Evaluation of the Efficacy and Safety of DA-9601 versus Its New Formulation, DA-5204, in Patients with Gastritis: Phase III, Randomized, Double-Blind, Non-Inferiority Study

Choi, Yoon Jin,Lee, Dong Ho,Choi, Myung-Gyu,Lee, Sung Joon,Kim, Sung Kook,Song, Geun Am,Rhee, Poong-Lyul,Jung, Hwoon-Yong,Kang, Dae-Hwan,Lee, Yong Chan,Lee, Si Hyung,Choi, Suck Chei,Shim, Ki-Nam,Seol, KOREAN ACADEMY OF MEDICAL SCIENCE 2017 JOURNAL OF KOREAN MEDICAL SCIENCE Vol.32 No.11

<P>This study compared the efficacy of DA-9601 (Dong-A ST Co., Seoul, Korea) and its new formulation, DA-5204 (Dong-A ST Co.), for treating erosive gastritis. This phase III, randomized, multicenter, double-blind, non-inferiority trial randomly assigned 434 patients with endoscopically proven gastric mucosal erosions into two groups: DA-9601 3 times daily or DA-5,204 twice daily for 2 weeks. The final analysis included 421 patients (DA-5204, 209; DA-9601, 212). The primary endpoint (rate of effective gastric erosion healing) and secondary endpoints (cure rate of endoscopic erosion and gastrointestinal [GI] symptom relief) were assessed using endoscopy after the treatment. Drug-related adverse events (AEs), including GI symptoms, were also compared. At week 2, gastric healing rates with DA-5204 and DA-9601 were 42.1% (88/209) and 42.5% (90/212), respectively. The difference between the groups was −0.4% (95% confidence interval, −9.8% to 9.1%), which was above the non-inferiority margin of −14%. The cure rate of gastric erosion in both groups was 37.3%. The improvement rates of GI symptoms with DA-5204 and DA-9601 were 40.4% and 40.8%, respectively. There were no statistically significant differences between the two groups in both secondary endpoints. AEs were reported in 18 (8.4%) patients in the DA-5204 group and 19 (8.8%) in the DA-9601 group. Rates of AE were not different between the two groups. No serious AE or adverse drug reaction (ADR) occurred. These results demonstrate the non-inferiority of DA-5204 compared to DA-9601. DA-5204 is as effective as DA-9601 in the treatment of erosive gastritis. Registered randomized clinical trial at ClinicalTrials.gov (NCT02282670)</P>

