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Steel scale-CaO composite catalyst for coke combustion and in-situ NO and SO2 removal
Li Zhang,Jingchong Yan,Zhiping Lei,Xianzhong Cao,Tiejun Chun,Zhanku Li,Hengfu Shui,Shibiao Ren,Zhicai Wang,Ying Kong 한국공업화학회 2022 Journal of Industrial and Engineering Chemistry Vol.110 No.-
The performance of the steel scale (SS)-CaO composite on the combustion of coke nuts and in-situ reductionof SO2 and NO emission was investigated. Combustion experiments show that SS-CaO compositeaccelerates coke combustion and reduces SO2 and NO emissions concurrently. X-ray diffraction (XRD),scanning electron microscopy (SEM), and electron spin resonance (ESR) were used to investigate thecatalysis mechanism. Results show that SS and CaO have synergistic effect in in-situ denitration. Theincrease of SS and CaO fraction in the composites improve the denitration and sulfur fixation performance,respectively. The denitration activity is mainly attributed to the Fe2O3 in SS and Ca2Fe2O5 formedduring combustion. The desulfurization is due to the sulfur fixation with CaO. The increasing fraction ofCaO in the composites leads to the agglomeration of ash particles. 2%CaO is confirmed as the optimumaddition for catalytic combustion and emission reduction. This work sheds light on the cheap and effectivecatalysts that are potentially useful for iron ore sintering.
TRAFFIC FLOW FORECASTING OF GRAPH CONVOLUTIONAL NETWORK BASED ON SPATIO-TEMPORAL ATTENTION MECHANISM
Zhang Hong,Chen Linlong,Cao Jie,Zhang Xijun,Kan Sunan,Zhao Tianxin 한국자동차공학회 2023 International journal of automotive technology Vol.24 No.4
Accurate traffic flow forecasting is a prerequisite guarantee for the realization of intelligent transportation. Due to the complex time and space features of traffic flow, its forecasting has always been a research hotspot in this field. Aiming at the difficulty of capturing and modelling the temporal and spatial correlation and dynamic features of traffic flow, this paper proposes a novel graph convolutional network traffic flow forecasting model (STAGCN) based on the temporal and spatial attention mechanism. STAGCN model is mainly composed of three modules: Spatio-temporal Attention (STA-Block), Graph Convolutional Network (GCN) and Standard Convolutional Network (CN), model the periodicity, spatial correlation and time dependence of traffic flow respectively. STA-Block module models the spatio-temporal correlation between different time steps through the spatio-temporal attention mechanism and gating fusion mechanism, and uses GCN and CN to capture the spatial and temporal features of traffic flow respectively. Finally, the output of the three components is predicted through a gated fusion mechanism. A large number of experiments have been conducted on two data sets of PeMS. The experimental results demonstrate that compared with the baseline method, the STAGCN model proposed in this paper has better forecasting performance.
Possible Epithelial Ovarian Cancer Association with HPV18 or HPV33 Infection
Zhang, Pei-Pei,Zhou, Lei,Cao, Jia-Shi,Li, Yi-Ping,Zeng, Zhi,Sun, Ni,Shen, Li,Zhu, Hao-Yue,Ruan, Yang,Zha, Wen-Ting,Wang, Xin-Yu,Zhang, Ke-Qiang,Zhang, Ran Asian Pacific Journal of Cancer Prevention 2016 Asian Pacific journal of cancer prevention Vol.17 No.6
The present study was conducted to investigate the prevalence of HPV infection in epithelial ovarian cancer (EOC) in Hunan province. DNA samples were collected from paraffin embedded ovarian tissue from 322 patients with EOC, 99 with ovarian benign tumors and 199 normal persons. The polymerase chain reaction and direct sequencing were used to identify the HPV types in the samples. The relationship between the infection of human papillomavirus (HPV) and the epithelial ovarian carcinoma (EOC) was investigated combined with clinical data. The prevalence of HPV18 and HPV33 in EOC group and benign group was higher than in the normal group. HPV18 and HPV33 may play a role in the development of both EOC and ovarian benign tumor and may participate in the development of EOC with traditional risk factors, family history and abortion, possibly exerting synergistic effects.
