근대전환기 역사, 전기 단형서사의 언론 매체별 비교 연구

문한별 ( Han Byoul Moon ) 한국문학교육학회 2011 문학교육학 Vol.35 No.-

Comparative Study on the Short Narratives in the Newspapers and Journals in the Transitional Period to Modern Era in Korea Moon, Han-Byoul There are different forms of short narratives in the newspapers and journals in the transitional period to modern era in Korea. Among them, the short narratives dealing with historical figures home and abroad are based on "Jeon(傳)", a traditional narrative form. However, clear differences are being shown between the newspapers and journals. In the journals, the narratives closely follow the structure and form of "Jeon". The narratives in the newspapers still have the characteristics of "Jeon". However, as they are under the categories such as "editorial" and "novel", which are not related to "Jeon", certain discrepancies exist between form and purpose. It means that the short narratives in the newspapers are being utilized for other values besides the ones represented by the historical figures in "Jeon" Meanwhile, the short narratives in the journals maintains the existing form while the ideology reflects the transition period to modern era, which clearly shows contents and purposes precede forms in the journals. As such, the short narratives show similarities and differences depending on the purposes and values of the media. The paper aims to go beyond a unilateral view on the short narratives in this era by highlighting such differences.

The expression of makorin ring finger protein 1 (MKRN1), pAKT, pmTOR, and PTEN in cervical neoplasias

( Han Byoul Cho ),( Joon Yong Chung ),( Mikiko Takikita ),( Stephen M Hewitt ),( Jae Hoon Kim ) 대한산부인과학회 2012 대한산부인과학회 학술대회 Vol.98 No.-

The protein kinase B (AKT) pathway plays a key role in the regulation of cell death and survival, and has been proposed as a central signaling event in carcinogenesis. We investigated the expression of MKRN1, which is a transcriptional co-regulator and an E3 ligase, and sought to define the role of AKT pathway in cervical neoplasias. One hundred eighty three cervical cancer, 415 cervical intraepithelial neoplasia, and 400 matched nonadjacent normal tissues were arrayed into tissue microarrays. MKRN1, phosphorylated AKT (pAKT), phosphorylated mammalian target of rapamycin (pmTOR), and total phosphatase and tensin homolog deleted on chromosome 10 (PTEN) protein expressions were assessed by immunohistochemistry (IHC) and the relationship between MKRN1 expression and clinicopathologic parameters including survival data was studied. MKRN1, pAKT, and pmTOR expressions were significantly increased in cervical cancer cases compared with normal epitheliums (p<0.001 for all markers), and this increased expression of MKRN1 was significantly associated with tumor stage (p=0.018) and tumor grade (p<0.001). Expression of MKRN1 was positively associated with pAKT expression (p=0.023), while negatively associated with PTEN expression (p=0.016) in cervical cancer specimens. In multivariate analysis, MKRN1+/pAKT+ (HR = 4.76 [1.66-13.58], p=0.004), pAKT+ (HR = 2.97 [1.02-8.06], p=0.045), and lymph node metastasis (HR = 3.94 [1.07-14.45], p=0.039) were independent prognostic factors for overall survival. This study provides evidence of an association between AKT pathway and cervical carcinogenesis and shows that MKRN1/pAKT expression predicts poor prognosis in cervical cancer. Our findings also suggest that future research assessing its clinical usefulness would be worthwhile.

GO-74 : MICA/B and ULBP1 NKG2D ligands are independent predictors of good prognosis in cervical cancer

( Han Byoul Cho ),( Joon Yong Chung ),( Till Braunschweig ),( Stephen M Hewitt ),( Jae Hoon Kim ) 대한산부인과학회 2012 대한산부인과학회 학술대회 Vol.99 No.-

