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Influence of Mammographic Screening on Breast Cancer Incidence Trends in South Australia
Beckmann, Kerri Rose,Roder, David Murray,Hiller, Janet Esther,Farshid, Gelareh,Lynch, John William Asian Pacific Journal of Cancer Prevention 2014 Asian Pacific journal of cancer prevention Vol.15 No.7
Purpose: To examine breast cancer (BC) incidence trends in relation to mammographic screening and risk factor prevalence in South Australia (SA). Materials and Methods: Trends in annual BC incidence rates were calculated using direct standardisation and compared with projected incidence derived from Poisson regression analysis of pre-screening rates. Annual percentage change and change time points were estimated using Joinpoint software. Biennial mammography screening participation rates were calculated using data from BreastScreen SA. Trends in overweight/obesity, alcohol use and hormone replacement therapy (HRT) use were examined using 1991-2009 Health Omnibus Survey data. Trends in total fertility were examined using data from the Australian Bureau of Statistics. Results: BC incidence increased around the time BreastScreen commenced and then stabilised in the mid-1990s. However rates have remained higher than projected, even though the proportion and age distribution of first time screening attendees stabilised around 1998. A decrease in BC incidence was observed among women aged 50-59yrs from the late-1990's but not among older women. Obesity and alcohol use have increased steadily in all age groups, while HRT use declined sharply from the late-1990s. Conclusions: BC incidence has remained higher than projected since mammography screening began. The sustained elevation is likely to be due to lead time effects, though over-diagnosis cannot be excluded. Declining HRT use has also impacted incidence trends. Implications: Studies using individual level data, which can account for changes in risk factor prevalence and lead time effects, are required to evaluate 'over-diagnosis' due to screening.
Cosmic evolution of stellar quenching by AGN feedback: clues from the Horizon-AGN simulation
Beckmann, R. S.,Devriendt, J.,Slyz, A.,Peirani, S.,Richardson, M. L. A.,Dubois, Y.,Pichon, C.,Chisari, N. E.,Kaviraj, S.,Laigle, C.,Volonteri, M. Oxford University Press 2017 MONTHLY NOTICES- ROYAL ASTRONOMICAL SOCIETY Vol.472 No.1
<P>The observed massive end of the galaxy stellar mass function is steeper than its predicted dark matter halo counterpart in the standard Lambda cold dark matter paradigm. In this paper, we investigate the impact of active galactic nuclei (AGN) feedback on star formation in massive galaxies. We isolate the impact of AGN by comparing two simulations from the HORIZON suite, which are identical except that one also includes supermassive black holes (SMBHs) and related feedback models. This allows us to cross-identify individual galaxies between simulations and quantify the effect of AGN feedback on their properties, including stellar mass and gas outflows. We find that massive galaxies (M-* >= 10(11) M-circle dot) are quenched by AGN feedback to the extent that their stellar masses decrease by up to 80 per cent at z = 0. SMBHs affect their host halo through a combination of outflows that reduce their baryonic mass, particularly for galaxies in the mass range 10(9) M-circle dot <= M-* <= 10(11) M-circle dot, and a disruption of central gas inflows, which limits in situ star formation. As a result, net gas inflows on to massive galaxies, M-* >= 10(11) M-circle dot, drop by up to 70 per cent. We measure a redshift evolution in the stellar mass ratio of twin galaxies with and without AGN feedback, with galaxies of a given stellar mass showing stronger signs of quenching earlier on. This evolution is driven by a progressive flattening of the M-SMBH-M-* relation with redshift, particularly for galaxies with M-* <= 10(10) M-circle dot. M-SMBH/M-* ratios decrease over time, as falling average gas densities in galaxies curb SMBH growth.</P>
ALLOCATION AND PRICING IN PUBLIC TRANSPORTATION AND THE FREE RIDER THEOREM
Martin J. Beckmann 한국경영과학회 1978 한국경영과학회지 Vol.3 No.1
