서울시 셰어하우스 임대료 영향요인 분석에 관한 연구

최단비 ( Choi Dan-bee ),정지훈 ( Jung Ji-hoon ),최준용 ( Choi Jun-yong ),김정섭 ( Kim Jeongseob ) 한국부동산분석학회 2018 不動産學硏究 Vol.24 No.3

This study aims to empirically explore factors affecting the rent of a shared house using a hedonic price model. The physical, operational and locational characteristics of the shared house are considered primary determinants of the rent of a shared house. The results show that single room occupancy, shared spaces for particular purposes, the living area per bedroom and proximity to subway station increased the rent of a shared house. The age of the building, less private rooms, and the public-private partnership reduced the rent of a shared house. The neighborhood rent significantly increases the rent of a shared house, but it only accounts for 26% of the rent, implying the rent of a shared house is relatively less sensitive to the market rate rent. This study confirms that there is a strong demand for securing personal privacy in the shared house, which should be addressed in the architectural design and property management of shared housing. Shared housing with public subsidy provides relatively affordable housing units, thus contributing to lowering the housing cost burden of young single person households.

고콜레스테롤 식이 투여 마우스에서 복분자 미숙과 추출물과 홍삼농축액 복합 투여의 콜레스테롤 개선 효과

이민정(Min Jung Lee),이수정(Su Jung Lee),최혜란(Hye Ran Choi),이정현(Jung-Hyun Lee),정종태(Jong Tae Jeong),최경민(Kyung-Min Choi),차정단(Jeong-Dan Cha),황승미(Seung-Mi Hwang),박종혁(Jong Hyuk Park),이주희(Joo Hee Lee),이태범(Tae Bum 한국식품영양과학회 2014 한국식품영양과학회지 Vol.43 No.10

본 연구는 복분자 미숙과 물 추출물과 홍삼농축액으로 C57BL/6J 수컷 마우스를 이용하여 콜레스테롤 억제 효과 및 지질대사에 미치는 영향을 살펴보고, 기능성 식품으로의 가능성을 알아보았다. 실험동물은 C57BL/6J 수컷 마우스를 사용하였으며, 12주 동안 고콜레스테롤 식이를 급여하면서 복분자 미숙과 물 추출물과 홍삼농축액을 경구투여 하였다. 그 결과로 고콜레스테롤 식이군과 비교하였을 때 복분자 미숙과 추출물과 홍삼농축액 식이군에서 체중증가량, 식이섭취량에는 변화가 없었다. 콜레스테롤 합성의 가장 중요한 기작인 LDL receptor와 SREBP2 발현에서는 복분자 미숙과 추출물 투여군과 복분자와 홍삼 복합 투여군 모두 유의적으로 증가하여 세포 안으로의 LDL 흡수를 촉진시킴으로써 체내 콜레스테롤을 낮추는 것으로 판단된다. HDL 관련 유전자 발현에서도 복분자 미숙과 추출물 투여군과 복분자와 홍삼 복합 투여군에서 HDL uptake 유전자인 SR-B1의 발현을 증가시켜 콜레스테롤 개선 효과를 보였다. 또한 간의 형태학적 변화에서는 고콜레스테롤 식이군과 비교하였을 때 복분자 미숙과 물 추출물과 홍삼농축액 복합 투여군에서 지방 형성이 현저히 줄어들었고, leptin과 FAS의 농도를 측정한 결과 유의적으로 감소하였다. 결과적으로 복분자 미숙과 물 추출물과 홍삼농축액 복합 투여가 콜레스테롤과 고지혈증 예방에 긍정적인 효과를 보일 것으로 사료된다. We examined the effects of unripe black raspberry (UBR) and red ginseng (RG) extracts on cholesterol improvement in C57BL/6J mice fed a HCD (high cholesterol diet) for 12 weeks. Hepatic total lipid and total cholesterol contents were significantly induced in hyperlipidemic mice. However, supplementation with UBR, RG and simvastatin effectively reduced these lipid profiles. Further, UBR and co-treatment with UBR and RG increased expression of LDL receptor, SREBP2, and SR-B1 mRNA compared with HCD. The ApoB/ApoA1 ratio was reduced by co-treatment with UBR and RG compared to treatment with UBR. In addition, histopathologic evaluation showed that co-treatment with UBR and RG suppressed lipid accumulation as well as FAS and leptin expression in plasma. These results indicate that co-treatment with UBR and RG may be useful for the prevention of hypercholesterolemia.

