Development and preliminary psychometric analysis of a quick screening form for referrals of individuals with neurogenic communication disorders to speechlanguage pathologists by laypersons

Diana Wai-Lam Ho,Anthony Pak-Hin Kong,Olivia Ho-Yi Yeung,Samson Wai Yeung 한국언어재활사협회 2020 Clinical Archives of Communication Disorders Vol.5 No.1

Purpose: The study aimed at developing and determining the preliminary reliability and validity of a new screening form for use by laypersons to refer individuals with neurogenic communication disorders to speech-language pathologists. Methods: Thirty-two native Cantonese speakers with neurogenic communication disorders were tested with the proposed screening form by fourteen volunteer raters and well-established speech and language tests for aphasia, dysarthria and apraxia of speech (AOS) by ten speech-language pathology students. Results: Statistical analyses showed that the internal consistency and inter-rater reliability were high in all the tasks for aphasia and most of the tasks for dysarthria and AOS of the proposed screening form. It was further identified that some of the tasks for aphasia, dysarthria, and AOS would be valid for laypersons to identify individuals with communications disorders. Conclusions: The results indicated that the tasks for screening aphasia, dysarthria, and AOS should be carefully selected so that untrained laypersons would be able to make correct judgements. Further investigations involving a larger sample size are needed to determine areas to enhance the sensitivity and discriminating power of the current screener to be used by laypersons without a clinical background.

Component Fracture after Total Elbow Arthroplasty

Ho Min Lee,Shawn W. O’Driscoll,Anthony Vaichinger 대한견주관절의학회 2019 대한견주관절학회 학술대회논문집 Vol.2019 No.3

A Study of Orbiting State Phenomenon in Nuclear Fission Process of Thorium (Th(??)), Uranium (U(??)) and Plutonium (Pu(??)) : Slow Neutron Process

Anthony M. Lemos,Choi, Ho Jin,Joo, Koan Sik 명지대학교 자연과학연구소 1999 자연과학논문집 Vol.18 No.-

It was known that any resonance in atomic collisions and nuclear reactions can occur through the formation of orbiting states. In the fission process(n, f),i.e., n+U?, n+? and Pu?, there exists the formation of the orbiting states. We evaluated the life time of an orbiting state before decaying in the (n,f) using Regge Pole formalism. The calculated values of the life time of an orbiting state in, for example, the (n+U?)reaction, seemed to appeare to be approximately of order of 10? sec. It seemed to be longer than have expected. The values of the tos seemed to be of the order of muclear excitation, although these values appeared to be longer than the nuclear excitation time. As a result, it seems to be reasonable.

[세션초청논문] Evaluation of Hydrogen Embrittlement Behaviors in Different Grade Pipeline Steels using in-situ Small Punch Test

Nick Anthony Custodio(닉 안토니),Ju-Ho Yeo(여주호),Hyung-Seop Shin(신형섭),Un-Bong Baek(백운봉) 대한기계학회 2019 대한기계학회 춘추학술대회 Vol.2019 No.11

Current Status of Endoscopic Gallbladder Drainage

Joey Ho Yi Chan,Anthony Yuen Bun Teoh 대한소화기내시경학회 2018 Clinical Endoscopy Vol.51 No.2

The gold standard for treatment of acute cholecystitis is laparoscopic cholecystectomy. However, cholecystectomy is often not suitablefor surgically unfit patients who are too frail due to various co-morbidities. As such, several less invasive endoscopic treatmentmodalities have been developed to control sepsis, either as a definitive treatment or as a temporizing modality until the patient is stableenough to undergo cholecystectomy at a later stage. Recent developments in endoscopic ultrasound-guided gallbladder drainage (EUSGBD)with EUS-specific stents having lumen-apposing properties have demonstrated potential as a definitive treatment modality. Furthermore, advanced gallbladder procedures can be performed using the stents as a portal. With similar effectiveness as percutaneoustranshepatic cholecystostomy and lower rates of adverse events reported in some studies, EUS-GBD has opened exciting possibilities inbecoming the next best alternative in treating acute cholecystitis in surgically unfit patients. The aim of this review article is to providea summary of the various methods of GBD with particular focus on EUS-GBD and the many new prospects it allows.

