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( Eun Bi Jang ),( Su Hyun Chae ),( Seung-hyuk Shim ),( Sun Joo Lee ),( Ji Young Lee ),( Soo-nyung Kim ),( Soon-beom Kang ) 대한산부인과학회 2019 대한산부인과학회 학술대회 Vol.105 No.-
Objective: Hormonal management is an alternative treatment for preserving fertility in patients with early stage endometrioid endometrial cancer (EC). The safety and clinical outcome in longer treatment more than 9 months has controversial. This study aimed to define the oncologic outcomes after hormone therapy more than 9 months for endometrioid EC. Methods: We retrospectively analyzed patients presumed to have stage IA, grade 1-2 endometrioid EC who underwent fertility-sparing treatment. Concurrent medroxyprogesterone (MPA) and levonorgestrel-release intrauterine devices were used for treatment. The remission rate and progression free survival were analysed of whom had treatment under 9 months (group A) and had treatment over 9 months (group B). Results: One hundred twenty patients presumed to have stage IA, grade 1 endometrioid EC had treated with hormonal medication for fertility sparing. The median age was 33.5 (range 22-43) years old and the median treatment duration was 10.7 (3-102) months. The Complete remission (CR) rate was 84.2% (101/120) and the median time interval to CR was 9.3 (2-84) months. The median follow-up time was 32.9 (1-130) months. The recurrence rate was 31.7% (38/120) and the median time to recurrence was 11 (1-92) months. The cumulative CR rate by 3, 6, 9, 12, 15, 18, 24 months was 21.7%, 36.7%, 50.8%, 61.7%, 70.8%, 74.2%, and 78.3% respectively. The CR rates in group A and B were 86.7% and 82.7% in group A and B. The recurrence rates in two group were 35.6% and 29.3%, respectively. Conclusion: Fertility sparing treatment with high dose progestin over 9 months in early stage endometrioid EC has showed high rate of CR. However, medical treatment over 9 months should counsel with patients in detail and oncologists should make careful decision.
이은비 ( Eun Bi Lee ),장은영 ( Eun Young Jang ),이선미 ( Soun Mee Lee ) 한국보건정보통계학회(구 한국보건통계학회) 2015 보건정보통계학회지 Vol.40 No.2
Objectives: Considering the importance of emotional distress and mental health among nurses in clinical practice, this study focused to anger expression of nursing students. Specifically, the present study explored the relation between childhood trauma and anger expression of nursing students and the mediational role of emotional regulation. Methods: Participants (122 nursing students; 138 students of other majors) indicated their gender, age and year, major, and then responded to the questionnaire including the childhood abuse, anger expression, and emotional intelligence. Results: Nursing students showed higher level of emotional intelligence and lower level of physical abuse during childhood than students of other majors. SEM showed direct link between neglect and physical confrontation, physical abuse and impulsive reaction, emotional abuse and verbal aggression. Also, emotional abuse associated with emotional intelligence, which related to four types of anger expression in turn. Conclusions: The results of this study suggest harmful effect of childhood trauma on difficulties in controlling anger in youths including nursing students. However, it was revealed that emotional intelligence had potential mediator which could relieve childhood abuse experience.
