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To Dao Cuong,Hoang Thi Ngoc Anh,Tran Thu Huong,Pham Ngoc Khanh,Vu Thi Ha,Tran Manh Hung,김영호,Nguyen Manh Cuong 한국생약학회 2019 Natural Product Sciences Vol.25 No.4
Soluble epoxide hydrolases (sEH) are enzymes present in all living organisms, metabolize epoxy fatty acids to 1,2-diols. sEH in the metabolism of polyunsaturated fatty acids plays a key role in inflammation. In addition, the endogenous lipid mediators in cardiovascular disease are also broken down to diols by the action of sEH that enhanced cardiovascular protection. In this study, sEH inhibitory guided fractionation led to the isolation of five phenolic compounds trans-resveratrol (1), trans-piceatannol (2), sulfuretin (3), (+)-balanophonin (4), and cassigarol E (5) from the ethanol extract of the seeds of Passiflora edulis Sims cultivated in Vietnam. The chemical structures of isolated compounds were determined by the interpretation of NMR spectral data, mass spectra, and comparison with data from the literature. The soluble epoxide hydrolase (sEH) inhibitory activity of isolated compounds was evaluated. Among them, trans-piceatannol (2) showed the most potent inhibitory activity on sEH with an IC50 value of 3.4 mM. This study marks the first time that sulfuretin (3) was isolated from Passiflora edulis as well as (+)-balanophonin (4), and cassigarol E (5) were isolated from Passiflora genus.
Do Manh Cuong,김경웅,Tran Quang Toan,Tran Dac Phu 한국자원공학회 2011 Geosystem engineering Vol.14 No.1
Human pharmaceuticals are considered emerging organic micro-pollutants, originating mostly from hospital and municipal wastewater treatment plants. They can be found widely in a variety of water media, including wastewater,surface water, ground water, coastal water and drinking water at trace levels (ng/L or low μg/L). Many pharmaceuticals show their persistence to biodegradation in water, however their bioaccumulation is still not clear and chronic effects to living organisms for long term exposure need further studies. The occurrences and fate of active pharmaceutical compounds and their metabolites in aquatic environments are complicated,which vary between their physio-chemical properties, environment conditions and removal efficiency of water treatment plants. Advanced treatment technologies such as ozonation, advanced oxidation processes (AOPs), membrane bioreactor (MBR)show high efficiency to reduce concentrations of pharmaceutical residues in water.
Inhibitory effects of indirubin derivatives on the growth of HL-60 leukemia cells.
Cuong, Nguyen Manh,Tai, Bui Huu,Hoan, Dang Hoang,Huong, Tran Thu,Kim, Young Ho,Hyun, Jae-Hee,Kang, Hee-Kyoung Natural Product Communications 2010 Natural product communications Vol.5 No.1
<P>Six indirubin derivatives have been synthesized and their inhibitory effects on the growth of HL-60 human promyelocytic leukemia cells investigated. Cell viability was determined using the trypan blue exclusion method. Indirubin-3'-oxime (I-1) inhibited the growth of HL-60 cells with a GI50 value of 36.6 microM, whereas I-0, I-2, I-3, I-4 and I-6 showed only weak cytotoxic activities against HL-60 cancer cells with GI50 values in the range of 97.3 to over 100 microM. These results indicate that indirubin derivatives might be useful candidate agents for exploring potential antileukemic drugs.</P>
Tran Thi Thu Thuy,Nguyen Manh Cuong,Tran Quoc Toan,Ngo Ngoc Thang,Bui Huu Tai,Nguyen Xuan Nhiem,Hye-Jin Hong,Sohyun Kim,Stephanie Legoupy,고영상,Young Ho Kim 대한약학회 2013 Archives of Pharmacal Research Vol.36 No.7
A series of N-substituted-1,2,3-triazole murrayafolineAderivativeswere successfully synthesized usingclick azide–alkyne Huisgen cycloaddition reaction between1-methoxy-3-methyl-9-(3-azido)-propyl-9H-carbazole andsubstituted alkynes. Their chemical structures were confirmedby 1H, 13C NMR and HR-ESI–MS spectral data. Inaddition, the interested effects on LPS-stimulated productionof pro-inflammatory cytokines in bone marrow-deriveddendritic cells of synthetic murrayafoline A derivatives werealso investigated. Our results indicated that murrayafoline Aderivatives containing 1,2,3-triazole nucleus potentiallypossessed anti-inflammatory action through inhibiting productionof IL-6, IL-12 p40 and TNF-a.
