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A laminated composite plate finite element a-priori corrected for locking
Filho, Joao Elias Abdalla,Belo, Ivan Moura,Pereira, Michele Schunemann Techno-Press 2008 Structural Engineering and Mechanics, An Int'l Jou Vol.28 No.5
A four-node plate finite element for the analysis of laminated composites which is developed using strain gradient notation is presented. The element is based on a first-order shear deformation theory and on the equivalent lamina assumption. Strains and stresses can be calculated at different points through the thickness of the plate. They are averaged values due to the equivalent lamina assumption. A shear correction factor is used as the transverse shear strain is taken to be constant over the plate thickness while its actual variation is parabolic. Strain gradient notation, which is physically interpretable, allows for the detailed a-priori analysis of the finite element model. The polynomial expansions are inspected and spurious terms responsible for modeling errors are identified in the shear strains polynomial expansions. The element is corrected by simply removing the spurious terms from the shear strains expansions. The element is implemented into a FORTRAN finite element code in two versions; namely, with and without spurious terms. Results are compared to show the effects of the spurious terms on the solutions. It is also shown that a refined mesh composed of corrected elements provides solutions which approximate very well the analytical solutions, validating the procedure.
A laminated composite plate finite element a-priori corrected for locking
João Elias Abdalla Filho,Ivan Moura Belo,Michele Schunemann Pereira 국제구조공학회 2008 Structural Engineering and Mechanics, An Int'l Jou Vol.28 No.5
A four-node plate finite element for the analysis of laminated composites which is developed using strain gradient notation is presented. The element is based on a first-order shear deformation theory and on the equivalent lamina assumption. Strains and stresses can be calculated at different points through the thickness of the plate. They are averaged values due to the equivalent lamina assumption. A shear correction factor is used as the transverse shear strain is taken to be constant over the plate thickness while its actual variation is parabolic. Strain gradient notation, which is physically interpretable, allows for the detailed a-priori analysis of the finite element model. The polynomial expansions are inspected and spurious terms responsible for modeling errors are identified in the shear strains polynomial expansions. The element is corrected by simply removing the spurious terms from the shear strains expansions. The element is implemented into a FORTRAN finite element code in two versions; namely, with and without spurious terms. Results are compared to show the effects of the spurious terms on the solutions. It is also shown that a refined mesh composed of corrected elements provides solutions which approximate very well the analytical solutions, validating the procedure.
Saeid Amini-Nik,Ali-Reza Sadri,Li Diao,Cassandra Belo,Marc G. Jeschke 생화학분자생물학회 2018 Experimental and molecular medicine Vol.50 No.-
Liver fibrosis is problematic after persistent injury. However, little is known about its response to an acute insult. Accumulation of myeloid lineage cells contributes into the promotion and resolution of inflammation and fibrosis. Using Cre-transgenic mice that specifically mark myeloid lineage cells with EYFP and burn as a model of acute systemic injury, we investigated the role of myeloid lineage cells in the liver after acute injury. Our data show that thermal injury in mice (30% total body surface area) induces fibrosis predominantly around portal venules whereas myeloid cells are enriched throughout the liver. The fibrosis peaks around 1–2 weeks post injury and resolves by week 3. Ablating myeloid cells led to lower fibrosis. Through FACS sorting, we isolated myeloid lineage cells (EYFP +ve cells) from injured animals and from the control uninjured animals and subjected the extracted RNA from these cells to microarray analysis. Microarray analysis revealed an inflammatory signature for EYFP +ve cells isolated from injured animals in comparison with control cells. Moreover, it showed modulation of components of the serotonin (5-HT) pathway in myeloid cells. Antagonizing the 5HT2A/2C receptor decreased fibrosis in thermally injured mice by skewing macrophages away from their pro-fibrotic phenotype. Macrophages conditioned with Ketanserin showed a lower profibrotic phenotype in a co-culture system with mesenchymal cells. There is a spatiotemporal pattern in liver fibrosis post-thermal injury, which is associated with the influx of myeloid cells. Treating mice with a 5HT2A/2C receptor antagonist promotes an anti-fibrotic effect, through modulating the phenotype of macrophages.