Analysis of succinate dehydrogenase subunit B gene alterations in gastric cancers
Cao, Zhang,Song, Jae Hwi,Kang, Young Whi,Yoon, Jung Hwan,Nam, Suk Woo,Lee, Jung Young,Park, Won Sang Blackwell Publishing Asia 2010 Pathology international Vol.60 No.8
<P>Recently, the succinate dehydrogenase subunit B gene, <I>SDHB</I>, has emerged as a novel tumor suppressor. In this study, we have examined the genetic and epigenetic alterations of the <I>SDHB</I> gene in sporadic gastric adenocarcinomas in order to investigate if the <I>SDHB</I> gene is involved in gastric carcinogenesis. The expression of <I>SDHB</I> proteins was also examined with immunohistochemistry and Western blot in 184 and eight gastric cancers, respectively. There was loss or reduced expression of <I>SDHB</I> in 45 (24.5%) of the 184 gastric cancers. Statistically, altered expression of <I>SDHB</I> was not associated with clinicopathological parameters, including tumor differentiation, location, depth of invasion, and lymph node metastasis (<I>P</I> > 0.05). Western blot analysis showed a reduced expression of <I>SDHB</I> in four (50.0%) of the eight paired gastric cancer tissues. Genetic analysis showed one missense mutation, GCC → ACC (Ala → Thr) at codon 29. In addition, promoter hypermethylation was not detected in the gastric cancer samples. This is the first investigation of the genetic and protein expression analysis of the <I>SDHB</I> gene in gastric cancers. Our results suggest that genetic, epigenetic, and protein expression pattern alterations of the <I>SDHB</I> gene might play a minor role in the development or progression of gastric cancers.</P>
Cao Sishi,Zhang Zhifei,Huang Yunwei,Zhang Quanzhou,Xu Zhongming 한국자동차공학회 2021 International journal of automotive technology Vol.22 No.1
In this study, the discrete adjoint approach with the grid deformation technique based on radial basis function was presented to solve the tough problem that the complex shape of the defrosting duct is very difficult to be optimized with multiple parameters in the improvement of the defrosting performance of vehicle. Firstly, the defrosting performance of a light truck was analyzed. Then the discrete adjoint approach was applied by taking the average Nusselt-number as the objective function. The normal surface sensitivity was used in the deformation of the defrosting duct. After 10 optimization cycles, the optimal model was acquired. The results show that, after optimization, the sum of the average Nusselt-number is increased from 3164.16 to 3350.54, which has a positive effect on improving the convection and heat transfer capacity on the windshield effectively. Compared with the initial model, the airflow of the outlet near the windshield is increased from 95.07 g/s to 96.94 g/s, the defrosting time required by the optimal model is reduced by more than 20s. Therefore, the discrete adjoint approach can optimize the complex shape of defrosting duct with multiple parameters effectively, which provides an effective method in the study of automobile defrosting performance.
Zhang, Yunfeng,Chen, Lele,Cao, Yifan,Chen, Si,Xu, Chao,Xing, Jun,Zhang, Kaiguang The Korean Gastric Cancer Association 2020 Journal of gastric cancer Vol.20 No.2
Purpose: Globally, there is a high incidence of gastric cancer (GC). Leucine zipper-EF-hand containing transmembrane protein 1 (LETM1) is reported to play a vital role in several human malignancies. However, there is limited understanding of the role of LETM1 in GC. This study aims to investigate the effects of LETM1 on proliferation, migration, and invasion of GC cells. Materials and Methods: The expression levels of LETM1 in the normal gastric mucosal epithelial cells (GES-1) and GC cells were analyzed by quantitative real-time polymerase chain reaction and western blotting. CCK-8, wound healing, and Transwell invasion assays were performed to evaluate the effect of LETM1 knockdown or overexpression on the proliferation, migration, and invasion of the GC cells, respectively. Additionally, the effect of LETM1 knockdown or overexpression on GC cell apoptosis was determined by flow cytometry. Furthermore, the effect of LETM1 knockdown or overexpression on the expression levels of PI3K/Akt signaling pathway-related proteins was evaluated by western blotting. Results: The GC cells exhibited markedly higher mRNA and protein expression levels of LETM1 than the GES-1 cells. Additionally, the knockdown of LETM1 remarkably suppressed the GC cell proliferation, migration, and invasion, and promoted the apoptosis of GC cells, which were reversed upon LETM1 overexpression. Furthermore, the western blotting analysis indicated that LETM1 facilitates GC progression via the PI3K/Akt signaling pathway. Conclusions: LETM1 acts as an oncogenic gene to promote GC cell proliferation, migration, and invasion via the PI3K/Akt signaling pathway. Therefore, LETM1 may be a potential target for GC diagnosis and treatment.
Zhang Weifeng,Li Gaocai,Luo Rongjin,Lei Jie,Song Yu,Wang Bingjin,Ma Liang,Liao Zhiwei,Ke Wencan,Liu Hui,Hua Wenbin,Zhao Kangcheng,Feng Xiaobo,Wu Xinghuo,Zhang Yukun,Wang Kun,Yang Cao 생화학분자생물학회 2022 Experimental and molecular medicine Vol.54 No.-
Low back pain (LBP) is a major musculoskeletal disorder and the socioeconomic problem with a high prevalence that mainly involves intervertebral disc (IVD) degeneration, characterized by progressive nucleus pulposus (NP) cell death and the development of an inflammatory microenvironment in NP tissue. Excessively accumulated cytosolic DNA acts as a damage-associated molecular pattern (DAMP) that is monitored by the cGAS-STING axis to trigger the immune response in many degenerative diseases. NLRP3 inflammasome-dependent pyroptosis is a type of inflammatory programmed death that promotes a chronic inflammatory response and tissue degeneration. However, the relationship between the cGAS-STING axis and NLRP3 inflammasome-induced pyroptosis in the pathogenesis of IVD degeneration remains unclear. Here, we used magnetic resonance imaging (MRI) and histopathology to demonstrate that cGAS, STING, and NLRP3 are associated with the degree of IVD degeneration. Oxidative stress induced cGAS-STING axis activation and NLRP3 inflammasome-mediated pyroptosis in a STING-dependent manner in human NP cells. Interestingly, the canonical morphological and functional characteristics of mitochondrial permeability transition pore (mPTP) opening with the cytosolic escape of mitochondrial DNA (mtDNA) were observed in human NP cells under oxidative stress. Furthermore, the administration of a specific pharmacological inhibitor of mPTP and self-mtDNA cytosolic leakage effectively reduced NLRP3 inflammasome-mediated pyroptotic NP cell death and microenvironmental inflammation in vitro and degenerative progression in a rat disc needle puncture model. Collectively, these data highlight the critical roles of the cGAS-STING-NLRP3 axis and pyroptosis in the progression of IVD degeneration and provide promising therapeutic approaches for discogenic LBP.