Hb Murcia (β118(G19)His>Gln): A New Hemoglobin Variant Found in a Spanish Woman

Fernández Beatriz González,Campuzano José Bartolomé Nieto,Rocamora Dolores García,Nieto Jorge M,Fernández Fernando Ataúlfo González,Villegas Ana,Cuesta Celina Benavente,Ropero Paloma 대한진단검사의학회 2021 Annals of Laboratory Medicine Vol.41 No.5

Experience of Virtual and Distance Training for Rural Teachers of Peru. Case study: Educational Robotics Course

Fernández Morales, Cecilia,Iriarte Gómez, Fernando,Mejía Solano, Carmen,Revuelta Domínguez, Francisco Ignacio APEC국제교육협력원 2017 Asia-Pacific Cybereducation Journal Vol.13 No.2

In Peru, according to the Census of Students (ECE) carried out by the Ministry of Education at 2016 (MINEDU), there are sustained differences between learning goals in rural and urban schools. There are more than 20 thousand educational robotic kits distributed nationwide. It requires trained teachers to develop their digital competence and integrate these resources into the teaching-learning process. In this context, a virtual course was designed and executed, showing rural teachers how to plan learning sessions that integrate Information and Communication Technologies (ICT) in their pedagogical practice. The course was validated with 2500 registered teachers. In the first court, 300 did not log into the virtual classroom, 500 did not to complete the course, 1170 remained active, 534 successfully completed the course and 473 gained a certificate through the virtual platform. In the second court, there are 667-registered teachers. The conclusions of the experience indicate that it is possible to implement strategies for electronic learning aimed at rural teachers in a sustainable and cost - effective way using ICT, which spontaneously create virtual communities of collaborative learning, which support the process allowing implementation the "Knowledge Management". This experience will allow us to make recommendations for rural education policy in Peru (Fernández Morales, Iriarte Gómez, Mejía Solano, & Revuelta Domínguez, 2017).

Un siglo de humor en La columna periodistica de autores gallegos: hacia una columna Ludica de autor y personaje

( Carlos Fernandez Gonzalez ) 한국스페인어문학회(구 한국서어서문학회) 2011 스페인어문학 Vol.0 No.61

El proposito de este articulo es analizar el humor como recurso estilistico, retorico y narrativo (es decir, literario) en la columna periodistica. Para ello, se ha seleccionado a cuatro autores gallegos que cubren un periodo temporal cercano a un siglo, el transcurrido desde principios del siglo XX hasta la actualidad: Julio Camba, Ricardo Outeirino, Wenceslao Fernandez Florez y Manuel Jabois. Mas en concreto, el presente trabajo pretende examinar los resortes empleados por estos autores para presentar a sus lectores informacion, analisis y opinion en clave humoristica, asi como los diferentes grados de protagonismo del autor como personaje. Se procura definir, al mismo tiempo, la evolucion general experimentada por el genero proteico denominado columna (desde un esquema basico facilmente reconocible: informacion-opinion-humor) y su tendencia actual hacia lo que se propone denominar columna ludica, que otorga al humor relevancia definitiva y encuentra especificidad, ademas, en la presentacion indisimulada de su autor como personaje protagonista. Para todo ello, se opta por una aproximacion teorica transversal y eclectica, integradora, articulada en torno a ideas, conceptos y propuestas para el analisis proporcionados por la teoria de los generos literarios y de los generos periodisticos, la narratologia, la retorica y el analisis del discurso.

Hyaluronic acid reduces inflammation and crevicular fluid IL-1β concentrations in peri-implantitis: a randomized controlled clinical trial

Sanchez-Fernandez, Elena,Magan-Fernandez, Antonio,O'Valle, Francisco,Bravo, Manuel,Mesa, Francisco Korean Academy of Periodontology 2020 Journal of Periodontal & Implant Science Vol.50 No.-

Purpose: This study investigated the effects of hyaluronic acid (HA) on peri-implant clinical variables and crevicular concentrations of the proinflammatory biomarkers interleukin (IL)-1β and tumor necrosis factor (TNF)-α in patients with peri-implantitis. Methods: A randomized controlled trial was conducted in peri-implantitis patients. Patients were randomized to receive a 0.8% HA gel (test group), an excipient-based gel (control group 1), or no gel (control group 2). Clinical periodontal variables and marginal bone loss after 0, 45, and 90 days of treatment were assessed. IL-1β and TNF-α levels in crevicular fluid were measured by enzyme-linked immunosorbent assays at baseline and after 45 days of treatment. Clustering analysis was performed, considering the possibility of multiple implants in a single patient. Results: Sixty-one patients with 100 dental implants were assigned to the test group, control group 1, or control group 2. Probing pocket depth (PPD) was significantly lower in the test group than in both control groups at 45 days (control 1: 95% CI, -1.66, -0.40 mm; control 2: 95% CI, -1.07, -0.01 mm) and 90 days (control 1: 95% CI, -1.72, -0.54 mm; control 2: 95% CI, -1.13, -0.15 mm). There was a trend towards less bleeding on probing in the test group than in control group 2 at 90 days (P=0.07). Implants with a PPD ≥5 mm showed higher levels of IL-1β in the control group 2 at 45 days than in the test group (P=0.04). Conclusions: This study demonstrates for the first time that the topical application of a HA gel in the peri-implant pocket and around implants with peri-implantitis may reduce inflammation and crevicular fluid IL-1β levels.

