서울의 Penicillinase Producing Neisseria gonorrhoeae 발생빈도(1998)

김재홍,김준호,반재용,이정우,황성주,정준규,정성태,강진문,조흔정,홍창의,정혜신,이한승,김이선,이봉길,이종호,선영우,한기덕,윤성필,이성훈,안종성,박석범,문승현,조항래,김형섭,류지호,황재영,박준홍,손상욱 한양대학교 의과대학 2001 한양의대 학술지 Vol.21 No.1

In recent years, gonorrhea has been pandemic and remains one of the most common STDs in the world, especially in developing countries. For the detection of a more effective therapeutic regimen and assessing the prevalence of Penicillinase Producing Neisseria gonorrhoeae(PPNG), we have been trying to study the patients who have visited the Venereal Disease Clinic of Choong-Ku Public Health Center in Seoul since 1980 by menas of the chromogenic cephalosporin method. In 1998, 93 strians of N. genorrhoeae were isolated, among which 60(64.5%) were PPNG. The prevalence of PPNG in Seoul, which had been decreased to 39% in 1996 after a peak of 74.3% in 1993, is increased to 64.5% in 1998.

2003년 국내 중증급성호흡기증후군 진료 현황 및 문제점 분석

이진수,김은실,정문현,백제중,정선화,안주희,최영화,이선희,고철우,김성범,김민자,박승철,기현균,송재훈,최상호,김양수,이상오,조용균,박영훈,정숙인,김연숙,이흥범,손창희,장성희,정희진,김우주 대한감염학회 2004 감염과 화학요법 Vol.36 No.3

목적 : 2002년 말 중국에서 SARS가 발생한 이후 국내에서도 2003년 10월까지 총 3명의 추정환자, 17명의 의심환자가 보고되었다. 향후 추가적인 SARS의 유행이 우려되는 상황에서, 그간의 SARS 환자 진료에 있어서의 실질적인 준비사항, 진료 현황 등에 대한 조사를 통해 문제점을 파악하여, 향후 더 나은 대비가 될 수 있도록 개선점을 제시하고자 하였다. 재료 및 방법 : SARS로 의심되는 환자를 진료 경험이 있는 병원의료진을 대상으로 2003년 10월에 설문조사를 실시하였다. 설문에는 SARS 환자 진료 시의 실질적인 조치, 진료 현황, 병실, 응급실 및 외래에서의 격리 시설과 준비사항, 보건당국의 관리와 지원에 관한 사항을 포함하였다. 결과 : 대상이 되는 22개 병원 중 17개(17/22, 77.2%) 병원이 설문에 응하였다. SARS 환자를 위한 격리실은 응급실, 외래, 일반병실 및 중환자실에서 각각 9개(9/17, 52.9%), 5개(5/17, 29.4%), 15개(15/16, 93.7%), 4개(4/16, 25%) 병원에서 음압처리가 되어있지 않은 일인실 혹은 다인실이 사용되었고, 1개(1/16, 6.3%) 병원에서만 일반병실에서 음압격리실이 운영되었다. 입원환자의 진찰 시 개인보호구의 착용은 거의 모든 의료기관에서 이루어졌다. 보건당국에서 SARS지정병원의 시설 등을 사전에 확인한 곳은 1곳(1/12, 8.3%)이였고, 14개 병원(14/15, 93.3%)에서는 보건당국에 의뢰한 검사결과를 통하 받지 못하였다. 결론 : 의료기관에서 SARS 환자용 격리실뿐만 아니라 기존의 격리실 설비 등이 미흡하였으며, 특히 중환자실 및 외래의 준비가 더욱 부족하였다. 보건당국의 의료기관에 대한 종합적인 지원이 부족하였고, 병원과의 원활한 연계가 잘 이루어지지 않았다. SARS 만이 아닌 격리를 필요로 하는 질환의 적절한 진료를 위해 향후 병원 시설의 정비와 정부차원에서의 보다 구체적이고 실질적인 대책마련이 필요하다. Background : There was an worldwide outbreak of the Severe Acute Respiratory Syndrome (SARS) originated from China in late 2002. During that period three cases of suspected SARS and 17 cases of probable SARS were reported in Korea. With the concerns about the reemergence of SARS-coV transmission, it is important to be prepared for any possibility. So, this study is aimed to analysis the past measures in managing SARS and propose the amendatory plans to improve the preparedness. Materials & Methods : Questionnaires were collected among clinicians with any experience in managing the probable or suspected SARS cases in Oct. 2003. 17 out of 22 hospitals responded to the questionnaire. The contents in the questionnaire were practical activities, personal equipments, response plans, isolation facilities in emergency centers, outpatient clinics, general wards and intensive care units, and relationship with the public health department. Results : The dedicated isolation rooms in emergency centers, outpatient clinics, general wards, and intensive care units were prepared in 9 (9/17, 52.9%), 5 (5/17, 29.4%), 15 (15/16, 93.7%), and 4 (4/16, 25.0%) hospitals, respectively. Except for one hospital that newly made negative pressure room for SARS, single or multi-bed rooms without airborne infection control were used in all the other hospitals. The personal precaution principles were kept quite well in general wards. Before the designation of SARS hospital by the public health department prior evalution to see if the hospital was suitable for managing SARS was conducted in only 1 (1/12, 8.3%) hospital. The results of laboratory diagnosis were reported back in 1 (1/15, 6.6%) hospital. Conclusions : The isolation facilities which can control airborne infection were almost deficient not only for SARS but also for other respiratory transmissible diseases. For the infection control of transmissible diseases including SARS, more investment is needed on medical facilities and comprehensive support from the public health department required.

