종 분포 모형을 이용한 구상나무림의 지속 및 쇠퇴에 관한 연구 - 전라남도 광양시 백운산을 중심으로 -

조선희 ( Seon Hee Cho ),박종영 ( Jong Young Park ),박정호 ( Jeong Ho Park ),이양근 ( Yang Geun Lee ),문이만 ( Lee Man Mun ),강상호 ( Sang Ho Kang ),김광현 ( Gwang Hyun Kim ),윤종국 ( Jong Guk Yun ) 한국산림과학회 2015 한국산림과학회지 Vol.104 No.3

The present study investigated the habitats of Korean fir trees (Abies koreana E. H. Wilson) on Mt. Baekwun (Baekwun-san), determined the current distribution, quantified the contribution of biological and nonbiological environmental factors affecting the distribution, derived actual and potential habitats, presented a plan for the establishment of protected areas, applied RCP 8.5 climate change scenario to analyze the effects of climate change on the future distribution of Korean fir trees, and predicted future potential habitats. According to the results of the study, 3,325 Korean fir trees (DBH >= 2.5 cm) inhabited Mt. Baekwun, and their distribution area was approximately 150 ha. Populations of Korean fir trees were confirmed to exist at an altitude of 900 m above sea level and were distributed up to 1,200 m. Based on potential distribution, areas appropriate for habitation by Korean fir trees were analyzed to be 450 ha, three times the current distribution area, with a focus on Sang Peak (Sang-bong), Eokbul Peak (Eokbul-bong), Ddari Peak (Ddari-bong), and Dosol Peak (Dosol-bong). The forest stands near Sang Peak, the main peak, were evaluated as those with the most appropriate potential for the habitation of Korean fir trees, and populations of the trees tended to prefer the northern slope rather than the southern slope. When climate change scenario RCP 8.5 was applied and future potential distribution was analyzed, the habitats were expected to decrease in area to 20 ha by 2050, with a focus on Sang Peak, and areas appropriate for habitation were predicted not to exist by 2080. Judging from such results, as global warming accelerates, the habitats of Korean fir trees are clearly expected to move from lowlands to highlands.

Original Articles : Clinical significance of occult hepatitis B virus infection in chronic hepatitis C patients

( Jae Young Jang ),( Soung Won Jeong ),( Sung Ran Cheon1 ),( Sae Hwan Lee1 ),( Sang Gyune Kim ),( Young Koog Cheon ),( Young Seok Kim1 ),( Young Deok Cho1 ),( Hong Soo Kim ),( So Young Jin ),( Yun Soo 대한간학회 2011 Clinical and Molecular Hepatology(대한간학회지) Vol.17 No.3

Background/Aims: We investigated the frequency of occult hepatitis B virus (HBV) infection in anti-hepatitis C virus (HCV)-positive individuals and the effects of occult HBV infection on the severity of liver disease. Methods: Seventy-one hepatitis B virus surface-antigen (HBsAg)-negative patients were divided according to their HBV serological status into groups A (anti-HBc positive, anti-HBs negative; n=18), B (anti-HBc positive, anti-HBs positive; n=34), and C (anti-HBc negative, anti-HBs positive/negative; n=19), and by anti-HCV positivity (anti-HCV positive; n=32 vs. anti-HCV negative; n=39). Liver biopsy samples were taken, and HBV DNA was quantified by real-time PCR. Results: Intrahepatic HBV DNA was detected in 32.4% (23/71) of the entire cohort, and HBV DNA levels were invariably low in the different groups. Occult HBV infection was detected more frequently in the anti-HBc-positive patients. Intrahepatic HBV DNA was detected in 28.1% (9/32) of the anti-HCV-positive and 35.9% (14/39) of the anti-HCV-negative subjects. The HCV genotype did not affect the detection rate of intrahepatic HBV DNA. In anti-HCV-positive cases, occult HBV infection did not affect liver disease severity. Conclusions: Low levels of intrahepatic HBV DNA were detected frequently in both HBsAg-negative and anti-HCV-positive cases. However, the frequency of occult HBV infection was not affected by the presence of hepatitis C, and occult HBV infection did not have a significant effect on the disease severity of hepatitis C. (Korean J Hepatol 2011;17:206-212)

Construction of Stably Transformed Bm 5 Cells by Using Autographa californica Nuclear Polyhedrosis Virus IE 0 Gene

Cho, Eun Sook,Jin, Byung Rae,Sohn, Hung Dae,Choi, Kwang Ho,Kim, Soung Ryul,Kang, Seok Woo,Yun, Eun Young,Kim, Sang Hyun,Kim, Keun Young,Je, Yeon Ho,Kang, Seok Kwon 한국잠사학회 1998 한국잠사곤충학회지 Vol.40 No.2

