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( Hiun Suk Chae ),( Hyung Keun Kim ),( Jin Soo Kim ),( Hye Sook Son ),( Yong Wan Park ),( Eun Deuck Chang ),( Hye Kyung Lee ) 대한소화기학회 2007 SIDDS Vol.9 No.-
Background/Aims: Signaling pathways via ILK and beta-catenin are important ones in cancer progression and apoptosis of various cancer including colon and stomach. It roles of cancer cell are cell to adhesion, cell migration and motility. In colon cancer, two molecules are highly expressed. So we investigated their expression in colon polyps according to gross morphology and pathologic type. Methods: The expression of ILK and beta-catenin are measured with immunohistochemistry (Santa Cruz Co.) According to morphology, we calssified polyps into pedunculated polyps (Ip, 19), sessile polyps (Is, 31) and laterally spreading tumor (LST, 26). In pathologic type, colon polyps classified into adenocarcinoma (2), tubular adenoma (TA, 47), hyperplastic polyp (HP, 22), tubulovillous polyp (TV, 4), villous type (1). Results: According to morphology, there was no significant difference of ILK and beta-catenin expression among Ip, Is and LST (P>0.05). 2 malignant polyps revealed high expression of ILK and beta-catenin. ILK and beta-catenin expression in tubular adenomatous polyps were significantly higher than hyperplastic polyps (P<0.05). And in tubular adenoma, ILK and beta-catenin were highly expressed in high grade dysplasia (P<0.05). Conclusions: ILK and beta-catenin are not different in gross morphology of colon polyps but more expressed in tubular adenoma, especially in severe dysplasia.
Acute appendicitis caused by colonoscopy.
Chae, Hiun-Suk,Jeon, Su-Yun,Nam, Woo-Seok,Kim, Hyung-Keun,Kim, Jin-Soo,Kim, Jeong-Soo,An, Chang-Hyeok 대한내과학회 2007 The Korean Journal of Internal Medicine Vol.22 No.4
<P>A 48-year-old woman who was without any abnormal past medical history underwent colonoscopy as a screening procedure for colorectal disease. The procedure was uneventful and there was no sign of inflammation around the appendicular orifice or the luminal surface of the cecum. The patient did not complain of pain or significant discomfort throughout the procedure. She then developed pain in the right lower quadrant of the abdomen that evening and this persisted for four days. She visited the outpatient department and underwent abdominal ultrasonography, which showed a swollen appendix with a collection of pericecal fluid. Surgical exploration and appendectomy were performed; the final diagnosis was acute suppurative appendicitis. Colonoscopists should be aware of this rare complication and consider it when making the differential diagnosis of post-colonoscopy abdominal pain.</P>
대장용종에서 ILK (Integrin-Linked kinase)와 beta-catenin의 발현
채현석 ( Hiun Suk Chae ),김진수 ( Jin Soo Kim ),손혜숙 ( Hye Sook Sohn ),노상영 ( Sang Young Rho ),김형근 ( Hyung Keun Kim ),조영석 ( Young Suk Cho ),이보인 ( Bo In Lee ),강진형 ( Jin Hyung Kang ),최규용 ( Kyu Yong Choi ),맹이소 ( 대한내과학회 2009 대한내과학회지 Vol.77 No.3
Background/Aims: Signaling pathways via integrin-linked kinase (ILK) and β-catenin are important in the initiation and progression of various malignant diseases. ILK modulates the transcription of β-catenin and is implicated in cell migration and invasiveness. Recently, premalignant colon polyps were found to express ILK and β-catenin. Therefore, we investigated the expression of ILK and β-catenin in colon polyps according to the gross morphology and pathologic type. Methods: Based on morphology, colon polyps (62) were classified as being a pedunculated polyp (Ip, 16), sessile polyp (Is, 22), or laterally spreading tumor (LST, 24). The colon polyps were classified pathologically as tubular adenomas (TAs, 47) and hyperplastic polyps (HPs, 15). The expression levels of ILK and β-catenin in colon polyps and normal colon (6) were evaluated with immunohistochemistry. Results: In normal colon, ILK was not expressed, and β-catenin stained in the cell membrane only. Based on the gross morphology of the colon polyps, no significant difference was seen in the expression of ILK and β-catenin (p>0.05). The expression of both ILK and β-catenin in TAs was greater than that in HPs (p<0.01): the greater the dysplasia in TAs, the more both ILK and β-catenin were expressed (p<0.05). The grade of expression of ILK was correlated with that of β-catenin in colon polyps (p<0.01). Conclusions: The expression of ILK and β-catenin did not differ according to the morphology of colon polyps, but was expressed more in TAs than in HPs, especially in severe dysplasia. (Korean J Med 77:315-320, 2009)