웹 카메라를 이용한 시설 내 국화생산 광 환경 원격 모니터링

정선옥(Sun-Ok Chung),김용주(Yong-Joo Kim),이규호(Kyu-Ho Lee),성남석(Nam-Seok Sung),이철휘(Cheol-Hwi Lee),노현권(Hyun-Kwon Noh) 충남대학교 농업과학연구소 2015 농업과학연구 Vol.42 No.4

Increase of national family income improved demand of high-quality and year-round horticultural products including chrysanthemum. To meet these demand, farmers have introduced protected facilities, such as greenhouses, of which environmental conditions could be monitored and controlled. Environment management up to three weeks after transplanting is critical for chrysanthemum quality. Artificial lighting and light-blocking screen are especially important for long-day (day period > 13 hours) and short-day (night period > 13 hours) treatments. In this study, a web-camera was installed, and the image was obtained and transmitted to mobile phones to monitor the status of 3-wavelength(RGB) lighting environments. RGB pixel values were used to determine malfunctioning of the lighting lamps, and leaking out and incoming illumination status during short-day and long-day treatment periods. Normal lighting lamps provided RGB pixel values of 240~255. During long-day treatment period, G pixel values were useful to detect abnormal lighting conditions (e.g., leaking). During short-day treatment period, R pixel values were useful to determine incoming light (e.g., sun-light). Results of this study would provide useful information for remote monitoring of light conditions for protected chrysanthemum production under artificial lights.

Purge & Trap-GC를 이용한 의약품 필름코팅 정제 중 잔류용제에 관한 연구

장준식,이명자,소유섭,문춘선,이주헌,박희라,김진숙,강경모,이선옥,방성연,유미자,유문균,금오성,이병욱 식품의약품안전청 2000 식품의약품안전청 연보 Vol.4 No.-

의약품은 약물을 생체에 적풋하기 위하여 유효성분의 효과가 언제나 일정하게 확보되고 사응에 편리하도록 만들어지는 것이므로 유효썽분 이외에 약효에 영향을 주지 않는 성분이 첨가되는 경운가 많다. 이 때 사용되는 용매들은 제피의 광택 및 건쪼시간의 단축 등을 위하여 휘발점이 낮을 용매들이 주로 사용되어진다. 본 연구는 의약품 필름코팅정제 중 잔류용매 4종(chlorofonr benzen, trichloro ethylen, 1,4-dioxane)에 대한 변형된 pirge & trap-GC 장치를 이용한 동시분석방법을 개발하였으며, 각 표준품의 RSD 값은 chloroform 3.03%, benzen 3.17%, trichloroethylen 3.69% and 1,4-dioxane 3.41%였다. 또한 시중 유통중인 의약품 50종에 대하여 잔류웅매 양을 측정하였으며, 검출되는 잔류용매는 한 건도 없었다. This study nras carried out to develope the analytical method for the mixture of chlorefonn, benzen, trichloroethylen and 1,4-dioxane simultaneously and determine the remainingorgauic solvents in coating tablets by Purge & Trap-GC. The results were as follouFs ; 1. Chloroform, benzen, trio:tloroethylen and 1,4-dioxane separated by tenax #5 trap by HP-624GC column by terrlperature programming. The peaks were separated completely at retentiontime of 6.88min for chloroform, 8.21min for benzen, 10.38miu for trichloroethylen and 11.95minfor 1,4-dioxane. 2. Standard RSD were individually chloroform 3.03%, benzen 3.17%, trichloroethylen 3.69%and 1,4-diorane 3.41%. 3. 60 samples were not detrcted chloroform, benzen, trichloroethylen and 1,4-dioxane.

