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Liang-Kun Chen,Ching-Chi Hsieh,Yi-Chao Huang,Yuan-Jung Huang,Chun-Fan Lung,Wei-En Hsu,Chao-Ling Yao,Tsung-Yu Tseng,Chi-Chung Wang,Yi-Chiung Hsu 한국생물공학회 2023 Biotechnology and Bioprocess Engineering Vol.28 No.3
Most of the gas exchange in the human body is carried out by the lungs, and the physiological activities of the lungs are uninterrupted. Due to the deterioration of the external environment, pulmonary cell lesions are common clinical lung diseases. Mechanical cyclic stretching is one kind of bionic technology to observe lung cancer cells. The A549 cell line is the human lung adenocarcinoma cell line derived from a primary lung tumor. This study investigated the effects of mechanical cyclic stretching on A549 cell activity and gene expression profile. Whereas mechanical cyclic stretching had no significant difference in colony formation and cell migration of A549 cells, the cell invasion increased significantly in A549 cells after stretching. In addition, the microarray data showed that mechanical cyclic stretching altered gene expression, induced inflammation of cells, and activation of Wnt/β- catenin and tumor necrosis factor pathways. More importantly, mechanical cyclic stretching activated the expression of tumor necrosis factor-alpha (TNF-α) protein. Therefore, the increase of cell invasion induced by mechanical cyclic stretching might be associated with the activation of TNF-α in human lung adenocarcinoma cells.
Glutathione S-Transferase Expression in Upper Urinary Tract Urothelial Carcinomas: a Taiwan Study
Chen, Szu-Han,Wu, Wen-Jeng,Tu, Hung-Pin,Li, Wei-Ming,Huang, Chun-Nung,Li, Ching-Chia,Lin, Hui-Hui,Ke, Hung-Lung Asian Pacific Journal of Cancer Prevention 2013 Asian Pacific journal of cancer prevention Vol.14 No.11
Objectives: Glutathione S-transferase (GST) isoenzymes play important roles in resistance to cell apoptosis and carcinogenesis. We aimed to establish the relationship between GST expression and the prognosis of upper urinary tract urothelial carcinoma (UTT-UC) in Taiwan. Methods: This study retrospectively reviewed 46 patients with pathologically confirmed UUT-UC at Kaohsiung Medical University Hospital. In each patient, expression of GSTT1 and GSTP1 was compared between urothelial carcinoma and normal urothelial cells by Western blotting. Results: GSTP1 expression in the UUT-UC cells was significantly higher than that in normal urothelial cells (1.6 fold, p<0.001). Expression of GSTT1 was significantly associated with the invasiveness of the carcinoma (p=0.006). Conclusions: In UUT-UC, GSTP1 might be a potential tumor marker, whereas high GSTT1 expression could be used as an indicator of cancer progression. This study is the first to demonstrate potential applications of different GST isoenzymes for biomolecular analysis of UUT-UCs in Taiwan.
Rapid Microfluidic Mixing-chip System for Sorbic Acid Detection in Foods
( Chun-ying Chen ),( Lung-ming Fu ) 한국농업기계학회 2018 한국농업기계학회 학술발표논문집 Vol.23 No.1
An integrated microfluidic experimental platform is presented for sorbic acid (C<sub>6</sub>H<sub>8</sub>O<sub>2</sub>) concentration detection purposes. The integrated microfluidic platform comprises a mixer and heater zone for species mixing / reaction and a micro-spectrometer system detection zone for C<sub>6</sub>H<sub>8</sub>O<sub>2</sub>concentration detection. The microfluidic reaction chip is patterned on low-cost PMMA substrates using a commercial CO<sub>2</sub>lasersystem and is packaged using a hot-press bonding technique. In the proposed platform, the C<sub>6</sub>H<sub>8</sub>O<sub>2</sub> sample and Iron(III) reagent are mixed under the effects of a high-pressure gas driving force. A colorimetric reaction (oxidation reaction) of the mixed species is then induced by means of an integrated micro heating / cooling system. The microfluidic reaction chip is then transferred to a micro-spectrometer system for detection purposes. Absorbance was measured at 529 nm using a micro-spectrometer wherein a line regression is obtained to determine the C<sub>6</sub>H<sub>8</sub>O<sub>2</sub>concentration. The experimental results show that correlation coefficients of R<sup>2</sup>=0.9910 is obtained with known concentrations ranging from 10~100 ppm. The real-world applicability of the proposed experimental platform is demonstrated by measuring the C<sub>6</sub>H<sub>8</sub>O<sub>2</sub> concentration in two commercial food samples. It is shown that the concentration measurements obtained using the proposed system deviate by no more than 5% from those obtained using standard macroscale methods.
