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신동현 ( Dong Hyun Sinn ) 대한간학회 2018 춘·추계 학술대회 (KASL) Vol.2018 No.1
Alcoholic hepatitis includes a broad spectrum of pathological process. In case of severe alcoholic hepatitis, the prognosis is worse with a 1-month mortality of 40%. Drink excessively, may induce recurrent episodes of alcoholic hepatitis in patients with alcoholic liver disease, and if this is severe or associated with liver cirrhosis, complications occur due to liver failure and portal hypertension, leading to a high short-term mortality. Recently, liver transplantation (LT) has shown improved outcome for patients with severe alcoholic hepatitis who were not abstinence for 6 months. In Korea, there is no limitation to enlist patients into waiting-list for patients with severe alcoholic hepatitis who presented to hospital while drinking. This brings a several questions that needs critical evaluations. Is it justifiable to transplant severe alcoholic hepatitis patient who were not abstinence? If so, when is optimal time to list patients into waiting-list?
신동현 ( Dong Hyun Sinn ) 대한간학회 2017 춘·추계 학술대회 (KASL) Vol.2017 No.1
Hepatitis B virus and hepatitis C virus-associated liver disease is a major indication for liver transplantation. There has been major advance in antiviral agents that can be used in Hepatitis B virus and hepatitis C virus patients. Recently, tenofovir alafenamide has been introduced to treat Hepatitis B virus patients. There are several oral antiviral regimens that can be used to treat hepatitis C virus in pre- or post-liver transplanting setting. Here, we will briefly discuss recent update of antiviral agents that can be used in liver transplantation for and hepatitis C virus.
신동현 ( Dong Hyun Sinn ),권용수 ( Yong Soo Kwon ),최소연 ( So Yeon Choi ),장우익 ( Woo Ik Chang ),박문경 ( Moon Kyung Park ),한정호 ( Joung Ho Han ),정만표 ( Man Pyo Chung ) 대한내과학회 2005 대한내과학회지 Vol.69 No.4
Coccidioidomycosis is a fungal infection caused by the soil fungus Coccidioides immitis, which is endemic to the south-western United States. Increasingly, cases are being recognized outside the endemic area, due to travelers who have visited the endemic area. Here, we report a case of pulmonary coccidioidomycosis in a Korean man who has traveled in Arizona, U.S.A. Cardinal clinical symptoms were fever, central lung mass with mediastinal lymphadenopathy on the chest X-ray which mimicked lung cancer, and a 14% eosinophilia in the peripheral blood. Coccidioidomycosis was diagnosed by serology and mediastinoscopic biopsy by identifying typical spherules. The symptoms disappeared spontaneously without specific treatment. Coccidioidomycosis must be considered in the differential diagnosis of pulmonary infiltrates with peripheral eosinophilia, especially if patient has lived in or visited endemic area.(Korean J Med 69:419-423, 2005)
신동현 ( Sinn Dong Hyun ),임성우 ( Lim Seong Woo ),김경묵 ( Kim Kyung Mook ),유호열 ( You Ho Yeol ),최종권 ( Choi Jong Kown ) 국군의무사령부 2010 대한군진의학학술지 Vol.41 No.1
Objectives: Gastroesophageal reflux disease (GERD) and functional dyspepsia (FD) is commonly diagnosed disease among military soldiers. We investigated the role of smoking in young military soldiers in GERD and FD. Methods: A survey was conducted to the random sample of military soldiers who visited Armed Forces Daejeon Hospital during March 2009 to April 2009. A total of 374 responded and completed the survey. Results: GERD and FD were diagnosed in 7.5% and 5.6% of participants, respectively. GERD was diagnosed more frequently among smokers (13.7%) compared to non-smoker (4.8%, p = 0.008). FD was diagnosed more frequently among smokers (12.6%) compared to past smoker (4.4%, p = 0.045) or non-smoker (2.7%, p = 0.001). Compared to smokers, non smoking was a protective factor for GERD (odds ratio: 0.34, 95% Confidence interval (CI): 0.13 - 0.83, p = 0.018) and FD (odd ratio: 0.20, 95% CI: 0.07 - 0.59, p = 0.004). Conclusions: Smoking is a factor associated with GERD and FD in the young military soldiers. Smoking cessation should be recommended for patients with GERD and FD, and anti-smoking campaign can be effective strategy to reduce GERD and FD in the military.