구연 / 제 2 회의장 / 위장관 39 : 흰쥐의 대장에서 Dimethylhydrazine 에 의해 유발된 aberrant crypt foci 의 부위와 시간에 따른 변화
채현석(Hiun Suk Chae),오수혁(Soo Hyun Oh),이봉수(Bong Soo Lee),한석원(S . W . Han),이창돈(Chang Don Lee),최규용(K . Y . Choi),정인식(I . S . Chung),선희식(H . S . Sun),맹이소(Lee so Maeng),이은정(Een Jung Lee) 대한소화기학회 1999 대한소화기학회 추계학술대회 Vol.1999 No.-
채현석 ( Hiun Suk Chae ),문도준 ( Do Jun Moon ),김윤태 ( Yoon Tae Kim ),이정수 ( Jung Soo Lee ) 대한내과학회 2009 대한내과학회지 Vol.76 No.5
Background/Aims: We analyzed patients with abdominal pain of undetermined etiology, referred to physiatrists by gastroenterologists, and determined the clinical features of patients with abdominal wall pain. Methods: A retrospective chart review of 100 patients referred by gastroenterologists over 4 years was performed. A visceral etiology of abdominal pain was excluded by the gastroenterology work-up using radiologic and endoscopic studies, and medical treatment. The clinical features and outcomes of abdominal wall pain were examined. We determined the long-term outcome by telephone. Results: Of 100 patients with abdominal pain of undetermined etiology, 89% of the patients were identified as having pain arising in the abdominal wall, and the right flank area was the most common site of pain. The pain had a musculoskeletal origin in 90.4% of the patients and a neurogenic origin in 9.6%. Treatment by the physiatrists resulted in complete or partial pain relief in 73% of the patients. The diagnosis remained unchanged after a mean of 22.67 (range 6.5-55) months in 95.5% of the patients. Long-term effects of management were seen in 73.6% of the patients. Conclusions: In a small group of patients with abdominal pain of unknown etiology, the source of pain could be in the abdominal wall. Recognizing abdominal wall pain could lead to an accurate diagnosis, reduced medical costs and effective treatment. (Korean J Med 76:564-570, 2009)
Helicobacter pylori에 감염된 십이지장궤양과 비궤양성 소화불량에서 ABO 혈액형과 HLA의 연관
채현석(Hiun Suk Chae),김태규(Tai Gyu Kim),한훈(Hoon Han),김성수(Sung Soo Kim),최규용(Kyu Yong Choi),정인식(In Sik Chung),차상복(Sang Bok Cha),박두호(Doo Ho Park),김부성(Boo Sung Kim) 대한소화기학회 1996 대한소화기학회지 Vol.28 No.5
N/A Background/Aims: It has been known that genetic factors, for example, blood group, non-secretor and HLA system, are associated with duodenal ulcer and that Helicobacter pylori infection is the major cause of peptic ulcer. However, Helicobacter pylori is also found in non-ulcer dyspepsia and asyrnptomatic patients without ulcer formation. But, it is still not known regarding what kind of genetic factors have an effect on ulcer formation at the time of Helicobacter pylori infection. This study was performed to make clear wbich genetic factors are re1ated with duodenal ulcers among Koreans, and what kind of genetic factors could influence on the ulcer formation in the patients with Helicobacter pylori infection according to ABO blood groups and HLA antigen.'.. Methods: The duodenal ulcer patients (36), non-ulcer dyspepsia (19) and norraal healthy controls (103) were included in this study. Helicobacter pylori infection was detected with phenol red spray method in vivo which was confirmed with Warthin-Starry silver stain. HLA antigen expression (HLA-A,B) of peripheral blood T lymphocytes was studied with microlymphocytotoxicity teclmique. Results: Tbe frequency of HLA-A 33 was higher in duodenal ulcer patients (l4/36, 38.9%) compared with the control group (21/103, 20.4%). On the contrary, no difference in HLA-B has been shown between duodenal ulcer patients and controls. Among patients with Helicobacter pylori infection, blood group 0 was significant1y more frequent in patients with duodenal ulcers (21/36, 58.3%) than in non-ulcer dyspepsia (5/19, 26.3%). In patients with HLA-A 33, blood group 0 was significantly more frequent in duodenal ulcer patients (7/)4, 50%) than in non-ulcer dyspepsia patients (0/7, 0%). Conclusions: In Helicobacter pylori-infected patients, HLA-A 33 is related with duodenal ulcers and the patients with both blood group 0 and HI.A-A 33 are more likely to have duodeual ulcers than those with HLA-A 33 and without blood groop O. (Korean J Gastrnenterol 1996; 28:623 - 631)
