Psidium guajava L. leaf extract inhibits adipocyte differentiation and improves insulin sensitivity in 3T3-L1 cells

Esther Choi,Seoyoung Baek,Kuanglim Baek,Hye-Kyeong Kim 한국영양학회 2021 Nutrition Research and Practice Vol.15 No.5

BACKGROUND/OBJECTIVES: Psidium guajava L. (guava) leaves have been shown to exhibit hypoglycemic and antidiabetic effects in rodents. This study investigated the effects of guava leaf extract on adipogenesis, glucose uptake, and lipolysis of adipocytes to examine whether the antidiabetic properties are mediated through direct effects on adipocytes. MATERIALS/METHODS: 3T3-L1 cells were treated with 25, 50, 100 μg/mL of methanol extract from guava leaf extract (GLE) or 0.1% dimethyl sulfoxide as a control. Lipid accumulation was evaluated with Oil Red O Staining and AdipoRed assay. Immunoblotting was performed to measure the expression of adipogenic transcription factors, fatty acid synthase (FAS), and AMP-activated protein kinase (AMPK). Glucose uptake under basal or insulin-stimulated condition was measured using a glucose analog 2-[N-(7-nitrobenz-2-oxa-1,3-diazol-4-yl) amino]-2-deoxy-D-glucose. Lipolysis from fully differentiated adipocytes was measured by free fatty acids release into the culture medium in the presence or absence of epinephrine. RESULTS: Oil Red O staining and AdipoRed assay have shown that GLE treatment reduced lipid accumulation during adipocyte differentiation. Mitotic clonal expansion, an early essential event for adipocyte differentiation, was inhibited by GLE treatment. GLE inhibited the expression of transcription factors involved in adipocyte differentiation, such as peroxisome proliferator-activated receptor γ (PPARγ), CCAAT/enhancer-binding protein α (C/EBPα), and sterol regulatory element-binding protein-1c (SREBP-1c). FAS expression was also decreased while the phosphorylation of AMPK was increased by GLE treatment. In addition, GLE increased insulin-induced glucose uptake into adipocytes. In lipid-filled mature adipocytes, GLE enhanced epinephrine-induced lipolysis but reduced basal lipolysis dose-dependently. CONCLUSIONS: The results show that GLE inhibits adipogenesis and improves adipocyte function by reducing basal lipolysis and increasing insulin-stimulated glucose uptake in adipocytes, which can be partly associated with antidiabetic effects of guava leaves.

서로 다른 의치 이장재간의 중합수축 비교

Esther Choi,Ji-Myung Bae,Seung-han Oh 대한치과재료학회 2013 대한치과기재학회 학술대회 Vol.2013 No.4

Incidence and Mortality Trends in Critically Ill Children: A Korean Population-Based Study

Choi Jaeyoung,Park Esther,Choi Ah Young,Son Meong Hi,Cho Joongbum 대한의학회 2023 Journal of Korean medical science Vol.38 No.23

Background: Monitoring mortality trends can help design ways to improve survival, but observation of national mortality trends in critically ill children is lacking for the Korean population Methods: We analyzed the incidence and mortality trends of children younger than 18 years admitted to an intensive care unit (ICU) from 2012 to 2018 using the Korean National Health Insurance database. Neonates and neonatal ICU admissions were excluded. Multivariable logistic regression analyses were performed to estimate the odds ratio of in-hospital mortality according to admission year. Trends in incidence and in-hospital mortality of subgroups according to admission department, age, presence of intensivists, admissions to pediatric ICU, mechanical ventilation, and use of vasopressors were evaluated. Results: The overall mortality of critically ill children was 4.4%. There was a significant decrease in mortality from 5.5% in 2012 to 4.1% in 2018 (P for trend < 0.001). The incidence of ICU admission in children remained around 8.5/10,000 population years (P for trend = 0.069). In-hospital mortality decreased by 9.2% yearly in adjusted analysis (P < 0.001). The presence of dedicated intensivists (P for trend < 0.001, mortality decrease from 5.7% to 4.0%) and admission to pediatric ICU (P for trend < 0.001, mortality decrease from 5.0% to 3.2%) were associated with significant decreasing trends in mortality. Conclusion: Mortality among critically ill children improved during the study period, and the improving trend was prominent in children with high treatment requirements. Varying mortality trends, according to ICU organizations, highlight that advances in medical knowledge should be supported structurally.

