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Flow and Learning Emotions in Computer Education
Chih-Chien Wang,Kai-Li Wang,Chien-Chang Chen,Yann-Jy Yang 한국데이타베이스학회 2014 Journal of information technology applications & m Vol.21 No.3
It is important to keep learners’ feeling positive during learning to enhance learning performance. According to flow theory,challenge-skill balance is a precondition for flow experience: Learnersfeel anxietywhen the challenge of learning is higher than their ability, feel boredom when the challenge of learning is lower than learners’ ability, and engage in flow status when the challenge of learning matches the learners’ ability. However, the current empirical study reveals that emotions related to enjoyment may appear when the learners’ skill is equal to or higher than the learning challenge. Nevertheless, boredom emotion may appear when learners perceive the courses are difficult but unimportant. These empirical survey results revealed the necessary of rethinking the appearance of boredom and enjoyment emotions in computer education.
Chen, Wen-Kwei,Liu, Ingrid Y,Chang, Ya-Ting,Chen, Yong-Cyuan,Chen, Chih-Cheng,Yen, Chen-Tung,Shin, Hee-Sup,Chen, Chien-Chang The Society 2010 The Journal of neuroscience Vol.30 No.31
<P>Treatments for chronic musculoskeletal pain, such as lower back pain, fibromyalgia, and myofascial pain syndrome, remain inadequate because of our poor understanding of the mechanisms that underlie these conditions. Although T-type Ca(2+) channels (T-channels) have been implicated in peripheral and central pain sensory pathways, their role in chronic musculoskeletal pain is still unclear. Here, we show that acid-induced chronic mechanical hyperalgesia develops in Ca(v)3.1-deficient and wild-type but not in Ca(v)3.2-deficient male and female mice. We also show that T-channels are required for the initiation, but not maintenance, of acid-induced chronic muscle pain. Blocking T-channels using ethosuximide prevented chronic mechanical hyperalgesia in wild-type mice when administered intraperitoneally or intracerebroventricularly, but not intramuscularly or intrathecally. Furthermore, we found an acid-induced, Ca(v)3.2 T-channel-dependent activation of ERK (extracellular signal-regulated kinase) in the anterior nucleus of paraventricular thalamus (PVA), and prevention of the ERK activation abolished the chronic mechanical hyperalgesia. Our findings suggest that Ca(v)3.2 T-channel-dependent activation of ERK in PVA is required for the development of acid-induced chronic mechanical hyperalgesia.</P>
Moscatilin Induces Apoptosis and Mitotic Catastrophe in Human Esophageal Cancer Cells
Chien-An Chen,Chien-Chih Chen,Chien-Chang Shen,Hen-Hong Chang,Yu-Jen Chen 한국식품영양과학회 2013 Journal of medicinal food Vol.16 No.10
Moscatilin, a bibenzyl derivative from the orchid Dendrobium loddigesii, has been shown to possess anticancer activity. We examined the effect of moscatilin on human esophageal cancer cells, including squamous cell carcinoma (SCC) and adenocarcinoma (ADC) cells and its possible mechanisms. Moscatilin suppressed the growth of both the histological cell lines in a dose- and time-dependent manner. Morphological changes indicative of apoptosis and mitotic catastrophe were observed following moscatilin treatment. The population of cells in the sub-G1 phase and polyploidy phase significantly increased after treatment. Immunofluorescence revealed multipolar mitosis and subsequent multinucleation in moscatilin-treated cells, indicating the development of mitotic catastrophe. Western blot showed a marked increase in expressions of polo-like kinase 1 and cyclin B1 after exposure to moscatilin. In conclusion, moscatilin inhibits growth and induces apoptosis and mitotic catastrophe in human esophageal SCC- and ADC-derived cell lines, indicating that moscatilin has broad potential against esophageal cancer
Chien-Wen Chen,Nguyen Duong Thuy Trang,Mingchang Chih,Pei-Ying Chen 글로벌지식마케팅경영학회 2023 Global Marketing Conference Vol.2023 No.07
With the development of social media, most people will use social media to watch the videos of digital influencers to get spiritual comfort, and they will think that digital influencers are like friends who are connected with their own lives. However, most of the previous studies focused on the influence of digital influencers on followers’ behavioral intentions (e.g. loyalty, and purchase intention). They rarely discussed the online social well-being obtained by followers after watching digital influencers' posts. Therefore, this study integrates the attributes of followers (loneliness, low self-esteem, empathy) and the characteristics of digital influencers (social attractiveness, expertise, homophily) to explore the influence of the parasocial interaction established between digital influencers and followers on followers’ online social well-being. This study uses the Internet to collect questionnaires and takes users who have watched digital influencers' posts on social media as the research object. A total of 597 valid questionnaires are collected. The research results show that: the characteristics of digital influencers (social attractiveness, expertise, and homophily), and followers' attributes (low self-esteem and empathy) have positively affected parasocial interaction. It is noteworthy that loneliness has no significant effect on parasocial interaction.