To construct transfurmed Bm5 cells, Autographa californica nuclear polyhedrosis virus(AcNPV) IE1 gene, an immediate early viral gene was firstly used in this study. AcNPV IE1 gene, which shares on 95.3% nucleotide sequence homology with Bombyx mori nuclear polyhedrosis virus (BmNPV) IE1 gene, was isolated and cloned into pBluescript. Neomycin gene from pKO-neo was inserted under the control of the IE1 promoter to yield pAcIE1-neo. The plasmid pAcIE1-neo was transfected into Bm5 or Sf9 cells, and neomycin-resistant cells were selected in TC100 medium containing 10% fetal bovine serum (FBS) and 1 mg/ml G4l8 for two weeks. Individual clones were picked and each was amplified for further characterization. The genomic DNA from neomycin-resistant cells was isolated and characterized by PCR using AcNPV IEI gene-specific primers and by Southern blot analysis using neomycin gene probe. We concluded that AcNPV IE1 gene was functional in B. mori-derived Bm5 cells as well as Spodoptera fugjprrda-derived Sf9 cells to produce stably-transformed insect cells

초등 교과교육학의 성격과 내용구조 연구

유한구(Han Ku Ryu),장성모(Sung Mo Chang),송광용(Kwang Yong Song),조주연(Joo Yun Cho),이학주(Hak Ju Lee) 한국초등교육학회 1997 초등교육연구 Vol.11 No.1

이 연구는 교과교육과 교과교육학의관계, 그리고 교과교육학과 교육학의 관계등을 분석하고, 그 결과를 토대로 하여 초등학교 교과교육과 교육대학 교과교육학 교육의 실제를 정확히 이해하고 그 발전 방향을 탐색하기 위한 것이다. 일반적으로, 교과교육학은 교육학에서 제시하고 있는 교육과정의 구성및 교육방법상의 일반 원리를 교과교육이라는 특수한 사태에 적용하는 과정에 관심을 두는 이론으로 간주되고 있다. 이 관점에 의하면, 교과교육학은 교육학의 일반적 원리에 따라 교과교육이라는 특수한 맥락에 처방을 내리기 위한 것으로 파악된다. 이 관점을 교과와 그것을 가르치는 교사의 삶을 사실상 별개의 것으로 분리하는 것이며, 그와 동일한 이유에서 교과교육학과 교과교육학자의 삶 또한 별개의 것임을 전제하는 것이다. 그러나 교과교육과 교과교육학, 그리고 교과교육학과 교육학의 관계는 이론에서 실제로 나아가는 앞의 방향과는 정반대 방향에서도 이해될 수 있다. 이 관점에 의하면, 교과교육학은 교과교육 실제에 처방을 내리기 위한 것이 아니라 그 실제를 기술하고 정당화하기 위한 것으로 파악된다. 교과교육과 교과교육학의 관련이 이렇게 파악될 때, 교과 교육학은 교사나 교과교육학자에게 자신이 지금 하는 일이 자신의 삶과 결코 무관한 것이 아니라는 믿음을 심어 주게 되며, 나아가 그들 자신이 참여하고 있는 초등학교나 교육대학의 교육실제를 기술하거나 정당화하려고 할 때 반드시 필요한 개념적 도구를 제공해 줄 수 있게 된다. 바로 여기에 교과교육학에 관한 종래의 접근과는 구분되는 새로운 접근방식이 요구되는 이유가 있다. The purpose of this study is threefold: The first is to analyse the relations between subject education and subject pedagogy, and between subject pedagogy and general pedagogy. The second is, based on the analysis result, to have the precise understanding of teaching various subjects in the elementary school, and of teaching subject pedagogy in the university of education. The third is to search for the desirable direction of developing the elementary education and the teacher education. Subject pedagogy is usually defined as a theory which is interested in the process of applying pedagogical principles regarding curriculum organization and teaching methods to specific teaching situations, that is, subject education situations. However, this definition has a limitation, because it assumes that a subject and the teacher's life who teaches the subject are separated from each other, and that subject pedagogy and the scholar who studies subject pedagogy are also separated. The relationship between subject teaching and subject pedagogy, and between subject pedagogy and general pedagogy can be understood with quite different viewpoint. This new viewpoint, which is the major discussion matter of this study, assumes that subject pedagogy is never separated from the life of subject teacher/subject pedagogist. This viewpoint will reveal the theoretical features of subject pedagogy better, and give us new meaning on the life of teachers/subject pedagogists. The subject pedagogy in the correct sense should provide teachers/pedagogists with the conceptual instrument based on the new viewpoint. This conceptual instrument will make teachers/pedagogists be able to describe, explain, and validate their own educational practice-such as the content structure of each subject-in the elementary school or the university of education.