복분자와 홍삼 발효 추출물의 복합투여가 고지방 고콜레스테롤 식이를 섭취한 흰쥐의 지질대사 및 비만에 미치는 영향

이민정(Min Jung Lee),최혜란(Hye Ran Choi),이정현(Jung-Hyun Lee),이수정(Su Jung Lee),권지웅(Ji Wung Kwon),최경민(Kyung-Min Choi),차정단(Jeong-Dan Cha),황승미(Seung-Mi Hwang),박종혁(Jong Hyuk Park),이상천(Sang Cheon Lee),박필재(Pill Ja 한국식품과학회 2015 한국식품과학회지 Vol.47 No.3

이 연구는 고지방 고콜레스테롤 식이를 12주 동안 랫트에게 공급하여 복분자와 홍삼, 복분자와 홍삼 발효 추출물의 지질대사 및 비만 개선효과를 조사하였다. 정상식이, 고지방 고콜레스테롤식이, 양성대조군, 유산균발효군, 복분자와 홍삼, 복분자와 홍삼발효 추출물 투여군의 체중증가, 음수, 식이 섭취량은 그룹간의 유의적인 차이를 보이지 않았다. 하지만 혈중 HDL-콜레스테롤은 고지방 고콜레스테롤 식이와 비교 했을 때 복분자와 홍삼 발효추출물에서 유의적인 증가를 보였으며, LDL-콜레스테롤, 중성지방은 유의적인 감소율을 보였다. 또한, 간 조직에서 복분자와 홍삼 발효추출물 처치에 의해 HMG-CoA reductase, LDL receptor 및 SREBP-2 mRNA의 발현 증가와 지방생성 억제를 확인하였다. 그리고 복분자와 홍삼 발효 추출물 투여군은 비만인자인 혈중 leptin과 FAS의 농도를 유의적으로 감소시켰을 뿐만 아니라 대변에서 체내 콜레스테롤 배출을 증가시켰다. 이러한 결과로 미루어보아 복분자와 홍삼 발효 추출물은 혈중 지질 대사 및 비만의 예방에 기여할 것으로 판단된다. This study investigated the effects of fermented black raspberry (BR) and red ginseng (RG) extract co-treatment on lipid metabolism and obesity in rats fed with a high fat/high cholesterol diet (HFHCD) for 12 weeks. Compared to the corresponding values in rats fed with a HFHCD, total cholesterol and low-density lipoprotein (LDL)-cholesterol and triglyceride levels decreased whereas high-density lipoprotein (HDL)-cholesterol levels increased in rats treated with fermented BR and RG extracts. These extracts significantly increased the expression of HMG-CoA reductase, LDL receptor, and sterol regulatory-element-binding protein-2 (SREBP-2) mRNA, but decreased the mRNA expression of SREBP-1. Additionally the serum levels of leptin and fatty acid synthase were decreased. Moreover, supplementation with fermented BR and RG effectively increased fecal cholesterol excretion. These results suggest that fermented BR and RG extracts might be effective at preventing hypercholesterolemia and obesity.