BEZ235 (PIK3/mTOR inhibitor) Overcomes Pazopanib Resistance in Patient-Derived Refractory Soft Tissue Sarcoma Cells

Kim, Hee Kyung,Kim, Sun Young,Lee, Su Jin,Kang, Mihyeon,Kim, Seung Tae,Jang, Jiryeon,Rath, Oliver,Schueler, Julia,Lee, Dong Woo,Park, Woong Yang,Kim, Sung Joo,Park, Se Hoon,Lee, Jeeyun Neoplasia Press 2016 Translational oncology Vol.9 No.3

<P><I>BACKGROUND:</I> Although pazopanib treatment has become the standard chemotherapy in salvage setting for metastatic sarcoma patients, most patients progress after pazopanib treatment in 4 to 6 months. After failure to pazopanib, patients have limited options for treatment. Therefore, subsequent therapy in patients who failed to pazopanib is urgently needed and the use of patient derived cells or patient derived tumors for accompanying testing with various pharmacological inhibitors could offer additional treatment options for these patients. <I>METHODS:</I> Patient derived tumor cells were collected from ascites at the time of progression to pazopanib and a 13-drug panel was tested for drug sensitivity. We confirmed the results using <I>in vitro</I> cell viability assay and immunoblot assay. We also performed the genomic profiling of PDX model. <I>RESULTS:</I> The growth of patient derived tumor cells was significantly reduced by exposure to 1.0 μM AZD2014 compared with control (control versus AZD2014, mean growth = 100.0% vs 16.04%, difference = 83.96%, 95% CI = 70.01% to 97.92%, <I>P</I> = .0435). Similarly, 1.0 μM BEZ235 profoundly inhibited tumor cell growth <I>in vitro</I> when compared to control (control versus BEZ235, mean growth = 100.0% vs 7.308%, difference = 92.69%, 95% CI = 78.87% to 106.5%, <I>P</I> < .0001). Despite the presence of CDK4 amplification in the patient-derived tumor cells, LEE011 did not considerably inhibit cell proliferation when compared with control (control vs LEE011, mean growth = 100.0% vs 80.23%, difference = 19.77%, 95% CI = 1.828% to 37.72%, <I>P</I> = .0377). The immunoblot analysis showed that BEZ235 treatment decreased pAKT, pmTOR and pERK whereas AZD2014 decreased only pmTOR. <I>CONCLUSION:</I> Taken together, upregulation of mTOR/AKT pathway in sarcoma patient derived cells was considerably inhibited by the treatment of AZD2014 and BEZ235 with downregulation of AKT pathway (greater extent for BEZ235). These molecules may be considered as treatment option in STS patient who have failed to pazopanib in the context of clinical trials.</P>

고추 가공 및 저장중 辛味成分 변화

李宙相,黃聖淵,曺哉銑 慶熙大學校 1993 論文集 Vol.22 No.-

The capsaicinoids of Korean red peppers were varied with cultivars from 30 mg% to 257mg%, highest in ˝Chungyang˝and medium in ˝Dabock˝ which is most popular to Korean and major capsicinoids were capsaicin and dihydrocapsaicin which are 88.5-94.8% of total capsaicinoids in red peppers. The capsaicinoids of red pepper were distributed 46% in placenta and septum and remainder were in pericarp, seed and stem in the order. The changes in capsaicinoids content of red peppers was not significant during hot-air drying at 65-75℃and sun drying. Fluorescent light was more destructive to capsaicinoids than incandescent light when red pepper powder was exposed to those lights. The larger amount of capsaicinoids was extracted with higher concentration of salt solution, but the water extractability was not affected by pH changes. During storage at 4,25,40℃ for 180 days, capsaicinoids content of red peppers was changed.

