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- 저자 : Doo Guen Yang (검색결과 4 건)
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Lee, Mi Kyeong,Kim, Seung Hyun,Yang, Hyekyung,Lim, Doo-Yeon,Ryu, Je-Ho,Lee, Eung Seok,Jew, Sang-Sup,Park, Hyeung-Guen,Sung, Sang Hyun,Kim, Young Choong Natural Product Communications 2009 Natural product communications Vol.4 No.6
<P>We attempted to elucidate the hepatoprotective mechanism of two asiatic acid (AS) derivatives, 3beta,23-dihydroxyurs-2-oxo-12-ene-28-oic acid (AS-10) and 3beta,23-dihydroxyurs-12-ene-28-oic acid (AS-14), which exhibited significant protective activity against carbon tetrachloride (CCl4)-induced hepatotoxicity in primary cultures of rat hepatocytes. Our findings showed that AS-10 and AS-14 preserved the level of glutathione and the activities of antioxidant enzymes such as glutathione reductase, glutathione peroxidase, superoxide dismutase and catalase. In addition, these compounds ameliorated lipid peroxidation, as demonstrated by a reduction in the production of malondialdehyde. Furthermore, AS-10 and AS-14 did not restore the reduced total GSH level by BSO, indicating that the hepatoprotective activities of these compounds may be involved, in part, by regulating GSH synthesis. From these results, we suggest that both AS-10 and AS-14 exerted their hepatoprotective activities against CCl4-induced injury by preserving the cellular antioxidative defense system.</P>
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Jae-Ryong Cha,Han Wook Kim,Doo Guen Yang,Hee-Yoon Chung,Il-Yeong Hwang 대한정형외과학회 2020 Clinics in Orthopedic Surgery Vol.12 No.4
Background: The purpose of this study was to evaluate the clinical usefulness of open-door laminoplasty using lateral mass anchoring screws and nonabsorbable sutures (ODLLM) for multilevel cervical myelopathy. Methods: We retrospectively studied 30 patients who underwent ODLLM. Clinical evaluations were performed using a visual analog scale (VAS), Japanese Orthopaedic Association (JOA) score, and Neck Disability Index (NDI) preoperatively, at 1 year postoperatively, and at the last follow-up. Radiographic evaluation was done using cervical spine radiographs to measure changes in the lordotic angle and range of motion (ROM) preoperatively, at 1 year postoperatively, and at the last follow-up and computed tomography at 1 year postoperatively to measure the opening angle and anteroposterior diameter of the spinal canal. Results: Significant improvement in VAS, JOA, and NDI was seen overall at 1 year after operation. However, there was no significant difference between 1 year after operation and the last follow-up. There were no significant changes in the lordotic angle and neck ROM. The mean opening angle of the opened lamina was measured as 39.04°. The mean anteroposterior diameter was significantly increased from 7.51 ± 1.79 mm before surgery to 13.98 ± 1.80 mm at 1 year of operation. Complications such as laminar reclosure and screw loosening were not observed in all cases. Conclusions: The ODLLM was technically easy to perform and showed good results comparable to those of conventional techniques. It can be suggested that ODLLM is an appropriate treatment option for multilevel cervical myelopathy.
