A Case Study on City Park’s Stormwater Management of Sponge City in China

Chen, Xiao Hui(진효훼),Pei, Fang Ming(배방명),Kim, Shin Won(김신원) 한국디자인문화학회 2018 한국디자인문화학회지 Vol.24 No.4

최근 중국에서 유행하는 경관생태 개념인 스펀지 도시(해면도시)는 점진적으로 중시되고 있다. 본 연구는 스펀지 도시의 이론을 파악해 중국 도시의 선진적인 우수관리 시스템 건설을 위한 기초 개념을 제공하고, 건설 방법을 제시하는 한편 이론적 결과를 바탕으로 하여 실천에 참고가 되는 자료를 제시하는데 연구의 목적을 둔다. 본 논문은 스펀지 도시 이론을 바탕으로 하여 건설된 예시를 연구의 대상으로 정하였다. 연구 방법은 스펀지 도시 이론의 우수관리를 분석하며, 우수관리의 구역적 특성, 조경 디자인의 생태성, 서비스의 다양성 등 3가지 특징을 나타낸다. 그 특징에 의해 지정된 3가지 부족한 면모는 천진 Qiaoyuan(橋園) 습지공원, 첸안 Sanlihe(三里河) 생태행랑과 하얼빈 Qunli(群力) 우수공원을 비교분석하였다. 예시 분석을 통하여 우수관리의 장점과 단점을 발견하여 스펀지 도시의 건설을 위한 지침을 제시하고자 하였다. 연구 결과, 해면체로서의 도시공원은 주민에게 휴식과 오락 장소를 제공함과 동시에 동식물에게 서식지를 제공하기도 하였다. 도시 홍수의 감소 및 수자원 재활용의 측면에서 도시 전체를 여전히 적용하지 않았는데, 지방의 환경은 발전과 개선의 측면에서 적극적으로 발휘되었다. 앞선 연구의 내용으로 보아 이론과 실천 경험의 부족함으로 인해 건설된 해면체로서의 도시공원은 수질 정화 및 지하수 보급의 측면에서 피할 수 없는 결점이 존재한다는 것을 확인하였다. 문화와 역사를 내포한 스펀지 도시를 건설하는 것은 인간의 과거와 미래 문명 발전을 지지하기도 한다. 본 연구는 미래 스펀지 도시의 발전 및 관련 연구에 가치 있는 자료로 활용되기를 기대한다. China has been aware of the popularity of an ecological concept, the Sponge City. This is a study of the theory for the Sponge City which points out an excellent direction of the stormwater management for Chinese cities. Meanwhile, the research of the construction of the Sponge City would provide references for theory and practice studies. This research takes examples of Sponge City as objects for study. The research methodology is infestation and analysis for stormwater management under the Sponge City theory, to summarize the three features of regional characteristics, ecology in landscape design, and diversity of services. By comparing these three features in Tianjin Qiaoyuan Wetland Park, Qian’an Sanlihe Ecological Corridor, and Harbin Qunli Stormwater Park, this paper discovered the advantages and disadvantages of stormwater management, provding inspirational suggestions for the construction of the Sponge City. Comprehensively, the Sponge City can provide residents not only a place to take a rest and entertain but an environment for plants and animals to live as an urban park. Although the problems of city stormwater management and the replenishment of water resources still exist, the Sponge City plays a vital role in the development and improvement of the zonule environment. Due to the lack of theoretical and practical experience, the established Sponge City park has certain defects in water purification and groundwater recharge. As a carrier of culture and history, the construction of the Sponge City also bears the development of human civilization in the past and the future. As a textual material, this research may be used as a reference for the future development of the Sponge City.

Image Classification via Active Learning and Probability Least Squares Support Vector Machine

Chen Xiao-hui,Gao Yan,Li Jun-yi 보안공학연구지원센터 2015 International Journal of Signal Processing, Image Vol.8 No.8

Aiming at properties of remote sensing image data such as high-dimension, nonlinearity and massive unlabeled samples, a kind of probability least squares support vector machine (PLSSVM) classification method based on hybrid entropy and L1 norm was proposed. Firstly, hybrid entropy was designed by combining quasi-entropy with entropy difference, which was used to select the most “valuable” samples to be labeled from massive unlabeled sample set. Secondly, a L1 norm distance measuring was used to further select and remove outliers and redundant data from the sample set to be labeled. Finally, based on originally labeled samples and screened samples, PLSSVM was gained through training. Experimental results on classification of ROSIS hyperspectral remote sensing images show that the overall accuracy and Kappa coefficient of the proposed classification method reach higher accuracy respectively. The proposed method can obtain higher classification accuracy with few training samples, which is much applicable to classification problem of remote sensing images.

