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        LPV/H ∞ CONTROLLER DESIGN FOR PATH TRACKING OF AUTONOMOUS GROUND VEHICLES THROUGH FOUR-WHEEL STEERING AND DIRECT YAW-MOMENT CONTROL

        Peng Hang,Xinbo Chen,Fengmei Luo 한국자동차공학회 2019 International journal of automotive technology Vol.20 No.4

        This paper focuses on the path-tracking controller design for autonomous ground vehicles (AGVs) using fourwheel steering (4WS) and direct yaw-moment control (DYC) systems. In order to deal with the parametric uncertainties, a linear parameter-varying (LPV) H∞ controller is designed as the high-level controller to generate the front and rear wheel steering angles and external yaw moment based on linear matrix inequality (LMI) approach. The lower-level controller is designed for torque allocation between the left and right side wheels to yield the desired total longitudinal force and external yaw moment utilizing weighted least square (WLS) allocation algorithm. To test the performance of the proposed pathtracking controller, numerical simulations are carried out based on a high-fidelity and full-vehicle model constructed in CarSim. Simulation results show that the LPV/H∞ controller has better path-tracking performance than the fixed gain H∞ controller. To show the superiority of 4WS+DYC control system, the contrast simulation is performed based on LPV/H∞ controller. Simulation results indicate that 4WS+DYC control system has better path-tracking performance and handling stability than active front steering (AFS), AFS+DYC and 4WS control systems.

      • KCI등재

        IRE1α protects against osteoarthritis by regulating progranulin-dependent XBP1 splicing and collagen homeostasis

        Liang Li,Zhang Fengmei,Feng Naibo,Kuang Biao,Fan Mengtian,Chen Cheng,Pan Yiming,Zhou Pengfei,Geng Nana,Li Xingyue,Xian Menglin,Deng Lin,Li Xiaoli,Kuang Liang,Luo Fengtao,Tan Qiaoyan,Xie Yangli,Guo Fen 생화학분자생물학회 2023 Experimental and molecular medicine Vol.55 No.-

        Osteoarthritis (OA) is a full-joint, multifactorial, degenerative and inflammatory disease that seriously affects the quality of life of patients due to its disabling and pain-causing properties. ER stress has been reported to be closely related to the progression of OA. The inositol-requiring enzyme 1α/X-box-binding protein-1 spliced (IRE1α/XBP1s) pathway, which is highly expressed in the chondrocytes of OA patients, promotes the degradation and refolding of abnormal proteins during ER stress and maintains the stability of the ER environment of chondrocytes, but its function and the underlying mechanisms of how it contributes to the progression of OA remain unclear. This study investigates the role of IRE1α/ERN1 in OA. Specific deficiency of ERN1 in chondrocytes spontaneously resulted in OA-like cartilage destruction and accelerated OA progression in a surgically induced arthritis model. Local delivery of AdERN1 relieved degradation of the cartilage matrix and prevented OA development in an ACLT-mediated model. Mechanistically, progranulin (PGRN), an intracellular chaperone, binds to IRE1α, promoting its phosphorylation and splicing of XBP1u to generate XBP1s. XBP1s protects articular cartilage through TNF-α/ERK1/2 signaling and further maintains collagen homeostasis by regulating type II collagen expression. The chondroprotective effect of IRE1α/ERN1 is dependent on PGRN and XBP1s splicing. ERN1 deficiency accelerated cartilage degeneration in OA by reducing PGRN expression and XBP1s splicing, subsequently decreasing collagen II expression and triggering collagen structural abnormalities and an imbalance in collagen homeostasis. This study provides new insights into OA pathogenesis and the UPR and suggests that IRE1α/ERN1 may serve as a potential target for the treatment of joint degenerative diseases, including OA.

      • KCI등재

        ROBUST CONTROL FOR FOUR-WHEEL-INDEPENDENT-STEERING ELECTRIC VEHICLE WITH STEER-BY-WIRE SYSTEM

        Peng Hang,Xinbo Chen,Shude Fang,Fengmei Luo 한국자동차공학회 2017 International journal of automotive technology Vol.18 No.5

        A four-wheel-independent-steering (4WIS) electric vehicle (EV) with steer-by-wire (SBW) system is proposed in this paper. The fast terminal sliding mode controller (FTSMC) is designed for the SBW system to suppress external disturbances. Taking unstructured and structured uncertainties into consideration, a robust controller is designed for the 4WIS EV utilizing μ synthesis approach and the controller order reduction is implemented based on Hankel-Norm approximation. Since sideslip angle is the feedback signal of robust controller and it is hard to measure, the extended Kalman filter (EKF) is employed to estimate sideslip angle. To evaluate the vehicle performance with the designed control system, step and sinusoidal steering maneuvers are simulated and analyzed. Simulation results show that the designed control system have good tracking ability, strong robust stability and good robust performance to improve vehicle stability and handing performance.

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