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P148 : A clinical study of skin diseases on vulvar
( Hye Rim Ko ),( So Min Kim ),( Chae Young Won ),( Hyung Jin Hahn ),( Young Bok Lee ),( Jin Wou Kim ),( Dong Soo Yu ) 대한피부과학회 2014 대한피부과학회 학술발표대회집 Vol.66 No.2
Background: Vulvar diseases are not rare in dermatology, however the clinical investigations of the vulvar lesions are insufficient. Objectives: The purpose of this study was to investigate the epidemiological aspects of the vulvar diseases, and to highlight the clinical features of dermatoses of the vulvar with the brief review of the common vulvar diseases. Methods: The retrospective clinical study was performed by reviewing charts, pathologic slide, and clinical photographs of 37 patients who had received skin biopsy for vulvar lesions at Uijeongbu St. Mary’s Hospital between February 2009 and September 2013. Results: The mean age was 47.3 years. The most frequent vulvar diseases were epidermal cyst, lichen sclerosus, lichen simplex chronicus, herpes simplex infection and condyloma accuminatum in the decreasing order of frequency. Except for the 11 asymptomatic patients, the rest of the patients complained of various symptoms such as a pain, prickling sensation, tenderness and pruritus. Of the 37 cases, 14 had patches or plaques, 11 had papules or nodules, 6 had erosions or ulcers and 6 had vulvar mass. Conclusion: We retrospectively studied 37 cases of vulvar diseases. The results of this study are similar to previousreports on the clinical features of vulvar diseases. This study suggests that various conditions can affect the vulvar. Further investigation with a larger group of patients is necessary to better understand the epidemiology of vulvar diseases.
Won, Hye Sung,Maeng, Lee So,Chae, Hiun Suk,Kim, Hyung Keun,Cho, Young Suk,Kang, Jin-Hyoung,Jang, Hong Seok,Ryu, Mi-Ryeong The Korean Society of Gastroenterology; the Korean 2012 Gut and Liver Vol.6 No.2
<P><B>Background/Aims</B></P><P>The purpose of this study was to investigate the malignant potential of aberrant crypt foci (ACF) by measuring the multiplicity of crypts and lectin expression in the early and late stages of 1,2-dimethylhydrazine (DMH)-induced colon carcinogenesis.</P><P><B>Methods</B></P><P>Six-week-old Wistar rats were injected subcutaneously with DMH for 27 weeks. We classified ACF according to the number of crypts per ACF as a few crypts (≤3 crypts, FC ACF) or numerous crypts (≥4 crypts, NC ACF). Immunohistochemistry was used to evaluate lectin expression.</P><P><B>Results</B></P><P>In the early stage, FC ACF (590/1,902, 31.0%) occurred more frequently than NC ACF (35/449, 7.8%); whereas in the late stage, NC ACF (176/449, 39.2%) occurred more frequently than FC ACF (324/1,902, 17.0%). The number of ACF peaked at 15 to 20 weeks. The ratio of NC/FC ACF increased gradually during carcinogenesis. The expression of both UEA1 and PNA was higher in NC ACF than FC ACF. Lectin expression increased in the late stage compared with the early stage.</P><P><B>Conclusions</B></P><P>The expression of lectin was higher in NC ACF and ACF in the late stage. Therefore, ACF with higher multiplicities in the late stage may have more malignant potential in DMH-induced colon carcinogenesis.</P>
Intrapartum predictive factors for failure of vaginal delivery in nulliparous women
( Hye Jung Cho ),( Hyun Soo Park ),( Chae Hyeong Lee ),( Sang Ho Yoon ),( Ju-won Roh ),( Hayan Kwon ) 대한산부인과학회 2018 대한산부인과학회 학술대회 Vol.104 No.-
Objective: This study was to identify intrapartum potential predictive factors for failure of vaginal delivery in nulliparous women undergoing a trial of labor. Methods: Retrospective study of singleton pregnancy in nulliparous women between 36 and 42 0/7 weeks conducted from 2007 through 2017. A failure of vaginal delivery was defined as a delivery that was initially attempted a vaginal delivery but was converted to emergency cesarean section. Pregnancies which need to cesarean section including preeclampsia, chronic hypertension, placenta previa, or cesarean section due to fetal anomalies or intrauterine growth restriction (IUGR) were excluded. Odds ratios (OR) and confidence intervals (CI) for emergency cesarean section were calculated with multivariable logistic regression to assess the risk for failure of vaginal delivery. Results: 2240 trials of vaginal delivery were performed in nulliparous women of which 457 (20.4%) failed. Among these women, 457 cases who underwent emergency cesarean section were compared to the data of 952 women who underwent a successful vaginal delivery. Predictors for failure of vaginal delivery were related with maternal pre-pregnant body mass index (OR 1.02), maternal height (OR 0.94 per cm), initial cervical effacement (OR 0.98), initial cervical dilatation (OR 0.73), premature rupture of membrane (OR 0.54), station of descent of the fetal head (OR 0.61 per station more descended), estimated fetal weight 3500g as compared to <3500g (OR 2.4). Maternal age, gestational age, induction and use of epidural anesthesia were not useful for predicting failed vaginal delivery. Conclusion: Failed vaginal delivery can be predicted using intrapartum characteristics. Premature rupture of membrane and estimated fetal weight is significantly related with emergency cesarean section. During labor, accurate measurement of fetal weight and amniotomy are helpful to progress successful labor.
( Hye Sung Won ),( Lee So Maeng ),( Hiun Suk Chae ),( Hyung Keun Kim ),( Young Suk Cho ),( Jin Hyoung Kang ),( Hong Seok Jang ),( Mi Ryeong Ryu ) 대한소화기학회 2012 Gut and Liver Vol.6 No.2
Background/Aims: The purpose of this study was to investigate the malignant potential of aberrant crypt foci (ACF) by measuring the multiplicity of crypts and lectin expression in the early and late stages of 1,2-dimethylhydrazine (DMH)- induced colon carcinogenesis. Methods: Six-week-old Wistar rats were injected subcutaneously with DMH for 27 weeks. We classified ACF according to the number of crypts per ACF as a few crypts (≤3 crypts, FC ACF) or numerous crypts (≥4 crypts, NC ACF). Immunohistochemistry was used to evaluate lectin expression. Results: In the early stage, FC ACF (590/1,902, 31.0%) occurred more frequently than NC ACF (35/449, 7.8%); whereas in the late stage, NC ACF (176/449, 39.2%) occurred more frequently than FC ACF (324/1,902, 17.0%). The number of ACF peaked at 15 to 20 weeks. The ratio of NC/FC ACF increased gradually during carcinogenesis. The expression of both UEA1 and PNA was higher in NC ACF than FC ACF. Lectin expression increased in the late stage compared with the early stage. Conclusions: The expression of lectin was higher in NC ACF and ACF in the late stage. Therefore, ACF with higher multiplicities in the late stage may have more malignant potential in DMH-induced colon carcinogenesis. (Gut Liver 2012;6:229-234)