Model Ortaisms in Development and Diseases : THO complex is required for Drosophila spermatogenesis

( Sung Jin Moon ),( Bong Ki Cho ),( Yun Doo Chung ) 생화학분자생물학회 2008 생화학분자생물학회 춘계학술발표논문집 Vol.2008 No.-

Relationship analysis of honeybee diseases and unexpected colony loss

Yun Sang Cho,Mi-Sun Yoo,A-Tai Truong,Thi-Thu Nguyen,So-Youn Youn,Se-Ji Lee,Su-Kyoung Seo,Chae I Oh,Soon-Seek Yoon 한국응용곤충학회 2023 한국응용곤충학회 학술대회논문집 Vol.2023 No.10

최근 국내에서는 꿀벌 대량소실 현상이 2022년부터 전국적으로 발생하고 있다. 우리나라 뿐 만 아니라, 전세계 적으로 양봉산업에 큰 위협이 되고 있는 봉군붕괴현상은 2016년 미국에서 세계 최초로 보고되었다. 국내에서는 2022년 민관 합동조사 결과, 이상기온, 응애, 말벌 등이 주요 원인으로 지목되었다. 대량소실 현상을 보인 양봉농 가와 정상 농가의 병원체 검출 비교 결과, 유의성있게 검출이 증가되는 병원체는 발견되지 않았다. 그러나, Tyrophagus mite, Trypanosome, Lake Sinai virus, Apis mellifera filamentous virus 등의 신종 응애, 원충 및 바이러 스 감염이 추가로 확인되었다. 국내에서 새롭게 감염이 확인된 기생충과 병원체가 대량소실, 나아가 봉군붕괴현 상에 직간접적으로 영향을 주었을 것으로 사료되며, 지속적인 조사와 연구개발을 통해 기후등 환경변화에 따른 신종 질병 검색과 대책을 마련해야 할 것이다.

Physiologically based pharmacokinetic (PBPK) modeling of fl urbiprofen in different CYP2C9 genotypes

Sang-Sup Whang,Chang-Keun Cho,Eui Hyun Jung,Pureum Kang,Hye-Jung Park,Yun Jeong Lee,Chang-Ik Choi,Jung-Woo Bae,Hyung Sik Kim,Choon-Gon Jang,Seok-Yong Lee 대한약학회 2022 Archives of Pharmacal Research Vol.45 No.8

The aim of this study was to establish the physiologicallybased pharmacokinetic (PBPK) model of fl urbiprofenrelated to CYP2C9 genetic polymorphism anddescribe the pharmacokinetics of fl urbiprofen in diff erentCYP2C9 genotypes. PK-Sim® software was used for themodel development and validation. A total of 16 clinicalpharmacokinetic data for fl urbiprofen in diff erent CYP2C9genotypes, dose regimens, and age groups were used for thePBPK modeling. Turnover number (k cat ) of CYP2C9 valueswere optimized to capture the observed profi les in diff erentCYP2C9 genotypes. In the simulation, predicted fractionmetabolized by CYP2C9, fraction excreted to urine, bioavailability,and volume of distribution were similar to previouslyreported values. Predicted plasma concentration-timeprofi les in diff erent CYP2C9 genotypes were visually similarto the observed profi les. Predicted AUC inf in CYP2C9*1/*2 ,CYP2C9*1/*3 , and CYP2C9*3/*3 genotypes were 1.44-,2.05-, and 3.67-fold higher than the CYP2C9*1/*1 genotype. The ranges of fold errors for AUC inf , C max , and t 1/2 were 0.84–1.00, 0.61–1.22, and 0.74–0.94 in development and0.59–0.98, 0.52–0.97, and 0.61–1.52 in validation, respectively,which were within the acceptance criterion. Thus, thePBPK model was successfully established and described thepharmacokinetics of fl urbiprofen in diff erent CYP2C9 genotypes,dose regimens, and age groups. The present modelcould guide the decision-making of tailored drug administrationstrategy by predicting the pharmacokinetics of fl urbiprofenin various clinical scenarios.