복분자 미숙과와 홍삼 추출물의 콜레스테롤 개선 효과

이수정(Su Jung Lee),이민정(Min Jung Lee),고영종(Young Jong Ko),최혜란(Hye Ran Choi),정종태(Jong Tae Jeong),최경민(Kyung-Min Choi),차정단(Jeong-Dan Cha),황승미(Seung-Mi Hwang),정후길(Hoo Kil Jung),박종혁(Jong Hyuk Park),이태범(Tae Bum 한국식품과학회 2013 한국식품과학회지 Vol.45 No.5

본 연구는 복분자 미숙과와 홍삼 물 추출물을 이용하여 인간 간암세포주(HepG2)와 위장관세포주(Caco-2)를 이용하여 콜레스테롤 억제효과 및 그와 연관된 HMG-CoA reductase 활성 억제효과 및 LDL 및 HDL과 관련된 분자기전을 조사하였다. 그 결과 복분자 미숙과와 홍삼 추출물은 모두 콜레스테롤 합성 억제 효과를 보였을 뿐만 아니라 HMG-CoA reductase 활성 억제효과를 보였다. 또한 두 추출물은 단독 투여시 보다 복합 투여시 부가효과를 보였다. 그리고 LDL receptor와 이를 조절하는 SREBP-2를 증가시키고 콜레스테롤 transport 인 ABCA1의 발현을 증가시켜 LDL를 낮추고 HDL를 높이는 효과가 있을 것으로 판단된다. 특히 두 추출물의 복합 투여시 훨씬 높은 시너지 효과를 나타냄을 확인하였다. 이러한 결과는 전통적으로 오랜 기간 사용되어온 천연물인 복분자와 홍삼이 콜레스테롤 예방에 효과적임을 입증한 결과로 관련 대사증후군의 예방에 기여할 것으로 사료된다. We investigated the effects of water extracts of unripe black raspberry (UBR) and red ginseng (RG) on cholesterol synthesis, 3-hydroxy-3-methylglutaryl (HMG)-CoA reductase activity, and expression of low-density lipoprotein (LDL) or high-density lipoprotein (HDL)-related genes in HepG2 and Caco-2 (human hepatoma and intestinal cell lines, respectively). Our results showed that cholesterol synthesis and HMG-CoA reductase activity in HepG2 cells were inhibited by UBR and RG. Further, co-treatment with UBR and RG had a greater effect than did treatment with either UBR or RG. In Caco-2 cells, treatment with UBR and RG increased the expression of LDL-regulated genes, such as LDL receptor and SREBP-2, and also upregulated the level of HDL-associated ABCA1. Moreover, co-treatment with UBR and RG appeared to be more effective than treatment with either UBR or RG. Taken together, our results indicate that UBR and RG regulate the level of HDL-associated ABCA1 via signaling pathway, thereby preventing cholesterol synthesis.

Protective role of V‐set and immunoglobulin domain‐containing 4 expressed on kupffer cells during immune‐mediated liver injury by inducing tolerance of liver T‐ and natural killer T‐cells

Jung, Keunok,Kang, Miseon,Park, Cheol,Hyun Choi, Yung,Jeon, Youkyung,Park, Se‐,Ho,Seo, Su‐,Kil,Jin, Dan,Choi, Inhak Wiley Subscription Services, Inc., A Wiley Company 2012 Hepatology Vol.56 No.5

<P><B>Abstract</B></P><P>V‐set and Ig domain‐containing 4 (VSIG4, CRIg, or Z39Ig), a newly identified B7‐related cosignaling molecule, is a complement receptor and a coinhibitory ligand that negatively regulates T‐cell immunity. Despite its exclusive expression on liver Kupffer cells (KCs) that play key roles in liver tolerance, the physiological role of VSIG4 in liver tolerance remains undefined. Mice lacking VSIG4 had poor survival rates and severe liver pathology in a concanavalin A (ConA)‐induced hepatitis (CIH) model, which could be prevented by adoptive transfer of VSIG4<SUP>+</SUP> KCs. The absence of VSIG4 rendered endogenous liver T‐ and natural killer T (NKT)‐cells more responsive to antigen‐specific stimulation and impaired tolerance induction in those cells against their cognate antigens. T‐cell costimulation with VSIG4.Ig suppressed Th1‐, Th2‐, and Th17‐type cytokine production and arrested the cell cycle at the G<SUB>0</SUB>/G<SUB>1</SUB> phase but did not induce apoptosis <I>in vitro</I>. VSIG4‐mediated tolerance induction and cell‐cycle arrest were further supported by down‐regulation of G<SUB>1</SUB> phase‐specific Cdk2, Cdk4, and Cdk6, and up‐regulation of tolerance‐inducing p27<SUP>KIP‐1</SUP> in VSIG4.Ig‐stimulated T‐cells. Administration of soluble VSIG4.Ig to wildtype mice prevented CIH development and prolonged the survival of mice with established CIH. Conclusion: Collectively, our results suggest that VSIG4<SUP>+</SUP> KCs play a critical role in the induction and maintenance of liver T‐ and NKT‐cell tolerance, and that modulation of the VSIG4 pathway using a VSIG4.Ig fusion protein may provide useful immunological therapies against immune‐mediated liver injury including autoimmune hepatitis. (H<SMALL>EPATOLOGY</SMALL> 2012;56:1838–1848)</P>

