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Lorazepam과 Diphenhydramine 의 추제외로증후군에 대한 효과비교
서미라,최보문,백인호 大韓神經精神醫學會 1986 신경정신의학 Vol.25 No.1
In this study, a comparative evaluation on clinical efficacy between intravenous lorazepam and diphenhydramine for extrapyramidal symptoms occurring on neuroleptic therapy was made. Subjects were consisted of 42 cases including 8 males and 34 females. They were under double-blind procedure, given single injections of 4 miligrams of lorazepam(21 cases) and 50 miligrams of diphenhydramine(21 cases) seperately. The effects were evaluated by Extrapyramidal Symptoms(EPS) Rating Scale for extrapyramidal Symptoms as well as by the Brief Psychiatric Rating Scale(BPRS) for psychotic symptoms and signs. The results were as follows: 1)Most of extrapyramidal symptoms including parkinsonian symptoms, akathisia and dystonia were noted to be significantly improved 60 minutes after injection on EPS Rating Scale scores. 2)BPRS evaluation 60 minutes after injection resulted in significant reduction of the total mean scores in both groups, although no significant difference can be made in terms of efficacy between the group when the two groups were compared. 3)Clinically it can be suggested that the sedative effect of diphenhydramine was less than that of lorazepam. The above mentioned results suggest that lorazepam and diphenhydramine may well be the drugs of choice for the treatment of extrapyramidal symptoms occurring on the neuroleptic therapy.
Choi Younjung,Kim Sun Mi,Jang Mijung,Yun Bo La,Kang Eunyoung,Kim Eun-Kyu,Park So Yeon,Kim Bohyoung,Cho Nariya,Moon Woo Kyung 대한영상의학회 2022 Korean Journal of Radiology Vol.23 No.9
Objective: The optimal imaging approach for evaluating pathological nipple discharge remains unclear. We investigated the value of adding ductography to ultrasound (US) for evaluating pathologic nipple discharge in patients with negative mammography findings. Materials and Methods: From July 2003 to December 2018, 101 women (mean age, 46.3 ± 12.2 years; range, 23–75 years) with pathologic nipple discharge were evaluated using pre-ductography (initial) US, ductography, and post-ductography US. The imaging findings were reviewed retrospectively. The standard reference was surgery (70 patients) or > 2 years of followup with US (31 patients). The diagnostic performances of initial US, ductography, and post-ductography US for detecting malignancy were compared using the McNemar’s test or a generalized estimating equation. Results: In total, 47 papillomas, 30 other benign lesions, seven high-risk lesions, and 17 malignant lesions were identified as underlying causes of pathologic nipple discharge. Only eight of the 17 malignancies were detected on the initial US, while the remaining nine malignancies were detected by ductography. Among the nine malignancies detected by ductography, eight were detected on post-ductography US and could be localized for US-guided intervention. The sensitivities of ductography (94.1% [16/17]) and post-ductography US (94.1% [16/17]) were significantly higher than those of initial US (47.1% [8/17]; p = 0.027 and 0.013, respectively). The negative predictive value of post-ductography US (96.9% [31/32]) was significantly higher than that of the initial US (83.3% [45/54]; p = 0.006). Specificity was significantly higher for initial US than for ductography and post-ductography US (p = 0.001 for all). Conclusion: The combined use of ductography and US has a high sensitivity for detecting malignancy in patients with pathologic nipple discharge and negative mammography. Ductography findings enable lesion localization on second-look post-ductography US, thus facilitating the selection of optimal treatment plans.
