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최영찬,고유봉,오봉철 濟州大學校 基礎科學硏究所 1996 基礎科學硏究 Vol.9 No.2
제주도 서부 고산 연안 용승역에 출현하는 표충 부유성 동물플랑크톤의 특성을 밝히기 위하여 용승역과 그 인접 외해역에서 1993년 4월부터 1994년 3월까지 격월로 부유성 요각류, 화살벌레류, 익족류 및 젤라틴성 동물플랑크톤(Siphonophora 와 Thaliacea)을 조사하였다. 요각류는 6월과 11월에 각각 235ind./㎥, 301ind./㎥로 2차례에 걸쳐 피크를 보여 제주도 주변 연안해역과 일치하고, 출현 개체수에 있어서도 용승역이라고 해서 특별히 높지는 않았다. 젤라틴성 동물플랑크톤은 용승역과 외해역에서는 거의 출현하지 않는 반면, 인접하는 중간역에서만 6월과 11월에 75~458ind./㎥로 다량 출현하는 특성을 보였다. 동물 플랑크톤의 평균 생물량은 35.8ind./㎥으로 11월에 가장 높고 1월에 가장 낮았다. 화살벌레류는 Sagitta의 사체가 6월과 11월의 용승역에서 43~74%로 매우 높게 나타나는 특징을 보였다. 11월의 용승역에 출현한 Sagitta는 48~71%가 요각류인 Oncaea venusta O. mediterranea 및 Candacia bipinata에 의해 부착된 상태에 있었다. 또 각을 갖고 있어서 그 분포가 제한을 받는 유각 익족류는 외해역에서 는 전혀 출현하지 않은 반면, 용승역에서 용승현상이 강한 시기인 11월에 27~64ind./㎥의 높은 밀도로 출현하므로써 요승에 의한 상승류를 이용, 적응하는 부유성 동물플랑크톤의 특성을 보이고 있었다. Daytime surface zooplankton were collected bimonthly from April 1993 to March 1994 at six stations around upwelling and adjacent areas of Gosan, western part of Cheju Island. This paper deals with the occurrence, biomass and some other characteristics of zooplankton in these areas. Copepods had two peaks in the abundance in June(235 ind./㎥)and November(301 ind./㎥), but were not especially abundant in upwelling area. While gelatinous organisms seldom occurred in the upwelling and the outer area with high density of 75ind./㎥(in June) and 458 ind./㎥( in November) at the intermediate area, seasonal values of biomass with mean of 35.8ind./㎥ were the highest in November and the lowest in January. Abundance of chaetognaths(mainly Sagitta spp.) ranged 15~37 ind./㎥, and carcasses of Sagitta occurred very highly in the upwelling area in June(54% of total Sagitta organisms) and November(70.5%). Especially 48~77% of sagitta individuals in upwelling area in November was attached by Oncaea mediterranea, O. venusta and Candacia bipinata. Pteropods with shells were sampled only in the upwelling area during strong upwelling season (November, 27~64 ind./㎥), indicating the characteristics of ascending behavioral adaptation form the bottom water by upwelling.
崔高峰,李健一 경북대학교 공과대학 1982 工大硏究誌 Vol.11 No.-
In this paper, a phase shifter using switched capacitor filters, switched capacitor PLL and switched capacitor weighted summer cirucits was designed. The available phase variation of it was 90 degrees, and it can be used at audio frequency level. The total harmonic distortion of the output wave was less than 8%, and especially above the 60 Hz, it was less than 2%. Overall experimental circuits of this paper can be implemented to one-chip IC.
뇌하수체 종양 제거술 시행 후 뒤늦게 발생한 횡문근 융해증과 동반된 중추성 열
장제혁,최규남,김일환,노은지,김윤정,유충헌,고정해,박봉수,김태균,권민정,이순희,박정현 인제대학교 2008 仁濟醫學 Vol.29 No.-
Body temperature is controlled by thermoregulatory center of the hypothalamus. We report a case of 24 years old man with central fever. He was subjected to a partial excision of pituitary tumor compressing optic chiasm four years ago. He has received hormonal therapy for panhypothyroidism after removal of pituitary tumor. And He received gamma knife operation for partially contrast-enhancing masses in suprasellar and both hypothalamic areas that is probably postoperatively remnant or recurrent tumor of pituitary adenoma. One year after gamma knife operation, he presented with a febrile syndrome of unknown origin including rhabdomyolysis. All usual investigations proved negative. We diagnosed him as central fever with rhabdomyolysis. He received medical ICU care with cooling bed, ice pack. And his symptom improved. Postoperative hyperthermia may result following resection of the pituitary tumor. When central fever is suspected taking note of past history, a quick recognition of course of fever can help reduce the using of unnecessary antibiotics and hospital stay.