Oxametallaborane 및 Metallacarborane과 Phenyl Carbene 반응에 대한 반응성과 반응메카니즘

성대동,이용희,심경옥 동아대학교 기초과학연구소 2000 基礎科學硏究論文集 Vol.17 No.1

거대고리 뭉치 붕소화합물 중 산소원자를 포함하는 oxametallaborane과 탄소원자를 포함하는 metallacaborane을 이용하여 새로운 metallacarborane을 합성할 수 있는 방법을 알아보고 [9,9-(PMe2Ph)2-arachno-9,6-PtOB8H10]과 [9,9-(PMe2Ph)2-arachno-9,6-PtOB8H12]를 합성한 후 이들에 phenyl diazomethane을 반응시켰다. [9,9-(PMe2Ph)2-arachno-9,6-PtOB8H10]과 phenyl diazomethane의 반응생성물은 예상과는 달리 cis-및 trans-stilbene과 trans, trans-benzaldehyde azine이었다. 카르벤의 이량화 반응은 [9,9-(PMe2Ph)2-arachno-9,6-PtOB8H10]의 촉매 작용에 의해 촉진 되었다. Oxametallaborane의 Pt-원자에 있는 d-오비탈이 카르벤의 삼중항 상태의 T1과 T2전자상태를 안정화 시켰다. [9,9-(PMe2Ph)2-arachno-9,6-PtOB8H12]와 phenyl diazomethane의 반응생성 oxametallaborane의 결과와 유사하였고 동시에 미량의 C-카르벤 삽입 반응생성물이 생성되었다. Metallacaborane의 탄소 원자궤도함수인 SOMO와 phenyl diazomethane의 LUMO가 반응하여 분자궤도함수 에너지를 낮추는데 기여하였다. The reaction mechanism and a new synthetic method using oxametallaborane and metallacarborane compounds are investigated. [9,9-(PMe2Ph)2-arachno-9,6-PtOB8H10] and [9,9-(PMe2Ph)2-arachno-9,6-PtCB8H12] are synthesized then, reacted with phenyl diazomethane to find out a new synthetic method corresponding to the metallacarborane cage compound. Unexpectedly cis- and trans-stilbene and trans, trans-benzaldehyde azine are produced from the reaction of [9,9-(PMe2Ph)2-arachno-9,6-PtOB8H10] with phenyl diazomethane. [9,9-(PMe2Ph)2-arachno-9,6-PtOB8H10] is operated as a kind of catalyst to yield dimerization product of carbene. The d-orbital in Pt-atom of oxametallaborane stabilizes the two triplet states of carbene, T1 and T2. A similar reaction products are produced from the reaction of [9,9-(PMe2Ph)2-arachno-9,6-PtOB8H12] with phenyl diazomethane and a trace amount of a new product is also produced such as C-carbene insertion reaction product simultaneously. The molecular orbital energy is lowered by the SOMO energy of metallacarborane and the LUMO energy of phenyl carbene.

수처리 부산물로 생성되는 염소산화물의 효율적 제거에 관한 연구

성대동,이성식 동아대학교 환경문제연구소 1999 硏究報告 Vol.22 No.1

The photodegradation efficiency of chlorine oxides in the drinking water has been studied by means of laser flash photolysis. The results are summarized as follows ; A high amount of ClO is produced just at the irradiation of laser flash. The absorption spectrum of ClO shows strong on the spectrophotometric measurement. The efficiency of removal of ClxOy reveals about 60~70% within 2㎲ after laser flash irradiation. The removal efficiency is decreased with the increase of the water thickness from 40㎝ to 80㎝ and also the efficiency is decreased about 4~6%. The removal rate of Cl₂O_(7) shows 3 times higher than one of Cl₂O_(6).

Seyferth시약의 발암성과 반응메카니즘 연구

성대동,박유미 동아대학교 환경문제연구소 1993 硏究報告 Vol.16 No.1

The reaction mechanism and molecular carcinogenetic property for the reaction of Seyferth's reagents such as phenyl(bromodichloromethyl)mercury and phenyl(tribromomethyl) mercury with food additives as dehydroacetic acid and coumarin has been studied under the conditions fo UV/vis photolysis and laser flash photolysis. 1. The reaction reactivities of Seyferth's regents as phenyl(bromodichloromethy1)mercury and phenyl(tribromomethyl) mercury are compared in all reaction conditions. The reactivity of phenyl(bromodichloromethy1) mercury is higher than the reactivity of phenyl(tribomomethy1) mercury at any reaction conditions in this research. This means that the leaving effect of : CCl₂carbene is higher than that of CBr₂carbene from mercury atom in Seyferth's reagent. 2. The yield of a highly toxic carcinogenetic carbene intermediate in the condition of UV/vis photolysis is less than those of laser flash photolysis. It is explainable that the reactions of Seyferth's reagent with the food additives are inhibited compared with the dimerization reaction of dihalogen carbenes each other. 3. The reactions of Seyferth' s reagents with dehydroacetic acid and coumarin are accelerated increasing with the negative(-) values of the bond energy of HgCCX₂and σ MO energy.