A case of cystic schwannoma

( Dan Bi Lee ),( Woong Suk Chae ),( Ha Na Jung ),( Ho Seok Suh ),( Yu Sung Choi ) 대한피부과학회 2012 대한피부과학회 학술발표대회집 Vol.64 No.1

우리나라 가축 매몰지 환경오염 현황 조사

이단비(Dan-Bi Lee),윤정환(Jung-Hwan Yoon),최유리(Yu-Ri Choi),김계훈(Kye-Hoon Kim) 한국토양비료학회 2018 한국토양비료학회 학술발표회 초록집 Vol.2018 No.10

Cell Cycle Progression and Morphology of Retinal Pigment Epithelial Cells Controlled By Three-Dimensional Micropatterned Surfaces

Lim, Jung-Min,Cho, Dong-Il 'Dan',Choi, Byoung-Doo,Park, Tai-Hyun,Chung, Seok,Chang, Jung-Kun 경북대학교 센서기술연구소 2002 센서技術學術大會論文集 Vol.13 No.1

인삼 중 DDT(DDD 및 DDE) 분석법의 개발

김성단(Sung-Dan Kim),조태희(Tae-Hee Cho),한은정(Eun-Jung Han),박성규(Seoung-Gyu Park),한창호(Chang-Ho Han),조한빈(Han-Bin Jo),최병현(Byung-Hyun Choi) 한국식품과학회 2008 한국식품과학회지 Vol.40 No.2

