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서영수,김용관,신동환,공보금,이정구,박정환,윤성환,정치영,이상경,김영훈 대한생물치료정신의학회 2001 생물치료정신의학 Vol.7 No.2
Objectives : This open prospective study was performed in order to evaluate the efficacy and extrapyramidal adverse effects of nemonapride in the schizophrenic patients, and was compared wit one of typical antipshchotics. haloperidol and one of atypical antipsychotics, risperidone. Methods : Thirty male and female schizophrenic patients(DSM-Ⅳ) were treated for 12 weeks with haloperidol(n=10), risperidone(n=10) and nemonapride(n=10). The overall efficacy was assessed at baseline, 1st week, 2nd week, 4th week, 8th week, and 12th week by the Positive and Negative Syndrome Scale for Schizophrenia(PANSS). Also the overall safety was assessed in the same time period by the Extrapyramidal Symptom Rating Scale(ESRS). Results : There were no significant differences in PANSS scores(total, positive, negative, and general psychopathology subscale) among haloperidol, risperidone, and nemonapride groups, Treatment responders, defined as at least 20% reduction of baseline total PANSS score, were achieved by 8 patients(80%) in haloperidol group, 10 patients(100%) in risperidone group, and 8 patients(80%) in nemonapride group. And there were no significant differences in ESRS total scores among haloperidol, risperidone, and nemonapride group. Inter-group comparison among haloperidol, risperidone and nemonapride group, as assessed by the ESRS, revealed no significant differences in the shifts to the maximum score, 9.4(±9.4), 6.2(±8.4), and 11.3(±8.1) respectively, and also revealed no significant differences in the mean time reaching the maximum score, 4.5(±4.5) week, 7.8(±4.8) week, and 4.6(±4.4) week, respectivily. Conclusion : There wee no significant differences in the efficacy and extrapyramidal adverse effects among haloperidal, rispecridone and nemonapride groups. These results suggest that nemonapride was as efficacious and safe in he treatment of schizophrenia, as well known and widely used antipsychotics, haloperidol and risperidone.
Wing form dimorphism in reaction to nymphal density in the brown planthopper, Nilaparvata lugens
Bo Yoon Seo,Jin Kyo Jung,Si-Woo Lee 한국응용곤충학회 2010 한국응용곤충학회 학술대회논문집 Vol.2010 No.05
An expression of adult wing form in reaction to rearing density during nymphal stage was investigated in the brown planthopper, Nilaparvata lugens. Under mass rearing condition, the S-BPH and the 2007-BPH population predominantly showed a short-winged, brachypterous, form and a long-winged, macropterous, form, respectively. At rearing density of less than 5 nymphs in the 2007-BPH, 90% of females showed brachypterous form, but all males became macropterous form. The ratio of macropterous form in the 2007-BPH males decreased by 75% in 10 to 15 rearing density, but increased by more than 95% again at 20 to 30 rearing density. In the case of the 2007-BPH females, the ratio of macropterous form gradually grew from 31% at 10 nymphal density to 92% at 20 nymphal density. All females originated from the S-BPH showed brachypterous form, regardless of nymphal density. The ratio of macropterous males in the S-BPH rapidly went down from 74% at 1 nymphal density to 10% at 10 nymphal density. At 20 nymphal rearing density, all males of the S-BPH showed brachypterous form. On the other hand, other brachypterous (OJ67-BPH) and macropterous (2006-BPH) population produced similar results with above the two populations at 1 nymphal rearing density. In summary, these results demonstrate that wing form dimorphism in N. lugens is largely influenced by nymphal density and the wing form at a specific density (low or high) can be different by sex or N. lugens populations.
Seo, Bo-Yoon,Jung, Jin-Kyo,Choi, Byeong-Reol,Park, Hyung-Man,Lee, Si-Woo,Lee, Bong-Hoon 한국응용곤충학회 2010 Journal of Asia-Pacific Entomology Vol. No.
