A randomized controlled trial to compare the efficacy of regenerated and non-regenerated oxidized cellulose gauze for the secondary treatment of local bleeding in patients undergoing hepatic resection

Chengshuo Zhang,Dazhi Fu,Fengshan Wang,Xinping Zhong,Lei Yang,Gang Wu,Baifeng Li,Jialin Zhang 대한외과학회 2021 Annals of Surgical Treatment and Research(ASRT) Vol.100 No.4

Purpose: Oxidized cellulose is available in many forms, but manufactured using either a regenerated or non-regenerated process. In this study, we evaluated the effects of 2 different hemostatic agents for the treatment of local bleeding in patients undergoing hepatic resection. Methods: This was a monocentric, parallel-group, randomized, and controlled clinical trial to compare oxidized regenerated cellulose gauze (ORCG) with oxidized non-regenerated cellulose gauze (ONRCG) in patients undergoing hepatectomy. The primary endpoint was the time to hemostasis at the target bleeding site. The secondary endpoints were the postoperative drainage volume on the first 2 days after surgery and the hospital stay. Results: There was no significant difference between the ORCG and ONRCG groups in time to hemostasis from column analysis (238.8 ± 121.6 seconds vs. 193.7 ± 85.3 seconds, P = 0.068), and there were no differences in the rates of hemostatic success between the 2 groups at 120 seconds (18.4% vs. 24.3%; odds ratio [OR], 0.703; 95% confidence interval [CI], 0.231–2.136) and 300 seconds (71.1% vs. 89.2%; OR, 0.298; 95% CI, 0.085–1.041). However, the ONRCG group was superior to the ORCG group in hemostasis according to the survival analysis (log-rank test, P = 0.044). Moreover, there were also no significant differences between the 2 groups in postoperative drainage volume on the first 2 days (P = 0.436, P = 0.381) and hospital stay (P = 0.537, P = 0.200). Conclusion: ONRCG was not inferior to ORCG as a hemostatic agent in patients undergoing liver resection.

Tumor Location Causes Different Recurrence Patterns in Remnant Gastric Cancer

Sun, Bo,Zhang, Haixian,Wang, Jiangli,Cai, Hong,Xuan, Yi,Xu, Dazhi The Korean Gastric Cancer Association 2022 Journal of gastric cancer Vol.22 No.-

Purpose: Tumor recurrence is the principal cause of poor outcomes in remnant gastric cancer (RGC) after resection. We sought to elucidate the recurrent patterns according to tumor locations in RGC. Materials and Methods: Data were collected from the Shanghai Cancer Center between January 2006 and December 2020. A total of 129 patients with RGC were included in this study, of whom 62 had carcinomas at the anastomotic site (group A) and 67 at the non-anastomotic site (group N). The clinicopathological characteristics, surgical results, recurrent diseases, and survival were investigated according to tumor location. Results: The time interval from the previous gastrectomy to the current diagnosis was 32.0±13.0 and 21.0±13.4 years in groups A and N, respectively. The previous disease was benign in 51/62 cases (82.3%) in group A and 37/67 cases (55.2%) in group N (P=0.002). Thirty-three patients had documented sites of tumor recurrence through imaging or pathological examinations. The median time to recurrence was 11.0 months (range, 1.0-35.1 months). Peritoneal recurrence occurred in 11.3% (7/62) of the patients in group A versus 1.5% (1/67) of the patients in group N (P=0.006). Hepatic recurrence occurred in 3.2% (2/62) of the patients in group A versus 13.4% (9/67) of the patients in group N (P=0.038). Patients in group A had significantly better overall survival than those in group N (P=0.046). Conclusions: The tumor location of RGC is an essential factor for predicting recurrence patterns and overall survival. When selecting an optimal postoperative follow-up program for RGC, physicians should consider recurrent features according to the tumor location.

Tumor Location Causes Different Recurrence Patterns in Remnant Gastric Cancer

Sun Bo,Zhang Haixian,Wang Jiangli,Cai Hong,Xuan Yi,Xu Dazhi 대한위암학회 2022 Journal of gastric cancer Vol.22 No.4

