Process Feasibility Study on Thermal-Plasma System for HFC-23 Decomposition

Lee, Joong Kee,Cho, Kyu Young,Lee, Sang Deuk,Lee, Hwa Young,Chang, Won Young,Lim, Jong Choo Trans Tech Publications, Ltd. 2010 Materials science forum Vol.658 No.-

<P>A feasibility study on the use of a thermal plasma process for the destruction of HFC-23 is carried out in comparison with an incineration process. The material and energy balances for both processes are calculated using the commercial simulator, Pro/II (ver. 8.0). Based on the computational analysis, the volume of the plasma process and NOx and CO2 emissions in the plasma process are 25, 10 and 40% of those in the incineration process, respectively. Therefore, more compact units can be employed in the plasma process. However, the operating cost of the plasma process would be higher than that of the incineration process using LNG as a fuel.</P>

The extent of minimal residual disease reduction after the first 4-week imatinib therapy determines outcome of allogeneic stem cell transplantation in adults with Philadelphia chromosome-positive acute lymphoblastic leukemia

Lee, Seok,Kim, Yoo-Jin,Chung, Nak-Gyun,Lim, Jihyang,Lee, Dong-Gun,Kim, Hee-Je,Min, Chang-Ki,Lee, Jong-Wook,Min, Woo-Sung,Kim, Chun-Choo Wiley Subscription Services, Inc., A Wiley Company 2009 Cancer Vol.115 No.3

<B>BACKGROUND:</B><P>Previously, the authors demonstrated the positive impact of imatinib on the outcome of allogeneic stem cell transplantation in adults with Philadelphia chromosome-positive acute lymphoblastic leukemia (Ph-positive ALL). Here, the authors analyzed for risk factors that affect transplantation outcome, and they focused particularly on the prognostic relevance of minimal residual disease level at each treatment stage.</P><B>METHODS:</B><P>Fifty-two patients with newly diagnosed Ph-positive ALL who completed allogeneic stem cell transplantation following imatinib therapy were enrolled in this study. For minimal residual disease monitoring, 548 marrow samples were analyzed by a real-time quantitative polymerase chain reaction assay.</P><B>RESULTS:</B><P>After the first 4-week imatinib therapy, 11 patients (21.2%) achieved molecular remission, and the remaining 41 patients had a reduction in BCR-ABL transcript levels (median, 3.21 log) from baseline value. The frequency of achieving a reduction in BCR-ABL transcript levels of at least 3 log at this stage was 36 (69.2%). Forty-eight (92.3%) of the 52 patients received stem cell transplantation during first complete remission. With a median follow-up of 49 months after stem cell transplantation, the 4-year relapse rate and disease-free survival rate were 21.2% and 69.8%, respectively. A reduction in BCR-ABL transcript levels of at least 3 log after the first 4-week imatinib therapy was identified as the most powerful predictor of lower relapse (12.1% vs 45.1%, P = .011) and better disease-free survival (82.1% vs 41.7%, P = .009) rates.</P><B>CONCLUSIONS:</B><P>Prospective assessment of the extent of minimal residual disease reduction after the first 4-week imatinib therapy may allow the authors to identify subgroups of Ph-positive ALL transplants at high risk of relapse. Cancer 2009. © 2008 American Cancer Society.</P>

In vitro maturation: Clinical applications

Lim, Kyung Sil,Chae, Soo Jin,Choo, Chang Woo,Ku, Yeon Hee,Lee, Hye Jun,Hur, Chang Young,Lim, Jin Ho,Lee, Won Don The Korean Society for Reproductive Medicine 2013 Clinical and Experimental Reproductive Medicine Vol.40 No.4

Oocyte in vitro maturation (IVM) is an assisted reproductive technology in which oocytes are retrieved from the antral follicles of unstimulated or minimally stimulated ovaries. IVM of human oocytes has emerged as a promising procedure. This new technology has advantages over controlled ovarian stimulation such as reduction of costs, simplicity, and elimination of ovarian hyperstimulation syndrome. By elimination or reduction of gonadotropin stimulation, IVM offers eligible infertile couples a safe and convenient form of treatment, and IVM outcomes are currently comparable in safety and efficacy to those of conventional in vitro fertilization. IVM has been applied mainly in patients with polycystic ovary syndrome or ultrasound-only polycystic ovaries, but with time, the indications for IVM have expanded to other uncommon situations such as fertility preservation, as well as to normal responders. In this review, the current clinical experiences with IVM will be described.