Au를 공침한 SnO₂후막센서의 가스 감응 특성

성정훈,강대원,이윤수,임준우,홍영호,이덕동 경북대학교 센서기술연구소 1998 센서技術學術大會論文集 Vol.9 No.1

High selective and sensitive thick film type methane gas sensors were fabricated and their sensing characteristics for various hydrocarbon gases were investigated. Raw material, SnO_(2)/Au, prepared by coprecipitation was even grain size. SEM, TEM, BET and XRD analyses were carried out for investigation of surface morphology and crystalline structure. The thick film devices using the above materials exhibited high sensitivity to methane gas at the operating temperature of 400°C. The sensitivity of SnO_(2)/Au+Pd thick film devices to methane gas was higher than that to the other hydrocarbon gases such as iso-butane and propane. The optimal adding amounts of Au and Pd were 1wt.% and 3wt.%, respectively. The sensitivity, S, is defined as {(R_(A)-R_(G))/R_(A)}><100, which R_(A) and R_(G) are resistance in air and that in the gas ambient, respectively.

염화나프토일의 親核性置換反應에 미치는 溶媒效果

成大東 東亞大學校 1980 東亞論叢 Vol.17 No.2

1-염화나프토일과 2-염화나프토일의 가매분해반응을 에탄올-아세토니트릴, 2-프로판올-아세토니트릴, 에탄올-아세톤, 2-프로판올-아세톤, 에탄올-물, 2-프로판올-물, 3차 부탄올-물 혼합용매 속에서 전기전도도법으로 측정하였다. 혼합용매의 조성에 관계없이 1-염화나프토일이 2-염화나프토일보다 속도가 크게 나타났다. 이것은 Dewar지수 Nr과 Streiwiesr의 σ+값과도 일치하였다. 1-염화나프토일은 Sn2전이상태에서 반응중심탄소가 sp²에서 sp³로 변하므로 peri-hydrogen effect가 relieve 됨을 알 수 있었으며 또한 모든 반응이 대체로 Sn2 반응메카니즘으로 진행됨을 알 수 있었다. 동일한 반응기질이 에탄올과 2-프로판올 및 공용매인 아세토니트릴의 혼합용매속에서도 메탄올-아세토니트릴 혼합용매에서와 같은 최대속도 현상이 나타났다. 즉 메탄올-아세토니트릴 혼합용매게에서는 메탄올의 물분율 0.85에서 최대치가 나타나는데 비해 등유전성이 아닌 에탄올-아세토니트릴 혼합용매게에서는 에탄올의 물분율 0.78에서 2-프로판올-아세토니트릴 혼합용매계에서는 2-프로판올도의 물분율 0.62에서 각각 최대속도상수를 갖는다. 이것으로 미루어 볼 때 에탄올과 2-프로판올도 메탄올과 같이 수소결합을 형성하여 다량체를 만들고, 가용매분해반응에서 아세토니트릴이 첨가될 때 이들 알코올의 다량체 구조가 파괴됨을 알 수 있었다. 또한 섭동분자이론(PMO)에서 구한 비결합분자궤도함수(NBMO)의 계수와 반응속도의 대수가 거의 직선적으로 비례함을 알 수 있었다. The kinetics for solvolysis of 1-naphthoyl and 2-naphthoyl chlorides have been measured in solvent mixtures, EtOH-Me추, 2-PrOH-MeCN, EtOH-(Me)₂CO, 2-PrOH-Me)₂CO, EtOH-H₂O, 2-PrOH-H₂O and t-BuOH-H₂O. The rate constants of 1-naphthoyl chloride were faster than 2-naphthoyl chloride in all solvent mixtures. This agrees with Dewar number, Nr and Streitwieser's σ+ value. It was concluded that the valence state of carbonyl carbon changed from sp² to sp³ in transition state and peri-hydrogen effect was relieved; the solvolytic reactions proceeded by Sn2 mechanism in all solvent mixtures system. There were maxima in rate of reaction for EtOH-MeCN, 2-PrOH-MeCN mixtures in the same way as for MeOH-MeCN mixture. The maximum rate in EtOH-MeCN mixture was observed at mole fraction of EtOH, 0.85 and in 2-PrOH-MeCN mixture was observed at mole fraction of 2-PrOH, 0.62. This behavior is interpreted as the structure of alcohols also has hydrogen bonding structure, and the polymer structure of alcohols is destroyed by adding aprotic solvent, MeCN. Comparing the perturbation molecular orbital theory in the transition state, the logarithms of solvolytic rate constants have been found to be proportional to the AO coefficient of nonbonding molecular orbital, 2a? in this solvolytic reaction.