Choi, Jin Woo,Kim, Dae Gyu,Lee, Al-Eum,Kim, Hye Rim,Lee, Jin Young,Kwon, Nam Hoon,Shin, Young Kee,Hwang, Soon-Kyung,Chang, Seung-Hee,Cho, Myung-Haing,Choi, Yoon-La,Kim, Jhingook,Oh, Seung Hyun,Kim, Bo Public Library of Science 2011 PLoS genetics Vol.7 No.3
<P>Although ARS-interacting multifunctional protein 2 (AIMP2, also named as MSC p38) was first found as a component for a macromolecular tRNA synthetase complex, it was recently discovered to dissociate from the complex and work as a potent tumor suppressor. Upon DNA damage, AIMP2 promotes apoptosis through the protective interaction with p53. However, it was not demonstrated whether AIMP2 was indeed pathologically linked to human cancer. In this work, we found that a splicing variant of AIMP2 lacking exon 2 (AIMP2-DX2) is highly expressed by alternative splicing in human lung cancer cells and patient's tissues. AIMP2-DX2 compromised pro-apoptotic activity of normal AIMP2 through the competitive binding to p53. The cells with higher level of AIMP2-DX2 showed higher propensity to form anchorage-independent colonies and increased resistance to cell death. Mice constitutively expressing this variant showed increased susceptibility to carcinogen-induced lung tumorigenesis. The expression ratio of AIMP2-DX2 to normal AIMP2 was increased according to lung cancer stage and showed a positive correlation with the survival of patients. Thus, this work identified an oncogenic splicing variant of a tumor suppressor, AIMP2/p38, and suggests its potential for anti-cancer target.</P><P><B>Author Summary</B></P> <P>Lung cancer is one of the most common cancers and a leading cause of death resulting from cancer. Despite intensive investigation, effective therapeutic targets and reliable biomarkers are still limited. Here we found that a tumor suppressor, AIMP2 (MSC p38), produces a variant lacking a part of its structure in cancer tissues. We designated it AIMP2-DX2. This smaller version of AIMP2 compromises the normal tumor suppressive activity of AIMP2 and induces tumor formation. We also found that the expression of AIMP2-DX2 was increased according to cancer progression. In addition, the patients with higher expression of AIMP2-DX2 showed lower survival than those with lower levels of this variant. Suppression of AIMP2-DX2 slowed tumor growth, suggesting it as a new therapeutic target. In summary, this work newly identified a tumor-inducing factor, AIMP2-DX2, that can be used as a therapeutic target and biomarker associated with lung cancer.</P>
Endometrioid stromal sarcoma of ovary; A case report
( Seu La Choi ),( Bo Ra Park ),( Dong Won Kim ),( Hyopyo Lee ) 대한산부인과학회 2012 대한산부인과학회 학술대회 Vol.99 No.-
Endometrial stromal sarcoma of ovary is very rare disease. It often coexist with endometriosis. The tumors are well differentiated and relatively good prognosis. Histologically endometrioid stromal sarcomas are composed of sheets of uniform cells, which are usually round or oval, resemble the stromal cells of normal proliferative endometrium. Numerous small blood vessels resembling the spiral arterioles of endometrium are present. Tumors with less than 10 mitotic field per 10 high power fields are classified as low grade and those with 10 or more as high grade. Primary therapy of endometrioid stromal sarcoma is complete resection of neoplasm. Chemotherapy, radiotherapy, progesterone therapy are useful. We present a case of endometrioid stromal sarcoma of ovary with review of literature.
최보금(Bo Geum Choi),김종화(Chong Hwa Kim),박지현(Ji Hyun Park),라방주(Bang Joo La),류완희(Wan Hee Yoo),김현각(Hyun Kag Kim),박태선(Tae Sun Park),백홍선(Hong Sun Baek) 대한내과학회 2000 대한내과학회지 Vol.59 No.5
Juvenile rheumatoid arthritis (JRA), an autoimmune disease, was characterized by chronic synovitis and associated with various extra-articular manifestations. Abnormal hematologic findings have been reported in all form of JRA, especially anemia due to chronic disease or iron deficiency. Dysplastic changes were rarely noted in the peripheral blood and bone marrow. We experienced a 15-year-old female patient with pauciarticular JRA who have pancytopenia in peripheral blood and a number of dysplastic changes in bone marrow, and present the case here with brief review of literatures.(Korean J Med 59:587-590, 2000)
Comparison of Effects between Lorazepam and Diphenhydramine for Extrapyramidal Symptoms
Seo, Mi-La,Choi, Bo-Moon,Paik, In-Ho CATHOLIC MEDICAL CENTER 1985 Bulletin of the Clinical Research Institute Vol.13 No.1
In this study, a comparative evaluation on clinical efficacy between intravenous lorazepam and diphenhydramine for extrapyramidal symptoms occurring on neuroleptic therapy was made. Subjects were consisted of 42 cases including 8 males and 34 females. They were under double-blind procedure, given single injection of 4 milligrams of lorazepam (21 cases) and of 50 milligrams of diphenhydramine (21 cases) separately. The results were as follows: 1. Most of extrapyramidal symptoms including parkinsonian symptoms, akathisia and dystonia were noted to be significantly improved 60 minutes after injection on EPS Rating Scale scores. 2. BPRS evaluation at 60 minutes after injection resulted in significant reduction of the total mean scores in both groups, although no significant difference can be made in terms of efficacy between the groups. 3. Clinically it can be suggested that the sedative effect of diphenhydramine was less potent than that of lorazepam. The above mentioned results suggest that lorazepam and diphenhydramine may well be the drugs of choice for the treatment of extrapyramidal symptoms occurring on the neuroleptic therapy.