제임스 로즈의 모더니즘 정원에서 재료 활용 방법에 대한 연구

진효훼(Chen, Xiao Hui),김신원(Kim, Shin Won) 한국디자인문화학회 2018 한국디자인문화학회지 Vol.24 No.1

우리는 예술, 건축 및 조경 등의 분야에서 모더니즘의 영향을 많이 받으며 발전하였다. 조경설계분야에서 모더니즘 이전의 조경가들은 재료를 정원을 장식하기 위한 용도로만 이용하였으며, 재료의 중요성을 인식하지 못하였다. 본 연구는 전통적인 조경설계를 비판한 모더니즘 초기의 조경가 제임스 로즈(James Rose)의 작품 연구를 통해, 로즈의 설계 개념에서 (철학적인 사상을 제시하고) 재료를 이용하는 방식과 그 재료가 설계에 미치는 영향의 중요성을 제시하고자 하였다. 로즈의 설계 작품 중 대표적인 로즈정원, 공중정원, 로즈주택과 매치주택을 대상으로 분석을 실시하였다. 로즈의 작품에 사용된 재료를 특성과 장단점을 제시하였고, 작품에 영향을 끼친 재료를 분석하였다. 로즈의 조경설계 이념을 살펴보고 조경재료에 대한 개념을 고찰하여 공간 형태, 공간 구조, 시각적 모호성, 공간의 유동성과 다변성이라는 5가지 유형으로 나누어 세부적으로 분석하였다. 로즈가 설계한 작품은 유리나 물과 같은 투명한 재료를 이용하여 실외와 실내의 공간을 통합시켰고, 또한 식물이나 판석 등의 자연적인 재료는 대상지의 주변 환경을 융합할 뿐만 아니라, 공간 구조와 형태를 조절하는 역할임을 알 수 있었다. 그중에서 공간 사이의 유동성과 공간의 다변성은 설계된 물과 식물을 통하여 유발하는 것임을 강조하며, 식물이 공간을 융합시키는 데에 중요한 재료로 보여주고 있다. 연구결과의 내용은 조경설계 교육 및 실무 수행을 위한 자료가 될 수 있으며, 과학기술이 발전함에 따라 향후 설계 재료의 특성에 대한 인식 고취, 활용 및 응용 영역 확충 등 조경공간 조성에 유용한 자료가 될 것으로 기대한다. We have been influenced by modernism in fields such as art, architecture and landscape. Before Modernism in landscape design, landscape architects used the materials only to decorate their gardens and did not recognize the importance of it. This research paper is focusing in the study of the works of James Rose, who was one of the first architects of modernism who criticized traditional landscape design. Rose explores how to use materials (presenting philosophical ideas) and the importance of them. Rose garden, Hanging garden, Rose residence and Match residence were analyzed. The characteristics, advantages and disadvantages of the materials used in Rose’s work were presented, and the materials that affected the work were analyzed. The concept of landscape design is examined in detail and it is divided into five types of spatial form, spatial structure, visual ambiguity, space fluidity and variability. The projects designed by Rose incorporates outdoor and indoor spaces using transparent materials such as glass and water. In addition, natural materials, such as plants and flagstone, are used not only to fuse the environment of the site, but also to control the spatial structure form. Among this characteristics, it is emphasized that the fluidity between the space and the variability of the space is caused by water and designed plants, and shows the plants as an important material for the fusion of space. The content of the research result can be used as material for the education and practice of landscape design. As the science and technology develops, it will become a useful data for the creation of landscape space.