GC-μECD 이용한 수삼, 건조인삼, 홍삼 중 DDT(o,p’-DDE, p,p’-DDE, o,p’-DDD, p,p’-DDD, o,p’-DDT, p,p’-DDT)의 효율적인 분석 방법을 살펴본 결과는 다음과 같다. 단순하며 소량의 용매를 사용하는 동시분석법을 이용하여 인삼으로부터 DDT(DDD 및 DDE포함)를 추출하고 헥산 및 6% 에테르 함유 헥산으로 SPE-Florisil(500 ㎎) 정제하는 것이 GC-μECD 크로마토그램에서 인삼고유성분과 DDT(DDD 및 DDE포함) 피크의 분리도와 회수율 측면에서 가장 효율적이었다. 또한 인삼 중 저농도(0.01-0.05 ㎎/㎏) DDT(DDD 및 DDE포함) 이성질체를 SPE-Florisil(500 mg) 정제 전 30% 황산 처리 후 원심분리로 인삼 고유성분을 제거하여 정확성을 높였다. 동시다성분법 추출 후 황산처리 및 SPE-Florisil(500 ㎎) 정제방법을 이용한 수삼, 건조 인삼분말, 홍삼분말에 DDT(DDD 및 DDE포함) 이성질체 표준용액을 0.01 ㎎/㎏ 농도가 되도록 첨가하여 실험한 회수율은 87.9-99.6%이었으며 표준편차는 0.9-5.9%였다. 또한 검출한계(Method Detection Limits)는 0.003-0.009 ㎎/㎏이었다. The MRLs (maximum residue limits) of DDT (DDD and DDE) in fresh ginseng, dried ginseng, and steamed red ginseng are set as low as 0.01 ㎎/㎏, 0.05 ㎎/㎏, and 0.05 ㎎/㎏, respectively. Therefore, this study was undertaken to develop a simple and highly sensitive analysis method, as well as to reduce interfering ginseng matrix peaks, for the determination of DDT isomers (o,p’-DDE, p,p’-DDE, o,p’-DDD, p,p’-DDD, o,p’-DDT, and p,p’-DDT) in fresh ginseng, dried ginseng, and steamed red ginseng at the 0.01 ㎎/㎏ level. The method used acetonitrile extraction according to simultaneous analysis, followed by normal-phase Florisil solid-phase extraction column clean-up. The purification method entailed the following steps: (1) dissolve the concentrated sample extract in 7 ㎖ hexane; (2) add 3 ㎖ of H₂SO₄; (3) vigorously shake on a vortex mixer; (4) cetrifuge at 2000 rpm for 5 min; (5) transfer 3.5 ㎖ of the supernatant to the Florisil-SPE (500 ㎎/6 ㎖); and (6) elute the SPE column with 1.5 ㎖ of hexane and 10 ㎖ of ether/hexane (6:94). The determination of DDT isomers was carried out by a gas chromatography-electron capture detector (GC-μECD). The hexane and ether/hexane (6:94) eluate significantly removed chromatographic interferences, and the addition of 30% H₂SO₄ to the acetonitrile extract effectively reduced many interfering ginseng matrix peaks, to allow for the determination of the DDT isomers at the 0.01 ㎎/㎏ level. The recoveries of the 6 fortified (most at 0.01 ㎎/㎏) DDT isomers from fresh ginseng, dried ginseng, and steamed red ginseng ranged from 87.9 to 99.6%. The MDLs (method detection limits) ranged from 0.003 to 0.009 ㎎/㎏. Finally, the application of this method for the determination of DDT isomers is sensitive, rapid, simple, and inexpensive.

소아 Helicobacter pylori 감염증에서 대변항원검사의 민감도와 특이도

최경단(Kyung Dan Choi),양혜란(Hye Ran Yang),서정기(Jeong Kee Seo),고재성(Jae Sung Ko),신언우(Eon Woo Shin),장주영(Ju Young Jang),정지아(Ji A Jung),서정완(Jeong Wang Seo) 대한소화기학회 2001 대한소화기학회지 Vol.38 No.3

Background/Aims: The interest in non-invasive tests for Helicobacter pylori (H. pylori) infection in children is increasing. The aim of this study was to assess the usefulness of a new non-invasive enzyme immunoassay for H. pylori antigen in stools of children. Methods: Seventy-seven children(32 boys and 45 girls) who were aged from 2 to 17(mean 9.1) years, and complained of dyspeptic symptoms, were submitted to upper gastrointestinal endoscopy. During endoscopic examination, biopsy specimens were taken from antrum for histology and rapid urease test. H. pylori status was defined as infected if the results of both histology and rapid urease test were positive. Stool specimen was collected from all patients for Helicobacter pyori stool antigen (HpSA) test. Urea breath test (UBT) was performed in sixty-one children of the 77 children. Results: Fourteen children were H. pylori-positive, the other 63 children were H. pylori-negative. The results of HpSA test were positive in 15 children and negative in 62 children. The sensitivity, specificity, positive and negative predictive value of HpSA test were 100%, 98.4%, 93.3%, and 100%, respectively. Sixty-one of the 77 children underwent both UBT and HpSA test. The sensitivity and specificity of UBT were 90.9% and 96.0%, and those of HpSA test were 100% and 98.0%, respectively. Conclusions: The HpSA test is a highly sensitive and specific non-invasive diagnostic tool for the qualitative detection of H. pylori infection in children. Thus, the HpSA test can be very helpful in diagnosing H. pylori infection in children. (Korean J Gastroenterol 2001;38:154-160)