Dimethylsulfoxide-soluble Smoking Particles and Nicotine Affect Vascular Contractibility

Jin-Yan Zhang,Lei Cao,Cang-Bao Xu,Yong-Xiao Cao,Xiao-Hui Zheng 대한약학회 2009 Archives of Pharmacal Research Vol.32 No.10

The aim is to study the effect of dimethylsulfoxide-soluble smoking particles (DSP) and nicotine on the contractility of rat mesenteric artery. The superior mesenteric artery segments were cultured with DSP or nicotine for 24 h. The vascular contractibility was recorded with myograph system. DSP 0.4 mL/L and nicotine 0.48 and 0.96 mg/L shifted the concentrationcontractile curves induced by sarafotoxin 6c, a selective agonist for ETB receptor toward the left with increased Emax. DSP 0.4 mL/L and nicotine 0.96 mg/L shifted ETA receptor-mediated the concentration-contractile curves toward the left with increased Emax. However, nicotine 0.06 mg/L which is the equivalent concentration of nicotine in DSP 0.4 mL/L did not affect the curves and the Emax mediated with ETA receptor and ETB receptor. DSP 0.2 and 0.4 mL/L shifted the concentration-contractile curves induced by noradrenaline toward the right with decreased Emax. Neither did nicotine 0.06 and 0.96 mg/L. Both DSP and nicotine shifted the concentration-contractile curves induced by 5-hydroxytryptamine (5-HT) toward the right parallely. DSP changed the phenotypes towards an increased efficacy of ETA receptor and ETB receptor, and a reduced efficacy of 5-HT receptor and α-adrenocceptor. The effects of DSP on ETB receptor, ETA receptor and α-adrenocceptor were independent of nicotine. The effect on 5-HT receptor was responsible to nicotine.

RGB tricolor produced by white-based top-emitting organic light-emitting diodes with microcavity structure

Jin Cao,Xiang Liu,M.A. Khan,WenQing Zhu,XueYin Jiang,ZhiLin Zhang,ShaoHong Xu 한국물리학회 2007 Current Applied Physics Vol.7 No.3

RGB pixels by microcavity top-emitting organic light-emitting diode (TOLED) is benecial to both minimizing the loss of light andimproving the color purity and the eciency. Based on the multi-emitting layers, white organic light-emitting diodes (OLEDs) andmicrocavity TOLEDs were prepared. TOLEDs were fabricated using Ag/ITO as the reector and adjusting layer, Al/Ag as semi-trans-cavity and the color of the device have been changed. So we get RGB tricolor devices. The peak wavelengths are 476 nm, 539 nm,601 nm, Commission Internationale d’Eclairage (CIE) coordinates are (0.133,0.201), (0.335,0.567), (0.513,0.360), FWHM are 32 nm,50 nm, 73 nm for blue, green and red, respectively.

Access Authentication of Mass Device Connections for MTC in LTE Networks

Jin Cao,Maode Ma,Hui Li 한국산학기술학회 2014 SmartCR Vol.4 No.4

Machine Type Communication, also called Machine to Machine communication, is one of the next generations of sophisticated techniques for future wireless communications. It is attracting tremendous interest in standardization organizations such as the third Generation Partnership Project. Accommodating data and signaling traffic from massive Machine Type Communication devices is a challenging task to ensure the security of Machine Type Communication applications in Long Term Evolution networks, as the number of Machine Type Communication devices continues to increase. Since each Machine Type Communication device has to implement an independent access authentication procedure specified by the current third Generation Partnership Project standard, it will incur severe signaling congestions in the Long Term Evolution networks when a large number of Machine Type Communication devices simultaneously connect to the network. In this paper, we propose a new access authentication and key agreement scheme based on an aggregate signature to avoid signaling overload in Long Term Evolution network elements. Our scheme can greatly reduce the signal traffic for a multitude of Machine Type Communication devices connected to the network and also provide robust security protection with desirable efficiency. The experimental results and formal verification using the AVISPA and SPAN tools show that the proposed scheme is efficient and secure against various malicious attacks.

DNMT3a rs1550117 Polymorphism Association with Increased Risk of Helicobacter pylori Infection

Cao, Xue-Yuan,Jia, Zhi-Fang,Cao, Dong-Hui,Kong, Fei,Jin, Mei-Shan,Suo, Jian,Jiang, Jing Asian Pacific Journal of Cancer Prevention 2013 Asian Pacific journal of cancer prevention Vol.14 No.10

Background: DNA methyltransferase-3a (DNMT3a) plays significant roles in embryogenesis and the generation of aberrant methylation in carcinogenesis. This study aimed to investigate associations between single nucleotide polymorphisms (SNPs) of the DNMT3a gene and risk of Helicobacter pylori infection, gastric atrophy and gastric cancer. Methods: The subjects comprised 447 patients with gastric cancer; 111 individuals with gastric atrophy and 961 healthy controls. Two SNPs (rs1550117 and rs13420827) of the DNMT3a gene were genotyped by Taqman assay. DNMT3a expression was analyzed in cancer tissues from 89 patients by tissue microarray technique. Odds ratio (ORs) and 95% confidence intervals were calculated by multivariate logistic regression. Results: Among healthy controls, risk of H.pylori infection was significantly higher in subjects with the rs1550117 AA genotype, compared to those with GG/AG genotypes of DNMT3a [OR=2.08, (95%CI: 1.02-4.32)]. However, no significant correlation was found between the two SNPs and risk of developing gastric atrophy or gastric cancer. In addition, no increase in DNMT3a expression was observed in the gastric cancer with H.pylori infection. Conclusions: This study revealed that DNMT3a rs1550117 polymorphism is significantly associated with an increased risk of H. pylori infection, but did not support any evidence for contributions of DNMT3a rs1550117 and rs13420827 to either gastric atrophy or gastric cancer. The biological roles of DNMT3a polymorphisms require further investigation.