Hyaluronic acid reduces inflammation and crevicular fluid IL-1β concentrations in peri-implantitis: a randomized controlled clinical trial

Elena Sánchez-Fernández,Antonio Magán-Fernández,Francisco O’Valle,Manuel Bravo,Francisco Mesa 대한치주과학회 2021 Journal of Periodontal & Implant Science Vol.51 No.1

Purpose: This study investigated the effects of hyaluronic acid (HA) on peri-implant clinical variables and crevicular concentrations of the proinflammatory biomarkers interleukin (IL)- 1β and tumor necrosis factor (TNF)-α in patients with peri-implantitis. Methods: A randomized controlled trial was conducted in peri-implantitis patients. Patients were randomized to receive a 0.8% HA gel (test group), an excipient-based gel (control group 1), or no gel (control group 2). Clinical periodontal variables and marginal bone loss after 0, 45, and 90 days of treatment were assessed. IL-1β and TNF-α levels in crevicular fluid were measured by enzyme-linked immunosorbent assays at baseline and after 45 days of treatment. Clustering analysis was performed, considering the possibility of multiple implants in a single patient. Results: Sixty-one patients with 100 dental implants were assigned to the test group, control group 1, or control group 2. Probing pocket depth (PPD) was significantly lower in the test group than in both control groups at 45 days (control 1: 95% CI, −1.66, −0.40 mm; control 2: 95% CI, −1.07, −0.01 mm) and 90 days (control 1: 95% CI, −1.72, −0.54 mm; control 2: 95% CI, −1.13, −0.15 mm). There was a trend towards less bleeding on probing in the test group than in control group 2 at 90 days (P=0.07). Implants with a PPD ≥5 mm showed higher levels of IL-1β in the control group 2 at 45 days than in the test group (P=0.04). Conclusions: This study demonstrates for the first time that the topical application of a HA gel in the peri-implant pocket and around implants with peri-implantitis may reduce inflammation and crevicular fluid IL-1β levels. Trial Registration: ClinicalTrials.gov Identifier: NCT03157193

Effects of D-002, a mixture of high molecular weight beeswax alcohols, on patients with nonalcoholic fatty liver disease

José Illnait,Iván Rodríguez,Sarahí Mendoza,Yolanda Fernández,Rosa Mas,Mirtha Miranda,Jesús Piñera,Julio César Fernández,Meilis Mesa,Lilia Fernández,Daisy Carbajal,Rafael Gámez 대한내과학회 2013 The Korean Journal of Internal Medicine Vol.28 No.4

Background/Aims: Nonalcoholic fatty liver disease (NAFLD) is intimately related to insulin resistance and ranges from a benign course to liver fibrosis and cirrhosis. NAFLD management mainly involves dietary modification and weight loss. Although no fully successful pharmacological intervention is available, alternative therapies to treat NAFLD have shown promising results. Experimental studies have shown that D-002, a mixture of beeswax alcohols with antioxidant effects, is hepatoprotective. The aim of this study was to investigate the efficacy and safety of D-002 in patients with NALFD. Methods: Fifty patients with NAFLD were randomized to receive a placebo or D-002 (100 mg/day) for 24 weeks. The primary endpoint was a significant ultrasonography-detected reduction of liver fat infiltration versus a placebo. Secondary endpoints were decreases in the homeostatic model assessment (HOMA) index,insulin levels, serum liver enzymes, increases in plasma total antioxidant status (TAS) and improved clinical symptoms versus the placebo recipients. Results: At randomization, all indicators were comparable in both groups. At study completion, seven (28.0%) D-002-patients, but none of the placebo recipients,exhibited a normal liver echo pattern on ultrasonography (p < 0.01). Also,D-002 significantly reduced (p < 0.01 vs. baseline and placebo) the HOMA index and insulin levels and increased the TAS, but did not affect other parameters. The proportion of D-002-patients (12/25, 48.0%) showing symptom improvement was higher (p < 0.001) than that of the placebo group (1/25, 4.0%). The treatment was safe and well tolerated. Three patients in each group withdrew from the study. Conclusions: D-002 (100 mg/day) improved ultrasonographic findings, indicators of insulin resistance, plasma TAS and clinical evolution on NAFLD patients. Further studies, however, are needed to confirm these results.

