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Arachchige Maheshika Kumari Ja,Eui Jeong Han,Soo-Jin Heo,Seo-Yeong Park,Hyeong Nam Jeon,Kirinde Gedara Isuru Sandanuwa,Ilekuttige Priyan Shanura Fern,Ginnae Ahn 한국식품영양과학회 2021 한국식품영양과학회 학술대회발표집 Vol.2021 No.10
The current study investigated the anti-inflammatory effect of 5-Bromo-3, 4-dihydroxybenzaldehyde from Polysiphonia morrowii in TNF-α/IFN-γ-stimulated HaCaT keratinocytes and in TPA-induced ear edema mouse model. None of the BDB concentrations exhibited cytotoxicity effects at tested concentrations and decreased intracellular ROS production. BDB effectively reduced inflammatory cytokines and chemokines expressions by suppressing the expression of epidermal-derived initial stimulating factors. BDB inhibited MAPK and NF-κB signaling pathways while activating Nrf2/HO-1 signaling. The cytoprotective effects of BDB were significantly reduced upon inhibition of HO-1. BDB ameliorated the ear edema and inhibited epidermal hyperplasia and hyperkeratosis by downregulating the expression of inflammatory mediators and the inflammatory cell infiltration. These results suggest that BDB has an anti-inflammatory effect in TNF-α/IFN-γ-stimulated HaCaT keratinocytes and a mouse model of TPA-induced ear edema. This work was supported by Basic Science Research Program through the National Research Foundation of Korea (NRF) funded (2017R1D1A1B04035921).
자외선 B가 조사된 피부각질형성세포에서 피부 보습력에 대한 다시마 열수 추출물의 효능 평가
( Arachchige Maheshika Kumari Jayasinghe ),( Kirinde Gedara Isuru Sandanuwan Kirindage ),안긴내 한국키틴키토산학회 2024 한국키틴키토산학회지 Vol.29 No.1
This study evaluated the effect of Saccharina japonica hot water extract (SJH) on the skin moisture in ultraviolet B (UVB)-exposed HaCaT keratinocytes. SJH significantly reduced the intracellular reactive oxygen species (ROS) production via the activation of nuclear factor erythroid 2-related factor 2 (Nrf2)/heme oxygenase-1 (HO-1) signalling in UVB-exposed HaCaT keratinocytes. Also, SJH significantly reduced the mRNA expression and/or production of inflammatory cytokines (interleukin (IL)-25, IL-33, thymic stromal lymphopoietin (TSLP), IL-6, IL-8, tumor necrosis factor (TNF)-α) and chemokines (macrophagederived chemokine (MDC) and thymus and activation regulated chemokine (TARC)) with the inactivation of MAPK signaling pathway in UVB-exposed HaCaT keratinocytes. In addition, SJH significantly increased the production of hyaluronic acid (HA) by regulating the protein expression levels of skin barrier (occludin, zonula occludens (ZO)-1, claudin-1, -4, -7 and -2) and skin moisture (lympho-epithelial kazal-type-related inhibitor (LEKT1), kallikrein (KLK)-5, protease activated receptor (PAR)-2, phospholipase (PLA)-2, involucrin and filaggrin) molecules in UVB-exposed HaCaT keratinocytes. These results suggest that SJH can effectively improve the skin moisture with the inhibition of oxidative stress, inflammation and dysfunction of skin barrier caused by UVB exposure in HaCaT keratinocytes.
Mercouri G. Kanatzidis: Excellence and Innovations in Inorganic and Solid-State Chemistry
Arachchige, Indika U.,Armatas, Gerasimos S.,Biswas, Kanishka,Subrahmanyam, Kota S.,Latturner, Susan,Malliakas, Christos D.,Manos, Manolis J.,Oh, Youngtak,Polychronopoulou, Kyriaki,P. Poudeu, Pierre. F ACS AMERICAN CHEMICAL SOCIETY 2017 Inorganic Chemistry Vol. No.