The miR-98-3p/JAG1/Notch1 axis mediates the multigenerational inheritance of osteopenia caused by maternal dexamethasone exposure in female rat offspring

Han Hui,Xiao Hao,Wu Zhixin,Liu Liang,Chen Ming,Gu Hanwen,Wang Hui,Chen Liaobin 생화학분자생물학회 2022 Experimental and molecular medicine Vol.54 No.-

As a synthetic glucocorticoid, dexamethasone is widely used to treat potential premature delivery and related diseases. Our previous studies have shown that prenatal dexamethasone exposure (PDE) can cause bone dysplasia and susceptibility to osteoporosis in female rat offspring. However, whether the effect of PDE on bone development can be extended to the third generation (F3 generation) and its multigenerational mechanism of inheritance have not been reported. In this study, we found that PDE delayed fetal bone development and reduced adult bone mass in female rat offspring of the F1 generation, and this effect of low bone mass caused by PDE even continued to the F2 and F3 generations. Furthermore, we found that PDE increases the expression of miR-98-3p but decreases JAG1/Notch1 signaling in the bone tissue of female fetal rats. Moreover, the expression changes of miR-98-3p/JAG1/Notch1 caused by PDE continued from the F1 to F3 adult offspring. Furthermore, the expression levels of miR-98-3p in oocytes of the F1 and F2 generations were increased. We also confirmed that dexamethasone upregulates the expression of miR-98-3p in vitro and shows targeted inhibition of JAG1/Notch1 signaling, leading to poor osteogenic differentiation of bone marrow mesenchymal stem cells. In conclusion, maternal dexamethasone exposure caused low bone mass in female rat offspring with a multigenerational inheritance effect, the mechanism of which is related to the inhibition of JAG1/Notch1 signaling caused by the continuous upregulation of miR-98-3p expression in bone tissues transmitted by F2 and F3 oocytes.

Perioperative Comprehensive Supportive Care Interventions for Chinese Patients with Esophageal Carcinoma: a Prospective Study

Zhang, Xiao-Dan,Zhao, Qing-Yu,Fang, Yi,Chen, Guan-Xuan,Zhang, Hui-Fang,Zhang, Wen-Xiao,Yang, Xiao-Ping Asian Pacific Journal of Cancer Prevention 2013 Asian Pacific journal of cancer prevention Vol.14 No.12

Objective: To assess the effects of perioperative comprehensive supportive care interventions on outcome of Chinese esophageal cancer patients in a prospective study. Methods: 60 patients with primary esophageal carcinoma were randomized into an intervention group (IG, n=31) and a control group (CG, n=29). The Chinese version of symptom checklist-90 (SCL-90) was adopted to assess their psychological status. The interventions, including health education, psychological support, stress management, coping strategies and behavior training, were carried out in 3 phases (preoperative, postoperative I and postoperative II), and psychological effects were thereafter evaluated accordingly before surgery, and 1 week, 4 weeks and 24 weeks post-surgery. Medical costs were estimated at discharge. Survival of patients was estimated each year post-surgery. General health status and satisfaction-with-hospital were surveyed by a follow-up questionnaire 4 years post-surgery. Results: All the subjects demonstrated higher scores in the preoperative phase than the normal range of Chinese population concerning 7 psychological domains including somatization, obsessive-compulsive, depression, anxiety, hostility, phobic anxiety and paranoid ideation. Although no significant difference was observed between the two groups at admission, the scores of IG, which tended to decrease at a faster rate, were generally lower than those of CG at weeks 1, 4 and 24 post-surgery. The length of hospital stay and medical costs of IG were significantly less than those of CG and satisfaction-with-hospital was better. However, there was no significant difference in 4-year survival or health status between two groups. Conclusions: Appropriate perioperative comprehensive supportive care interventions help to improve the psychological state of Chinese patients with esophageal carcinoma, to reduce health care costs and to promote satisfaction of patients and their families with hospital.

Attenuation of Experimental Autoimmune Hepatitis in Mice with Bone Mesenchymal Stem Cell-Derived Exosomes Carrying MicroRNA-223-3p

Yong-Ping Chen,Feng-Bin Lu,Da-Zhi Chen,Lu Chen,En-De Hu,Jin-Lu Wu,Hui Li,Yue-Wen Gong,Zhuo Lin,Xiao-Dong Wang,Ji Li,Xiao-Ya Jin,Lan-Man Xu 한국분자세포생물학회 2019 Molecules and cells Vol.42 No.12

