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( Chao Chun Yang ),( Chun Te Lee ),( Chao Kai Hsu ),( Yi Pei Lee ),( Tak Wah Wong ),( Sheau Chiou Chao ),( Julia Yu Yun Lee ),( Hamm Ming Sheu ),( Wenchieh Chen ) 대한피부과학회 2013 Annals of Dermatology Vol.25 No.4
Background: Spontaneous recovery of severe alopecia areata is rare and the condition is difficult to treat. Objective: The aim of this study is to investigate and compare the effects and safety of steroid pulse therapy between oral and intravenous administrations between 1999 and 2010 at the Department of Dermatology, National Cheng Kung University Hospital. Methods: Data were retrospectively retrieved. A satisfactory response was defined as more than 75% hair regrowth in the balding area. Results: A total of 85 patients with more than 50% hair loss were identified and treated, with an overall satisfactory response rate of 51.8%. The mean follow-up time was 37.6 months, with a relapse rate of 22.7%. Patients with alopecia areata (hereafter, AA) of recent onset within one year showed higher response rates (p< 0.001) and lower relapse rates compared to patients with AA persisting for more than 1 year. Further, even in patients with alopecia totalis, alopecia universalis or ophiasis type, early treatment resulted in a satisfactory response rate of 47% among the treated patients. In general, oral therapy was as effective and well-tolerated as intravenous therapy. Conclusion: The response rate is determined by disease severity and time of intervention, not by the administration form of steroid pulse therapy. Oral steroid pulse therapy can be considered as the first-line treatment for patients with severe AA of recent onset within one year. (Ann Dermatol 25(4) 471∼474, 2013)
Transfer matrix for rotor coupler with parallel misalignmen
Chao-Yang Tsai,Shyh-Chin Huang 대한기계학회 2009 JOURNAL OF MECHANICAL SCIENCE AND TECHNOLOGY Vol.23 No.5
A transfer matrix for shafts coupler with parallel misalignment (offset) was derived. The responses of a rotor system composed of flexible shafts, unbalanced disks, elastic supports and shafts coupler with misalignment were then investigated. Through the derivation, the boundary shears induced by a rotating shaft were first discovered to be coupled in two perpendicular directions. These coupling shears might reduce the first critical speed up to 50% in the free-free case. The studies showed that the shafts coupler altered the rotor’s critical speeds and the misalignment played as an external load resulting through the whole driven shaft. The combined effects of disk unbalance and shaft misalignment showed that the misalignment predominated the response in most of the rotation speeds, but the unbalance could become significant at high speed. The whirling orbits before and after the misalignment were illustrated as well, and numerical results showed that the two ends of the misalignment whirled asynchronously as the rotation fell into some regions.
Study on Waterborne Polyurethanes Based on Poly(dimethyl siloxane) and Perfluorinated Polyether
Yang Du,Chao Zhou,Zhihui Yang 한국고분자학회 2015 Macromolecular Research Vol.23 No.9
Methylsiloxane and fluorinated segments were introduced into the polymer backbone of polyurethane by direct reaction of isocyanate with dialcohol terminated perfluoropolyether (E10-H) and poly(dimethyl siloxane) (PDMS). The polyurethane structure was revealed by Fourier transform infrared spectrometer in ATR mode and Xray photoelectron spectroscope. It was found that the silicon and fluorine moieties easily migrated to the surface of material in film-forming process due to their lower energy, so the water contact angle on membrane surface was greatly enhanced (maximum 100.1º), and the hydrophobic property of material was improved. Different degree of phase separation was observed by scanning electron microscope. Increment of PDMS or E10-H content caused the phase separation obviously, but section of PDMS and E10-H modified polyurethane showed that phase separation reduced. The linear dynamic viscoelastic measurements indicated that the dynamic storage modulus of all samples increased with the increment of frequency, and PDMS modified WPU’s grew fastest. The slope of G' vs. G'' showed a decrement, so each sample had a shear thinning behavior. The perfluoropolyether oil was to reduce viscosity of the system.
The IC Design of A High Speed RSA Processor
Yang, Ching Chao,Jen, Chein Wei,Chang, Tian Sheuan 대한전자공학회 1996 APCCAS:Asia Pacific Conference on Circuits And Sys Vol.1 No.1
In this paper, we proposed a new algorithm based on Montgomery's algorithm[I] to calculate modular multiplication that is the core arithmetic operation in RSA cryptosystem. Since the critical path delay in modular multiplication operation is reduced, the new design yields a very fast implementation. We have implemented a 512-bit single chip RSA processor based on our modified algorithm with Compass 0.6㎛ SPDM cell library. By our modified modular exponentiation algorithm, it takes about 1.5n² clock cycles to finish one n-bit RSA modular exponentiation operation in our architecture. The simulation results show that we can operate up to 125Mhz, therefore the baud rate of our 512-bit RSA processor is about 164k bits/sec.
Arching Effect between the Pipes of a Pipe Umbrella Support Systemin a Shallow-Buried Tunnel
Chao Yang,Yanhua Chen,Da Huang,Lehua Wang 대한토목학회 2019 KSCE JOURNAL OF CIVIL ENGINEERING Vol.23 No.12
The pipe umbrella is one of the most commonly used prereinforcement techniques in tunnel construction. Current theoretical analyses of the pipe umbrella support mechanism are primarily based on the elastic foundation beam principle, whereby only a single pipe is concerned, and the interactions among pipes are ignored. In this study, a double-parameter elastic foundation beam theory-based model was established with consideration of the arching effect between two pipes. The model can simulate the support mechanism of the pipe umbrella system in shallow-buried tunnels. The support mechanisms of a pipe umbrella system installed in a rectangular tunnel and an arched tunnel were investigated. In the two cases, the arching effect and a single pipe were considered. The results indicate that the arching effect leads to larger pipe deflection and internal forces than considering a single pipe. The influences of the diameter of a single pipe, the distance between two pipes and the shear parameters of the surrounding rock on the pipe deflection and the arching effect are discussed. In addition, the proposed model was validated by the in situ monitoring results.
Yang Yang,Jinguan Lin,Chao Huang,Xin Ma 한국통계학회 2012 Journal of the Korean Statistical Society Vol.41 No.2
This paper considers an ordinary renewal risk model and a compound renewal risk model with constant interest rate, subexponential claims and a general premium process. We derive some asymptotic results on the finite-time ruin probabilities.
Yang Gao,Chao Wang,Chao Liu 보안공학연구지원센터 2016 International Journal of u- and e- Service, Scienc Vol.9 No.12
The vehicle routing problem with time window (VRPTW) is a well-known combinatorial optimization problem, which is to find the lowest-cost routes from a central depot to a set of geographically scattered points with various demands. This paper deals with a multi-objective variant of the VRPTW that simultaneously minimizes the number of the vehicles and the traveled distance. A metaheuristic based on simulated annealing was proposed, and the concept of archive was introduced, in order to provide a set of tradeoff solutions for the problem. The accuracy of solutions is defined as their proximity to the best known solution of Solomon’s benchmarking tests. Computational results demonstrate that the proposed approach is quite effective, as it provides solutions competitive with the best known in the literature.