흡착제 및 오존발생기를 이용한 질소산화물 제거

이주혁,목영선 제주대학교 공과대학 첨단기술연구소 2005 尖端技術硏究所論文集 Vol.16 No.2

The injection of ozone, generally produced by a dielectric barrier discharge device, into the exhaust gas gives rise to a rapid oxidation of NO that is the main component of nitrogen oxides (NO_(x)) in most practical exhaust gases. Unlike NO, NO_(2) has a strong adsorptivity. Thus, once NO is converted into NO_(2), it can easily be removed by an adsorbent. The adsorbent used in this study was a mixture of activated carbon and calcium oxide. The present two-step process (NO oxidation followed by adsorption) was able to remove 55-80% of nitrogen oxides initially contained in the exhaust gas.

적응적 스캔 변환기의 설계 및 구현

이범근,홍주선,정연모 경희대학교 산학협력기술연구원 1999 산학협력기술연구논문집 Vol.5 No.-

The purpose of format conversion is to convert a wide range of personal computer video formats to a target format. Circuits for the conversion have been developed by means of interpolation techniques, such as zero-order interpolation, bilinear interpolation, and bisigmoidal Interpolation. This paper purposes an adaptive scan converter using bisigmoidal interpolation The value of the control constant of the bisigmoidal interpolation polynomial is adaptively selected according to the difference of neighboring pixel values for a new pixel on the target format. The converter has been modeled in VHDL, on Max+PlusⅡ and implemented with a FPGA chip. The circuit gives much better conversion performance than a scan converter with a fixed control constant based on the bisigmoidal interpolation.