MicroRNA-223-3p (miR-223-3p) is one of the potential microRNAs that have been shown to alleviate inflammatory responses in pre-clinical investigations and is highly encased in exosomes derived from bone mesenchymal stem cells (MSC-exosomes). MSC-exosomes are able to function as carriers to deliver microRNAs into cells. Autoimmune hepatitis is one of the challenging liver diseases with no effective treatment other than steroid hormones. Here, we examined whether MSC-exosomes can transfer miR-223-3p to treat autoimmune hepatitis in an experimental model. We found that MSC-exosomes were successfully incorporated with miR-223-3p and delivered miR-223-3p into macrophages. Moreover, there was no toxic effect of exosomes on the macrophages. Furthermore, treatments of either exosomes or exosomes with miR-223-3p successfully attenuated inflammatory responses in the liver of autoimmune hepatitis and inflammatory cytokine release in both the liver and macrophages. The mechanism may be related to the regulation of miR-223-3p level and STAT3 expression in the liver and macrophages. These results suggest that MSC-exosomes can be used to deliver miR-223-3p for the treatment of autoimmune hepatitis.

Risk Factors for Anxiety in Major Depressive Disorder Patients

Li-Min Xin,Lin Chen,Zhen-Peng Ji,Suo-Yuan Zhang,Jun Wang,Yan-Hong Liu,Da-Fang Chen,Fu-De Yang,Gang Wang,Yi-Ru Fang,Zheng Lu,Hai-Chen Yang,Jian Hu,Zhi-Yu Chen,Yi Huang,Jing Sun,Xiao-Ping Wang,Hui-Chun 대한정신약물학회 2015 CLINICAL PSYCHOPHARMACOLOGY AND NEUROSCIENCE Vol.13 No.3

Objective: To analyze the sociodemographic and clinical factors related to anxiety in patients with major depressive disorder (MDD). Methods: This study involved a secondary analysis of data obtained from the Diagnostic Assessment Service for People with Bipolar Disorders in China (DASP), which was initiated by the Chinese Society of Psychiatry (CSP) and conducted from September 1, 2010 to February 28, 2011. Based on the presence or absence of anxiety-related characteristics, 1,178 MDD patients were classified as suffering from anxious depression (n=915) or non-anxious depression (n=263), respectively. Results: Compared with the non-anxious group, the anxious-depression group had an older age at onset (t=−4.39, p<0.001), were older (t=−4.69, p<0.001), reported more lifetime depressive episodes (z=−3.24, p=0.001), were more likely to experience seasonal depressive episodes (χ2=6.896, p=0.009) and depressive episodes following stressful life events (χ2=59.350, p <0.001), and were more likely to have a family history of psychiatric disorders (χ2=6.091, p=0.014). Their positive and total scores on the Mood Disorder Questionnaire (MDQ) and the 32-item Hypomania Checklist (HCL-32) (p<0.05) were also lower. The logistic regression analysis indicated that age (odds ratio [OR]=1.03, p<0.001), a lower total MDQ score (OR=0.94, p=0.011), depressive episodes following stressful life events (OR=3.04, p<0.001), and seasonal depressive episodes (OR=1.75, p=0.039) were significantly associated with anxious depression. Conclusion: These findings indicate that older age, fewer subclinical bipolar features, an increased number of depressive episodes following stressful life events, and seasonal depressive episodes may be risk factors for anxiety-related characteristics in patients with MDD.

Attenuation of Experimental Autoimmune Hepatitis in Mice with Bone Mesenchymal Stem Cell-Derived Exosomes Carrying MicroRNA-223-3p

Lu, Feng-Bin,Chen, Da-Zhi,Chen, Lu,Hu, En-De,Wu, Jin-Lu,Li, Hui,Gong, Yue-Wen,Lin, Zhuo,Wang, Xiao-Dong,Li, Ji,Jin, Xiao-Ya,Xu, Lan-Man,Chen, Yong-Ping Korean Society for Molecular and Cellular Biology 2019 Molecules and cells Vol.42 No.12

MicroRNA-223-3p (miR-223-3p) is one of the potential microRNAs that have been shown to alleviate inflammatory responses in pre-clinical investigations and is highly encased in exosomes derived from bone mesenchymal stem cells (MSC-exosomes). MSC-exosomes are able to function as carriers to deliver microRNAs into cells. Autoimmune hepatitis is one of the challenging liver diseases with no effective treatment other than steroid hormones. Here, we examined whether MSC-exosomes can transfer miR-223-3p to treat autoimmune hepatitis in an experimental model. We found that MSC-exosomes were successfully incorporated with miR-223-3p and delivered miR-223-3p into macrophages. Moreover, there was no toxic effect of exosomes on the macrophages. Furthermore, treatments of either exosomes or exosomes with miR-223-3p successfully attenuated inflammatory responses in the liver of autoimmune hepatitis and inflammatory cytokine release in both the liver and macrophages. The mechanism may be related to the regulation of miR-223-3p level and STAT3 expression in the liver and macrophages. These results suggest that MSC-exosomes can be used to deliver miR-223-3p for the treatment of autoimmune hepatitis.