Consider a time interval during which the demand for trips is fixed (e.g. the rush hour period). The traveller has a choice between various public modes, whose travel times and fares are fixed, and the automobile mode, for which travel time and cost depend on the volume of traffic flow on those roads, which are subject to congestion. We consider the equilibrium in terms of a representative traveller, who choses for any trip the mode and route with the least combined money and time cost. When several (parallel) modes or routes are chosen, then the combined cost of money and time must be equal among these. Our problem is first, to find the optimal flows of cars and of public mode carriers on the various links of their networks and second the optimal fares for trips by the variousmodes. The object is to minimize the total operating costs of the carriers and cars plus the total time costs to travellers. The optimal fares are related to, but not identical with the dual variables of the underlying Nonlinear Program. They are equal to these dual variables only in the cose, when congestion tolls on trips or on the use of specific roads are collected from automobile users. When such tolls are not collected, they must be passed on as subsidies to travellers using competing modes. The optimal fares of public modes are then reduced by the amounts of these subsidies. Note that subsidies are not a flat payment to public carriers, but are calculated on the basis of tickets sold. Fares and subsidies depend in general on the period considered. They will be higher during periods of higher demand. When the assumption of fixed trip demand is relaxed, this fare system is no longer best, but only second best since too much traffic will, in be generated. The Free Rider Theorem states the following: Suppose road tolls can be charged, so that a best pricing system for public modes is possible. Then there may exist free rides on some routes and modes, but never on a complete round trip.
정철,Karl Wackerbauer,Martin Beckmann,장기효,강순아 한국생물공학회 2008 Biotechnology and Bioprocess Engineering Vol.13 No.6
The effects of variations in cultivation conditions on trehalose concentration and the viability of brewing yeasts following preservation by filter paper or lyophilization methods were evaluated. In case of filter paper preservation, the cultivation period had no affect on yeast viability, while agitation and aeration during cultivation had a positive effect regarding viability of the bottom-fermenting strains, Rh and Frank. For effective preservation, it was necessary to harvest yeast cells from the stationary phase during cultivation. For lyophilization preservation, the yeast strains tested showed a negative effect on viability, independent of strain or cultivation method. No significant correlation was found between trehalose concentration and yeast viability following either filter paper or lyophilization preservation. However, the filter paper preservation method was suitable for both bottom and top brewing yeast strains with regard to feasibility, viability, and maintenance of the yeast’s specific character.
Influence of preserved brewing yeast strains on fermentation behavior and flocculation capacity
Chul Cheong,Karl Wackerbauer,Martin Beckmann,Soon Ah Kang 한국영양학회 2007 Nutrition Research and Practice Vol.1 No.4
Preservation methods on the physiological and brewing technical characters in bottom and top brewing yeast strains were investigated. The preserved yeasts were reactivated after 24 months storage and grown up to stationary phase. The samples of filter paper storage indicated a higher cell growth and viability during propagation than those of nitrogen and lyophilization storage independent on propagation temperature. In addition, the filter paper storage demonstrated a faster absorption of free amino nitrogen and a highest level of higher aliphatic alcohols production during propagation than other preservation methods, which can be attributed to intensive cell growth during propagation. Moreover, the filter paper storage showed a faster accumulation for glycogen and trehalose during propagation, whereas, in particular, lyophilization storage noted a longer adaptation time regarding synthesis of glycogen and trehalose with delayed cell growth. In beer analysis, the filter paper storage formed an increased higher aliphatic alcohols than control. In conclusion, the preservation of filter paper affected positively on yeast growth, viability and beer quality independent on propagation temperature. In addition, in this study, it was obtained that the HICF and Helm-test can be involved as rapid methods for determination of flocculation capacity.
Galaxy–halo alignments in the Horizon-AGN cosmological hydrodynamical simulation
Chisari, N. E.,Koukoufilippas, N.,Jindal, A.,Peirani, S.,Beckmann, R. S.,Codis, S.,Devriendt, J.,Miller, L.,Dubois, Y.,Laigle, C.,Slyz, A.,Pichon, C. Oxford University Press 2017 MONTHLY NOTICES- ROYAL ASTRONOMICAL SOCIETY Vol.472 No.1