Molecular Beam Epitaxy of Highly Crystalline Monolayer Molybdenum Disulfide on Hexagonal Boron Nitride

Fu, Deyi,Zhao, Xiaoxu,Zhang, Yu-Yang,Li, Linjun,Xu, Hai,Jang, A-Rang,Yoon, Seong In,Song, Peng,Poh, Sock Mui,Ren, Tianhua,Ding, Zijing,Fu, Wei,Shin, Tae Joo,Shin, Hyeon Suk,Pantelides, Sokrates T.,Zho American Chemical Society 2017 JOURNAL OF THE AMERICAN CHEMICAL SOCIETY - Vol.139 No.27

<P>Atomically thin molybdenum disulfide (MoS2), a direct-band-gap semiconductor, is promising for applications in electronics and optoelectronics, but the scalable synthesis of highly crystalline film remains challenging. Here we report the successful epitaxial growth of a continuous, uniform, highly crystalline monolayer MoS2 film on hexagonal boron nitride (h-BN) by molecular beam epitaxy. Atomic force microscopy and electron microscopy studies reveal that MoS2 grown on h-BN primarily consists of two types of nucleation grains (0 aligned and 60 degrees antialigned domains). By adopting a high growth temperature and ultralow precursor flux, the formation of 60 degrees antialigned grains is largely suppressed. The resulting perfectly aligned grains merge seamlessly into a highly crystalline film. Large-scale monolayer MoS2 film can be grown on a 2 in. h-BN/sapphire wafer, for which surface morphology and Raman mapping confirm good spatial uniformity. Our study represents a significant step in the scalable synthesis of highly crystalline MoS2 films on atomically flat surfaces and paves the way to large-scale applications.</P>

A Piperidine Alkaloid and Limonoids from Arisaema decipiens, a Traditional Antitumor Herb Used by the Dong People

Fu-Wei Zhao,Min Luo,Yue-Hu Wang,Ma-Lin Li,Gui-Hua Tang,Chun-Lin Long 대한약학회 2010 Archives of Pharmacal Research Vol.33 No.11

A new piperidine alkaloid and three known tetranortriterpenoids were isolated from the methanol extracts of the rhizomes of Arisaema decipiens Schott (Araceae) and their chemical structures were identified as (-)-(2R*,3S*,6S*)-N,2-dimethyl-3-hydroxy-6-(9-phenylnonyl) piperidine (1), 6-deacetylnimbin (2), 28-deoxonimbolide (3) and nimbin (4). The N-methylated derivative (1a) of 1 was synthesized. Compound 1 exhibited weak inhibitory activity against the MCF-7 cell line, while compound 1a showed potential inhibitory activity against the MCF-7 cell line with an IC50 value of 4.6 μM and weak inhibitory activity against K562 and SK-OV-3 cells. This plant in genus Arisaema is firstly reported as the source of limonoids that are considered a natural antitumor herbal medicine.

Drinking Deep Seawater Decreases Serum Total and Low-Density Lipoprotein–Cholesterol in Hypercholesterolemic Subjects

Zhao-Yang Fu,Feili Lo Yang,Hsin-Wen Hsu,Yi-Fa Lu 한국식품영양과학회 2012 Journal of medicinal food Vol.15 No.6