NKG2D (natural killer group 2, member D) binds to a diverse array of cellular ligands of the MIC and ULBP/RAET family and is thought to participate in anticancer immune response. In this study, we investigated the clinical significance of NKG2D in the pathogenesis of cervical cancer. We assessed the expression of all MICA/B, ULBP1, ULBP2, ULBP3, RAET1E, and RAET1G proteins in archival tumor tissue specimens from 200 cervical cancers, 327 high-grade cervical intraepithelial neoplasias (CINs), 99 low-grade CINs, and 541 matched nonadjacent normal cervical epithelial tissues by immunohistochemical staining. MICA/B, ULBP1, and RAET1E expression were higher in cervical cancer than in low grade CIN (p<0.001, p=0.012, p=0.013, respectively) and normal cervix (all p<0.001). Among these markers, expression of ULBP1 was significantly different in FIGO stage (p=0.010) and tumor size (p=0.045). ULBP1 expression was correlated with MICA/B (p<0.001) and ULBP2 expression (p=0.002) in cervical cancer. MICA/B+ or ULBP1+ showed improved disease-free survival time (p=0.027 and p=0.009, respectively) than low expression group, whereas RAET1E+ or RAET1G+ showed shorter survival time (p=0.018 and p=0.029, respectively). In case of overall survival, ULBP1+ group showed significantly longer survival time (p=0.009). By using multivariate analysis, MICA/B+/ULBP1+ (HR=0.16, p=0.015), ULBP1+ (HR=0.31, p=0.024), tumor stage (HR=3.60, p=0.010), and lymph node metastasis (HR=2.71, p=0.032) were found to be independent predictors of prognosis for disease-free survival in cervical cancer. We demonstrate that MICA/B and ULBP1 expression is significantly increased in cervical cancer, which is consistent with immunoediting mechanism that select selects tumor cells that have lost or reduced expression of NKG2D ligands. Furthermore, the combination of MICA/B and ULBP1 was found to be the independent predictor of survival, suggesting clinical values in clinical assessment.

Loss of ARID1A/BAF250a expression is associated with cervical carcinogenesis and predicts shorter overall survival

( Han Byoul Cho ),( Jane Seon Young Kim ),( Hyun Soo Chung ),( Hee Jeong Lee ),( Jae Hoon Kim ) 대한산부인과학회 2012 대한산부인과학회 학술대회 Vol.98 No.-

ARID1A, the tumor suppressor gene, encodes BAF250a which is a component of human SWI/SNF chromatin-remodeling complexes and has recently reported loss of expressions in several tumor types. Here, we investigate the expression levels of the BAF250a during the sequential steps of cervical carcinogenesis and assess its prognostic value. One hundred forty seven cervical cancer patients, 191 cervical intraepithelial neoplasia, and 376 matched nonadjacent normal tissues were arrayed into tissue microarray. BAF250a expressions were assessed by immunohistochemistry (IHC) and studied the relationship between BAF250a expression and clinicopathologic parameters including survival data. The transcriptional level of BAF250a was also evaluated by SYBR Green real-time PCR in 5 cell lines and 10 clinical specimens. We showed that the mRNA expression levels of BAF250a decreased in cervical cancer cell lines (p=0.005) and tissues (p=0.001), compared with normal cervical epithelial tissues, respectively. BAF250a was detected in nuclear factions of HeLa cells and nucleus of cervical cancer tissue sample by western blotting and IHC, respectively. The expression level of BAF250a gradually decreased during the normal to tumor transition of cervical carcinoma (p<0.001), and this loss of the expression was significantly associated with tumor stage (p=0.005), tumor grade (p=0.029), tumor size (p=0.003), and lymph node metastasis (p=0.020). In multivariate analysis, overall survival in cervical cancer was significantly shorter in cases with the loss of BAF250a expression (HR = 2.78 [1.01-7.63], p=0.047). Our results suggest that BAF250a expression has the potential to provide valuable prognostic information to clinicians for risk assessment in cervical cancer.

다발성으로 전이된 저등급 자궁내막 간질성 육종

조한별 ( Han Byoul Cho ),김재훈 ( Jae Hoon Kim ),홍순원 ( Soon Won Hong ),이현준 ( Hyun Joon Lee ),김민경 ( Min Kyoung Kim ),김성훈 ( Sung Hoon Kim ),김영태 ( Young Tae Kim ),김재욱 ( Jae Wook Kim ) 대한산부인과학회 2006 Obstetrics & Gynecology Science Vol.49 No.9

Uterine sarcomas are rare tumors of mesodermal origin and constitute 2-6% of uterine malignancies. They are classified into leiomyosarcoma (LMS), malignant mixed mullerian tumors (MMMTs), and endometrial stromal sarcoma (ESS) by histologic types. Endometrial stromal sarcomas account for about 7-15% of uterine sarcomas, about 0.2% of female genital tract malignancies. Endometrial stromal sarcomas are divided into endometrial stromal nodule, low-grade endometrial stromal sarcoma, and high-grade endometrial stromal sarcoma on the basis of mitotic activity and vascular invasion. Clinical outcome of low-grade endometrial sarcoma is better than that of high-grade endometrial stromal sarcoma and has a propensity for slow metastasis. We have experienced a case of low-grade endometrial stromal sarcoma with multiple metastasis in a 41-year-old woman and was treated by surgical resection and combination chemotherapy, which is presented with a review of brief literature.