<P>Over the last 3-4 decades, solid-state chemistry has emerged as the forefront of materials design and development. The field has revolutionized into a multidisciplinary subject and matured with a scope of new synthetic strategies, new challenges, and opportunities. Understanding the structure is very crucial in the design of appropriate materials for desired applications. Professor Mercouri G. Kanatzidis has encountered both challenges and opportunities during the course of the discovery of many novel materials. Throughout his scientific career, Mercouri and his group discovered several inorganic compounds and pioneered structure-property relationships. We, a few Ph.D. and postdoctoral students, celebrate his 60th birthday by providing a Viewpoint summarizing his contributions to inorganic solid-state chemistry. The topics discussed here are of significant interest to various scientific communities ranging from condensed matter to green energy production.</P>
Fipronil impairs the fertilization competence of boar spermatozoa
Adikari Arachchige Dilki Indrachapa Adikari,MALAVIGE ROMESHA CH-ANDANEE,김병연,이영주 충남대학교 농업과학연구소 2022 Korean Journal of Agricultural Science Vol.49 No.1
Fipronil is a popular insecticide used in both agricultural and domestic fields. Factors that affect sperm and eggs have a direct influence on reproductive outcomes. This study was undertaken to assess the effect of varying concentrations (10 - 200 μM) of fipronil and incubation times (30 min and 2 hrs) on boar spermatozoa. Spermatozoa were evaluated for motility, motion kinematics, viability, chromatin stability, and for the generation of intracellular reactive oxygen species (ROS) and the results were compared to those from corresponding controls. The findings revealed a significant, dose-dependent reduction in sperm motility in all fipronil treatment groups at 30 min of incubation (p < 0.05). A similar dose-dependent reduction in sperm motility was observed subsequent to fipronil exposure for 2 hrs of incubation (p < 0.05). Groups treated with fipronil showed a gradual reduction in motion kinematics (p < 0.05). Moreover, a significantly higher percentage of dead sperm was observed at 200 μM fipronil, as compared to the highest live percentage obtained in controls (p < 0.05). Evaluating the sperm chromatin integrity revealed a significantly higher percentage of damaged chromatin in spermatozoa incubated with 200 μM of fipronil. Moreover, ROS production was significantly higher in fipronil-exposed sperm (p < 0.05). In conclusion, boar spermatozoa incubated with fipronil showed decreased levels of sperm motility and viability, weaker chromatin integrity, and increased levels of intracellular ROS generation, all of which indicate that exposure to fipronil potentially impairs the fertilization competence of boar spermatozoa.
Kodithuwakku Arachchige Sachini N.K.,Chander Harish,Turner Alana J.,Shojaei Alireza,Knight Adam C.,Griffith Aaron,Burch Reuben F.,Chen Chih-Chia 한국산업안전보건공단 산업안전보건연구원 2023 Safety and health at work Vol.14 No.3
Background: Occupational workers at altitudes are more prone to falls, leading to catastrophic outcomes. Acrophobia, height-related anxiety, and affected executive functions lead to postural instabilities, causing falls. This study investigated the effects of repeated virtual height exposure and training on cognitive processing and height-related anxiety. Methods: Twenty-eight healthy volunteers (age 20.48 ± 1.26 years; mass 69.52 ± 13.78 kg) were recruited and tested in seven virtual environments (VE) [ground (G), 2-story altitude (A1), 2-story edge (E1), 4-story altitude (A2), 4-story edge (E2), 6-story altitude (A3), and 6-story edge (E3)] over three days. At each VE, participants identified occupational hazards present in the VE and completed an Attitude Towards Heights Questionnaire (ATHQ) and a modified State-Trait Anxiety Inventory Questionnaire (mSTAIQ). The number of hazards identified and the ATHQ and mSTAIQ scores were analyzed using a 7 (VE; G, A1, A2, A3, E1, E2, E3) x 3 (DAY; DAY 1, DAY 2, DAY 3) factorial repeated measures analysis of variance. Results: The participants identified the lowest number of hazards at A3 and E3 VEs and on DAY 1 compared to other VEs and DAYs. ATHQ scores were lowest at G, A1, and E1 VEs. Conclusion: Cognitive processing is negatively affected by virtual altitudes, while it improves with short-term training. The features of virtual reality, such as higher involvement, engagement, and reliability, make it a better training tool to be considered in ergonomic settings. The findings of this study will provide insights into cognitive dual-tasking at altitude and its challenges, which will aid in minimizing occupational falls.