Drinking deep seawater (DSW) with high levels of magnesium (Mg) decreased serum lipids in animal studies. Therefore the effects of drinking DSW on blood lipids and its antioxidant capacity in hypercholesterolemic subjects were investigated. DSW was first prepared by a process of filtration and reverse osmosis, and then the concentrated DSW with high levels of Mg was diluted as drinking DSW. Forty-two hypercholesterolemic volunteers were randomly divided into three groups: reverse osmotic (RO) water, DSW (Mg: 395 mg/L, hardness 1410 ppm), and magnesium-chloride fortified (MCF)water (Mg: 386 mg/L, hardness 1430 ppm). The subjects drank 1050mL of water daily for 6 weeks, and blood samples were collected and analyzed on weeks 0, 3, and 6. Drinking DSW caused a decrease in blood total cholesterol levels and this effect was progressively enhanced with time. Serum low-density lipoprotein–cholesterol (LDL-C) was also decreased by DSW. Further, total cholesterol levels of subjects in the DSW group were significantly lower than those in the MCF water or RO water groups. Compared with week 0, the DSW group had higher blood Mg level on weeks 3 and 6, but the Mg levels were within the normal range in all three groups. DSW consumption also lowered thiobarbituric acid-reactive substances (TBARS)values in serum. In conclusion, DSW was apparently effective in reducing blood total cholesterol and LDL-C, and also in decreasing lipid peroxidation in hypercholesterolemic subjects.

S100A14 Promotes the Growth and Metastasis of Hepatocellular Carcinoma

Zhao, Fu-Tao,Jia, Zhan-Sheng,Yang, Qun,Song, Le,Jiang, Xiao-Jing Asian Pacific Journal of Cancer Prevention 2013 Asian Pacific journal of cancer prevention Vol.14 No.6

Background: S100A14 has recently been implicated in the progress of several types of cancers. This study aimed to investigate the clinical significance and possible mechanisms of action of S100A14 in the invasion and metastasis of hepatocellular carcinoma (HCC). Methods: S100A14 expression in HCC was detected at mRNA and protein levels and its prognostic significance was assessed. Functional roles of S100A14 in HCC were investigated using MTT, BrdU, wound healing, transwell invasion assay and HCC metastatic mouse model. Results: S100A14 was significantly elevated in HCC tissues, correlated with multiple tumor nodes, high Edmondson-Steiner grade and vascular invasion. Multivariate Cox analysis showed that the S100A14 expression level was a significant and independent prognostic factor for overall survival (OS) of HCC patients (hazard ratio=1.98, 95% confidence interval=1.14-3.46, P=0.013). S100A14 promoted cell proliferation, invasion and metastasis of HCC in vitro and in vivo. Conclusion: These results suggest S100A14 is a novel prognostic marker and therapeutic target for HCC.

중국 진출 한국기업의 인적자원관리 현지화에 관한 연구 -산동지역 및 강소지역 중심으로

( Zhao-fu Chang ),위오기 ( Oh-gie We ) 공주대학교 KNU 기업경영연구소 2010 기업경영리뷰 Vol.1 No.1

본 연구에서는 중국진출 한국기업의 인적자원관리가 현지화에 미치는 영향변수 중 어떠한 요인이 영향을 미치는지를 분석하기위하여, 중국 현지자회사 인사부분 의사결정의 자율성을 중심으로 인적자원관리 현지화에 미치는 영향변수에 대한 설문조사를 실시하였다. 실증분석 결과 다음과 같은 결론을 도출하였다. 첫째, 현지자회사의 본사에 대한 자원의존도가 높을수록 현지자회사의 인적자원관리 현지화정도는 낮은 것으로 나타났다. 즉 자원에 대해 본사에 의존도가 높을수록 현지 자회사의 인사부분 의사결정의 자율성은 낮은 것으로 나타났다. 둘째, 현지 자화사의 규모는 클수록 현지자회사의 인적자원관리 현지화 정도는 낮은 것으로 나타났다. 즉 중국 주재 한국기업 중에 대기업보다 중소기업의 인사부분 의사결정시 자율성 또는 인적자원관리의 현지화 정도가 더 높은 것으로 나타났다. This study focuses on Human Resource Management Localization of Korean Companies in China. The concept of Human Resource Management Localization is defined as the degree of autonomic while the subsidiary company in foreign make a decision of the part of personnel management. This study suggests that the factors affecting local company's Human Resource Management Localization include the dependent degree of resources towards the parent company, the period of local company's foundation and the scale of the local company. This study used the method of questionnaire to collect data and used the spss 12.0 to analysis the relationship between the Human Resource Management and the affected factors of it. The data was collected through a survey of 63 Korean firms in ShanDong Province and JiangSu Province in China. The results of the analysis are as follows. First, the dependent degree of resources towards the parent company show negative effect to the Human Resource Management Localization. That is if the local company has a high dependent degree of resources towards the parent company the local company will have a low degree of Human Resource Management Localization. Second, the scale of the local company show negative effect to the Human Resource Management Localization. That is if the local company have a big scale it will have a low degree of Human Resource Management Localization. What can be learned from the empirical results is that the factors such as the dependent degree of resources towards the parent company and the size of the local company have different degrees of influence on the Human Resource Management Localization.