Porphyra Species: A Mini-Review of Its Pharmacological and Nutritional Properties

Jin Cao,Jianping Wang,Shicheng Wang,Ximing Xu 한국식품영양과학회 2016 Journal of medicinal food Vol.19 No.2

Porphyra sensu lato belongs to Bangiales, the most genetically diverse order of red algae. Porphyra or Pyropia is widely cultivated in East Asian countries, such as China, Japan, and Korea. Dried Porphyra contains numerous nutritional and biofunctional compounds, including proteins, minerals, dietary fiber, polyunsaturated fatty acids, carotenoids, saccharides, and mycosporine-like amino acids. In addition, the compound is most abundant in Porphyra, such as polysaccharides and phycobiliproteins, and demonstrates various immunomodulating, anticancer, antihyperlipidemic, and antioxidative activities. This review summarizes our current knowledge concerning the pharmacologically active substances found in Porphyra species. The biological activities and potential applications of certain carbohydrates, proteins, peptides, and other small molecules purified from Porphyra are also described, and possible areas for future studies are discussed.

External Test & Clinical Observation and Evaluation of the Caries Preventive Effect of Tea

Cao Jin 한국식품과학회 1995 식품과학과 산업 Vol.28 No.4

An Optimized Method of Translating SQL to More Efficient Map-reduce Tasks

Jin Cao,Honglin Han,Mingming Zhao,Sijing Ye,Dehai Zhu,Lin Li 보안공학연구지원센터 2015 International Journal of Grid and Distributed Comp Vol.8 No.4

충치예방 효과에 관한 차의 의용적, 임상적 연구와 평가

Cao Jin 한국식품과학회 1995 국제녹차심포지엄 Vol.1995 No.1

An immunoassay using biotinylated single-walled carbon nanotubes as Raman biomarkers

Cao, Chengfan,Kim, Jung Heon,Kwon, Ye-Jin,Kim, Young-Jin,Hwang, Eung-Soo,Baik, Seunghyun Royal Society of Chemistry 2009 The Analyst Vol.134 No.7

<P>A new immunoassay with biotinylated single-walled carbon nanotubes as persistent, non-photobleaching Raman biomarkers demonstrated excellent sensitivity and specificity.</P> <P>Graphic Abstract</P><P>A new immunoassay with biotinylated single-walled carbon nanotubes as persistent, non-photobleaching Raman biomarkers demonstrated excellent sensitivity and specificity. <IMG SRC='http://pubs.rsc.org/services/images/RSCpubs.ePlatform.Service.FreeContent.ImageService.svc/ImageService/image/GA?id=b900501n'> </P>

Determination of Highly Soluble L-Carnitine in Biological Samples by Reverse Phase High Performance Liquid Chromatography with Fluorescent Derivatization

Cao, Qing-Ri,Ren, Shan,Park, Mi-Jin,Choi, Yun-Jaie,Lee, Beom-Jin 대한약학회 2007 Archives of Pharmacal Research Vol.30 No.8

This study was performed in order to validate an effective high performance liquid chromatograpy (HPLC) method to determine L-carnitine in biological samples such as plasma, milk and muscle in cows. An L-carnitine derivative for fluorescence absorption was synthesized with 1-aminoanthracene (16 mg/mL in acetone) and 1-ethyl-3-(3-dimethylaminopropyl) carbodiimide hydrochloride (EDAC: 160 mg/mL in 0.01 M $NaH_2PO_4$ buffer) as a precolumn fluorescent derivative reagent. ${\gamma}-Butyrobetaine$ HCI was used as an internal standard. A reversed-phase column with fluorescence detection at the excitation and emission wavelengths of 248 and 418 nm were used. The mobile phase consisted of 30% acetonitrile with 0.1 M ammonium acetate in water (pH 3.5) adjusted with acetic acid and delivered at a flow rate of 1.5 mL/min. The L-carnitine concentration in plasma, milk and muscle samples of cows after oral feeding with 24 g L-carnitine/day for 2 months was then determined. All biological samples were deproteinated by barium hydroxide and zinc sulfate heptahydrate before the derivative reaction. Blank cow plasma was dialyzed using cellulose membrane for standard calibration. The calibration curve showed good linearity ($r^2$ >0.999) over the concentration range of 50 to 5000 ng/mL. The precision and accuracy were also satisfactory with less than 15% intra- and inter- day coefficiency of variations. The peaks of L-carnitine and internal standard in HPLC chromatography were successfully separated in plasma, milk and muscle samples of cows. The current derivatization method of L-carnitine for fluorescence detection was simple and adequately sensitive and could be applied to determine L-carnitine in biological samples.