A lower hybrid current drive system for ITER
Hoang, G.T.,Bé,coulet, A.,Jacquinot, J.,Artaud, J.F.,Bae, Y.S.,Beaumont, B.,Belo, J.H.,Berger-By, G.,Bizarro, Joã,o P.S.,Bonoli, P.,Cho, M.H.,Decker, J.,Delpech, L.,Ekedahl, A.,Garcia, J. International Atomic Energy Agency 2009 Nuclear fusion Vol.49 No.7
<P>A 20 MW/5 GHz lower hybrid current drive (LHCD) system was initially due to be commissioned and used for the second mission of ITER, i.e. the <I>Q</I> = 5 steady state target. Though not part of the currently planned procurement phase, it is now under consideration for an earlier delivery. In this paper, both physics and technology conceptual designs are reviewed. Furthermore, an appropriate work plan is also developed. This work plan for design, R&D, procurement and installation of a 20 MW LHCD system on ITER follows the ITER Scientific and Technical Advisory Committee (STAC) T13-05 task instructions. It gives more details on the various scientific and technical implications of the system, without presuming on any work or procurement sharing amongst the possible ITER partners. This document does not commit the Institutions or Domestic Agencies of the various authors in that respect.</P>
A Web-Based Global Educational Model for Training in Semen Analysis during the COVID-19 Pandemic
Agarwal Ashok,Finelli Renata,Durairajanayagam Damayanthi,Leisegang Kristian,Sharma Rakesh,Gupta Sajal,Singh Neha,Belo Andrea,Darbandi Mahsa,Madani Sarah,Covarrubias Simryn,Darbandi Sara,Sadeghi Raha,P 대한남성과학회 2021 The World Journal of Men's Health Vol.39 No.4
Purpose: In response to the COVID-19 pandemic, the American Center for Reproductive Medicine (ACRM) transitioned its annual training in assisted reproductive technology (ART) from a hands-on, laboratory-based training course to a fully online training endorsed by the American College of Embryology. Here we describe our experience and assess the quality of an online training format based on participant outcomes for the first three modules of a planned series of online ART training. Materials and Methods: These modules included manual semen analysis, sperm morphology and ancillary semen tests (testing for leukocytospermia, sperm vitality, and anti-sperm antibody screening). The virtual format consisted of lecture presentations featuring laboratory protocols with corresponding video demonstrations of routine techniques and best practices. Practical scenarios, troubleshooting, and clinical interpretation of laboratory results were also discussed. At the end of each module, an optional multiple choice question test was held as a prerequisite to obtain certification on the topics presented. Course quality was assessed using participant responses collected via online surveys. Results: The digital delivery methods used were found to have largely or completely met the participants’ expectations for all questions (>85%). The majority (>87%) of the participants either strongly agreed or agreed that the course content was well-structured with appropriate depth, and that their overall expectations of the course had been met. Conclusions: This training format appears to be a realistic teaching option to freely share highly specialized expertise and technical knowledge with participants from anywhere in the world with varying levels of competency or experience.
Ashok Agarwal,Sharma Rakesh,Gupta Sajal,Finelli Renata,Parekh Neel,Selvam Manesh Kumar Panner,Pompeu Camila Pinho,Madani Sarah,Belo Andrea,Darbandi Mahsa,Singh Neha,Darbandi Sara,Covarrubias Simryn,Sa 대한남성과학회 2022 The World Journal of Men's Health Vol.40 No.1
Semen analysis is a basic test for evaluating male fertility potential, as it plays an essential role in driving the future management and treatment of infertility in couples. Manual semen analysis includes the evaluation of both macroscopic and microscopic parameters, whereas automated semen analysis is conducted through a computer-aided sperm analysis system and can include additional parameters that are not evaluated by manual analysis. Both quality control (QC) and quality assurance (QA) are important to ensure reproducible results for semen analysis, and represent fundamental checks and balances of all stages (pre-analytical, analytical, and post-analytical) of semen analysis. To ensure accuracy and precision, the laboratory technicians’ performance should be evaluated biannually. This narrative review aims to describe standardized laboratory procedures for an accurate assessment of semen parameters that incorporate both QC and QA practices.