Localization of QTLs for Husk Proportion and Lignin Content Using a High-Density Genetic Linkage Map of Brassica napus

Fu You Fu,Lie Zhao Liu,You Rong Chai,Li Chen,Tao Yang,Ai Fen Ma,Cun Ming Qu,Lin Jiang,Zheng Sheng Zhang,Jia Na Li 한국유전학회 2007 Genes & Genomics Vol.29 No.3

Husk proportion (HP) and lignin content (LC) are two important traits of seed quality of B. napus. Efficient selection of these two traits is an important way to improve the seed quality in meal improvement. A set of recombinant inbred lines (RILs) of B. napus (GH06 × Zhongyou 821) was used for mapping QTLs of HP and LC in a two-year study in different environments. 509 markers (78 SSR markers, 66 RAPD markers and 365 SRAP markers) were mapped on 26 linkage groups with an average length of 73.96 cM. The map covered a total of 1923 cM, and the average distance between two adjacent markers was 3.78 cM. Analysis of variance of LC and HP indicated that. LC might not be significantly affected by environment (F = 2.96 < 3.02) and HP might be affected by genotype × environment interactions. A total of 15 significant QTLs were detected in eight linkage groups with a LOD threshold value of 2.5 (LR ≥ 11.5) by CIM, explaining 4.99-16.14% of phenotype variation. Some QTLs of LC and HP were detected in near regions of the same linkage groups, such as qLCBB05-6-1 and qLCWZ06-6-1, qLCBB05-10-2 and qLCBB06-10-1 and qLCWZ06-10-2, qHPBB05-9-3 and qHPBB06-9-1, qHPBB05-10-4 and qHPBB06-10-2 and qHPBB06-10-3 and qHPWZ06-10-1. This study indicates that the repeatedly detected QTLs of LC and HP might be major-effect QTLs of LC and HP.

CFD-DEM modeling of snowdrifts on stepped flat roofs

Zhao, Lei,Yu, Zhixiang,Zhu, Fu,Qi, Xin,Zhao, Shichun Techno-Press 2016 Wind and Structures, An International Journal (WAS Vol.23 No.6

Snowdrift formation on roofs should be considered in snowy and windy areas to ensure the safety of buildings. Presently, the prediction of snowdrifts on roofs relies heavily on field measurements, wind tunnel tests and numerical simulations. In this paper, a new snowdrift modeling method by using CFD (Computational Fluid Dynamics) coupled with DEM (Discrete Element Method) is presented, including material parameters and particle size, collision parameters, particle numbers and input modes, boundary conditions of CFD, simulation time and inlet velocity, and coupling calculation process. Not only is the two-way coupling between wind and snow particles which includes the transient changes in snow surface topography, but also the cohesion and collision between snow particles are taken into account. The numerical method is applied to simulate the snowdrift on a typical stepped flat roof. The feasibility of using coupled CFD with DEM to study snowdrift is verified by comparing the simulation results with field measurement results on the snow depth distribution of the lower roof.