서울여자대학교 평생교육원 설치 타당성에 관한 조사 연구

이옥주,김선요 서울여자대학교 여성연구소 1992 여성연구논총 Vol.6 No.-

장애 영·유아 조기발견 및 진단·평가 방안 연구

이미선,강병호,김주영,조광순 국립특수교육원 2001 연구보고서 Vol.- No.6

본 연구는 유아특수교육 분야에 있어 장애영·유아 조기발견 및 진단·평가의 중요성을 인식하고, 조기발견 및 진단-평가의 대상이 되는 우리 나라 유아특수교육 대상자의·새로운 정의와 기준 및 장애영·유아 조기발견 및 진단·평가 방안을 모색함으로써 향후 이들의 장애를 예방하거나 최소화하고, 교육 및 가족의 삶의 질을 향상시키며, 궁극적으로는 이들의 사회통합 강화와 국가 예산의 절감 효과를 가져오도록 하는데 그 목적이 있다. 이와 같은 목적을 달성하기 위해 본 연구에서는 장애영·유아 사정 단계별 개념과 절차 및 최근의 사정 동향과 쟁점, 우리 나라와 주요 선진국의 장애영·유아 조기발견 및 진단·평가 정책과실제에 관한 문헌을 분석하였고, 유아특수교육기관의 교사, 유아특수교육기관에 재학하고 있는 장애영·유아 부모, 그리고 기타 장애영·유아 조기발견 및 진단·평가 관련 전문가를대상으로 심층면담을 실시하였으며, 연구자 협의회를 개최하였다. 본 연구는 문헌분석, 심층면담 분석 및 연구자 협의회 결과를 모두 종합하여 다음과 같은 방안을 제시하였다. 첫째, 1차 예방적 접근에 따라 우리 나라 유아특수교육 대상자의 새로운 정의와 기준을규정하되, 비범주적 접근인 '발달지체'라는 개념을 도입한다. 따라서, "장애영·유아"는 유아특수교육을 필요로 하는 만 6세 미만의 아동을 말하며, 인지발달, 언어(의사소통) 발달,사회·정서발달, 운동발달, 자조기술(적응행동)에 심각한 발달지체를 나타내는 경우로서 발달지체 기준에 부합하는 경우, 의학적 진단에 의한 장애 조건, 기타 심리·정신적 문제를 가진 아동 및 장애위험 아동을 포함한다. 이 때, 발달지체를 판정할 수 있는 기준으로서 양적 기준과 질적 기준을 모두 사용한다. 둘째, 장애아동을 조기에 발견하기 위해 조기발견 정책은 발견·등록 및 관리·진단 대상 아동의 정의, 대중 인식 프로그램의 실시, 의뢰체계 구축, 주 선별담당 기관에 의한 주기적인 선별검사 실시, 해당 아동의 등록·관리, 장애 가능성이 있는 아동의 진단 의뢰,조기발견에 대한 인식 유지 활동 등의 절차에 의해 체계적으로 이루어지도륵 한다. 셋째, 장애영 유아 특성에 적절한 진단·평가 절차와 방법에 관한 지침을 개발하고, 아동 및 부모 모두에게 중요한 의사결정이 이루어지는 유아특수교육 대상자의 적격성 판정 및교육기관 배치를 위한 진단 단계와 IEP 개발을 위한 평가 단계의 최소한의 중요 요소는 법규로 제정하며, 보다 구체적인 진단·평가 절차와 방법은 각 시·도 교육과정 편성·운영지침이나 지역교육청의 장학 자료로 사용될 수 있도록 널리 보급한다. 또한, 현재 시범 운영되고 있는 특수교육지원센터는 수요자들의 접근성 및 인적·물적 자원의 이용이 용이한특수학교에 우선 설치한다. 특수교육지원센터는 진단·평가팀을 구성하여 운영하되, 한정된 예산 및 전문가의 활용 가능성 등을 고려하여 진단·평가팀 구성원의 탄력적인 조직,연중 상시의 진단보다는 연중 정해진 날의 질단 실시, 의학적 진단을 포함한 다양한 분야의 종합적인 진단이 이루어지도록 한다. 진단·평가팀은 종합적인 진단 결과에 기초하여아동의 유아특수교육 대상자로서의 적격성과 교육기관 배치를 결정하도록 한다. 넷째, 선별, 진단, 교육 프로그램 계획, 아동의 진전 점검 등 각 사정 단계에 따른 다양한 사정도구 즉, 선별검사, 표준화 규준참조형 사정도구, 교육과정중심 사정도구를 국가차원의 지원 하에 개발하거나 외국의 것을 재표준화한다. 또한, 다양한 비형식적 가족진단 검사를개발하여 가족 요구,관심사 및 강점 등을 사정할 수 있도록 한다. 다섯째, 아동을 조기에 발견하고, 발견된 아동을 정화하게 진단하며, 이들에게 적절한중재 프로그램을 계획하기 위해 유아(특수)교육 교사나 관련 전문가들을 대상은로 하늘 선별요원 양성 과정, 유차특수교육 교사를 대상으로 한 장애영 '유아 진단'평가요원 연수과정을 개선하여 실시한다. 또한, 의료 보건 전문의를 비롯한 유아특수교육 관련 분얀의 전문가들이 다양한 분야의 전문가들을 서로 만나서 토의하고 협력할 수 있는 연수 혹은 워크숍의 기회를 제공하고, 이들의 직전교육을 강찬한다. 사정 과정에 있어 교사를 포함한 관련 전문가들은 가족참여의 중요성을 인식하곤, 가족과 동반자적인 관계를 구축하고 긴밀하게 협력하며, 가족을 다학문적팀의 완전한 구성원으로 인정해야 한다. 또한, 사정 과정에 가족들이 보다 적극적으로 참여할 수 있도록 부모에게 친숙한 사정 자료를 사용하거나 교사와 부모간의 사정 결과를 공유하는 등 다양한 전략을 사용하도록 한다. 마지막으로, 장애위험 영·유아 및 장애영아를 무상의 유아특수교육 대상자로 포함시키되, 순차적으로 실시하며, 장애아동의 조기발견, 진단·평가 및 이에 따른 교육 서비스가 효율적으로 이루어지도록 중앙정부 수준부터 지역사회 수준에 이르기까지 관련 부처간 협력체계를 구축하고, 이를 위해 관련 부처간 혹은 관련 기관간 협의체를 구성한다. 또한, 장애아동의 조기발견 정책을 보다 효율적으로 추진할 수 있도록 조기발견 시범사업을 실시 하고 이에 대한 예산을 지원하도록 한다. 조기발견 시범사업에 의해 도출된 선별의 효과, 비용 및 참여율 등의 평가 결과는 추후 조기발견 사업 계획에 적극 반영하도록 한다. Based on the recognition of the importance of early detection(child-find and screening) of ifants and preschoolers with disabilities along with their . diagnosis, and evaluation in the field of early childhood special education, the purpose of this study is to set a new definition and eligibility criteria for those who are subject to early detection, diagnosis, and evaluation; and to find strategies that will help early detecaon, diagnosis, and evaluation in order to henceforth prevent or minimize their disability, improve the quality of education of infants and preschoolers with disabilities and their families' living and eventually strengthen their social integration and reduce the national budget. To achieve the purpose of this study, Iiterature related to the concept and procedure of assessment by stage of ifants and preschoolers with disabilities, along with the recent tendencies and issues, policies and practices of child-find, screening, diagnosis, program planning, and program evaluation of infants and preschoolers with disabilities in Korea and developed nations were analyzed; in-depth interviews were conducted with teachers from education institutions for ifants and preschoolers with disabitities, mothers whose children attend the institutions, and other specialisls who are relevant to the field of early detection, diagnosis, and evaluation of infants and preschoolers with disabilities; and conferences by the researchers of this study were held several times. Putting together the results from the aforementioned analysis of literature, in-depth interviews, and conferences, this study presents the following strategies. First, according to the primary prevention appreach, form the new definition of children who receive early childhood special education and eligibility criteria for early childhood special education, but introduce the notion of "developmerltal delay" which is an un-categorical approach. Therefore, infants and preschoolers with disabilities refer to children under age 6 who need early childhood special education, and this includes children who show developmental delays in cognitive development, language(communication) development, social-emetional development, physical developent, and self-help stills(adaptive behaviors) that meet the criteria for developmental delays pesented in this study, children who are medically diagnosed to have disabled conditions, children