삼배위 황화합물의 산촉매 가수분해 반응

성대동,이종팔,엄태섭 東亞大學校 大學院 1995 大學院論文集 Vol.20 No.-

The acid catalyzed hydrolysis of N-substituted sulfinamides have been studied in agueous solution of perchloric acid at 25℃ by spectrophotometrically. The pH-rate profile for N-phenylbenzene-sulfinamide(a); N-p-chlorophenybenzenesulfinamide(d), N-phenyl-p-chlorobe enesulfinamide(f) and N-phenyl-o-chlorobenzenesulfinamide (h) shows linearity, while those for N-p-methoxyphenylbenzenesulfin-amide(b), N-p-methylphenylbenzenesulfinamide(c) and N-phenyl-p-ethylbenzenesulfinamide(e) have a break at about pH 3. The break of pH-rate profile is ascribed to a change in the rate-determining step of the reaction involving a hypervalent intermediate.

Dabsyl Chlorides의 親核性 置換反應

成大東,朴現錫,柳俊夏,金良姬,李鍾八,嚴泰燮 東亞大學校 1990 東亞論叢 Vol.27 No.1

Kinetic studies of nuclsophilic substitution reaction of dabsyl chloride with pyridines have been investigated at 30℃ in a range of methanol-acetonitrile bianary solvent mixtures. The order of magnitude fo reactivity is β-picoline > pyridine > 1.5-N D A > α-picoline to react with dabsyl chloride, especially in case of α-picoline, the reactivity revealed lower than others, it is suggestd that nitrogen atom of pyfidine ring has a steric hinderance by the neightboring methyl group. The value of ρ(-0.96∼4.59) and β(0.36∼0.67) associated with a change of substituent in the nucleophile are large and indicate a realtively advanced bond formation in the transition state. Solvatochraomic correlations were predicted the importance of bond formation transition state, showing a greater contribution of polaritypolarizability (π*) lone paired to hydro-gen bond donar acidity (α). We conclude that the reaction of dabsyl chloride with pyridine proceed via S2 type reaction mechanism, as well as the reaction of dansyl chloride pyridine.

체내 카드뮴 농도에 따른 신세뇨관 미세손상 유병률

임동혁, 문선인, 엄상용, 김용대, 강종원, 김헌 충북대학교 의과대학 충북대학교 의학연구소 2011 忠北醫大學術誌 Vol.21 No.2

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親核性 置換反應에서 最大速度現象과 Hammett 相關關係

성대동,이종팔,이미정,엄태섭 東亞大學校 大學院 1996 大學院論文集 Vol.21 No.-

The nucleophilic substitution reactions of p-substituted benyl bromide with p-substituted N,N-dimethyl anilines in methanol and acetonitrile binary solvent mixtures which are known as an isodielectric olvent system kinetically and the results are as follows. 1.The postive dharge is developed on the reaction center of the substrate and it means that the bond cleavage is preceded more than bond formation in the transition on the analogy of Hammett ?? values. 2.The bond formation is not progressed in the case of electron donating substituent of substrate. however, the bond formation is much developed in the case of electron withdrawing substituent of substrate on the anlogy of Hammett ?? values. 3.The nucleophilic attacking ability is shown a highest at 80%(V/V) methanol content and the bond formation is well progressed at the same methanol composition on the result of a cross interacton coefficient, ??.