The Presence of Borrelia valaisiana-Related Genospecies in Ticks and a Rodent in Taiwan
Chun-Man Huang,Hsi-Chieh Wang,Ying-Chun Lin,Shih-Hui Chiu,Ying-Shun Kao,Pei-Lung Lee,Hsiu-I Wang,Ruei-Chen Hung,Huang-I Chan,Ho-Sheng Wu,Chuen-Sheue Chiang,Jung-Jung Mu 한국미생물학회 2010 The journal of microbiology Vol.48 No.6
A field survey was conducted to investigate the presence of Borrelia burgdorferi sensu lato (s.l.) in six counties of Taiwan. Spirochetes were successfully isolated from one rodent ear sample out of 485 rodent ears and 53live, fed tick (Ixodes granulatus) samples. The spirochetes were confirmed to be B. burgdorferi s.l. by real-time PCR. In addition, 23 of 113 tick samples were tested positive for Borrelia DNA according to real-time PCR. The Borrelia isolate from the rodent and the 23 Borrelia DNA samples from the ticks were identified as B. valaisiana-related genospecies by phylogenetic analysis based on flagellin gene sequences. These findings suggest that the Borrelia valaisiana-related strains are maintained in a zoonotic cycle between tick vectors and reservoir hosts in Taiwan.
Yea-Chen Liu,Yu-Ying Hsiao,Kuo-Lung Ku,Hui-Fen Liao,Wei-Chun Chao 한국식품영양과학회 2018 Journal of medicinal food Vol.21 No.7
Macrophages play an indispensable role in the host immune defense. Macrophages can undergo polarization into classically (M1) and alternatively (M2) activated macrophages. M1 macrophages activate immune and inflammatory response, while M2 macrophages are involved in tissue remodeling. Mahonia oiwakensis (Mo) is a herbal medicine in Asia used for its anti-inflammatory and analgesic properties; however, the mechanism is unclear. This study analyzed the effect of Mo extracts and its effects on the polarization of both macrophage RAW264.7 cells and mouse splenic macrophages. Water (Mo-W) and EtOH extracts (Mo-E) did not change the viability of RAW264.7 cells, whereas Mo-E inhibited nitric oxide (NO) production. The major compounds, berberine and palmatine, decreased the viability and NO levels of cells. The secretion of inflammatory cytokines CXCL16, IL-6, L-selectin, MCP1, RANTES, and sTNF-R1 was downregulated, whereas the production of vascular endothelial growth factor (VEGF) was upregulated by Mo-E, berberine, and palmatine treatments. Mo-E, berberine, and palmatine stimulated the expression of macrophage CD68 and M2-type CD204 markers, decreased M1-mediated p-STAT1 and NF-κB, and increased M2-mediated p-STAT6 expression. Similar effects on M2 polarization were also observed in splenic macrophages from mice. In conclusion, Mo-E, berberine, and palmatine modulated macrophages through the suppression of M1-mediated inflammation and the recruitment of M2-mediated VEGF secretion and STAT6 expression.