황련(Coptis chinensis) 추출물의 항균, 항진균 효과와 BCOP 분석을 이용한 안전성 검증
김은희 ( Eun-hee Kim ),장영아 ( Young-ah Jang ),김솔비 ( Sol-bi Kim ),김한혁 ( Han-hyuk Kim ),이진태 ( Jin-tae Lee ) 한국응용생명화학회(구 한국농화학회) 2018 Journal of Applied Biological Chemistry (J. Appl. Vol.61 No.3
황련은 한의학에서 진정, 소염, 항균 및 해열에 쓰이고 있으며, 주성분인 berberine은 강력한 항균작용을 가지는 것으로 알려져 있다. 본 연구에서는 황련에 대한 피부상재균 및 주거환경의 실내 낙하균에 대한 항균효과와 주거 환경에서 검출빈도가 높은 곰팡이에 대한 항진균 효과 및 인체에 대한 안전성을 조사하였다. 황련 열수 추출물(CW)은 Propionibacterium acnes, Staphylococcus aureus, Staphylococcus epidermidis에 대해 항균 효과를 보였으며, 각기 다른 4곳에서 포집된 실내 낙하균에 대해서도 항균효과를 보였다. 100 mg/mL의 농도에서 42일까지 항균의 지속력과 열처리 후에도 항균력의 변화가 없는 열 안정성을 보여주었다. CW의 MIC와 MBC는 S. aureus는 0.03, 0.05 mg/mL, S.epidermidis는 0.50, 0.75 mg/mL, P. acne는 0.10, 0.15 mg/mL였다. 주변 환경에서 검출빈도가 높은 5종의 곰팡이 중 4종에 대해 항진균 활성을 보였으며, 균사 생장의 100%를 억제할 수 있는 최저 농도로 결정하여 MIC를 측정한 결과 Gliocladium virens는 65 mg/mL이었다. Aureobasidium pullulans에 대한 MIC는 90 mg/mL, Penicilium pinophilum 및 Chaetomium globosum에 대한 MIC는 100 mg/mL로 측정되었다. 피부자극테스트인 패치테스트와 안자극 테스트인 ocular mucous membrane irritation evaluation test에서도 CW는 자극을 보이지 않는 안전한 추출물로 간주되었다. 따라서, 이러한 결과는, 황련(Coptis chinensis)은 항균, 항진균 활성 및 인체 안전성을 가지는 화장품 및 주거 환경 산업의 소재 개발에 응용될 수 있음을 시사한다. Coptis chinensis is used in oriental medicine for soothing, anti-inflammation, antimicrobial and antipyretic properties, and its main ingredient berberine is known to have strong antibacterial activity. In this study, we investigated the antimicrobial effect of hot water extract of Coptis chinensis (CW) on skin related microorganism and the airborne microbe, the antifungal effects of fungi, which are frequently detected in residential environments. CW showed antibacterial effect against Propionibacterium acnes, Staphylococcus aureus and Staphylococcus epidermidis, against the airborne microbe, which was collected in four different places. At the concentration of 100 mg/mL, the antimicrobial activity continued for 42 days, showed heat stability without change in the antimicrobial activity even after heat treatment. The MIC and MBC of CW against S. aureus was 0.03, 0.05 mg/mL, against S. epidermidis was 0.50, 0.75 mg/mL and against P. acne was 0.10, 0.15 mg/mL. As a result of measuring the MIC of four kinds of fungi with high detection frequency in the surrounding environment, Gliocladium virens was 65 mg/mL by determined as MIC which can inhibit one hundred percent of mycelial growth. The concentration 90 mg/mL was determined as MIC against Aureobasidium pullulans and 100 mg/mL against Penicilium pinophilum and Chaetomium globosum. CW was considered a safe extract that showed no irritation even in the ocular mucous membrane irritation evaluation test, a patch test. Therefore, these results suggest that Coptis chinensis has antimicrobial, antifungal and safety on human body and can be applied to the development of materials for cosmetic and residential environment industries.
치과 종사자의 감염성 폐기물관리 실천에 영향을 미치는 요인
이은비 ( Eun-bi Lee ),장종화 ( Jong-hwa Jang ) 대한예방치과·구강보건학회 2018 大韓口腔保健學會誌 Vol.42 No.4
Objectives: This study aimed to evaluate the relationship between oral health professionals’ knowledge, attitude, and practice with regard to infectious waste management and to identify related factors influencing it. Methods: The study comprised of 219 oral health professionals from select dental clinics and public health centers recruited between August 25, 2016 and September 5, 2016, who agreed to participate in the study with full understanding of the study objectives. A self-reported questionnaire was administered, which consisted of 22 items on knowledge of infectious waste management, 9 items on attitude, and 16 items on practice. Data were analyzed using Pearson’s correlation coefficient and stepwise multiple regression analyses. Results: The age, knowledge, and clinical attitude of oral health professionals significantly correlated with waste management practice. Specifically, infectious waste management practice improved with increasing age, a greater level of knowledge, and a more positive clinical attitude. Additionally, the standardized regression coefficient demonstrated that, of these three factors, clinical attitude more strongly correlated with effective waste management practice, followed by age and level of knowledge. Conclusions: These results indicated that oral health professionals had a low level of knowledge regarding infectious waste management, and a more positive clinical attitude resulted in better practices. Therefore, the development of detailed and active education guidelines and strategies are needed to enhance the attitude, knowledge, and practice of oral health professionals with regard to infectious waste management.