Silane coupling agent인 MPS 농도별처리에 따른 열중합 레진과 자가중합 레진 간의 전단결합강도

최에스더(Esther Choi),권은자(Eun-Ja Kwon) 한국콘텐츠학회 2015 한국콘텐츠학회논문지 Vol.15 No.2

본 논문은 치과에서 많이 사용되고 있는 silane coupling agent로 표면 처리한 의치상 레진과 자가중합레진 간의 전단 결합력에 미치는 영향에 대해 알아보고자 하였다. 의치상 레진에 silane coupling agent 농도별 표면 처리 후 자가중합레진을 주입하여 전단결합강도를 측정하였다. Silane coupling agent(MPS)의 농도별 표면 처리에 따른 의치상 레진과 자가중합레진 간의 전단결합강도에서는 Vertex self curing resin에서 5%, 7%에서 유의적으로 높게 나타났고(P<0.05), Kooliner에서는 5%에서 유의적으로 가장 높게 나타났다(P<0.05). 따라서 의치상 레진과 자가중합레진 사이에 MPS 5%를 이용한 표면처리가 전단결합강도에 효과적으로 영향을 미치는 것이라 사료된다. The purpose of this study was to evaluate the effect of the surface treatment of widely used in dental of silane coupling agent concentration on the shear bond strength of denture base resin and self curing resins. Denture base resin surface was treated with silane coupling agent concentration, after self curing resins were injected shear bond strength was measured. The results of silane coupling agent(MPS) concentration on the shear bond strength of Vertex self curing resin showed that the value of 5%, 7% groups were higher than that of other group(P<0.05). Silane coupling agent concentration on the shear bond strength of Kooliner resin showed that the value of 5% was highest(P<0.05). Therefore, we could conclude 5% MPS to strengthen effectively the shear bonding property of denture base resin and self curing resins of this study.

고령자 환자의 임플란트 구강건강 기능별 만족도에 관한 연구

최에스더(Esther Choi),권은자(Eun-Ja Kwon),한민수(Min-Su Han) 한국의료정보교육협회 2022 보건의료생명과학논문지 Vol.10 No.2

본 연구는 충청남도 홍성 지역에 거주하는 노인들을 대상으로 임플란트 의료보험 적용 시행 후 임플란트 전· 후의 기능별 만족도 요인을 비교하여 노인들의 구강건강 관련 삶의 질을 향상하기 위한 기초자료를 제공하고자 하였다. 2020년 11월 1일부터 20211년 3월 31일까지 충청남도 홍성군에 거주하는 55세 이상을 대상으로 설문조사를 하였다. 저작, 사회적, 심리적 기능을 조사하여 Likert 5점 척도를 사용하였고 기능별 만족도 비교를 위해 paried T-test를 실시하였다. 임플란트 시술 전·후에 대한 저작 기능, 사회적 기능, 심리적 기능에 대한 모든 문항에서 임플란트 시술 전보다 시술 후에서 유의적으로 높게 나타났다(p<0.001). 임플란트 시술은 노인의 구강건강 뿐만 아니라 삶의 질 변화에도 많은 영향을 주므로 노인의 구강건강 증진을 위해서 노인들의 구강 건강 문제와 임플란트에 대한 연구가 더 많이 시행되고, 그에 따른 방안이 필요하겠다. This study aimed to provide basic data for improving the quality of life related to oral health of the elderly by comparing the satisfaction factors by function before and after implantation targeting the elderly living in Hongseong, Chungcheongnam-do. From November 1, 2020 to March 31, 2021, a survey was conducted targeting people aged 55 or older living in Hongseong-gun, Chungcheongnam-do. A Likert 5-point scale was used to investigate chewing, social, and psychological functions, and a paried T-test was conducted to compare satisfaction by function. All factors for masticatory, social, and psychological function before and after implant surgery were significantly higher after implant surgery than before implant surgery(p<0.001). Implant surgery has a great influence on not only the oral health of the elderly but also the change in the quality of life, so more research on this is needed and measures are needed accordingly.