연설의 근대적 서사화 가능성 ―연설체의 서사적 특질을 중심으로

문한별 ( Han Byoul Moon ) 현대문학이론학회 2012 現代文學理論硏究 Vol.0 No.48

연설은 근대적 행위이다. 다수의 청자가 모인 공간 속에서 자신의 주장을 어떻게 효과적으로 전달할 것인가의 문제는 근대로 넘어가는 근대전환기에 이르러 본격적으로 논의되었다. 주로 협회와 학회 등이 주도한 연설의 행위는 근대적 언론 매체의 등장과 더불어 서사 속으로 틈입되었다. 즉 연설이 가지고 있는 당대성과 현장성이 서사의 추동 원리로 작용하기 시작했던 것이다. 근대전환기의 언론 매체에 수록된 글들 가운데에는 이 같은 연설의 공간을 서사 속으로 투영시킨 많은 작품들이 존재한다. 연설 자체가 근대적인 행위이자 근대적 이데올로기를 전파하는 목적성을 가진다는 점에서 ``연설``체가 사용된 글들은 매우 근대전환기적인 성격을 가질 수밖에 없다. 또한 연설체는 화자와 청자가 정해져 있고, 인물로 이해된다는 점에서 서사적 성격을 지니고 있다. 연단이라는 공간과 인물의 등장이라는 점은 연설체가 서사체로 나갈 수 있는 가능성을 보여주는 요소인 것이다. 본고는 이 같은 ``연설``체 서사가 활용된 글들을 통하여 연설이 가지고 있는 특징들은 무엇이며, 실질적 공간에서 이루어지는 연설이라는 행위가 어떤 방식으로 서사에 투영되고 있는가를 살피고자 한다. 대상 작품들은 근대전환기에 발표된 ``연설``체 서사가 사용된 단형서사와 신소설, 역사 전기소설 등이며, 이들을 분석함으로써 ``연설``이 근대적 서사로 어떻게 수용될 수 있는가를 살펴보기로 한다. Speech is modern behavior. The act to deliver his/her point has started to be mainly seen in the transition period to modern era in Korea. The act of making a speech led by associations and academic societies has flown into narratives along with the emergence of modern media. The characteristics of speech, which are contemporaneity and field-based, have started to drive narratives. Such characteristics are reflected in many writings in the media during this period. Writings, to which speech style narrative is applied, have characteristics of the period considering that speech is an modern act to spread modern ideology. In this paper, the speech-style-applied writings are reviewed to see what characteristics speech has and how speech is reflected in narratives. The writings including short narratives, shin-soseol(new novel), and history-biography novel are analyzed in the paper to see how "speech" is embraced in modern narratives.

서정인 소설 「달궁」에 나타나는 탈근대주의적 서술 방법 연구

문한별 ( Han Byoul Moon ) 민족어문학회 2010 어문논집 Vol.- No.62

서정인의 작품 세계는 1983년 작 <철쭉제>를 기점으로 변모하기 시작한다. 이전의 작품들이 근대주의를 태생적 모태로 하고 있다면, <철쭉제> 이후의 작품들은 이를 극복하고 부정하기 위한 실험적 방법들이 다양하게 시도되고 있는 것이다. 이 같은 변모 양상에서 소설 <달궁>이 주목되는 이유는 아래와 같다. 첫째, 근대주의의 상하 종적인 이분법의 사유 방식을 해체하기 위하여 탈근대주의의 방법론이 실제로 작품 내에 반영되고 있으며, 둘째, 근대주의적 사고를 해체하기 위한 방법론으로서 탈근대주의가 지닌 한계마저도 작품 내에서 극복하고자 노력하고 있다는 점이다. 이 가운데 탈근대주의적 방법론은 대화의 연쇄와 개념의 확장을 .통하여 사고의 다양성을 최대한 확보하게 해주었다고 평가할 수 있으며, 탈근대 주의를 넘어서기 위한 전통 문학 양식의 수용은 근대주의를 주체적으로 극복할 수 있는 가능성을 열어주었다고 볼 수 있다. 또한 이와 같은 다양한 서술 방법의 .실험적 도입은 근대가 가지고 있는 배타성과 종적 관계를 한국 문학 스스로가 자발적으로 극복하려는 시도라는 점에서 주목 받아야 한다고 생각한다. <Cheolchook-Je>(royal azalea festival) in 1983 is a turning point in the works of Seo Jeong-In. While modernism is intrinsic to the works before <Cheolchook-Je>, various experiments are taken afterward to overcome the value. In that sense, <Dall-Gung> is noteworthy for two reasons: first, post-modernist methodology is reflected to deconstruct the thinking of vertical dichotomy in modernism; and second, this work even tries to overcome the limitations of post-modernism. The methodology, in particular, helps to maximize the diversity of thinking through the sequences of dialogue and expansion of concept. Embracing the styles of traditional literature to go beyond post-modernism opens the possibility to get over modernism. Such experimental introduction of various narrative methods deserves attention as it attempts to voluntarily overcome the exclusiveness and vertical relation of modernism.