Isl1 Directly Controls a Cholinergic Neuronal Identity in the Developing Forebrain and Spinal Cord by Forming Cell Type-Specific Complexes

Cho, Hyong-Ho,Cargnin, Francesca,Kim, Yujin,Lee, Bora,Kwon, Ryuk-Jun,Nam, Heejin,Shen, Rongkun,Barnes, Anthony P.,Lee, Jae W.,Lee, Seunghee,Lee, Soo-Kyung Public Library of Science 2014 PLoS genetics Vol.10 No.4

<▼1><P>The establishment of correct neurotransmitter characteristics is an essential step of neuronal fate specification in CNS development. However, very little is known about how a battery of genes involved in the determination of a specific type of chemical-driven neurotransmission is coordinately regulated during vertebrate development. Here, we investigated the gene regulatory networks that specify the cholinergic neuronal fates in the spinal cord and forebrain, specifically, spinal motor neurons (MNs) and forebrain cholinergic neurons (FCNs). Conditional inactivation of <I>Isl1</I>, a LIM homeodomain factor expressed in both differentiating MNs and FCNs, led to a drastic loss of cholinergic neurons in the developing spinal cord and forebrain. We found that Isl1 forms two related, but distinct types of complexes, the Isl1-Lhx3-hexamer in MNs and the Isl1-Lhx8-hexamer in FCNs. Interestingly, our genome-wide ChIP-seq analysis revealed that the Isl1-Lhx3-hexamer binds to a suite of cholinergic pathway genes encoding the core constituents of the cholinergic neurotransmission system, such as acetylcholine synthesizing enzymes and transporters. Consistently, the Isl1-Lhx3-hexamer directly coordinated upregulation of cholinergic pathways genes in embryonic spinal cord. Similarly, in the developing forebrain, the Isl1-Lhx8-hexamer was recruited to the cholinergic gene battery and promoted cholinergic gene expression. Furthermore, the expression of the Isl1-Lhx8-complex enabled the acquisition of cholinergic fate in embryonic stem cell-derived neurons. Together, our studies show a shared molecular mechanism that determines the cholinergic neuronal fate in the spinal cord and forebrain, and uncover an important gene regulatory mechanism that directs a specific neurotransmitter identity in vertebrate CNS development.</P></▼1><▼2><P><B>Author Summary</B></P><P>Neurons utilize various chemicals to transmit signals to a target cell. Distinct types of neurons in the spinal cord and forebrain, collectively termed cholinergic neurons, utilize the same chemical, acetylcholine, for signal transmission. These neurons play critical roles in controlling locomotion and cognition. In this study, we have found that the <I>Isl1</I> gene orchestrates the process to generate cholinergic neurons in the spinal cord and forebrain. Isl1 forms two different types of multi-protein complexes in the spinal cord and forebrain. Both complexes bind the same genomic regions in a group of genes critical for cholinergic signal transmission, and promote their simultaneous expression. These cholinergic genes include enzymes that synthesize acetylcholine and proteins required to package acetylcholine into vesicles. The Isl1-containing multi-protein complexes were able to trigger the generation of cholinergic neurons in embryonic stem cells and neural stem cells. Our study reveals crucial mechanisms to coordinate the expression of genes in the same biological pathway in different cell types. Furthermore, it suggests a new strategy to produce cholinergic neurons from stem cells.</P></▼2>

Applicability and Safety of in Vitro Skin Expansion Using a Skin Bioreactor: A Clinical Trial

Jeong, Cheol,Chung, Ho Yun,Lim, Hyun Ju,Lee, Jeong Woo,Choi, Kang Young,Yang, Jung Dug,Cho, Byung Chae,Lim, Jeong Ok,Yoo, James J.,Lee, Sang Jin,Atala, Anthony J. Korean Society of Plastic and Reconstructive Surge 2014 Archives of Plastic Surgery Vol.41 No.6

Background Tissue expansion is an effective and valuable technique for the reconstruction of large skin lesions and scars. This study aimed to evaluate the applicability and safety of a newly designed skin expanding bioreactor system for maximizing the graft area and minimizing the donor site area. Methods A computer-controlled biaxial skin bioreactor system was used to expand skin in two directions while the culture media was changed daily. The aim was to achieve an expansion speed that enabled the skin to reach twice its original area in two weeks or less. Skin expansion and subsequent grafting were performed for 10 patients, and each patient was followed for 6 months postoperatively for clinical evaluation. Scar evaluation was performed through visual assessment and by using photos. Results The average skin expansion rate was $10.54%{\pm}6.25%$; take rate, $88.89%{\pm}11.39%$; and contraction rate, $4.2%{\pm}2.28%$ after 6 months. Evaluation of the donor and recipient sites by medical specialists resulted in an average score of 3.5 (out of a potential maximum of 5) at 3 months, and 3.9 at 6 months. The average score for patient satisfaction of the donor site was 6.2 (out of a potential maximum of 10), and an average score of 5.2 was noted for the recipient site. Histological examination performed before and after the skin expansion revealed an increase in porosity of the dermal layer. Conclusions This study confirmed the safety and applicability of the in vitro skin bioreactor, and further studies are needed to develop methods for increasing the skin expansion rate.