마우스 소장에서 배양한 카할간질세포 군집에서의 박동 조율성 칼슘 변화에 대한 세로토닌에 의한 조절효과
신동현 ( Dong Hyun Sinn ),이풍렬 ( Poong Lyul Rhee ),손희정 ( Hee Jung Son ),김재준 ( Jae J. Kim ),이지연 ( Ji Yeon Lee ),서인석 ( In Suk So ) 대한소화기기능성질환·운동학회 2006 Journal of Neurogastroenterology and Motility (JNM Vol.12 No.2
Background/Aims: Interstitial cells of Cajal (ICCs) are considered to be pacemaker cells in the gastrointestinal tracts and Ca(2+) oscillation in ICCs is intimately linked to the pacemaker function. Although serotonin is one of most importance substance involved in gastrointestinal motility, it`s effects on the ICCs are not known. We wanted to study the effect of serotonin on Ca(2+) oscillation in ICCs. Methods: Using cultured cell clusters isolated from the mouse ileum, we measured spontaneous Ca(2+) oscillation as an index of pacemaker activity in the ICCs. The cultured cell clusters showed spontaneous contraction and they contained c-Kit immunopositive cells. We visualized the changes in intracellular Ca2 concentration in the ICCs within the cultured cell clusters that were loaded with a fluorescent Ca2 indicator, fura-2. Results: There was no significant change in the fluorescence emission intensity and spike frequency between the baseline and after the addition of TTX. The addition of serotonin in the buffer solution caused an increase in the fluorescence emission intensity and the spike frequency per minute of Ca(2+) oscillations. The addition of serotonin in the presence of TTX caused increases in the spike frequency per minute of the calcium oscillation. Conclusions: These results suggest that serotonin may modulate the pacemaker Ca(2+) activity in ICCs by the TTX-resistant, direct serotonergic pathway. (Kor J Neurogastroenterol Motil 2006;12:151-156)
B형간염 만연 지역에서 수술적 절제술을 시행한 C형간염 연관 간세포암 환자에서의 간경변 동반비율
신동현 ( Dong Hyun Sinn ),곽금연 ( Geum Youn Gwak ),백용한 ( Yong Han Paik ),최문석 ( Moon Seok Choi ),이준혁 ( Joon Hyeok Lee ),고광철 ( Kwang Cheol Koh ),조재원 ( Jae Won Joh ),백승운 ( Seung Woon Paik ),유병철 ( Byung Chul Y 대한간암학회 2014 대한간암학회지 Vol.14 No.2
Background/Aims: Cirrhosis has generally been considered a prerequisite for hepatitis C virus (HCV)-infected livers to develop hepatocellular carcinoma (HCC), but HCCs that arise in absence of cirrhosis has been reported. We assessed the prevalence and significance of cirrhosis in HCV-related HCC patients who underwent surgical resection. Methods: A total of 78 HCC patients (65 male [83.3%]; mean age, 64.2 ± 8.6 years) were evaluated for the presence of cirrhosis. Cirrhosis was assessed based on histology, aspartate aminotransferase-to-platelet ratio index (APRI) as well as clinical criteria, such as ascites, varices, thrombocytopenia, splenomegaly, and radiographic configuration of cirrhosis. Results: Based on histology, cirrhosis, septal fibrosis, periportal fibrosis and no fibrosis was noticed in 33.3%, 60.3%, 5.1% and 1.3% of patients, respectively. The clinical criteria of cirrhosis were present in 76.9% of patients. APRI > 1.0 was seen in 47.4% of patients. There was no evidence of cirrhosis in 18 patients (23.1%), either by histology or clinically. Cirrhosis by histology was an independent factor for overall survival [hazard ratio: 3.87 (95% CI: 1.24 ? 12.00), P=0.019]. Conclusions: Quite proportion of HCC patients had no evidence of cirrhosis, either by histology or clinically. Careful follow-up for HCC may be necessary even for non-cirrhotic HCVinfected Korean patients. (J Liver Cancer 2014;14:108-114)