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- 저자 : Jiayin Fu (검색결과 2 건)
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Jiayin Fu,Qiongjun Zhu,Zhezhe Chen,Jing Zhao,Shaofei Wu,Meng Zhao,Shihui Xu,Dongwu Lai,Guosheng Fu,Wenbin Zhang 한국생체재료학회 2023 생체재료학회지 Vol.27 No.00
Background Bioresorbable stents are designed to provide temporary mechanical support to the coronary arteries and then slowly degrade in vivo to avoid chronic inflammation. Zinc (Zn) is a promising material for bioresorbable stents; However, it can cause inflammation and neointimal formation after being implanted into blood vessels. Methods To improve biocompatibility of Zn, we first coated it with polydopamine (PDA), followed by immobilization of endothelial vascular growth factor (VEGF) onto the PDA coatings. Adhesion, proliferation, and phenotype maintenance of endothelial cells (ECs) on the coated Zn were evaluated in vitro. Then, a wire aortic implantation model in rats mimicking endovascular stent implantation in humans was used to assess vascular responses to the coated Zn wires in vivo. Thrombosis in aortas post Zn wire implantation, degradation of Zn wires in vivo, neointimal formation surrounding Zn wires, and macrophage infiltration and extracellular matrix (ECM) remodeling in the neointimas were examined. Results In vitro data showed that the PDA-coated Zn encouraged EC adhesion, spreading, proliferation, and phenotype maintenance on its surfaces. VEGF functionalization on PDA coatings further enhanced the biocompatibility of Zn to ECs. Implantation of PDA-coated Zn wires into rat aortas didn’t cause thrombosis and showed a faster blood flow than pure Zn or the Zn wires coated with VEGF alone. In addition, the PDA coating didn’t affect the degradation of Zn wires in vivo. Besides, the PDA-coated Zn wires reduced neointimal formation, increased EC coverage, decreased macrophage infiltration, and declined aggrecan accumulation in ECM. VEGF immobilization onto PDA coatings didn’t cause thrombosis and affect Zn degradation in vivo as well, and further increased the endothelization percentage as compared to PDA coating alone, thus resulting in thinner neointimas. Conclusion These results indicate that PDA coatings with VEGF immobilization would be a promising approach to functionalize Zn surfaces to increase biocompatibility, reduce inflammation, and inhibit neointimal formation after Zn implantation in vivo.
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Wang, Jiayin,Fu, Yuping,Lee, Yong-cheol 한국중앙영어영문학회 2020 영어영문학연구 Vol.62 No.4
With a corpus-assisted discourse analysis (CADA) on South China Sea (SCS) issues in Chinese, American, and Philippine newspapers over the past 10 years, this paper aimed to reveal ways of representing the SCS issues from three leading newspapers (China Daily, the Manila Times, and the New York Times) and expound the complicated relations between language use and the historical-socio-political contexts, which, in the end, provides valuable context for the study of the dispute between Japan and South Korea as well as other significant issues. The synchronic and diachronic analyses of the issues from 2010 to 2019 were conducted through a synergy of critical discourse analysis (CDA) and corpus linguistics (CL). The results showed that the representations in China Daily are generally cooperative negotiation-oriented. Those in the Manila Times were inclined toward being proactively and radically oriented during the Aquino III period, while they were moderately oriented during the Duterte period, which is characterized by instability. Those in the New York Times showed a tendency be militarization- and internationalization-oriented. The method used in this study enabled us to find semantic fields within text corpora to explore political issues connected to relevant countries.
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