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김태현,신동호,이두현,박성용,윤명근,신경환,표홍렬,김주영,김대용,조관호,양대식,김철용,Kim Tae Hyun,Shin Dong Ho,Lee Doo Hyun,Park Sung Yong,Yun Myung Guen,Shin Kyung Hwan,Py Hong Ryull,Kim Joo-Young,Kim Dae Yong,Cho Kwan Ho,Yang Dae-Sik,K 한국의학물리학회 2005 의학물리 Vol.16 No.4
입체조형 동적회전조사 방사선치료(Dynamic Conformal Arc Radiotherapy, DCAR)에서 필름 선량계를 이용한 선량검증시 필름 회전중심점 이동 보정값을 최적화법으로 구하고 최적화 후 DCAR에 대한 선량 검증의 정량적 허용기준을 제시하고자 하였다. 정위방사선치료를 시행했던 7명의 전이성 뇌암 환자에서 DCAR 치료계획을 시행하고 필름 선량계로 선량을 측정하였다. 필름 선량계의 가장 큰 계통적 오차 요인인 회전중심점 이동 보정값을 최적화법으로 구하고 치료계획과 필름으로 측정된 선량분포를 비교하여 최적화 전후의 평균 선량오차와 점선량오차가 $5\%$ 이상인 지점의 비율을 얻었다. 모든 환자에서 필름 선량계의 회전중심점 이동 보정값은 1 mm 이내였다. 필름 회전중심점 이동 보정 최적화전, 후로 선량오차 결과를 산출하였다. 최적화 전, 후의 평균 선량오차의 평균은 각각 $1.70{\pm}0.36\%$, $1.34{\pm}0.20\%$이었고 점선량오차가 $5\%$ 이상인 지점 비율의 평균은 각각 $4.54{\pm}3.94\%$, $0.11{\pm}0.12\%$로서 최적화 후 선량오차가 현저히 감소하였다. 본 연구의 결과와 같이 최적화법을 이용한 필름의 회전중심점 이동값을 구하고 최적화 후의 평균 선량오차와 점선량오차가 $5\%$ 이상인 지점의 비율을 구하는 방법은 임상에서 DCAR에 대한 선량 검증 방법으로 유용하게 사용될 수 있을 것으로 기대된다. The purpose of this study is to develop the optimization method for adjusting the film isocenter shift and to suggest the quantitative acceptable criteria for film dosimetry after optimization In the dynamic conformal arc radiation therapy (DCAR). The DCAR planning was peformed In 7 patients with brain metastasis. Both absolute dosimetry with ion chamber and relative film dosimetry were peformed throughout the DCAR using BrainLab's micro-multileaf collimator. An optimization method for obtaining the global minimum was used to adjust for the error in the film isocenter shift, which is the largest pan of systemic errors. The mean of point dose difference between measured value using ion chamber and calculated value acquired from planning system was $0.51{\pm}0.43\%$ and maximum was $1.14\%$ with absolute dosimetry These results were within the AAPM criteria of below $5\%$. The translation values of film isocenter shift with optimization were within ${\pm}$1 mm in all patients. The mean of average dose difference before and after optimization was $1.70{\pm}0.35\%$ and $1.34{\pm}0.20\%$, respectively, and the mean ratios over $5\%$ dose difference was $4.54{\pm}3.94\%$ and $0.11{\pm}0.12\%$, respectively. After optimization, the dose differences decreased dramatically and a ratio over $5\%$ dose difference and average dose difference was less than $2\%$. This optimization method is effective in adjusting the error of the film isocenter shift, which Is the largest part of systemic errors, and the results of this research suggested the quantitative acceptable criteria could be accurate and useful in clinical application of dosimetric verification using film dosimetry as follows; film isocenter shift with optimization should be within ${\pm}$1 mm, and a ratio over $5\%$ dose difference and average dose difference were less than $2\%$.
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이채칠(Chae-Chil Lee),박기봉(Ki-Bong Park),황일영(Il-Yeong Hwang),양두근(Doo-Guen Yang) 대한정형외과학회 2021 대한정형외과학회지 Vol.56 No.1
방사선 검사상 골용해성 병변이 슬관절에서 발견되는 경우 다양한 원인을 감별해야 한다. 특히 슬관절 전치환술을 받은 수술력이 있다면 골용해도 가능한 원인이 될 수 있다. 저자들은 우측 무릎 통증으로 내원한 83세 여성 환자에서 시멘트를 사용한 슬관절 전치환술의 경골 삽입물의 비감염성 해리가 선행된 비골 두의 골용해성 병변을 진단하였고 슬관절 재치환술을 통해 치료한 경험을 문헌 고찰과 함께 보고하는 바이다. The radiographic findings of an osteolytic lesion in the knee may indicate numerous possible impressions. Furthermore, osteolysis is a possible cause if there is a surgical history of total knee arthroplasty (TKA). The authors diagnosed osteolysis of the fibular head after aseptic loosening of the tibial component of a cemented TKA in an 83-year-old female patient who visited with right knee pain and report their treatment with revision TKA along with a literature review.
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