Optimal Utilization of a Cognitive Shared Channel with a Rechargeable Primary Source Node

Pappas, Nikolaos,Jeon, Jeong-Ho,Ephremides, Anthony,Traganitis, Apostolos The Korea Institute of Information and Commucation 2012 Journal of communications and networks Vol.14 No.2

This paper considers the scenario in which a set of nodes share a common channel. Some nodes have a rechargeable battery and the others are plugged to a reliable power supply and, thus, have no energy limitations. We consider two source-destination pairs and apply the concept of cognitive radio communication in sharing the common channel. Specifically, we give high-priority to the energy-constrained source-destination pair, i.e., primary pair, and low-priority to the pair which is free from such constraint, i.e., secondary pair. In contrast to the traditional notion of cognitive radio, in which the secondary transmitter is required to relinquish the channel as soon as the primary is detected, the secondary transmitter not only utilizes the idle slots of primary pair but also transmits along with the primary transmitter with probability p. This is possible because we consider the general multi-packet reception model. Given the requirement on the primary pair's throughput, the probability p is chosen to maximize the secondary pair's throughput. To this end, we obtain two-dimensional maximum stable throughput region which describes the theoretical limit on rates that we can push into the network while maintaining the queues in the network to be stable. The result is obtained for both cases in which the capacity of the battery at the primary node is infinite and also finite.

Capability of Thermal Field-Flow Fractionation for Analysis of Processed Natural Rubber

이성호,은철훈,Lee, Seong Ho,Eun, Cheol Hun,Anthony R. Plepys Korean Chemical Society 2000 Bulletin of the Korean Chemical Society Vol.21 No.1

Applicability of Thermal field flow fractionation (ThFFF) was investigated for the analysis of masticated natural rubber (NR) adhesives produced bya hot melt mastication process. An optimum ThFFF condition for NR analysis was found by using tetrahydrofuran (THF) as a solvent/carrier and a field-programming. Low flowrate (0.3 mL/min) was used to avoid stopping the flow for the sample relaxation. Measured molecular weight distribution was used to monitor degradation of rubber during the mastication process. Rubber samples collected at three different stages of the mastication process and were analyzed by ThFFF. It was found that in an anaerobic process rubber degradation occurs at the resin-mixing (compounding) zone as well as in the initial break-down zone, while in an aerobic process most of degradation occurs at the initial breakdown zone. It was also found that E-beam radiation on NR causes a slight increase in the NR molecular weight due to the formation of a branched structure.

Comparison of drug-eluting stents and drug-coated balloon for the treatment of drug-eluting coronary stent restenosis: A randomized RESTORE trial

Wong, Yiu Tung Anthony,Kang, Do-Yoon,Lee, Jin Bae,Rha, Seung-Woon,Hong, Young Joon,Shin, Eun-Seok,Her, Sung-Ho,Nam, Chang Wook,Chung, Woo-Young,Kim, Moo Hyun,Lee, Cheol Hyun,Lee, Pil Hyung,Ahn, Jung-M Elsevier 2018 American Heart Journal Vol.197 No.-

<P><B>Background</B></P> <P>This study sought to evaluate the optimal treatment for in-stent restenosis (ISR) of drug-eluting stents (DESs).</P> <P><B>Methods</B></P> <P>This is a prospective, multicenter, open-label, randomized study comparing the use of drug-eluting balloon (DEB) versus second-generation everolimus-eluting stent for the treatment of DES ISR. The primary end point was in-segment late loss at 9-month routine angiographic follow-up.</P> <P><B>Results</B></P> <P>A total of 172 patients were enrolled, and 74 (43.0%) patients underwent the angiographic follow-up. The primary end point was not different between the 2 treatment groups (DEB group 0.15±0.49 mm vs DES group 0.19±0.41 mm, <I>P</I> =.54). The secondary end points of in-segment minimal luminal diameter (MLD) (1.80±0.69 mm vs 2.09±0.46 mm, <I>P</I> =.03), in-stent MLD (1.90±0.71 mm vs 2.29±0.48 mm, <I>P</I> =.005), in-segment percent diameter stenosis (34%±21% vs 26%±15%, <I>P</I> =.05), and in-stent percent diameter stenosis (33%±21% vs 21%±15%, <I>P</I> =.002) were more favorable in the DES group. The composite of death, myocardial infarction, or target lesion revascularization at 1 year was comparable between the 2 groups (DEB group 7.0% vs DES group 4.7%, <I>P</I> =.51).</P> <P><B>Conclusions</B></P> <P>Treatment of DES ISR using DEB or second-generation DES did not differ in terms of late loss at 9-month angiographic follow-up, whereas DES showed better angiographic results regarding minimal MLD and percent diameter stenosis. Both treatment strategies were safe and effective up to 1year after the procedure.</P>