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Doo‑Won Kim,Dae Ho Kim,Sung Ryong Kim,Bo‑Hye Kim,Yun Hyuk Bang,Duck Joo Yang,Go Bong Choi,Yoong Ahm Kim,Kap Seung Yang 한국탄소학회 2019 Carbon Letters Vol.29 No.5
This study demonstrates that low processing rate for producing polyacrylonitrile (PAN)-based carbon fiber is a critical to obtain a homogeneous radial microstructure with high resistance to oxidation, thereby resulting in their improved mechanical strength. The dry-jet wet spun PAN organic fibers were processed (e.g., stabilized and then carbonized) utilizing two different rates; one is 1.6 times longer than the other. The effect of processing rate on the microstructural evolutions of carbon fibers was analyzed by scanning electron microscopy after slow etching in air, as well as Raman mapping after graphitization. The rapidly processed fiber exhibited the multilayered radial structure, which is caused by the radial direction stretching of the extrusion in the spinning. In case of the slowly processed fiber, the layered radial structure formed in the spinning process was changed into a more homogeneous radial microstructure. The slowly processed fibers showed higher oxidation resistance, higher mechanical properties, and higher crystallinity than the rapidly processed one. Raman mapping confirmed that the microstructure developed during spinning was sustained even though fiber was thermally treated up to 2800 °C.
HPLC-ICP/MS 와 ICP/MS를 이용한 FAPAS 07187 쌀의 총비소, 무기비소, 카드뮴 측정
노현명 ( Hyun Myung Noh ),김지영 ( Ji Young Kim ),김원일 ( Won Il Kim ),( Anitha Kunhikrishnan ),김민지 ( Min Ji Kim12 ),김경진 ( Gyeong Jin Kim ),박기문 ( Ki Moon Park ),류지혁 ( Ji Hyock Yoo ),김두호 ( Doo Ho Kim ),이영자 ( Y 한국환경농학회 2013 한국환경농학회 학술대회집 Vol.2013 No.-
Metal (loid)s such as environmental contaminants affect food safety. Metal (loid)s exist trace extremely in agriculture products. Therefore it is important to analyze accurately about trace these metals. High resolution techniques and quality controls are needed to analyze these materials. In order to achieve quality results, standardized methods and techniques are required. So ISO(International Organization for Standardization) of laboratory proficiency testing is determination of laboratory testing performance by means of inter-laboratory comparison. The values have been derived as a consensus of a number of laboratories using a variety of methods. Proficiency tests were applied to analyze the metal(loid)s [inorganic arsenic (As), total As and cadmium (Cd)] in powdered rice FAPAS 07187 (Food Analysis Performance Assessment Scheme; February-April 2013). The rice powder sample was extracted with 1% HNO3 for inorganic As for microwave-assisted extraction using water at 95℃ for 90 min and their analysis by HPLC/ICPMS. Also, HNO3 for total As and Cd using microwave-assisted extraction using at 200℃ for 50 mins and analysis by ICP/MS. Validation check was performed for accuracy using CRM (NMIJ CRM 7503-a) for inorganic As, and CRM (IRMM-Rice CRM) for total arsenic and cadmium. The result were satisfactory. FAPAS 07187 the z-scores of inorganic As, total As and Cd in powdered rice were-1.8,-0.9 and 0.2(lzl<2, respectively).
Doo-Ho Lee,Yeon Ho Park,Seok Won Choi,Kug Hyun Nam,Sang Tae Choi,Doojin Kim 대한외과학회 2021 Annals of Surgical Treatment and Research(ASRT) Vol.101 No.6
Purpose: In June 2016, the Model for End-Stage Liver Disease (MELD) score was employed in South Korea instead of the Child-Turcotte-Pugh (CTP) score. This study compared the outcomes of deceased donor liver transplantation (DDLT) before and after the MELD system application. Methods: This retrospective study reviewed 48 patients who underwent DDLT for end-stage liver disease at a single tertiary referral center between January 2014 and December 2018. The patients were categorized into the pre-MELD (22 patients) and post-MELD (26 patients) groups. The demographics, postoperative outcomes, and overall survival time were evaluated between the 2 groups. Results: The 2 groups had no differences in age, sex, ABO type, etiology for liver transplantation, CTP-score, operation time, cold ischemic time, and amount of red blood cell transfusion, although their MELD score differed significantly (post-MELD group, 36.2 ± 4.9; pre-MELD group, 27.7 ± 11.8; P < 0.001). The post-MELD group has longer intensive care unit stay (11.2 ± 9.5 days vs. 5.7 ± 4.5 days, P = 0.018) and hospital stay than the pre-MELD group (36.8 ± 26 days vs. 22.8 ± 9.3 days, P = 0.016). The 1-year survival rate was lower in the post-MELD group (61.5% vs. 86.4%, P = 0.029). Conclusion: After MELD allocation, patients with high MELD scores had increased DDLT and consequently required a longer recovery time, which could negatively affect survival. According to the experience of a small-volume center, these problems were related to both severe organ shortages in South Korea and MELD allocation.