Purpose Tumor recurrence is the principal cause of poor outcomes in remnant gastric cancer (RGC) after resection. We sought to elucidate the recurrent patterns according to tumor locations in RGC. Materials and Methods Data were collected from the Shanghai Cancer Center between January 2006 and December 2020. A total of 129 patients with RGC were included in this study, of whom 62 had carcinomas at the anastomotic site (group A) and 67 at the non-anastomotic site (group N). The clinicopathological characteristics, surgical results, recurrent diseases, and survival were investigated according to tumor location. Results The time interval from the previous gastrectomy to the current diagnosis was 32.0±13.0 and 21.0±13.4 years in groups A and N, respectively. The previous disease was benign in 51/62 cases (82.3%) in group A and 37/67 cases (55.2%) in group N (P=0.002). Thirty-three patients had documented sites of tumor recurrence through imaging or pathological examinations. The median time to recurrence was 11.0 months (range, 1.0–35.1 months). Peritoneal recurrence occurred in 11.3% (7/62) of the patients in group A versus 1.5% (1/67) of the patients in group N (P=0.006). Hepatic recurrence occurred in 3.2% (2/62) of the patients in group A versus 13.4% (9/67) of the patients in group N (P=0.038). Patients in group A had significantly better overall survival than those in group N (P=0.046). Conclusions The tumor location of RGC is an essential factor for predicting recurrence patterns and overall survival. When selecting an optimal postoperative follow-up program for RGC, physicians should consider recurrent features according to the tumor location. Purpose Tumor recurrence is the principal cause of poor outcomes in remnant gastric cancer (RGC) after resection. We sought to elucidate the recurrent patterns according to tumor locations in RGC. Materials and Methods Data were collected from the Shanghai Cancer Center between January 2006 and December 2020. A total of 129 patients with RGC were included in this study, of whom 62 had carcinomas at the anastomotic site (group A) and 67 at the non-anastomotic site (group N). The clinicopathological characteristics, surgical results, recurrent diseases, and survival were investigated according to tumor location. Results The time interval from the previous gastrectomy to the current diagnosis was 32.0±13.0 and 21.0±13.4 years in groups A and N, respectively. The previous disease was benign in 51/62 cases (82.3%) in group A and 37/67 cases (55.2%) in group N (P=0.002). Thirty-three patients had documented sites of tumor recurrence through imaging or pathological examinations. The median time to recurrence was 11.0 months (range, 1.0–35.1 months). Peritoneal recurrence occurred in 11.3% (7/62) of the patients in group A versus 1.5% (1/67) of the patients in group N (P=0.006). Hepatic recurrence occurred in 3.2% (2/62) of the patients in group A versus 13.4% (9/67) of the patients in group N (P=0.038). Patients in group A had significantly better overall survival than those in group N (P=0.046). Conclusions The tumor location of RGC is an essential factor for predicting recurrence patterns and overall survival. When selecting an optimal postoperative follow-up program for RGC, physicians should consider recurrent features according to the tumor location.

The Focused Electrode Ring for Electrohydrodynamic Jet and Printing on Insulated Substrate

Zeshan Abbas,Dazhi Wang,Liangkun Lu,Zhaoliang Du,Xiangyu Zhao,Kuipeng Zhao,Meng Si,Penghe Yin,Xi Zhang,Yan Cui,Junsheng Liang 한국정밀공학회 2022 International Journal of Precision Engineering and Vol.23 No.5

Drop-on-demand electrohydrodynamic jet (DoD E-Jet) printing is considered a well-known type of fabrication method contemporary since it can be used to print high-resolution microstructures (< 1 μm) on various insulating substrates. This paper presents a numerical study of DoD E-Jet printing using a novel combination of needle and focused electrode ring to print stable and consistent microdroplets on a Polyethylene terephthalate substrate. Primarily, a phase field method was used to generate a stable cone-jet morphology that can allow the production of high-resolution micron/nano structures on PET substrates. The numerical simulation of cone-jet morphology was performed by COMSOL multiphysics software. Further, the impact of key parameters such as flow rate and dc positive pulse voltage was studied on cone-jet morphology through numerical simulation. Subsequently, optimized operating parameters i.e., f = 5.3 . 10 –15 m 3 s −1 , V n = 1.9 kV and V r = 0.7 kV were achieved by performing a series of numerical experiments. Then, optimized parameters by simulation were directly used to print arrays of stable droplets on PET substrate using the focused electrode ring in different locations by regulating distance 0.2 mm to 1.3 mm between needles to focused electrode ring. The minimum size of stable microdrop was measured 3 μm on PET substrate (thickness = 0.2 mm) using a 50 μm size quartz capillary maintaining a distance of 0.2 mm between combined needle and focused electrode ring. The experimental results proved that the simulation model is useful for printing different microstructures on insulating substrates and creating a promising production path for micro-electro mechanical system and nano-electro mechanical system (MEMS and NEMS).

Study of the Electric Field Screening Effect for Field Emitter Arrays

Nannan Li,Fei Yan,Shucai Pang,Lei Chen,Dazhi Jin,Wei Xiang,De Zhang,Jingyi Dai,Baoqing Zeng 한국물리학회 2015 THE JOURNAL OF THE KOREAN PHYSICAL SOCIETY Vol.66 No.8

Understanding the influence of the interaction of emitters on the field emission performance of a field emitter array is of great importance for the design of a multi-emitter device. In this work, a screening factor S is defined to quantify the effect of electric field screening due to the interaction of emitters in an array. A three-dimensional finite integration technique is used to study the electric field screening effect for Spindt-type field emitter arrays which have potential applications in flatscreen displays and high-power vacuum electronics. The dependences of the electric field screening on the tip-to-tip spacing, half-angle of the emitter, height of the emitter and radius of the tip’s curvature are analyzed. The effects of the variations in the size of the emitter’s geometry on the most efficient arrangement to achieve maximum emission efficiency in an array are discussed.

Design, Synthesis, and Biological Evaluation of Novel 1, 2, 4-Triazole Derivatives as Antifungal Agent

Xiaoyun Chai,Qingyan Sun,Shichong Yu,Yongwei Jiang,Yan Zou,Qiuye Wu,Dazhi Zhang,Yuan-Ying Jiang,Yongbing Cao 대한약학회 2012 Archives of Pharmacal Research Vol.35 No.11

A series of novel 1, 2, 4-triazole derivatives (9a-p) have been designed and synthesized as the potential antifungal agents. All compounds were characterized by 1H-NMR, 13C-NMR, and LCMS. Their antifungal activities against seven human pathogenic fungi were evaluated in vitro by measuring the minimal inhibitory concentrations. Most of the tested compounds were found to be more potent against Candida albicans than the control drug fluconazole.