Phenolic Compounds from <i>Caesalpinia sappan</i> Heartwood and Their Anti-inflammatory Activity
Cuong, To Dao,Hung, Tran Manh,Kim, Jin Cheol,Kim, Eun Hee,Woo, Mi Hee,Choi, Jae Sue,Lee, Jeong Hyung,Min, Byung Sun American Chemical Society and American Society of 2012 Journal of natural products Vol.75 No.12
<P>Four new phenolic compounds, caesalpiniaphenols A–D (<B>1</B>–<B>4</B>), together with eight known compounds were isolated from <I>Caesalpinia sappan</I> heartwood. The chemical structures were established mainly by NMR, MS, ECD, and Mosher’s method. Compounds <B>4</B>, <B>5</B>, and <B>7</B> showed weak inhibitory activity against the LPS-induced NO production in macrophage RAW264.7 cells with IC<SUB>50</SUB> values of 12.2, 3.5, and 5.7 μM, respectively.</P><P><B>Graphic Abstract</B> <IMG SRC='http://pubs.acs.org/appl/literatum/publisher/achs/journals/content/jnprdf/2012/jnprdf.2012.75.issue-12/np3003673/production/images/medium/np-2012-003673_0007.gif'></P><P><A href='http://pubs.acs.org/doi/suppl/10.1021/np3003673'>ACS Electronic Supporting Info</A></P>
Compounds from the Seeds of Myristica fragrans and Their Cytotoxic Activity
TODAO CUONG,Chae Jin Lim,Tran Thi Thu Trang,Yoon Ho Bae,NGUYENVAN THU,Nguyen The Tung,Tran Manh Hung,우미희,최재수,민병선 한국생약학회 2012 Natural Product Sciences Vol.18 No.2
Six lignan compounds, 1-(17,21-dihydroxyphenyl)-9-(12,13-dihydroxyphenyl)-1-nonanone (malabaricone C) (1), 7'-(3',4'-methylenedioxyphenyl)-8,8'-dimethyl-7-(3,4-dihydroxyphenyl)-butane (2), 7'-(3',4'-dimethoxyphenyl)-8,8'-dimethyl-7-(3-methoxy-4-hydroxyphenyl)-butane (3), 7-(4-hydroxy-3-methoxyphenyl)-7′-(3′,4′-methylenedioxyphenyl)-8,8′-lignan-7-methyl ether (4), (+)-erythro-(7S,8R)-Δ8′-7-hydroxy-3,4,3′,5′-tetramethoxy-8-O-4′-neolignan (5), and (+)-erythro-(7S,8R)-Δ8′-7-acetoxy-3,4,3′,5′-tetramethoxy-8-O-4′-neolignan (6), were isolated from the seeds of Myristica fragrans. The chemical structures of these compounds were determined on the basis of spectroscopic analyses including 2D NMR. Compounds 1 - 6 were evaluated for their cytotoxic activity against the HL-60, MCF-7, and A549 cancer cell lines in in vitro.
Power Control for Interference Management and QoS Guarantee in Heterogeneous Networks
Tai Manh Ho,Tran, Nguyen H.,Do, Cuong T.,Ahsan Kazmi, S. M.,Eui-Nam Huh,Choong Seon Hong IEEE 2015 IEEE communications letters Vol.19 No.8
<P>We consider the sum-rate optimization problem with power control for uplink transmission in a heterogeneous network (HetNet) consisting of a macrocell and multiple femtocells. The considered problem includes the HetNet's crucial constraints of both cross-tier interference protection and user QoS in terms of outage probability and average delay. We transform the original nonconvex problem into a convex problem and develop a distributed algorithm that can attain the global optimal transmit power values. This algorithm, however, has heavy network overheads, which may lead to increased energy consumption for femtocell user equipment. We propose a new practical near-optimal distributed algorithm that eliminates these network overheads. Numerical results show that the schemes have nearly identical performance.</P>
Isolation of Compounds from Cimicifugae Rhizoma and their Cytotoxic Activity
TODAO CUONG,Chae Jin Lim,Sang Won Kim,Ji Eun Park,Tran Manh Hung,민병선 한국생약학회 2011 Natural Product Sciences Vol.17 No.2
Five known compounds, cimigenol (1), 25-O-acetylcimigenol (2), cimigenol 3-O-b-D-xylopyranoside (3), ferulic acid methyl ester (4), and visnagin (5), were isolated from Cimicifugae Rhizoma (Ranunculaceae). The chemical structures of these compounds were determined on the basis of spectroscopic analyses including 2D NMR. Compounds 1 - 5 were evaluated for their cytotoxic activity against the HL-60, MCF-7, and A549 cancer cell lines in in vitro. Among them, compounds 4 and 5 showed moderate inhibitory activity against HL-60 cancer cell lines with IC50 values of 24.8 and 18.1 ?M, respectively.