Folate Deficiency and FHIT Hypermethylation and HPV 16 Infection Promote Cervical Cancerization

Bai, Li-Xia,Wang, Jin-Tao,Ding, Ling,Jiang, Shi-Wen,Kang, Hui-Jie,Gao, Chen-Fei,Chen, Xiao,Chen, Chen,Zhou, Qin Asian Pacific Journal of Cancer Prevention 2014 Asian Pacific journal of cancer prevention Vol.15 No.21

Fragile histidine triad (FHIT) is a suppressor gene related to cervical cancer through CpG island hypermethylation. Folate is a water-soluble B-vitamin and an important cofactor in one-carbon metabolism. It may play an essential role in cervical lesions through effects on DNA methylation. The purpose of this study was to observe effects of folate and FHIT methylation and HPV 16 on cervical cancer progression. In this study, DNA methylation of FHIT, serum folate level and HPV16 status were measured using methylation-specific polymerase chain reaction (MSP), radioimmunoassay (RIA) and polymerase chain reaction (PCR), respectively, in 310 women with a diagnosis of normal cervix (NC, n=109), cervical intraepithelial neoplasia (CIN, n=101) and squamous cell carcinoma of the cervix (SCC, n=101). There were significant differences in HPV16 status (${\chi}^2=36.64$, P<0.001), CpG island methylation of FHIT (${\chi}^2=71.31$, P<0.001) and serum folate level (F=4.57, P=0.011) across the cervical histologic groups. Interaction analysis showed that the ORs only with FHIT methylation (OR=11.47) or only with HPV 16 positive (OR=4.63) or with serum folate level lower than 3.19ng/ml (OR=1.68) in SCC group were all higher than the control status of HPV 16 negative and FHIT unmethylation and serum folate level more than 3.19ng/ml (OR=1). The ORs only with HPV 16 positive (OR=2.58) or with serum folate level lower than 3.19ng/ml (OR=1.28) in CIN group were all higher than the control status, but the OR only with FHIT methylation (OR=0.53) in CIN group was lower than the control status. HPV 16 positivity was associated with a 7.60-fold increased risk of SCC with folate deficiency and with a 1.84-fold increased risk of CIN. The patients with FHIT methylation and folate deficiency or with FHIT methylation and HPV 16 positive were SCC or CIN, and the patients with HPV 16 positive and FHIT methylation and folate deficiency were all SCC. In conclusion, HPV 16 infection, FHIT methylation and folate deficiency might promote cervical cancer progression. This suggests that FHIT may be an effective target for prevention and treatment of cervical cancer.

Uterine Intravenous Leiomyomatosis with Intracardiac Extension and Pulmonary Benign Metastases on FDG PET/CT: A Case Report

Hui-Chun Wang,Yu-Bin Wang,Xiao-Hong Chen,Lan-Lan Cui 대한영상의학회 2016 Korean Journal of Radiology Vol.17 No.2

A 48-year-old woman presented with a 50-day history of irregular vaginal bleeding and lower abdominal pain. Ultrasound indicated an extremely large occupying lesion in the pelvic cavity that was highly suggestive of malignancy. Fluorodeoxyglucose (FDG) positron emission tomography/computed tomography (PET/CT) was performed to further assess the nature of pelvic abnormality. PET/CT images demonstrated a diffusely lobulated mass ranging from cervix up to the inferior pole of kidneys with mild FDG uptake. Simultaneously, multiple nodules in bilateral lungs and a hypodense lesion in the right ventricle were shown without FDG-avidity. Based on the imaging results, the presumptive diagnosis was uterine intravenous leiomyomatosis with intracardiac extension and pulmonary benign metastases, which was subsequently confirmed by MRI and the lesion biopsy.