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Anqi Fan,Bao-Long Hou,Zhishu Tang,Ting Wang,Dongbo Zhang,Yanni Liang,Zheng Wang 한국식품영양과학회 2023 Journal of medicinal food Vol.26 No.12
Ulcerative colitis (UC), often known as UC, is an inflammatory disease of the intestines that has frequent andlong-lasting flare-ups. It is unknown precisely how the traditional Chinese drug Indigo Naturalis (IN) heals inflammatorybowel disease, despite its long-standing use in China and Japan. Finding new metabolite biomarkers linked to UC couldimprove our understanding of the disease, speed up the diagnostic process, and provide insight into how certain drugs work totreat the condition. Our work is designed to use a metabolomic method to analyze potential alterations in endogenoussubstances and their impact on metabolic pathways in a mouse model of UC. To determine which biomarkers and metabolismsare more frequently connected with IN’s effects on UC, liquid chromatography-tandem mass spectrometry analysis ofthe serum metabolomics of UC mice and normal mice was performed. The outcomes demonstrated that IN boosted the healthof UC mice and reduced the severity of their metabolic dysfunction. In the UC model, it was also found that IN changed theway 17 biomarkers and 3 metabolisms functioned.
Anqi Luo,Min Meng,Guanying Wang,Rui Han,Yujiao Zhang,Xin Jing,Lin Zhao,Shanzhi Gu,Xinhan Zhao 한국유방암학회 2020 Journal of breast cancer Vol.23 No.2
Purpose: Numerous studies have shown that the frequency of myeloid-derived suppressor cells (MDSCs) is associated with tumor progression, metastasis, and recurrence. Chemokine (C-C motif ) ligand 3 (CCL3) may be secreted by tumor cells and attract MDSCs into the tumor microenvironment. In the present study, we aimed to explore the molecular mechanisms whereby CCL3 is involved in the interaction of breast cancer cells and MDSCs. Methods: The expression of CCL3 and its receptors was investigated using real-time polymerase chain reaction, western blotting, and enzyme-linked immunosorbent assay. The cell counting Kit-8, wound healing, and transwell assays were performed to study cell growth, migration, and invasion. Cell cycling, apoptosis, and the frequency of MDSCs were investigated through flow cytometry. Transwell assays were used for co-culture and chemotaxis detection. Markers of the epithelial-mesenchymal transition (EMT) were determined with western blotting. The role of CCL3 in vivo was studied via tumor xenograft experiments. Results: CCL3 promoted cell proliferation, migration, invasion, and cycling, and inhibited apoptosis of breast cancer cells in vitro. Blocking CCL3 in vivo inhibited tumor growth and metastases. The frequency of MDSCs in patients with breast cancer was higher than that in healthy donors. Additionally, MDSCs might be recruited by CCL3. Co-culture with MDSCs activated the phosphoinositide 3-kinase-protein kinase B-mammalian target of rapamycin (PI3K-Akt-mTOR) pathway and promoted the EMT in breast cancer cells, and their proliferation, migration, and invasion significantly increased. These changes were not observed when breast cancer cells with CCL3 knockdown were co-cultured with MDSCs. Conclusion: CCL3 promoted the growth of breast cancer cells, and MDSCs recruited by CCL3 interacted with these cells and then activated the PI3K-Akt-mTOR pathway, which led to EMT and promoted the migration and invasion of the cells.
Optical properties of Ag@cicada wing substrate deposited by Ag nanoparticles
Wang Mingli,Yan Xiaoya,Shi Guochao,Shang Zubin,Zhang Anqi,Ma Wanli 한국물리학회 2020 Current Applied Physics Vol.20 No.11
In this paper, Ag nanoparticles were deposited on Ag@cicada wing array by using the cicada wings as templates to study its optical properties, including surface enhanced Raman scattering (SERS), polarization and surface enhanced fluorescence (SEF). The nanogaps between adjacent conical protrusion can be well dominated by adjusting the sputtering time and the optimal substrate AgNPs@Ag@cicada wing arrays have a noteworthy enhancement of SERS signal. Characterization of the prepared optimal substrate certified that it possesses the excellent SERS performances. Basically consistent SERS signal strength at the different polarization angles of the optimal substrate indicates that its polarization-independence. The SEF spectra shows that the optimal substrate has a slightly lower and unstable enhancement at this initial stage of repeated examination due to the weak adhesion between the Ag@cicada wing arrays and Ag nanoparticles. The outstanding optical properties indicate that it has enormous potential in the label-free detection and biological analytes determination.
Mingzhi Wang,Anqi Xu,Ruolin Peng,Liangsheng Qiu,Jie Tao 대한금속·재료학회 2021 METALS AND MATERIALS International Vol.27 No.11
Al/Ni energetic laminates with various Al/Ni thickness ratios were prepared by electrodeposition and hot pressing method toinvestigate the effect of the thickness ratios on mechanical properties and exothermic energy of the composites. In this study,the different Al/Ni thickness ratios of 9:4, 9:6, 9:8 and 9:10 were determined by varying the initial thickness of Ni layers. Theresults showed that the Al/Ni laminate with the thickness ratio of 9:4 had the largest exothermic heat of 1139 J/g, while thelaminate with 9:10 possessed the optimum mechanical properties, such as the tensile strength of 395.8 MPa, the elongationof 13.3% and the bending strength of 706 MPa. It was found that the tensile properties and plastic forming properties of thelaminates were enhanced continuously with the increasing proportion of nickel layers due to higher strength and the improvingcollaborative deformation of Al/Ni multilayers, when the Al/Ni thickness ratio altered from 9:4 to 9:10. Meanwhile,the exothermic reaction energy was declined significantly because of the increasing proportion of the exothermic reactionto form AlNi3compounds, which possessed the lower energy density. In addition, the effect of Al/Ni thickness ratio on thereaction paths in the continuous heating process was also studied.
Zhang Anqi,Guo Liting,Li Na,Zhu Yanying,Jiao Tifeng,Wang Mingli 한국물리학회 2021 Current Applied Physics Vol.25 No.-
Composite structures have been widely concerned in the preparation of surface enhanced Raman scattering (SERS) substrates. In this paper, by solving the problem that the magnetic material was difficult to glow in magnetron sputtering, ferro-nickel (NiFe) alloy was deposited on the cicada wing (CW) and the NiFe/CW substrate was obtained. The results of sliver nanoparticles (Ag NPs) modified on the substrate were subsequently compared, and the SERS properties of the new Ag/NiFe/CW substrate were analyzed. Obviously, the intensity of SERS signals has been greatly improved after the modification of Ag NPs, and the substrate exhibits excellent reproducibility. The Ag NPs modified substrates were also applied to the detection of toxic crystal violet (CV) solution, which showed remarkable SERS activity. It has been proved that the strategy of modifying Ag NPs on the substrate to form a composite structure has great potential for improving the SERS performance of the substrate.