A Study on Personalized Beauty Care for the Elderly Using an AI-based Digital Skin Analysis System

최에스더 ( Esther Choi ),이명주 ( Myoung-joo Lee ) 한국미용학회 2024 한국미용학회지 Vol.30 No.2

This study aims to provide customized skin care services for the elderly living alone. To this end, an AI-based digital skin analysis system using deep learning technology and skin analysis algorithms was used to measure skin and analyze skin features according to skin type. The results of the study are summarized below. First, the skin condition of the elderly varies depending on the age, gender, and lifestyle of the subjects, so it is necessary to accurately diagnose and analyze the skin in advance to support customized beauty care. Second, aging skin is more likely to have an imbalance of oil and moisture compared to other ages, so a care program that can restore it is necessary. Third, a special care program should be implemented for wrinkles, elasticity, and pigmentation. In conclusion, in order to manage aging skin healthily, digital technology should be used to diagnose skin types more accurately and build management programs accordingly. The elderly living alone are often emotionally depressed and have low self-esteem. They need customized beauty care, but currently, beauty care services are mainly centered on hair care, so it is necessary to activate service support in the area of skin care. It is expected that it will be possible to properly diagnose their skin condition, find problems and provide solutions, and establish a series of customized skin care programs to help them age well.

치기공과 학생들의 구강위생에 대한 지식 및 관리실태

최에스더(Choi, Esther),권은자(Kwon, Eun-Ja) 한국산학기술학회 2011 한국산학기술학회논문지 Vol.12 No.11

이 연구의 목적은 치기공과 학생들의 구강위생관리 실태 및 지식을 파악하여 지역사회의 구강건강을 향상 시킬 수 있는 동기를 부여하고, 구강보건 교육에 도움이 되고자 함이다. 조사대상자는 충청도 소재 대학의 치기공과 에 재학 중인 학생 160명을 대상으로 2010년 11월 10부터 12월 9일까지 설문조사를 실시하였고, 다음과 같은 결론 을 얻었다. 일반적 특성에 따른 구강관리 지식차이는 성별로 남자가 여자보다 높았고, 연령별로는 연령이 높아질수록 높았고, 학년별 항목에서는 학년이 높을수록 높았고, 통계적으로 유의한 차이가 있었다(p<0.05). 구강위생관리 실태에 따른 구강관리지식차이는 일일 잇솔질 횟수가 5회 이상에서 가장 높았고, 잇솔질 방법은 옆으로 치아만 한다에서 높 았다. 치간 칫솔 이용유무 항목에서는 사용한다가 높았고, 통계적으로 유의한 차이가 있었다(p<0.05). 따라서 전반적 인 구강위생관리 실태는 구강보건교육의 경험이 있는 치기공과 학생들이 양호한 것으로 나타났으며, 이를 통해 수업 시간에 계속적으로 구강보건교육을 받고 익히는 사람들에게서 구강건강관리가 달라지는 것을 알 수 있었다. 이에 지 역사회에서도 구강보건교육의 기회를 확대시켜 국민의 구강건강을 향상시키도록 해야하겠다. The purpose of this study was to examine the oral health status and knowledge of dental laboratory technology student for the community to improve oral health and oral health education to help. The subjects in this study were 160 students in dental laboratory technology at the University located in Chung-cheong and surveyed from November 2010 to December 2010. The finding of the study were as follows: The differences in oral care knowledge according general characteristics of subjects was statistically significant to the gender was higher in men than women, age was higher and higher the grade was higher in grade level(p<0.05). The differences in oral care knowledge according oral health status of subjects was statistically significant to regarding the frequency of tooth brushing was highest rate in five times, method was on the side tooth higher and using the dental floss and interdental brush are used by the higher availability(p<0.05). Thus, in the classroom oral health education and continuous learning from the people know that oral health care could differ. Oral health education in local communities to increase opportunities and people will need to improve oral health.

치과기공사의 이미지와 선호도 조사

최에스더(Esther Choi),권은자(Eun-Ja Kwon),송귀숙(Kwui-Sook Song) 한국콘텐츠학회 2009 한국콘텐츠학회논문지 Vol.9 No.1