Imaging Diagnosis of Perianal Leiomyoma: A Case Report

Enrique González-Díaz,Blanca García Cengotitabengoa,Ana Belen Dominguez Carbajo,Camino Fernández Fernández,A. Fernández Corona 대한대장항문학회 2021 Annals of Coloproctolgy Vol.37 No.S

A leiomyoma is a benign mesenchymal neoplasm that usually develops where smooth muscle is present. In this report, we present the case of a 75-year-old woman who sought medical attention due to pelvic organ prolapse and urinary incontinence, and without defecatory symptoms. Both pelvic floor ultrasound and magnetic resonance imaging (MRI) examination showed a well-defined mass in the ischioanal fossa, eventually diagnosed as a perianal leiomyoma. It is considered a rare entity because of its location involving the anal sphincter and clinical features. We describe the ultrasonographic and MRI findings of this perianal leiomyoma, together with differential diagnoses and immunohistochemical characterization.

Effect of synthetic fertilization dose on the diameter increase, height and mortality of Cinchona officinalis L. (Rubiaceae)

Fernandez-Zarate Franklin Hitler,Huaccha-Castillo Annick Estefany,Quiñones-Huatangari Lenin,Vaca-Marquina Segundo Primitivo,Goñas Malluri,Milla-Pino Manuel Emilio,Seminario-Cunya Alejandro 한국산림과학회 2024 Forest Science And Technology Vol.20 No.2

Cinchona officinalis, is a South American tree species, commonly used for medicine, and is currently threatened by agricultural expansion and cattle ranching. The objective was to determine the effect of chemical fertilization on the nursery growth to increase growth potential and survival of C. officinalis. A completely randomized design with six treatments and three replicates was used; 20 C. officinalis plants were used per replicate. Two months after transplanting the C. officinalis seedlings to the polyethylene bags, inorganic fertilizer (YaraMila® HYDRAN) was applied. Monthly evaluations were carried out and the number of dead plants, plant height, diameter and number of leaves were recorded. The highest mortality rate was recorded when fertilizer was applied (73%) while in the non-fertilized treatment mortality reached 36%. Regarding the increase in height, diameter and number of leaves in all cases, the best results were obtained in the fertilized treatments, exceeding by 85, 70 and 17% (respectively) those obtained in the treatment to which fertilization was not applied. This study shows the effects that the application of fertilizers to C. officinalis plants at the nursery level can have on growth and mortality variables, the results suggest the use of this product for a sustainable and large-scale production of this species taking into consideration the appropriate dosage.

Technological Innovation and Entrepreneurship: Education, Social Good and Economic Development

Fernandez, Ramon Emilio,Ferguson, David L.,Magsi, Komal World Technopolis Association 2016 World Technopolis Review Vol.5 No.1

The innovation ecosystem provides benefits and challenges for multiple institutional actors like universities, industry, government, NGOs, and private funding agencies, as well as individuals in a rapidly evolving and dynamic environment. First, we describe the changing role of universities-whereby, the support of innovation and entrepreneurship is developing into a core mission of universities. We then describe strategies within the United States and globally to help students learn about innovation and entrepreneurship. Finally, we explore the benefits and challenges of technological innovation for economic development, emphasizing how such development relates to the global problem of underprivileged communities, both in developed and developing countries, and the special concerns of economic development for developing countries.

Understanding Current Issues in Research and Education in Science and Technology: A Framework of Knowledge and Action Sharing between Universities and Science and Technology Parks

Fernandez, Ramon Emilio,Ferguson, David L. World Technopolis Association 2017 World Technopolis Review Vol.6 No.1

Humanity is experiencing a very fast-paced technological evolution. As technological systems evolve exponentially, societies are becoming more global and are starting to have impacts beyond their geographic demarcations. This implies that, the actions of a person who is across the ocean from where we live could have significant impacts on our everyday lives. This article explores the complexity of globalization, identifies a number of global issues, and looks at the University and the Science and Technology Parks as potential sources of human capital to tackle current and forthcoming global challenges, ranging from new energy sources to potable water distributions. The article focuses on current efforts that are taking place across universities and science and technology parks around the world. We propose a new methodology whereby interdisciplinary work can inform the development of multidisciplinary approaches to solve some of the most complex global issues such as cyber security and educating the next generations of global leaders, providing them them with the necessary skills to be successful in a globally distributed workforce.