( Ming-lung Yu ),( Chao-hung Hung ),( Yi-hsiang Huang ),( Cheng-yuan Peng ),( Chun-yen Lin ),( Pin-nan Cheng ),( Rong-nan Chien ),( Shih-jer Hsu ),( Chen-hua Liu ),( Jee-fu Huang ),( Chung-feng Huang 대한간학회 2018 춘·추계 학술대회 (KASL) Vol.2018 No.1
Aims: The current study aims to elucidate the treatment efficacy (defined as undetectable HCV RNA throughout 12 weeks of post-treatment follow-up, SVR12) and safety DCV/ASV plus ribavirin for 12 weeks in HCV-1b patients without NS5A RAS. Methods: This is a single-arm, open-label phase 2 study. Seventy directly acting antivirals (DAA)-naïve HCV-1b patients without L31/Y93 RAS are planned to receive daclatasvir (60 mg/ day) and asunaprevir (100 mg twice daily) plus weight-based ribavirin (1000-1200 mg/day) for 12 weeks. After treatment they were followed up for 12 weeks. Results: As of 31 Oct 2017, 58 eligible patients are allocated to treatment, with a mean age of 59.3 years and female predominance (67.2%, 39/58). The mean HCV RNA was 5.87+0.77 log10 IU/mL; 23 patients (39.7 %) had significant hepatic fibrosis (>F2). In the modified intention-to-treat analysis, the rate of undetectable HCV at week 1, week 2, week 4, week 8 and endof- treatment was 25 % (14/56), 84.8 % (39/46), 100 % (46/46), 100 % (38/38) and 100 % (27/27), respectively. Undetectable HCV RNA were observed in all of the patients with HCV RNA assessable 4 weeks (SVR4, 18/18) and 12 weeks (SVR12, 12/12) post treatment. None of the 18 patients who completed the 12-week treatment experienced relapse during post-treatment follow-up. The most common adverse event was fatigue (78.3 %), followed by pruritus (65.2 %) and dizziness (52.2 %), of which were considered as ribavirin related. None of the participating subjects withdrew treatment or follow-up throughout the trial peroid. Three serious adverse events were reported which included urosepsis, appendicitis and left ureteral stone. All were unrelated to the investigating drugs. Conclusions: 12 weeks of DCV/ASV plus ribavirin was highly effective and safe in HCV-1b patients without NS5A RAS in the interim analysis. The satisfactory results would be anticipated in the full patient set.
Chao-Lung Hwang,Le Anh-Tuan Bui,Chun-Tsun Chen 사단법인 한국계산역학회 2012 Computers and Concrete, An International Journal Vol.10 No.6
This paper focuses on the application of Fuller’s ideal gradation curve to theoretically design blended ratio of all solid materials of high performance concrete (HPC), with the aid of error function, and then to study the effect of rice husk ash (RHA) on the performance of HPC. The residual RHA, generated when burning rice husk pellets at temperatures varying from 600 to 800oC, was collected at steam boilers in Vietnam. The properties of fresh and hardened concrete are reviewed. It is possible to obtain the RHA concrete with comparable or better properties than those of the specimen without RHA with lower cement consumption. High flowing concrete designed by the proposed method was obtained without bleeding or segregation. The application of the proposed method for HPC can save over 50% of the consumption of cement and limit the use of water. Its strength efficiency of cement in HPC is 1.4-1.9 times higher than that of the traditional method. Local standards of durability were satisfied at the age of 91 days both by concrete resistivity and ultrasonic pulse velocity.
Karthick Mani,Wei-Chen Lin,Chun-Fang Wang,Bivas Panigrahi,Yong-Jin Wu,Cheng-Lung Wu,Chia-Yuan Chen 한국바이오칩학회 2020 BioChip Journal Vol.14 No.4
3D bioprinting is one of the rapidly evolving fields of tissue engineering where microengineering meets cells biology within an unprecedented precision to construct tissue structures of various forms with complexity. However, enabling simultaneous printing of heterogeneous biomaterial along with scaffold components through the currently available printers is still considered as a major challenge due to the lack of instrumentation. Flow control is one of the major issues associated with the process. In this aspect, a microfluidic nozzle head equipped with two shape-memory alloy (SMA) actuators was proposed and integrated with a commercially available 3D printer to assist the biomaterial printing in a more systematic manner. The SMA actuator restrains the amount of flows for fabricating the desired scaffold components. Experimental results illustrated that the use of SMA actuator ensued a rapid and precise flow control of biomaterial and can further facilitate to maintain the width of any printed structures. As a proof of concept for the profound biomedical applications with the present manufacturing configuration, a 3D printed hydrogel platform was fabricated with demonstrated characters for later cell seeding after the printing further opens a new chapter in terms of biomaterial printing.