일반 논문 : 근대전환기 번역 및 번안 서사의 두 가지 양상 -애국과 교육 계몽 담론의 수용 양상을 중심으로

문한별 ( Han Byoul Moon ) 현대문학이론학회 2010 現代文學理論硏究 Vol.0 No.42

지금까지 근대전환기 서사에 대한 연구는 창작 서사를 중심으로만 이루어져왔다. 전통 문학 양식의 변개와 자생적 근대 소설 양식에 대한 탐구는 이 시기 서사 연구의 주된 테마였고 많은 성과들을 이끌어냈던 것이다. 그럼에도 불구하고 동일한 시기, 서사의 또 다른 중요한 한 축이었던 번역 및 번안 서사에 대한 연구는 소외되어 왔다. 일부 번역자 혹은 소설가에 대한 부차적 연구에서 소략하게 다뤄진 것이 전부인 것이다. 그렇기에 본고는 근대전환기의 번역 및 번안 서사를 본격적으로 다루기 위하여 이 시기 지배적인 언론 매체, 즉 신문과 단행본, 학회나 협회의 기관지인 학술지와 학회지들을 망라하여 각 매체에 수록된 번역 및 번안 서사를 추적하고 각 작품들의 원본과 원저자, 번역자와 중역자 등의 성격을 고증함으로써 그 실체를 파악하고자 하였다. 그 결과 근대전환기의 번역 및 번안 서사의 번역자들은 전문적 번역 활동에 종사했던 부류와 당대의 개화 지식인들이 각기 다른 목적으로 번역 및 번안 작업을 진행했음을 확인할 수 있었다. 또한 이들이 번역한 외래 서사들이 특정한 목적을 위하여 선별적으로 수용되고 있었음도 밝힐 수 있었다. The studies on the narrative during the transition period to modern era have focused on novels. As new literature types and the transformation of traditional literature form have been explored in the studies, academic achievement has been made. On the other hand, translation and adaptation works, which are another important pillar of the narrative, have gotten little attention. Only sub-studies on some translators or writers have briefly dealt with the subjects. This paper focused on translation and adaptation works during the transition period to modern era. It tracked down the works shown in the influential media during the period including newspapers, books, and journals of academic societies and associations, and conducted a historical studies on the characteristics of their original works (and the writers), translators, and retranslators. As a result, the paper found that while there were professional translators, some intellectuals were engaged in translation and adaption for different purposes. It also found that the intellectuals selectively chose the original works for translation for certain purposes.

일제강점기 단행본 납본 목록에서 발견된 새로운 소설들의 의미 -『조선출판경찰월보』를 중심으로

문한별 ( Han Byoul Moon ) 현대문학이론학회 2013 現代文學理論硏究 Vol.0 No.52

Chosun Gyoengchal Wolbo was published by the police of the Government-General of Chosun. These materials were published from September 1928 to November 1938. These materials had remained in the deposit book list for censorship in publishing June 1930~March 1931. This deposit book list doesn`t exist in other materials. It is important that can look more specifically publishing situation of the Japanese colonial period. This paper analyzed the deposit book list in Chosun Gyoengchal Wolbo. As the result, this list has 752 books, among them, 515 books were published in 1930``s. This paper tracked that these 515 books included 102 novels, 102 novels had 25 new novels. These new novels did not exist in korean modern literature. This paper studied the 25 new novels``s progress and the specific bibliographic and publisher.

잡지 『소년』 수록 설명문의 서사적 성격

문한별(Han Byoul Moon) 한국현대소설학회 2012 현대소설연구 Vol.- No.51

Until now, the studies on 『So-Nyeon』 have focused on functions as a modern educational magazine and Choi Namsun`s translation work etc. This paper is to analyze about the possibility of new narrative style of transition period to modern era based on two narrative explanatory texts in magazine 『So-Nyeon』. The narrative explanatory texts mean that seasoned with nature of the narrative in explanatory writing that described for the purpose of transferring modern knowledge. The narrative style used in such writings`s is appropriation of questions and answers-style, setting of fictional characters, description of background etc. Investigation results of this paper, the narrative explanatory texts in 『So-Nyeon』 are new style`s texts that difficult to find in other media of transition period to modern era, it is significant that shows new aspects of the narrative`s mixture in this period. Also it was found that the combination of explanatory texts and narrative style for modern enlightening education opened up the possibility of Korean Bildungsroman(educational nove.