Design Improvement of the Splitter Blade in the Centrifugal Pump Impeller Based on Theory of Boundary Vorticity Dynamics

ZHAO, Binjuan,ZHANG, Chenghu,ZHAO, Youfei,FU, Yanxia,LIU, Qi,CHEN, Huilong Korean Society for Fluid machinery 2018 International journal of fluid machinery and syste Vol.11 No.1

To improve the design of the splitter blade in the centrifugal pump impeller, inner flow numerical simulations are performed on the centrifugal pump impeller without splitter blades firstly, inner flow diagnoses are performed based on the theory of the boundary vorticity dynamics, and distributions of the boundary vorticity flux (BVF), friction force as well as vorticity on the inner walls of the impeller are carefully analyzed to find the location of bad flows and their dynamic sources. Later, according to the inner flow diagnosis results, splitter blades are designed and reformed for the original impeller. The inner flow filed in the impellers equipped with the preliminary splitter blade and reformed splitter blade are numerically simulated and diagnosed. Finally, comparisons are made among the three impellers, and it is found that, compared to the original impeller (impeller 0), the BVF, friction force and vorticity distribution in the impeller equipped with the preliminary splitter blade (impeller 1) has no obvious improvement, although the pump head increases, the efficiency decreases; the BVF, friction force and vorticity distribution in the impeller equipped with the reformed blade (impeller 2) has improved obviously, BVF peak decreases evidently and BVF distributes more uniformly, flow separation is inhibited, the hydraulic force acting on the impeller increases, with the pump head and efficiency increasing dramatically. It is proven that, flow diagnosis based on the theory of the boundary vorticity dynamics is an effective supplemental way for the design of the splitter blade in the centrifugal pump impeller, and will provide reference for the design of other turbo machinery as well.

Anti-proliferation Effects of Interferon-gamma on Gastric Cancer Cells

Zhao, Ying-Hui,Wang, Tao,Yu, Guang-Fu,Zhuang, Dong-Ming,Zhang, Zhong,Zhang, Hong-Xin,Zhao, Da-Peng,Yu, Ai-Lian Asian Pacific Journal of Cancer Prevention 2013 Asian Pacific journal of cancer prevention Vol.14 No.9

IFN-${\gamma}$ plays an indirect anti-cancer role through the immune system but may have direct negative effects on cancer cells. It regulates the viability of gastric cancer cells, so we examined whether it affects their proliferation and how that might be brought about. We exposed AGS, HGC-27 and GES-1 gastric cancer cell lines to IFN-${\gamma}$ and found significantly reduced colony formation ability. Flow cytometry revealed no effect of IFN-${\gamma}$ on apoptosis of cell lines and no effect on cell aging as assessed by ${\beta}$-gal staining. Microarray assay revealed that IFN-${\gamma}$ changed the mRNA expression of genes related to the cell cycle and cell proliferation and migration, as well as chemokines and chemokine receptors, and immunity-related genes. Finally, flow cytometry revealed that IFN-${\gamma}$ arrested the cells in the G1/S phase. IFN-${\gamma}$ may slow proliferation of some gastric cancer cells by affecting the cell cycle to play a negative role in the development of gastric cancer.

CFD-DEM modeling of snowdrifts on stepped flat roofs

Lei Zhao,Zhixiang Yu,Fu Zhu,Xin Qi,Shichun Zhao 한국풍공학회 2016 Wind and Structures, An International Journal (WAS Vol.23 No.6

Snowdrift formation on roofs should be considered in snowy and windy areas to ensure the safety of buildings. Presently, the prediction of snowdrifts on roofs relies heavily on field measurements, wind tunnel tests and numerical simulations. In this paper, a new snowdrift modeling method by using CFD (Computational Fluid Dynamics) coupled with DEM (Discrete Element Method) is presented, including material parameters and particle size, collision parameters, particle numbers and input modes, boundary conditions of CFD, simulation time and inlet velocity, and coupling calculation process. Not only is the two-way coupling between wind and snow particles which includes the transient changes in snow surface topography, but also the cohesion and collision between snow particles are taken into account. The numerical method is applied to simulate the snowdrift on a typical stepped flat roof. The feasibility of using coupled CFD with DEM to study snowdrift is verified by comparing the simulation results with field measurement results on the snow depth distribution of the lower roof.