To understand the development of host plant resistance-breaking ability of the current BPH populations in Korea, we conducted nymphal survivorship tests and electrical penetration graph (EPG) studies on susceptible and resistant rice varieties with four different BPH populations, which were collected in the early 1980s (S-BPH) and in 2005, 2006, and 2007. The S-BPH had low survival rates on resistant rice varieties carrying either Bph1 or bph2. However, the current BPH populations have high resistance-breaking ability on the varieties with their elevated survival rates, whereas their survival rates were still low on the other resistant varieties, Gayabyeo (Bph1 the other unknown gene) and Rathu Heenati (Bph3). The EPG analysis also revealed that the ratio of BPH that could reach the phloem sap ingestion waveform (N4-b) within 15 h on the resistant rice varieties containing Bph1 or bph2 was higher in the current BPH populations (16.7-50%) than in the S-BPH population (0-4.2%). However, the pre-reaching time from the penetration start to the first N4-b waveform in the current BPH populations was significantly longer on resistant varieties (Bph1 or bph2) than on susceptible varieties. Furthermore, the total duration of N4-b waveform was significantly shorter on the resistant varieties. From these results, we suggest that, although the current BPHs collected in Korea have a high resistance-breaking ability through the increase of survival rate on resistant rice varieties carrying either Bph1 or bph2, they still have some difficulties feeding on the phloem sap of the resistant rice varieties.
Bo Yoon Seo,Jin Kyo Jung,Byeong-Reol Choi,Hyung Man Park 한국응용곤충학회 2008 한국응용곤충학회 학술대회논문집 Vol.2008 No.05
Resistance-breaking ability of wild brown planthopper (BPH), Nilaparvata lugens, on resistant rice cultivars has been reported in many Asian countries. To understand the development of resistance-breaking ability of wild BPH in Korea, we conducted the nymphal survivorship test and the electrical penetration graph (EPG) on susceptible and resistant rice cultivars with four different BPH populations, which were collected in the early 1980s (S-BPH), 2005, 2006, and 2007, respectively. The S-BPH showed low survival rates on resistant rice cultivars carrying Bph1 and bph2, respectively. On the other hand, recent(2005~2007) wild BPH populations seemed to have high resistance-breaking ability because they maintained elevated survival rates on most other resistant rice cultivars except Gayabyeo (Bph1 and bph2) and Rathu Heenati (Bph3). In the EPG monitoring, however, wild BPHs could not easily feed on the phloem sap of resistant rice cultivars, Cheongcheongbyeo (Bph1), ASD7 (bph2), and Gayabyeo. Wild BPHs spent more time on reaching the phloem sieve elements of resistant cultivars. Ph waveform duration and honeydew excretion amount of wild BPHs also decreased. From the results, we suggest that though recent wild BPHs collected in Korea have high resistance-breaking ability simultaneously on rice cultivars carrying Bph1 and bph2 through the increase of survivorship, they still have to pay some cost to feed on the phloem sap of resistant rice cultivars.
Introduction of Neodryinus typhlocybae and biological control of invasive Metcalfa pruinosa
Bo Yoon Seo,Jum-Rae Cho,Chang-Gyu Park,Jeong Hwan Kim,Gwan-Seok Lee,Kwang-Ho Kim,Jin-Kyo Jung,Sung Jun Hong,Ki-Su Ahn 한국응용곤충학회 2018 한국응용곤충학회 학술대회논문집 Vol.2018 No.10
미국선녀벌레(Metcalfa pruinosa)는 외래 침입해충으로 조사가 시작된 2009년 이후 발생지역과 발생면적이 계속 증가하여 2018년에는 123개 시군구의 21,154ha에서 발생이 보고되고 있다. 미국선녀벌레는 농경지와 그 주변 산림지에서 활동하기 때문에 정부와 지자체간 협업을 통해 농림지 동시방제를 5월하순경(부화약충 대상)과 7월 중순경(성충 대상) 2회 실시하고 있다. 농촌진흥청에서는 미국선녀벌레의 기생천적인 선녀벌레집게벌(Neodryinus typhlocybae)의 안정적인 도입과 미국선녀벌레에 대한 생물적 방제원으로서 국내 정착을 위해 이탈리아 파도바대학과 국제협력사업을 2017년부터 수행하고 있다. 선녀벌레집게벌은 완주에서 월동이 가능하였으며 6월 초에 50%이상 우화를 하였다. 2018년도에 온실(완주)과 야외(수원, 태안)에서 증식하여 1,000여 개체 이상을 확보하였으며 도입천적의 안정적인 국내 정착과 확산 및 활용 방안에 대해 논의하고자 한다.