way restraint mechanism, and strengthening supervision and management, so that procedural defects can be cured.

论医疗纠纷仲裁困境之化解

Zhu Fu Yong(朱福勇),Yang Wen Wu(杨,文午) 원광대학교 법학연구소(의생명과학법센터) 2018 의생명과학과 법 Vol.19 No.-

중국의 학계에서 의료분쟁에 대하여 중재가 가능한 분쟁으로 인식하고 있지만, 의료분쟁을 강제중재로 할 것인지 임의중재로 할 것인지에 대하여는 여전히 이론연구가 비교적 부족하다. 실무에 있어서, 심천의료분쟁중재원의 임의중재를 보면, 의료분쟁을 중재함에 있어 편리성 면에서는 높은 점수를 줄 수 있지만, 의료분쟁에의 중재적용율 면에 있어서는 여전히 많은 문제점이 나타나고 있다. 즉, 심첨의료분쟁중재원의 임의중재방식의 주요 문제점은 중재해결의 적용율에 있다고 할 수 있다. 이러한 이유로 심천의료분쟁중재원은 임의중재방식을 취하면서 극소수의 의료분쟁에 대하여 당사자간 중재협의를 달성한다. 이처럼 의료분쟁중재방식은 의료분쟁중재의 적용율에 지대한 영향을 준다. 본 연구에서는 임의중재와 강제중재의 장단점을 분석하여 의료기관과 환자간의 중재에 있어 적용율 제고 및 의료기관과 환자 쌍방당사자의 의사자치 등 모든 요소를 종합적으로 고려하여 의료분쟁중재에 있어 임의와 강제의 상호결합된 중재방식을 제안한다. 이러한 연구를 통하여, 오늘날 중국의 다원화된 분쟁해결방식에 있어, 특히 의료분쟁중재제도에 대한 법률적 완비를 위한 문제점과 그 해결방법을 제시하고자 한다. Medical disputes have arbitrability. Most of the academic circles have reached consensus. However, there are big differences in theoretical research on whether medical dispute arbitration should adopt compulsory arbitration or arbitrary arbitration. In practice, the Shenzhen Medical Dispute Arbitration Institute’s trial of medical dispute arbitration under the Arbitrary Arbitration Model confirms that arbitration is an efficient and convenient solution to medical disputes, but it also exposes the shortcomings of the low rate of arbitration for medical disputes in the Shenzhen Medical Disputes Court. The reason for this is Shenzhen. Under the arbitrary arbitration model adopted for arbitration of medical disputes, very few parties to the dispute can reach an arbitration agreement and submit it to arbitration. The arbitration model of medical disputes has a great influence on the application rate of medical dispute arbitration. Therefore, this paper analyzes the advantages and disadvantages of arbitrary arbitration and compulsory arbitration, comprehensively considers increasing the application rate of arbitration in doctor-patient disputes, and taking into account the autonomy of both doctors and patients. It is believed that arbitration of medical disputes should adopt arbitrary and compulsory arbitration models. At present, under the background of the establishment of a diversified dispute resolution mechanism in China, it is advisable to improve the system rules and regulations on medical dispute arbitration as soon as possible, properly handle the connection between medical dispute arbitration and judicial litigation, and improve the supporting measures related to medical dispute arbitration. 医疗纠纷具备可仲裁性在学界大多已取得共识,但在医疗纠纷仲裁应采取强制仲裁还是任意仲裁论题上,理论研究存在较大分歧。实务中,深圳医疗纠纷仲裁院的任意仲裁模式下的医疗纠纷仲裁试点证实仲裁解决医疗纠纷高效便捷,但也暴露了深圳医疗纠纷仲裁院医疗纠纷仲裁适用率低的缺陷,究其原因,在于深圳医疗纠纷仲裁所采取的任意仲裁模式下,极少纠纷主体能够达成仲裁协议并提交仲裁。医疗纠纷仲裁模式对医疗纠纷仲裁适用率的影响至巨,故本文在分析任意仲裁和强制仲裁优缺点,综合考虑提高仲裁在医患纠纷中的适用率以及兼顾医患双方意思自治的基础上,认为医疗纠纷仲裁宜采取任意与强制相结的仲裁模式。当前,在我国构建多元化纠纷解决机制的大背景下,应当顺势尽快完善有关医疗纠纷仲裁的制度规章,妥善处理医疗纠纷仲裁与司法诉讼的衔接,完善与医疗纠纷仲裁相关的配套措施。

Polydopamine (PDA) coatings with endothelial vascular growth factor (VEGF) immobilization inhibiting neointimal formation post zinc (Zn) wire implantation in rat aortas

Jiayin Fu,Qiongjun Zhu,Zhezhe Chen,Jing Zhao,Shaofei Wu,Meng Zhao,Shihui Xu,Dongwu Lai,Guosheng Fu,Wenbin Zhang 한국생체재료학회 2023 생체재료학회지 Vol.27 No.00