본 연구는 일반인들의 치과기공사에 대한 이미지를 알아보기 위하여 치과계에 관련이 없는 만 18세 이상의 일반성인 350명을 대상으로 선정하여 자기기입식 설문지를 이용하여 조사하였다. 자료의 분석은 SPSS 12.0 for Windows 통계 패키지 프로그램을 활용하여 전산처리 하였다. 분석기법으로는 빈도와 백분율, T-test, F-test(ANOVA)분석을 하였으며, 다음과 같은 결론을 얻었다. 치과기공사의 이미지에 관한 연구는 직업적 이미지가 3.62, 업무적 이미지 3.46 순으로 나타났다. 이 중에서 직업적 이미지인 ‘전문적 지식과 기술이 필요하다’가 4.17로 가장 높았으며, ‘전문적이다’가 4.14로 높았다. ‘힘들고 스트레스가 많지 않다’가 2.43으로 가장 낮은 이미지를 나타났다. 치과기공사에 대한 선호도에 관한 연구는 2.67로 낮은 것으로 나타났다. 이 중에서 연령별은 20대 미만이 3.53으로 높게 나타났으며, 직업은 학생이 3.29로 높게 나타났다. 수입은 150만원 미만이 2.91로 높게 나타났다. The study surveyed 350 people who are over 18 and not related to dentistry with questionnaires in order to examine image and preference of dental technicians. The data analysis was done using the SPSS 21.0 for Windows. As for the analysis methods, the study used the frequency analysis, percentage, t-test, f-test. Through these analyses, the following conclusions were made. The score on the image of dental technicians declined in the order of occupational image(3.62), work image(3.46). The necessity of professional knowledge and techniques in the occupational image had the highest score with 4.17. Also, the image showing that it is professional had a score of 4.14 and the image that shows hardworking and stressful occupation showed the lowest score with 2.43. The study on the preference of dental technicians showed a low score of 2.67. The respondents who are in the 20s(3.53), and who are students(3.29) showed a high score. Also, people who have monthly income of less than 1.5 million won showed a high score of 2.91.With the help of information technology

화학적 표면처리에 따른 의치상 레진과 이장재 간의 전단 결합강도

최에스더(Choi, Esther),권은자(Kwon, Eun-Ja) 한국산학기술학회 2013 한국산학기술학회논문지 Vol.14 No.11

본 논문은 monomer에서 결합증진에 많은 역할을 하는 MMA와 TEGDMA의 농도별 표면 처리와 silane coupling agent로 표면 처리한 것이 의치상 레진과 이장재간의 결합력에 미치는 영향에 대해 알아보고자 하였다. 의치 상 레진에 MMA와 TEGDMA의 농도별 표면 처리와 silane coupling agent로 표면처리 후 이장재를 주입하여 전단결 합강도를 측정하였다. MMA와 TEGDMA의 농도별 표면 처리에 따른 의치상 레진과 이장재간의 전단결합강도에서는 Vertex self curing resin에서 95%, 90%, 80%, Kooliner에서는 95%, 90%에서 유의적으로 높게 나타났다(P<0.05). 또한, silane coupling agent 5%로 표면 처리한 그룹이 Vertex self curing resin과 Kooliner 모두에서 전단결합강도가 유의적 으로 높게 나타났다(P<0.05). 따라서 적절한 화학적 표면 처리는 의치상 레진과 이장재간의 결합력 증가에 영향을 미 치리라 사료된다. The purpose of this study was to evaluate the effect of the surface treatment of MMA and TEGDMA concentration, silane coupling agent on the shear bond strength of denture base resin and denture reliners. Denture base resin surface was treated with MMA and TEGDMA concentration, silane coupling agent. After denture reliners were injected bond strength was measured. The results of MMA and TEGDMA concentration on the shear bond strength of Vertex self curing resin showed that the value of MMA 95% and TEGDMA 5%, MMA 90% and TEGDMA 10%, MMA 80% and TEGDMA 20% groups were higher than that of other group(P<0.05). MMA and TEGDMA concentration on the shear bond strength of Kooliner resin showed that the value of MMA 95% and TEGDMA 5%, MMA 90% and TEGDMA 10% were higher than that of other group(P<0.05). Silane coupling agent on the shear bond strength of Vertex self curing resin and Kooliner showed that the value of MMA 95% and silane coupling agent 5% groups was higher than that of other group(P<0.05). Therefore, we could conclude that appropriate chemical surface treatments are supposed to affect the bond of denture base resin and denture reliners.

트리구조에 대한 효율적인 버전 관리 방법

최진희(Esther J. Choi),권용래(Yong Rae Kwon) 한국정보과학회 1996 한국정보과학회 학술발표논문집 Vol.23 No.1A

본 논문에서는 트리 구조를 갖는 자료가 계속 변화할 때 변경 내용을 효율적으로 관리할 수 있는 버전 관리 방법을 제안한다. 제안된 방법은 변경에 대한 정보를 변경이 일어난 노드의 부모노드에 보관하고 트리는 최선의 상태를 유지함으로써 최신 트리 상태를 쉽게 구할 수 있다. 버전을 효율적으로 관리하기 위해 필요한 알고리즘들을 제시하며, 이를 다른 트리 버전 관리 방법과 비교 분석한다. 제안된 방법은 저장 공간과 수행 속도 측면에서 버전 관리를 위한 추가적인 비용이 거의 들지 않으며, 기존의 버전 관리 방법과 비교해 볼 때 더욱 효율적이다.