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DMPO 와 ㆍOH 의 Spin添加生成物에 대한 EPR 分析 및 ㆍOH 의 毒性作用
김정렬,이미녕,박윤창 성균관대학교 기초과학연구소 1989 論文集 Vol.40 No.2
The hydroxyl radical (·OH) generated from the Iron-catalyzed Haber-Weiss reaction was detected. The ability of Fe(Ⅱ) to this reaction depends upon the particular ligands around the metal ion. The formation of hydroxyl radical, spin trapped with 5, 5-dimethyl-1-pyrroline-N-oxide (DMPO), increased with the amount of ATP added in the Fe (Ⅱ)-H_2O_2 system. Specially, when the concentration of H_2O_2 was high, the perhydroxyl radicals were formed from the system. Human erythrocyte ghosts were covalently labeled with 4-maleimido-2,2,6,6-tetramethylpiperidine-N-oxyl(4-Maleimido-Tempo) and their electron paramagnetic resonance(EPR) spectra revealed two major binding environments representing strongly (h_1) and weakly (h_2) immobilized) species. The ratio of h_2/h_1, determined from the respective peak amplitudes, decreased from 14.8 to 5.5 when the labeled ghosts were exposured with hydroxyl radicals produced in the system, whereas lipid peroxidation of erythrocyte ghosts was increased with the concentration of hydroxyl radicals. These effects suggested that the fluidity of membrane and/or protein mobility were decreased as a result of lipid peroxidation and the structural and the functional alterations of membrane were. initiated by hydroxyl radicals.
유기인계 농약 중독환자에서 기계환기 필요성에 대한 예측인자 분석
박동찬 ( Dong Chan Park ),박정배 ( Jung Bae Park ),김윤정 ( Yun Jeong Kim ),신수정 ( Soo Jeong Shin ),문유호 ( You Ho Mun ),박신률 ( Sin Ryul Park ),류현욱 ( Hyun Wook Ryoo ),서강석 ( Kang Suk Seo ),정제명 ( Jae Myung Chung ) 대한임상독성학회 2010 대한임상독성학회지 Vol.8 No.2
Purpose: The purpose of this study is to investigate the factors that predict using mechanical ventilation for patients with organophosphate intoxication. Methods: We retrospectively reviewed the medical records of 111 patients with acute organophosphate intoxication and who were treated in our emergency center from January 2000 to December 2008. We compared the toxicologic characteristics, the laboratory findings and the APACHE II scores between the Mechanical Ventilation group (MV group) and the non-Mechanical Ventilation group (the non MV group). Results: Sixty three patients were in the MV group and 48 patients were in the non MV group. In the MV group, the patients had an older age (p<0.001), a larger amount of ingestion (p<0.001), a lower initial serum cholinesterase level (p=0.003), a higher APACHE II score (p<0.001) and they ingested a more toxic agent (p=0.001). There were no significant differences in gender, the type of visit and the arrival time between the MV group and the non MV group. Conclusion: We suggest that the patient’s age, the amount of organophosphate ingestion, the toxicity of the agent, the initial serum cholinesterase level and the APACHE II score are important factors to determine if mechanical ventilation will be applied for patients with organophosphate intoxication.
조현병 환자에서 비정형 장기지속형 주사제와 경구제의 6개월 추적관찰 기간 효과비교
박찬미(Chan mi Park),박은정(Eun jung Park),이승환(Seung Hwan Lee),김영훈(Young Hoon Kim),정영철(Young Chul Chung),원승희(Seung hee Won),이상규(Sang Kyu Lee),박선철(Seon Cheol Park),배경열(Kyung ryul Bae),최진아(Jin A Choi),최하진(Ha 한국보건의료연구원 2016 근거와 가치 Vol.2 No.2
Objectives: To compare the clinical outcomes between the schizophrenia patients using long-acting injection (LAI) and those using oral agent (Oral). Methods: A prospective multicenter registry conducted at 7 hospitals comparing a one-year treatment effectiveness of LAI to reduce recurrence and to improve medication adherence (MA) and quality of life (QOL). This interim analysis presents data from the first 6 months of the follow-up period. Results: Among a total of 393 patients enrolled in this study, 385 patients (LAI 87, Oral 298) were analyzed as the interim analysis. There were no significant differences in clinical global impression (CGI), global improvement (GI), positive and negative symptom scale (PANSS), and QOL (CGI, P=0.618; GI, P=0.599; PANSS, P=0.289; EuroQol five dimensions questionnaire, P=0.254; Korean version of 4th revision of Schizophrenia Quality of Life Scale, P=0.416; visual analogue scale, P=0.581). LAI was associated with improved doctor’s perspective MA (P=0.021), but no difference was observed in patient’s perspective MA (P=0.355). Recurrence for 6 months occurred in 8 cases (9.2%) of LAI and in 43 cases (14.4%) of Oral. Kaplan-Meier analysis showed that there was no significant difference in time to recurrence after enrollment between LAI and Oral. The multivariate Cox analysis also showed no difference (hazard ratio=1.710; 95% confidence interval=0.758~3.855). Conclusion: In patients with schizophrenia experiencing recurrence, the difference of effectiveness between LAI and oral therapy could not be observed during 6 months of follow-up.
Park, Kyung-Ae,Kim, Kyung-Ryul,Kim, Kuh,Chung, Jong-Yul,Conillor, Peter-C. The Korean Society of Oceanography 2003 Journal of the Korean Society of Oceanography Vol.38 No.4
Major differences between wind speeds from atmospheric pressure maps (Na wind) and nearsurface wind speeds derived from satellite scatterometer (NSCAT) observations over the East (Japan) Sea have been examined. The rootmeansquare errors of Na wind and NSCAT wind speeds collocated with Japanese Meteorological Agency (JMA) buoy winds are about $3.84\;ms^{-1}\;and\;1.53\;ms^{-1}$, respectively. Time series of NSCAT wind speeds showed a high coherency of 0.92 with the real buoy measurements and contained higher spectral energy at low frequencies (>3 days) than the Na wind. The magnitudes of monthly Na winds are lower than NSCAT winds by up to 45%, particularly in September 1996. The spatial structures between the two are mostly coherent on basinwide large scales; however, significant differences and energy loss are found on a spatial scale of less than 100 km. This was evidenced by the temporal EOFs (Empirical Orthogonal Functions) of the two wind speed data sets and by their twodimensional spectra. Since the Na wind was based on the atmospheric pressures on the weather map, it overlooked smallscale features of less than 100 km. The center of the coldair outbreak through Vladivostok, expressed by the Na wind in January 1997, was shifted towards the North Korean coast when compared with that of the NSCAT wind, whereas NSCAT winds revealed its temporal evolution as well as spatial distribution.