who have other psychological or mental poblems, and children at risk Here, both quantitative and qualitative standards are used as the criteria to determine developental delays. Secorid, in order to detect children with disabilities at an early stage, systematic pocedures should be introduced in the policr of early detection such as defining the children who is subject to discovery, registration and tracking, and diagnosis; providing pblic awareness programs; establishing referral systems; carrying out screening tese that will be conducted periodically by the main sneening institution; registering and tracking pertinent children; referring children who show possibilities of disabilities to be diagnesed; and maintaining awareness on early detection. Third, develop guidelines for diagnosis and evaluation that are appropriate to the characteristics of infents and preschoolers with disabilities; regulate by law and regulation the minimum important elements that relate to·assessment process for diagnosis to make an eligibility and placement decision of the childreri who will receive early childhood special education, which will be important decision-making both for the children and parents and that relate to the assessment pocess for IEP development; and spread more detailed pocedures and mrthods so that they can be used as guidelines for the developerlt and management of the curriculum at the metropolitan and provinrial level or as materials for supervision at regional level. In addition establish special education support centers, which are currently being operated as the model, at special schools that are easily accessible by demanders and that are easy to acquire human and material resources. Special education support centers should form and operate multidisciplinary assessment teams. However, they should take in consideration aspects such as limited budget and availability of multidisciplinaiy specialists, and make flexible composition of assessment teams, operating on fixed days throughout the year rather than ordinary times year round, and making comprehensive diagnosis of various fields, including medical diagnosis. The assessment teams should allow the compehensive diagnosis results to be the basis of eligibility for a subject to receive early childhood special edtlcation and for placement of education institiltions. Fourth, develop various instruments aided by the government such as screening tests, standardized nom-referenced assessment instruments, assessment curriculum-based assessment instruments, or re-standardize appopriate foreign assessment instruments for each assessment stage, which indudes stages such as screening, diagnosis, program planning, and progress monitoring. Furthermore, develop various informal family diagnosis instruments to assess the family’s piorities, concerns, and strengths. Fifth, in order to find children with disabilities at an early stage; correctlydiagnose the discovered children; and plan appropriate inteuention program forthenL provide early childhood (special) education teachers and pe.tinent specialistswith training programs that teach the process of screening. Allow early childhoodspecial education teachers to receive training programs that teach how to diagnoseand evaluate infanc and peschoolers with disabilities. Ill additiof povide the opportunities of in-service training or wortshops so that specialists in various fieldsrelating to early childhood special education, including medical care professionals, can meet to discuss and cooperate, and strengthen their pre-service training programs. Teachers and specialists should be aware of the importance of flmily participation in the assessment process, and they should build partnership, keep close cooperation, and acknowledge the family as a full meuber of the multidisciplinaly assessment team. They should also allow the parents and other flmily members to participate even more actively by strategies such as usirg assessment materials that is familiar to the parents or having joint ownership of the assessment results between parents and teachers. Last, include infants and preschoolers at risk of disabilities and infants wilh disabilities as the subjects to receive free early childhood special education, but conduct it gradually. Also, establish collaborative systems among those from fields of education, medical service, and welfare from the central government to the regional level, so that early detection, diagnosis, evaluation of children with disabilities and education services can run effectively, and for this there must be a council of collaboration among related departments or institutions. Moreover, to promote an even more effective policy to find children with disabilities at an early stage, a model program for early detection should be conducted and the budget for this should be granted. Evaluation results such as screening effectiveness, budget used, and the rate of participation in the screening should be deduced from the model program, and afterwards positively reflected in the project of the early detection programs.