Development of the Proton Beam Monitoring System at the 45-MeV Proton Irradiation Test Facility

Sang-Pil Yun,In-Seok Hong,Yong-Sub Cho 한국물리학회 2008 THE JOURNAL OF THE KOREAN PHYSICAL SOCIETY Vol.52 No.3

A proton beam monitoring system has been developed to measure the intensity and the profile of an external proton beam. The beam monitoring system, which consists of a beam intensity monitor and a beam profile monitor (BPM), can provide the intensity and the profile of a proton beam. As a beam monitor for the intensity measurement, a parallel plate ionization chamber (PPIC) is chosen because of its stable operation and wide dynamic range for the detection of a proton beam. To maintain the beam quality, the PPIC electrodes were fabricated with a very thin aluminized polyester film (25 μm). The structure of the BPM is similar to that of the PPIC, except that the BPM is equipped with a position-sensitive electrode. This position-sensitive electrode allows the BPM to measure the profile of a proton beam. The signals from the beam intensity monitor and the BPM are recorded by using a Lab-view-based PXI system (National Instruments Co.), which displays information on both the intensity and the profile by using a proton beam analysis program supported by Lab-view. As a result, we can monitor information on the proton beam during irradiation tests by using a remote control. A proton beam monitoring system has been developed to measure the intensity and the profile of an external proton beam. The beam monitoring system, which consists of a beam intensity monitor and a beam profile monitor (BPM), can provide the intensity and the profile of a proton beam. As a beam monitor for the intensity measurement, a parallel plate ionization chamber (PPIC) is chosen because of its stable operation and wide dynamic range for the detection of a proton beam. To maintain the beam quality, the PPIC electrodes were fabricated with a very thin aluminized polyester film (25 μm). The structure of the BPM is similar to that of the PPIC, except that the BPM is equipped with a position-sensitive electrode. This position-sensitive electrode allows the BPM to measure the profile of a proton beam. The signals from the beam intensity monitor and the BPM are recorded by using a Lab-view-based PXI system (National Instruments Co.), which displays information on both the intensity and the profile by using a proton beam analysis program supported by Lab-view. As a result, we can monitor information on the proton beam during irradiation tests by using a remote control.

Feedback flow control using the POD method on the backward facing step wall model

Sung-In Cho,In Lee,Seung-Jun Lee,Choong Yun Lee,Soo Hyung Park 한국항공우주학회 2012 International Journal of Aeronautical and Space Sc Vol.13 No.4

Missiles suffer from flight instability problems at high angles of attack, since vortex flow over a fuselage cause lateral force to the body. To overcome this problem at a high angle of attack, the development of a real time vortex controller is needed. In this paper, Proper Orthogonal Decomposition (POD) and feedback controllers are developed for real time vortex control. The POD method is one of the most well known techniques for modeling low order models that represent the original full-order model. An adaptive control algorithm is used for real time control.

Effects of Plant Oils and Minerals for the Inhibition of Lipase Activity of Staphylococcus aureus Isolated from Fermented Pork Meat

Cho, Sang-Buem,Chang, Woo-Kyung,Kim, Yun-Jung,Moon, Hyung-In,Joo, Jong-Won,Choi, In-Soo,Seo, Kun-Ho,Kim, Soo-Ki Korean Society for Food Science of Animal Resource 2010 한국축산식품학회지 Vol.30 No.5

Staphylococcus aureus lipase is regarded as a virulence factor. The response of lipase activity to various factors can provide important insights concerning the prevention of S. aureus during meat fermentation. This study was conducted to evaluate the main effects of nutrients used in culture media, and their combined effects on the inhibition of lipase activity and cell growth of pathogenic S. aureus SK1593 isolated from fermented pork meat. A Plackett-Burman design was used to evaluate the main effects of variables, including olive oil, soybean oil, grapeseed oil, sesame oil, $CuSO_4$, $MgCl_2$, $KNO_3$, $CaCl_2$, and KCl. Significant negative effects on lipase activity were detected with soybean oil, grapeseed oil, $KNO_3$, and $CaCl_2$. Additionally, these nutrients were further selected as variables for the investigation of their combined effect on lipase activity, via response surface methodology. In order to confirm the regression model, a situation that only inhibits lipase activity was simulated. The predicted lipase activity and cell growth of the simulated situation were 14.0 U/mL and $9.6\;{\log}_{10}$ (CFU/mL), respectively, and the estimated value of those in the same medium showed 15.14 U/mL and $9.4\;{\log}_{10}$(CFU/mL) respectively. The lipase activity of the simulated medium was inhibited approximately 5-fold as compared to the basal medium, but no significant differences in cell counts were noted to exist between the basal and simulated media. These results suggest that soybean oil, grapeseed oil, $KNO_3$, and $CaCl_2$ can be used to inhibit the growth of pathogenic S. aureus during the process of meat fermentation.