Background Bioresorbable stents are designed to provide temporary mechanical support to the coronary arteries and then slowly degrade in vivo to avoid chronic inflammation. Zinc (Zn) is a promising material for bioresorbable stents; However, it can cause inflammation and neointimal formation after being implanted into blood vessels. Methods To improve biocompatibility of Zn, we first coated it with polydopamine (PDA), followed by immobilization of endothelial vascular growth factor (VEGF) onto the PDA coatings. Adhesion, proliferation, and phenotype maintenance of endothelial cells (ECs) on the coated Zn were evaluated in vitro. Then, a wire aortic implantation model in rats mimicking endovascular stent implantation in humans was used to assess vascular responses to the coated Zn wires in vivo. Thrombosis in aortas post Zn wire implantation, degradation of Zn wires in vivo, neointimal formation surrounding Zn wires, and macrophage infiltration and extracellular matrix (ECM) remodeling in the neointimas were examined. Results In vitro data showed that the PDA-coated Zn encouraged EC adhesion, spreading, proliferation, and phenotype maintenance on its surfaces. VEGF functionalization on PDA coatings further enhanced the biocompatibility of Zn to ECs. Implantation of PDA-coated Zn wires into rat aortas didn’t cause thrombosis and showed a faster blood flow than pure Zn or the Zn wires coated with VEGF alone. In addition, the PDA coating didn’t affect the degradation of Zn wires in vivo. Besides, the PDA-coated Zn wires reduced neointimal formation, increased EC coverage, decreased macrophage infiltration, and declined aggrecan accumulation in ECM. VEGF immobilization onto PDA coatings didn’t cause thrombosis and affect Zn degradation in vivo as well, and further increased the endothelization percentage as compared to PDA coating alone, thus resulting in thinner neointimas. Conclusion These results indicate that PDA coatings with VEGF immobilization would be a promising approach to functionalize Zn surfaces to increase biocompatibility, reduce inflammation, and inhibit neointimal formation after Zn implantation in vivo.

중국 중재 절차의 이의 포기와 이의 심사

주복용 ( Zhu Fu Yong ),도회천 ( Tao Huai Chuan ) 한중사회과학학회 2022 한중사회과학연구 Vol.20 No.1

중재 절차에서 이의 포기는 이미 국제 상업 중재가 보편적으로 따르는 규칙이 되었다. 그러나 실천 과정에서 중국이 이의 포기에 대한 사법 심사 원칙과 기준이 미흡하고 이론 연구가 상대적으로 부족하며 법관이 이의 포기 심사에 대한 인식 차이가 있어 사법심사 결과를 일정 부분 다르게 만들어 중재 공신력과 사법심사 결과의 권위를 위축시켰다. 이를 위해 비교와 실증연구를 통해 중재 기초이론과 실천에서 출발하여 중국의 이의 포기 사법 심사는 의사자치를 존중하고 최소한의 정당한 절차를 보장하며 금반언의 원칙과 분쟁을 신속하게 해결하는 원칙을 지켜야 한다. 역외의 경험을 참고하여 당사자가 법정 중재절차 또는 선택한 중재규칙을 알거나 지키지 않은 것을 알아야 한다고 명시하고 중재기구 또는 중재 정의 특별 제시를 받은 후에도 여전히 혹은 계속적으로 중재절차에 참가하여 이의를 제기하지 않고 중재판결이 나온 후 법정절차를 위반한 했다는 이유로 중재판결을 철회하거나 집행하지 않겠다고 신청하는 경우 법원은 마땅히 지지하지 말아야 한다. 이를 바탕으로 ‘알거나 알아야 한다’라는 의미, ‘특별 제시’의 파악, ‘이의를 제기하지 않았다’와 ‘이의를 포기한다’의 적용, 그리고 사법 심사의 내용과 근거를 정확하게 정의하고 규범화된 이의 포기 사법심사 기준을 구축해 이의 포기를 사법 심사 활동의 과학적이고 규범화된 궤도에 올려놓는다. In arbitration proceedings, waiver of objection has become a rule commonly followed in international commercial arbitration. However, in practice, the absence of principles and standards for judicial review of objection waivers in China, the relative absence of theoretical research, and the differences in judges’ perceptions of the basis for review of objection waivers have, to a certain extent, caused differences in the results of judicial review and inhibited the credibility of arbitration and the authority of judicial review results. In this regard, using comparative and empirical research methods, from the basic theory and practice of arbitration, we propose that the judicial review of waiver of objection in China should follow the principles of respecting the party autonomy, guaranteeing minimum due process, estoppel, and speedy resolution of disputes; Drawing on overseas experience, it is expressly provided that the court shall not support an application for setting aside or non-enforcement of an arbitral award by a party who knows or should know that the statutory arbitration procedures or the chosen arbitration rules have not been followed and who, after being specifically recommended by the arbitral institution or the arbitral tribunal, still participates or continues to participate in the arbitration proceedings without raising any objection, on the ground that the arbitral award has been made in violation of the statutory procedures. On this basis, we define the connotation of “know or should know”, the grasp of “special recommendation”, the application of “failure to object” and “waiver of objection”, and the content and basis of judicial review, to construct a standardized judicial review of objection waivers so as to put the judicial review of objection waiver into a scientific and standardized track.