신입생 오리엔테이션을 위한 이-러닝 콘텐츠 설계 및 구현

추문식(Choo mun-sik),이대영(Lee dae-young),이관기(Lee kwan-ki),손영주(Son young-joo),권현숙(Kown hyon-sook),손정은(Son jeonh-eun),임양원(Lim yang-won),임한규(Lim han-kyu) 한국콘텐츠학회 2013 한국콘텐츠학회 종합학술대회 논문집 Vol.2013 No.5

글리세롤계 계면활성제 합성 및 계면 특성에 관한 연구

임종주 ( Jong Choo Lim ),이슬 ( Seul Lee ),김병조 ( Byeong Jo Kim ),이종기 ( Jong Gi Lee ),최규용 ( Kyu Yong Choi ) 한국공업화학회 2011 공업화학 Vol.22 No.4

글리시돌과 라우릴 알코올을 반응시켜 합성한 LA와 LA3 비이온계면활성제의 CMC는 각각 0.97×10 -3 mol/L, 1.02×10 -3 mol/L이며, 1 wt% 농도에서의 표면장력은 26.99 mN/m과 27.48 mN/m이었다. 동적 표면장력 측정 결과에 의하면 LA와 LA3 비이온 계면활성제 모두, 공기와 수용액의 계면이 계면활성제 단분자에 의하여 비교적 짧은 시간 내에 포화 되었으며, 1 wt% LA와 LA3 계면활성제 시스템들의 접촉각은 각각 27.8, 20.9°를 나타내었다. 비극성 오일 n-decane과 1 wt% 계면활성제 수용액 사이의 시간에 따른 계면장력은 시간에 따라 감소하며, LA와 LA3 시스템 모두 2∼3 min 이내의 짧은 시간에 평형에 도달하였고, 평형에서의 계면장력 값은 각각 0.1524, 0.1716 mN/n을 나타내었다. 25℃에서 의 계면활성제 수용액은 두 시스템 모두 비교적 안정한 상태를 유지하였고, LA 비이온 계면활성제가 LA3 비이온 계 면활성제에 비하여 거품 안정성이 큼을 확인하였으며, 이러한 거품 안정성 측정 결과는 표면장력 측정 결과와도 일치 하였다. 계면활성제, 물, 비극성 탄화수소 오일로 이루어진 3성분 시스템에 대하여 25∼60℃의 온도에서 상평형 실험 을 수행한 결과, lower phase 마이크로에멀젼 혹은 oil in water (O/W) 마이크로에멀젼이 excess oil 상과 평형을 이루는 2상 영역만이 관찰되었을 뿐, lamellar liquid crystalline phase 혹은 middle-phase 마이크로에멀젼을 포함한 3상 영역은 나타나지 않았다. The CMCs of LA and LA3 nonionic surfactants obtained from the reaction between glycidol and lauryl alcohol were found to be 0.97×10 -3 mol/L and 1.02×10 -3 mol/L respectively and the surface tensions for 1 wt% surfactant were 26.99 and 27.48 mN/m respectively. Dynamic surface tension measurements using a maximum bubble pressure tensiometer showed that the adsorption rate of surfactant molecules at the interface between the air and the surfactant solution was found to be relatively fast in both surfactant systems, presumably due to the high mobility of surfactant molecules. The contact angles of LA and LA3 nonionic surfactants were 27.8 and 20.9° respectively and the dynamic interfacial tension measurement by a spinning drop tensiometer showed that interfacial tensions at equilibrium condition in both systems were almost the same. Also both surfactant systems reached equilibrium in 2∼3 min. Both surfactant solutions showed high stability when evaluated by conductometric method and the LA nonionic surfactant system provided the higher foam stability than the LA3 nonionic surfactant system. The phase behavior experiments showed a lower phase or oil in water (O/W) microemulsion in equilibrium with an excess oil phase at all temperatures studied. No three-phase region was observed including a middle-phase microemulsion or a lamellar liquid crystalline phase.