( Yoon Suk Jung ),( Dong Il Park ),( Byong Duk Ye ),( Jae Hee Cheon ),( You Sun Kim ),( Young Ho Kim ),( Joo Sung Kim ),( Hiun Suk Chae ),( Kwang Ho Baik ),( Dong Soo Han ) 대한내과학회 2014 대한내과학회 추계학술발표논문집 Vol.2014 No.1
Background: Environmental factors and genetic predisposition are thought to play an important role in the pathogenesis of Crohn`s disease (CD). Although numerous studies have reported the positive association between urban environment and CD development, few studies have compared the clinical outcomes between urban and rural environments. Therefore, this study aimed to compare the clinical characteristics and long-term prognosis between urban and rural populations of patients with CD. Methods: This retrospective multicenter cohort study included 1002 Korean patients with CD (743 urban residents and 259 rural residents) from 32 medical centers. The clinical outcomes of urban versus rural populations were compared using the Kaplan-Meier method and log-rank test. Results: Disease distribution and behavior of the urban population did not differ from those of the rural population. There were no signifi cant differences in the cumulative probabilities of perianal fi stula (P=0.086) and intestinal complications such as stricture (P=0.109), fi stula (P=0.952), abscess (P=0.227), and perforation (P=0.382) between the two groups.In addition, no signifi cant differences were observed between the two groups with regard to the cumulative probabilities of immunosuppressant use (P=0.527) and biological agent use (P=0.731). However, the cumulative probability of surgery in the urban population was signifi cantly higher than that in the rural population (19.2%, 25.8%, and 35.8% vs. 13.6%, 20.4%, and 29.8% at 1 year, 5 years, and 10 years, respectively; P=0.040). Conclusions: The urban population required surgical treatment more frequently than the rural population, although there were no significant differences in cumulative probabilities of immunosuppressant and biological agent use. Our results suggest that factors associated with an urban lifestyle may infi uence poor prognosis of CD.
( Young Seok Cho ),( Hiun Suk Chae ),( Se Na Jang ),( Jin Soo Kim ),( Hye Suk Son ),( Hyung Keun Kim ),( Byung Wook Kim ),( Sok Won Han ),( Kyu Yong Choi ),( Hae Kyung Lee ),( Eun Deok Chang ) 대한내과학회 2008 The Korean Journal of Internal Medicine Vol.23 No.3
Background/Aims: The 13C-urea breath test (UBT) is a semiquantitative test for measuring Helicobacter pylori infection loading. H. pylori produces ammonia, which elevates the pH of the gastric mucosa and is detectable via endoscopy using a phenol red indicator. We evaluated whether this test could be used to diagnose H. pylori infection and whether phenol red staining was correlated with 13C-UBT results. Methods: One hundred and twenty-three patients participated. The UBT was performed after ingestion of a capsule containing urea. A change in 13C-UBT >2‰ was selected as the cutoff value for diagnosing infection. After spraying evenly with a 0.1% phenol red solution, the pH of the gastric mucosal surface was measured using an antimony electrode through the biopsy channel. Results: The pH of stained mucosa (6.9±0.4) was significantly higher than that of unstained mucosa (1.9±0.8; p<0.001), and the H. pylori detection rate confirmed via histology was higher in stained versus unstained mucosa (p<0.01). Extensive mucosal staining resulted in a higher detection rate (p<0.001). The UBT produced results were very similar to those obtained via histological detection in stained mucosa (p<0.001). The extent of staining, expressed as a staining score, was positively correlated with the change in 13C-UBT (r=0.426, p<0.001). A significant correlation was also observed between the histologically determined H. pylori density and 13C-UBT results (r=0.674, p<0.001). Conclusions: H. pylori infection elevates gastric mucosal surface pH, and endoscopic phenol red staining may be an alternative method for the diagnosis of H. pylori infection.