Effects of Magnetic Infrared Laser on Dinitrofluorobenzene-induced Contact Dermatitis in Mice
Kim, Cheol-Young,Back, Young-Doo,Chang, Jeong Hyun,Lee, Hyeung-Sik,Park, Kyung-Won,Choi, Seong-Hun,Chung, In-Kwon,Cheon, Woo-Hyun,Ku, Sae-Kwang The Society of Physical Therapy Science 2011 JOURNAL OF PHYSICAL THERAPY SCIENCE Vol.23 No.3
<P>[Purpose] The purpose of the present study was to investigate the effect of a magnetic infrared laser (MIL) on the 2, 4-dinitrofluorobenzene (DNFB)-induced contact dermatitis, type I allergic mouse model. [Subjects] Male ICR mice. [Methods] Contact dermatitis was induced by sensitization with dinitrophenyl-derivatized ovalbumin (DNP-OVA) and DNFB challenge as antigen. MIL radiation doses of 1.33, 2.66 and 6.65 J/cm<SUP>2</SUP> were given, once a day for 7 continuous days, to DNP-OVA sensitized mice and compared with 15 mg/kg dexamethasone (intraperitoneal treatment). The edematous changes and scratching behavior were measured together with ear histopathological observations. [Results] Immediately after DNFB challenge to the ear or paw of DNP-OVA sensitized mice, increases of ear and paw thicknesses and weights were detected as well as anterior ear skin (dermis to epidermis) thickness and paw scratching behavior increases. However, these DNFB-induced increases of edematous changes and scratching behavior were significantly and dose-dependently decreased by MIL irradiation. [Conclusion] The results obtained in this study suggest that MIL radiation has relatively favorable effects on allergic dermatitis, and MIL therapy may represent an alternative approach for the treatment of allergic cutaneous diseases.</P>
Kim, Won-Hyoung,Jung, Doo-young,Lee, Joo-Young,Chang, Sung-Man,Jeon, Hong-Jin,Lee, Jun-Young,Cho, Seong-Jin,Lee, Dong-Woo,Bae, Jae-Nam,Hong, Jin Pyo,Cho, Maeng-Je,Hahm, Bong-Jin Informa UK (TaylorFrancis) 2017 Chronobiology international Vol.34 No.6
<P>Chronotypes are classified as morning, evening, or intermediate, but there are reports of a bimodal type. This study was undertaken to describe the characteristics of the bimodal chronotype and to explore relationships between the bimodal type and psychiatric disorders, fatigue, and quality of life. A total of 2389 subjects from a Korean national epidemiological survey of psychiatric disorders responded during face-to-face interviews. The Korean Composite International Diagnostic Interview was used to diagnose psychiatric disorders, and the Composite Scale of Morningness was used to assess chronotypes. Among intermediate-type subjects, those with a positive bimodal index were classified as bimodal type. In the present study, the proportions of bimodal, morning, intermediate, and evening types were 4.8%, 10.8%, 73.3%, and 11.1%, respectively. Distributions of sociodemographic variables were similar for the bimodal and intermediate types. After controlling for sociodemographic variables, any mood disorder and major depressive disorder were found to be significantly more associated with the bimodal type than the morning type, and dysthymic disorder was significantly more associated with the bimodal type than the intermediate type. For quality-of-life domains, moderate or extreme pain/discomfort was complained about more by subjects with the bimodal type than other types. In summary, the study shows chronotypes differ with respect to their relationships with mood disorder and quality of life. Before the bimodal type is classified as a clinically valid type, further investigations are needed to examine its psychological, physiological, and genetic characteristics.</P>
Kim, Hyoun Sook,Kim, Jieun,Im, Ha Na,Yoon, Ji Young,An, Doo Ri,Yoon, Hye Jin,Kim, Jin Young,Min, Hye Kyeoung,Kim, Soon-Jong,Lee, Jae Young,Han, Byung Woo,Suh, Se Won International Union of Crystallography 2013 Acta crystallographica. Section D, Biological crys Vol.69 No.3
<▼1><P>The crystal structure of <I>M. tuberculosis</I><SMALL>L</SMALL>,<SMALL>D</SMALL>-transpeptidase (Ldt<SUB>Mt2</SUB>; Rv2518c) has been determined in both ligand-free and meropenem-bound forms. The detailed view of the interactions between meropenem and Ldt<SUB>Mt2</SUB> will be useful in structure-guided discovery of new antituberculosis drugs.