Sorbitan Laurate 계면활성제 합성 및 계면 특성에 관한 연구

임종주 ( Jong Choo Lim ),이슬 ( Seul Lee ),김병조 ( Byeong Jo Kim ),이종기 ( Jong Gi Lee ) 한국공업화학회 2011 공업화학 Vol.22 No.1

합성한 sorbitan laurate SP 20의 CMC 값은 약 7.216×10-4 mol/L로서 옥틸페놀 에톡실레이트 OPE 10에 비하여 약간 크지만, CMC에서의 표면장력은 26.0 mN/m로 OPE 10에 비하여 작았다. 또한 SP 20의 경우에는 OPE 10 계면활성제와 비교하며 공기와 수용액의 계면이 계면활성제 단분자에 의하여 포화되는 데 더 많은 시간이 소요되었다. SP 20 계면 활성제 수용액의 접촉각은 계면활성제 농도가 증가함에 따라 감소하였으며, 동일한 계면활성제 농도에서 OPE 10에 비하여 접촉각이 큼을 알 수 있었다. OPE 10과 SP 20 계면활성제 수용액의 거품 반감기는 각각 770, 1268s로서 SP 20 계면활성제가 OPE 10 계면활성제에 비하여 거품의 안정성이 크며, 이러한 결과는 표면장력 측정 결과와 일치하였다. OPE 10에 비하여 SP 20의 가용화 속도는 매우 낮으며, 이러한 결과는 foam stability, 접촉각 및 CMC 실험 결과와 일치하였다. OPE 10과 SP 20 시스템의 평형에서의 계면장력은 각각 0.659, 0.742 mN/m으로서 비슷한 값을 나타내었으나, OPE 10의 경우에는 비교적 짧은 시간 내에 계면장력이 평형에 도달하는 것에 비하여 SP 10의 경우에는 계면장력 이 평형 값에 도달하는데 약 25 min이 소요되었다. The critical micelle concentration (CMC) of sorbitan laurate SP 20 surfactant in this paper was near 7.216×10-4 mol/L and the surface tension at CMC was about 26.0 mN/m, which showed higher CMC and lower surface tension than those of octyl-phenol ethoxylate octylphenol ethoxylate (OPE) 10 surfactant. Dynamic surface tension measurement using a maximum bubble pressure tensiometer showed that the adsorption rate at the interface between air and surfactant solution was found to be slower with SP 20 surfactant, presumably due to a low mobility of SP 20 surfactant monomer. The contact angle of SP 20 surfactant solution was observed to decrease with an increase in surfactant concentration and showed a larger value than that of OPE 10 surfactant solution. Half-life time for foams generated with 1 wt% surfactant solution was also larger with SP 20 surfactant, which indicated higher foam stability with SP 20 surfactant. Dynamic behavior study reveals that the solubilization of n-decane oil was much lower with SP 20, which is in good agreement with experimental results of foam stability, contact angle and CMC. Dynamic interfacial tension measurement by a spinning drop tensiometer shows that interfacial tensions at equilibrium condition in both systems were almost the same but the time required to reach equilibrium was longer with SP 20.

Expression patterns of gangliosides in lipopolysaccharid-stimulated normal PK-15 cells and gangliosides knock-down PK15 cells

Ju-Taek Lee,Jae-Sung Ryu,Ghislain Moussavou,Malg-Um Lim,Hyun-Ki Min,Yoon-Ju Na,Su-Bin Lee,In-Sun Kim,Ju-Hyoung Lee,Ji-Su Kim,Sun-Uk Kim,Kyu-Tae Chang,Young-Kug Choo 한국당과학회 2012 한국당과학회 학술대회 Vol.2012 No.1