디지털경제시대 하에서 중국 기업데이터권의 균형보호에 관한 고찰

朱福勇 ( Zhu Fu Yong ),刘梦云 ( Liu Meng Yun ) 한중사회과학학회 2021 한중사회과학연구 Vol.19 No.3

디지털경제가 한창인 상황에서 데이터는 인터넷기업의 발전에 중요한 자원이 될 뿐만 아니라, 국가차원에서도 중시되고 있다. 기업은 데이터의 지배 및 효율적 이용에 대해 디지털 경제의 발전을 직접적으로 추진하며, 기업데이터의 속성이 아직 명확하지 않아 그 보호방식 등과 관련하여 논란이 있기 때문에 기업데이터를 보호하는 정도뿐만 아니라, 기업데이터의 건전한 활용과 발전에도 부분적으로 제한되고 있는 실정이다. 이에 데이터의 질서 있는 유통을 보장하기 위해 기업 간 데이터의 고품질 사용을 촉진하고, 특히, 기존의 법률에 의해 기업데이터에 대한 명확한 규정이 없는 경우에는 기업데이터를 보호하는 과정에서 상응하는 문제점들을 더욱 명확히 해결함으로써 기업데이터에 대한 현 제도의 모순적인 해결방안을 보완할 필요가 있다. 본 연구에서는 기업의 데이터 권익 분쟁해결이 시급한 상황에서는 사례분석, 문헌분석 및 이론연구의 방법, 즉 중국기업의 데이터를 정리ㆍ해석하는 전형적인 사례를 통해 데이터 속성의 모호함, 재판 근거 부족과 책임부담방식의 차이 등 기존 해결책의 부족을 분석한다. 기존 학계의 관점을 정리하고, 변증법적으로 기존의 “신흥재산권”과 “지적재산권” 등과 관련한 학설을 탐구하고, 관련 이론을 채택하여 논증분석하면 “사회본체론”과 “노동부세권” 등의 이론을 채택하여 해석함으로써 기업의 데이터 분쟁 해결방안의 타당성을 높일 수 있다. 또한, 기업 데이터 분쟁의 해결은 기업 데이터 분쟁의 해결 방안을 확정하기 위해서는 기업데이터의 속성과 부여된 권리를 명확히 해야 하기 때문에 기업데이터 자체의 범위와 성격을 확정해야 한다. 데이터의 가공여부, 공개상태, 유형화에 대한 구분과 함께 기업데이터와 개인데이터 등 관련 데이터 간의 차이를 확정함으로써 명료한 기업데이터는 기업의 신흥재산권에 속하며, 이는 민법전에서 재차 확인한다. 기업은 그 원초적 및 공개데이터에 대한 점유와 제3자 사용허가의 권익 및 식별불가능한 원시데이터에 대한 수익권, 파생적 미공개 데이터에 대한 점유, 사용, 수익과 제한적 처분권을 갖는다. 또한 침해책임의 구성요건, 재판근거 및 침해책임의 부담 등을 혁신적으로 발전시켜 기업데이터 분쟁의 획일성과 구제방식의 공정성을 보장하고 데이터 권익의 균형보호를 도모함으로써 기업의 데이터 개발이 건전하고 데이터 유통이 용이하게 이루어질 수 있도록 최적화할 수 있을 것이다. Enterprises’ control and effective use of data directly promote the development of the digital economy. Due to the ambiguity of data attributes, insufficient basis for refereeing and differences in the way of assuming responsibility, to a certain extent, the strength and healthy development of enterprise data protection are inhibited. The solution of enterprise data dispute is by using the methods of case analysis, literature analysis and theoretical research, analyzing existing cases and theoretical viewpoints systematically, so as to improve the feasibility of enterprise data dispute resolution. While distinguishing from data processing or not, public status, and categorization, it is clearly analyzed that enterprise data belongs to a kind of emerging property rights of enterprises, which is confirmed in the “Civil Code”: enterprises enjoy possession and possession of their original and public data. The rights of the three parties to use the license, as well as the right to benefit from unidentifiable raw data; the right to possess, use, benefit from and limited disposal of derived undisclosed data, and have a certain degree of exclusivity to the malicious behavior of third parties. In addition, the principles of innovation and development, the constituent elements of infringement liability, the basis for judgment, and the undertaking of infringement liability shall be improved in order to achieve balanced protection of data rights and interests, to ensure the unity of the determination of enterprise data disputes and the fairness of relief methods, so that enterprise data development is stable and data circulation is convenient, and optimized utilization.