다발성 골수종에서 저용량 thalidomide, cyclophosphamide, dexamethasone (TCD) 요법의 효과
류충헌,정재현,고정해,장제혁,박영진,최규남,박봉수,이상민,주영돈 인제대학교 2008 仁濟醫學 Vol.29 No.-
Background and Objectives : The immunomodulatory drug thalidomide can inhibit angiogenesis and induce apoptosis in experimental models. It can also induce marked and durable response in newly diagnosed myeloma patients. Thalidomide has been used at doses ranging from 200 to 800 mg with significant toxicity. No data are available on the impact of low-dose thalidomide, cyclophosphamide and dexamethasone as initial therapy for myeloma patients. Design and Methods : To address this issue, newly diagnosed myeloma patients were treated with 50 mg/day thalidomide continuously and cyclophosphamide 150 mg/m², days 1-4 and dexamethasone 20 mg/m², days 1-5 and day 15-19, every month. Between October 2005 and October 2006, 14 patients (median age 54.5 years) were treated with low-dose thalidomide, cyclophosphamide and dexamethasone. Results : After a minimum of two cycles of treatment, 5 patients (55.5%) showed a partial remission. After four cycles of treatment, 10 patients (83.3%) showed a partial remission (n=6) and complete remission (n=4). After a median follow-up of 15.4 months, 1 year overall survival rate was 82.0%. Thalidomide was well tolerated without serious toxic effects. Conclusions : The combination of low-dose thalidomide, cyclophosphamide and dexamethasone demonstrates favorable response rate and 1 year overall survival rate in newly diagnosed myeloma. Severe toxicities were not seen with this combination.
진행성 비소세포폐암에 대한 2차 화학요법으로 paclitaxel과 cisplatin의 제 2상 임상연구
서영태,김봉석,고지영,최동석,최성호,김혜진,안영미,노용호,이경희 영남대학교 의과대학 2004 Yeungnam University Journal of Medicine Vol.21 No.2
gemcitabine과 carboplatin으로 치료받은 경력이 있는 진행성 비소세포폐암 환자 25명을 대상으로 2차 화학요법으로 paclitaxel과 cisplatin을 사용하여 다음과 같은 결과를 확인하였다. 전체 25명 중 5명에서 부분반응이 관찰되었으며, 반응군의 반응지속기간은 2~11개월로 중앙값 4.3개월이었다. 전체 환자의 무진행생존기간은 0~11개월로 중앙값 3.3개월이었으며, 생존기간은 1.3~39개월로 중앙값 7.4개월이었다. 전체 83회의 화학요법 중 WHO 3도의 혈소판감소증이 1회에서만 관찰되었으며, 비혈액학적 부작용도 감내할 만 하였다. 이상의 결과, paclitaxel과 cisplatin 복합화학요법은 진행성 비소세포폐암 환자에서 2차 요법으로 사용하였을 때 부작용이 적으며 효과적인 치료법의 하나로 판단된다. Background: To evaluate the efficacy and safety of paclitaxel and cisplatin against advanced non-small cell lung cancer (NSCLC) as a second-line chemotherapy. Subjects and Methods: Twenty-five patients were enrolled. The patients received 200 mg/㎡ paclitaxel as a 3-hour intravenous infusion and 60 mg/㎡ cisplatin as 30-minute intravenous infusion with vigorous hydration on day 1 every 28 days. The response was assessed every 2 cycles. Results: All 25 patients were assessed for their response and toxicity. Partial responses were observed in 5 patients. The overall response rate was 20%(95% confidence interval, 4%~36%) and the median response duration was 4.5(range, 2-11) months. The median time to progression was 3.3(range, 0-14) months. The median overall survival of all patients was 7.4(range, 1.3-39) months. The hematologic toxicities were minor and easily controlled. Conclusion: The combination chemotherapy of paclitaxel and cisplatin as a second-line treatment has a moderate efficacy with an acceptable toxicity in patients with advanced NSCLC.
A Table Integration Technique Using Query Similarity Analysis
Go-Bong Choi(최고봉),Yong-Tae Woo(우용태) 한국컴퓨터정보학회 2019 韓國컴퓨터情報學會論文誌 Vol.24 No.3
In this paper, we propose a technique to analyze similarity between SQL queries and to assist integrating similar tables. First, the table information was extracted from the SQL queries through the query structure analyzer, and the similarity between the tables was measured using the Jacquard index technique. Then, similar table clusters are generated through hierarchical cluster analysis method and the co-occurence probability of the table used in the query is calculated. The possibility of integrating similar tables is classified by using the possibility of co-occurence of similarity table and table, and classifying them into an integrable cluster, a cluster requiring expert review, and a cluster with low integration possibility. This technique analyzes the SQL query in practice and analyse the possibility of table integration independent of the existing business, so that the existing schema can be effectively reconstructed without interruption of work or additional cost.