Glycosphingolipids including gangliosides play important regulatory roles in cell prolifera-tion and differentiation. UDP-glucose:ceramide glucosyltransferase(Ugcg) catalyze the initial step in glycosphingolipids biosynthesis pathway. In this study, Ugcg expression was reduced to approximately 80% by short hairpin RNAs(shRNAs) to evaluate the roles of glycosphingolipids in proliferation and gangliosdies differentiation of PK15. HPTLC/immunofluorescence analyses of shRNA transfected PK15 revealed that treatment with Ugcg-shRNA decreased expression of major gangliosides, GM1 and GD1b. Furthermore, MTT and western blot/immunofluorescence analyses demonstreated that inhibition of the Ugcg expression in PK15 resulted in decrease of cell proliferation. In addition to we showed that inflammatory respon-ses in PK15 and gangliosides knock-down PK15 cells stimulated with Escherichia coli lipopolysaccharide(LPS). The gangliosides GM3, GM2, GD3, GD1a and GD1b were detected in normal PK15 cell. However almost gangliosides undetected in gangliosides knock-down PK15 cell. In addition we found that the expression levels of TNF-α, indu-cible nitric oxide synthase (iNOS) and cyclooxygenase-2 (COX-2) and we measured the production of NO. The expression of inflammatory proteins, TNF- α, iNOS and COX-2 the elevated concentration in gangliosides knock-down PK15 cell. These results suggest that gangliosides interact with components of the proinflammatory response pathway and might, therefore, be relevant for designing future therapeutic strategies intended to prolong xenograft survival.

Study on Preparation and Morphology of Silver Chlorobromide Microcrystals in Photographic Emulsion

Myung Cheon Lee,Hyeon Sup Lee,Dong Joo Kwon,Kil Yong Jung,Jong Choo Lim,Euy Soo Lee,Hyun Song,Hyun So Shin 한국공업화학회 2002 Journal of Industrial and Engineering Chemistry Vol.8 No.1

연구 논문 : 에틸렌 옥사이드가 부가된 양쪽성 계면활성제의 등전점 및 유연력에 관한 연구

임종주 ( Jong Choo Lim ),박준석 ( Jun Seok Park ),한동성 ( Dong Sung Han ),김지성 ( Ji Sung Kim ),이슬 ( Seul Lee ),모다희 ( Da Hee Mo ),이진선 ( Jin Sun Lee ) 한국공업화학회 2012 공업화학 Vol.23 No.6

본 연구에서는 에틸렌 옥사이드가 부가된 양쪽성 계면활성제에 대하여 기본적인 물성(임계 마이셀 농도, 표면장력, 계면장력, 접촉각, 점도, 계면활성제 시스템의 상거동 등)을 측정하였다. 또한 계면활성제 수용액에 대한 제타 전위 측정과 QCM 실험을 통하여 양쪽성 계면활성제가 양이온 계면활성제에서 비이온 계면활성제로 작용이 전환되는 등전점을 결정하였다. 제타 전위 측정에 의하여 결정한 DE3-OSA82-AO, DE5-OSA82-AO 및 DE9-OSA82-AO 계면활성제 시스템의 등전점은 각각 6.97, 6.93 및 7.10이며, 이 결과는 QCM 측정 실험으로부터 결정한 각각의 등전점 6.97, 6.83 그리고 7.02의 값과 거의 일치하였다. 표면 마찰 시험기를 사용하여 계면활성제로 세정한 섬유의 평균 마찰계수 값을 측정한 결과, 계면활성제 수용액의 pH가 중성인 조건에서 섬유 유연 효과가 우수함을 확인하였다. In this study, we analyzed the physical properties of an ethylene oxide adducted amphoteric surfactant such as critical micelle concentration, surface tension, interfacial tension, contact angle, viscosity and phase behavior. The dual function characteristics of an amphoteric surfactant were investigated by determining an isoelectric point, which were attained using zeta potential measurements and quartz crystal microbalance (QCM) experiments. The isoelectric points of DE3-OSA82-AO, DE5-OSA82-AO and DE9-OSA82-AO surfactant systems determined by zeta potential measurements were 6.97, 6.93 and 7.10 respectively and they are in good agreement with the isoelectric point values measured by QCM experiments. The frictional property measured using an automated mildness tester showed that the DE-OSA82-AO surfactant could provide a good softening effect at neutral condition.

Expression of gangliosides during differentiation to endothelial cells of mouse embryonic stem cells

Malg-Um Lim,Jae-Sung Ryu,Ghislain Moussavou,Ju-Taek Lee,Hyun-Ki Mun,Yoon-Ju Na,Su-Bin Lee,In-Sun Kim,Ju-Hyoung Lee,Ji-Su Kim,Sun-Uk Kim,Kyu-Tae Chang,Young-Kug Choo 한국당과학회 2012 한국당과학회 학술대회 Vol.2012 No.1