</P></▼1><▼2><P>Difficulty in the treatment of tuberculosis and growing drug resistance in <I>Mycobacterium tuberculosis</I> (<I>Mtb</I>) are a global health issue. Carbapenems inactivate <SMALL>L</SMALL>,<SMALL>D</SMALL>-transpeptidases; meropenem, when administered with clavulanate, showed <I>in vivo</I> activity against extensively drug-resistant <I>Mtb</I> strains. Ldt<SUB>Mt2</SUB> (Rv2518c), one of two functional <SMALL>L</SMALL>,<SMALL>D</SMALL>-transpeptidases in <I>Mtb</I>, is predominantly expressed over Ldt<SUB>Mt1</SUB> (Rv0116c). Here, the crystal structure of N-terminally truncated Ldt<SUB>Mt2</SUB> (residues Leu131–Ala408) is reported in both ligand-free and meropenem-bound forms. The structure of meropenem-inhibited Ldt<SUB>Mt2</SUB> provides a detailed structural view of the interactions between a carbapenem drug and <I>Mtb</I><SMALL>L</SMALL>,<SMALL>D</SMALL>-transpeptidase. The structures revealed that the catalytic <SMALL>L</SMALL>,<SMALL>D</SMALL>-transpeptidase domain of Ldt<SUB>Mt2</SUB> is preceded by a bacterial immunogloblin-like Big_5 domain and is followed by an extended C-terminal tail that interacts with both domains. Furthermore, it is shown using mass analyses that meropenem acts as a suicide inhibitor of Ldt<SUB>Mt2</SUB>. Upon acylation of the catalytic Cys354 by meropenem, the ‘active-site lid’ undergoes a large conformational change to partially cover the active site so that the bound meropenem is accessible to the bulk solvent <I>via</I> three narrow paths. This work will facilitate structure-guided discovery of <SMALL>L</SMALL>,<SMALL>D</SMALL>-transpeptidase inhibitors as novel antituberculosis drugs against drug-resistant <I>Mtb</I>.</P></▼2>
Kim, Dong-Ha,Jang, Ji-Soo,Koo, Won-Tae,Kim, Il-Doo The Royal Society of Chemistry 2018 Journal of Materials Chemistry A Vol.6 No.28
<P>A new method of graphene oxide (GO) templating is pioneered to prepare highly porous oxide fibers consisting of crumpled two-dimensional (2D) SnO2 nanosheets (NSs). GO flakes, which are functionalized with Sn<SUP>2+</SUP> ions through electrostatic interactions between negatively charged GO and positively charged Sn ions (Sn-loaded GO), are directly electrospun. During electrospinning, Sn-loaded GO flakes undergo self-crumpling on the as-spun polymeric nanofibers. After subsequent pyrolysis, highly porous oxide NFs comprised of crumpled SnO2 NSs are achieved, offering three distinct benefits, <I>i.e.</I>, (i) a high surface area and broad pore size distribution stemming from the co-existence of 1D and 2D structures, (ii) formation and effective modulation of the electron depletion region due to the ultrasmall thickness of SnO2 NSs and small crystallite size, and (iii) the enhanced catalytic effect of Pt nanoparticles anchored on porous SnO2 NSs. As a result, under high humidity (95% RH), the Pt-functionalized SnO2 NS-assembled NFs exhibited an exceptionally high acetone response (<I>R</I>air/<I>R</I>gas = 79.4@1 ppm), excellent selectivity, fast response speed (∼12.7 s), and outstanding stability at 350 °C. Sensor arrays were further utilized to discriminate simulated diabetic breath from healthy breath <I>via</I> pattern recognition, thus demonstrating potential feasibility for reliable sensing of breath biomarkers.</P>
Protective Effect of Paulownia tomentosa Fruits in an Experimental Animal Model of Acute Lung Injury
Kim, Seong-Man,Ryu, Hyung Won,Kwon, Ok-Kyoung,Min, Jae-Hong,Park, Jin-Mi,Kim, Doo-Young,Oh, Sei-Ryang,Lee, Seung Jin,Ahn, Kyung-Seop,Lee, Jae-Won The Korean Society for Microbiology and Biotechnol 2022 한국미생물·생명공학회지 Vol.50 No.2
The fruits of Paulownia tomentosa (Thunb.) (PT) Steud. have been reported to exert a variety of biological activities. A previous study confirmed that compounds isolated from PT fruits (PTF) exerted anti-inflammatory effects on TNF-α-stimulated airway epithelial cells. However, there is no report on the protective effects of PTF on acute lung injury (ALI). Here, we examined the ameliorative effects of PTF in an experimental animal model of lipopolysaccharide (LPS)-induced ALI. In ALI mice, increased levels of inflammatory cell influx were confirmed in the lungs of mice, and an increase of microphage numbers, TNF-α, IL-6 and MCP-1 production and protein content were detected in mouse bronchoalveolar lavage fluid. However, these increases were significantly reversed with PTF pretreatment. In addition, PTF inhibited the increased expression of iNOS and COX-2 in the lungs of ALI mice. Furthermore, the upregulation of MAPK and NF-κB activation was decreased in the lungs of ALI mice by PTF. In the in vitro experiment, PTF pretreatment exerted an anti-inflammatory effect by inhibiting the secretion of nitric oxide, TNF-α and IL-6 in LPS-stimulated RAW264.7 macrophages. Collectively, these results indicated that PTF has ameliorative effects on airway inflammation in an experimental animal model of ALI.