Flow and Learning Emotions in Computer Education: An Empirical Survey
Wang, Chih-Chien,Wang, Kai-Li,Chen, Chien-Chang,Yang, Yann-Jy Korea Data Strategy Society 2014 Journal of information technology applications & m Vol.21 No.3
It is important to keep learners' feeling positive during learning to enhance learning performance. According to flow theory,challenge-skill balance is a precondition for flow experience: Learners feel anxiety when the challenge of learning is higher than their ability, feel boredom when the challenge of learning is lower than learners' ability, and engage in flow status when the challenge of learning matches the learners' ability. However, the current empirical study reveals that emotions related to enjoyment may appear when the learners' skill is equal to or higher than the learning challenge. Nevertheless, boredom emotion may appear when learners perceive the courses are difficult but unimportant. These empirical survey results revealed the necessary of rethinking the appearance of boredom and enjoyment emotions in computer education.
Dental arch wires with tooth-like color
Chen, Sinn-Wen,Wu, Hsin-Jay,Liu, Chih-Hao,Chien, Yuan-Chun,Hu, Chih-Chang Techno-Press 2012 Advances in materials research Vol.1 No.1
Unique tooth-like (milky white) color ${\beta}$-Ti dental arch wires are prepared by anodization in a 1M $H_2SO_4$ electrolyte at $30^{\circ}C$ and 30 V for 88 min and 40 s. Aggregates are formed on these surfaces of the anodized wires with tooth-like colors, and the results are different from those of the anodized wires with monochromatic colors which have smooth oxide surfaces. Similar to the monochromatic wires, the composition of the oxide layer is $TiO_{2-x}$ and the x approaches zero at the outer layer. But different from the amorphous structure observed in monochromatic wires, the oxide layers are partially crystallized with an anatase structure. The milky white colors result from the rough and crystalized oxide layers, not by the interference effect as observed in monochromatic wires.
REVIEW : Intestinal Stricture in Crohn`s Disease
( Chen Wang Chang ),( Jau Min Wong ),( Chien Chih Tung ),( I Lun Shih ),( Horng Yuan Wang ),( Shu Chen Wei ) 대한장연구학회 2015 Intestinal Research Vol.13 No.1
Crohn`s disease (CD) is a disease with chronic inflammation of unknown etiology involving any part of the gastrointestinal tract. The incidence and prevalence of CD are increasing recently in Asia. Half of the CD patients will have intestinal complica-tions, such as strictures or fistulas, within 20 years after diagnosis. Twenty-five percentage of CD patients have had at least one small bowel stricture and 10% have had at least one colonic stricture and lead to significant complications. Most of these pa-tients will require at least one surgery during their lifetime. Early diagnosis and evaluation with adequate managements for the patients can prevent disability and mortality of these patient. Here, we reviewed the current incidence of CD with stricture, the etiology of stricture, and how to diagnose and manage the stricture. (Intest Res 2015;13:19-26)
Thyroid fine-needle aspiration cytology in Taiwan: a nationwide survey and literature update
Chien-Chin Chen,Jen-Fan Hang,Chih-Yi Liu,Yeh-Han Wang,Chiung-Ru Lai 대한병리학회 2020 Journal of Pathology and Translational Medicine Vol.54 No.5
In Taiwan, thyroid fine-needle aspiration cytology is easily accessible and reliable for evaluating thyroid nodules. The sonographic pattern plays a major role and is the deciding factor for aspiration. We conducted a nationwide survey in 2017 and it revealed that 31% of laboratories had adopted The Bethesda System for Reporting Thyroid Cytopathology. There was a relatively high unsatisfactory rate (24.04%) and low rates of indeterminate diagnoses, including atypia of undetermined significance/follicular lesions of undetermined significance: 4.87%, and follicular neoplasm/suspicious for a follicular neoplasm: 0.35%. Moreover, the risks of malignancy in benign, atypia of undetermined significance, and suspicious for a follicular neoplasm were relatively high. These may reflect strict diagnostic criteria for indeterminate categories and better patient selection for surgery. Improvements in specimen sampling and continuing education programs are crucial. Newly-developed thyroid cytology technologies, such as immunocytochemistry, molecular testing, and computerized cytomorphometry, may further facilitate cytology diagnoses.