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( Sang Hun Lee ),( Soo Jeong Lee ),( Jun Woo Ahn ),( Hyun Jin Roh ),( Yong Soon Kwon ) 대한산부인과학회 2014 대한산부인과학회 학술대회 Vol.100 No.-
Ovarian microcystic stromal tumors (MCSTs) are a very rare cancer, hence even its nomenclature was recently designated as ‘Distinctive morphologic and immunohistochemical feature’ in 2009. Its exact origins and etiological genetic alterations and background are not yet clearly known. Familial adenomatous polyposis (FAP) is autosomal dominant, leading to initial development in the early stage of tumor via germ-line mutations of the APC gene on chromosome 5q21~q22. Cases of APC gene mutations, colon cancers and extra-colonic tumors by germ-line mutations and the second somatic mutations in the wild-type APC allele, respectively, have been found. Rare cases of extra-colonic tumors involving thyroid, liver, bile ducts, central nervous system have been reported, due to the scarcity of disease prevalence. In this study, we reported a 40-year-old female patient with both ovarian MCST and FAP. Collaborative operation involving Gynecology (LSO, ROWR) and Surgery (total colectomy) teams were performed. On sequencing the APC gene of ovarian MSCT, we detected the novel somatic mutation of the APC gene in exon 11, with a heterozygous deletion at nucleotide position c.1540delG (p.Ala514 Profs*9). On mutation analyses, ß-catenin (CTNNB1) and FOXL2 were not detected in ovarian MCST. The result of the analysis revealed that this was the second somatic mutation in the ovary. As far as we know, this is the first report on ovarian MCST with somatic mutation of APC, in a patient with FAP.
Ahn, Sae Ryun,An, Ji Hyun,Song, Hyun Seok,Park, Jin Wook,Lee, Sang Hun,Kim, Jae Hyun,Jang, Jyongsik,Park, Tai Hyun American Chemical Society 2016 ACS NANO Vol.10 No.8
<P>For several decades, significant efforts have been made in developing artificial taste sensors to recognize the five basic tastes. So far, the well-established taste sensor is an E-tongue, which is constructed with polymer and lipid membranes. However, the previous artificial taste sensors have limitations in various food, beverage, and cosmetic industries because of their failure to mimic human taste reception. There are many interactions between tastants. Therefore, detecting the interactions in a multiplexing system is required. Herein, we developed a duplex bioelectronic tongue (DBT) based on graphene field-effect transistors that were functionalized with heterodimeric human umami taste and sweet taste receptor nanovesicles. Two types of nanovesicles, which have human T1R1/T1R3 for the umami taste and human T1R2/T1R3 for the sweet taste on their membranes, immobilized on micropatterned graphene surfaces were used for the simultaneous detection of the umami and sweet tastants. The DBT platform led to highly sensitive and selective recognition of target tastants at low concentrations (ca. 100 nM). Moreover, our DBT was able to detect the enhancing effect of taste enhancers as in a human taste sensory system. This technique can be a useful tool for the detection of tastes instead of sensory evaluation and development of new artificial tastants in the food and beverage industry.</P>
Sang Hun Lee,Myung Ho Jeong,Joon Ho Ahn,Dae Young Hyun,Kyung Hoon Cho,Min Chul Kim,Doo Sun Sim,Young Joon Hong,Ju Han Kim,Youngkeun Ahn,Jin Yong Hwang,Weon Kim,Jong Seon Park,Chang-Hwan Yoon,Seung Ho 대한내과학회 2022 The Korean Journal of Internal Medicine Vol.37 No.4
Background/Aims: Recurrent acute myocardial infarction (AMI) is an adverse cardiac event in patients with a first AMI. The predictors of recurrent AMI after the first AMI in patients who underwent successful percutaneous coronary intervention (PCI) have not been elucidated. Methods: We analyzed the data collected from 9,869 patients (63.2 ± 12.4 years, men:women = 7,446:2,423) who were enrolled in the Korea Acute Myocardial Infarction Registry-National Institute of Health between November 2011 and October 2015, had suffered their first AMI and had received successful PCI during the index hospitalization. Multivariable logistic regression analysis was performed to identify the independent predictors of recurrent AMI following the first AMI. Results: The cumulative incidence of recurrent AMI after successful PCI was 3.6% (359/9,869). According to the multivariable logistic regression analysis, the significant predictive factors for recurrent AMI were diabetes mellitus, renal dysfunction, atypical chest pain, and multivessel disease. Conclusions: In this Korean prospective cohort study, the independent predictors of recurrent AMI after successful PCI for the first AMI were diabetes mellitus, renal dysfunction, atypical chest pain, and multivessel disease.
Ahn, Sujin,Wi, Hun,Oh, Tong In,McEwan, Alistair Lee,Jun, Sung Chan,Woo, Eung Je Hindawi Limited 2014 Journal of applied mathematics (JAM) Vol.2014 No.-
<P>A continuous Nondestructive monitoring method is required to apply proper feedback controls during tissue regeneration. Conductivity is one of valuable information to assess the physiological function and structural formation of regenerated tissues or cultured cells. However, conductivity imaging methods suffered from inherited ill-posed characteristics in image reconstruction, unknown boundary geometry, uncertainty in electrode position, and systematic artifacts. In order to overcome the limitation of microscopic electrical impedance tomography (micro-EIT), we applied a 3D-specific container with a fixed boundary geometry and electrode configuration to maximize the performance of Graz consensus reconstruction algorithm for EIT (GREIT). The separation of driving and sensing electrodes allows us to simplify the hardware complexity and obtain higher measurement accuracy from a large number of small sensing electrodes. We investigated the applicability of the GREIT to 3D micro-EIT images via numerical simulations and large-scale phantom experiments. We could reconstruct multiple objects regardless of the location. The resolution was 5 mm<SUP>3</SUP>with 30 dB SNR and the position error was less than 2.54 mm. This shows that the new micro-EIT system integrated with GREIT is robust with the intended resolution. With further refinement and scaling down to a microscale container, it may be a continuous nondestructive monitoring tool for tissue engineering applications.</P>
Sang-Hun Kim(김상현),Kwang-Youn Kim(김광연),Sun-Nyoung Yu(유선녕),Seul-Ki Park(박슬기),In-Seok Kwak(곽인석),Moon-Soo Rhee(이문수),Byung-Ho Bang(방병호),Sung-Sik Chun(전성식),Soon-Cheol Ahn(안순철) 한국생명과학회 2012 생명과학회지 Vol.22 No.11
Pipernonaline은 후추나무과에 속하는 필발(Piper longum Linn.)의 유도체로서 전립선 암세포에 대한 항암활성이 보고되고 있다. 하지만 실제 암세포 내에서 생물학적 정보를 가진 수 많은 유전자들에 대한 발현이 어떻게 이루어지고 있는지 알려진 바가 없다. 본 연구에 사용된 microarray 분석은 동시에 수 만개 이상의 유전자 발현양상을 한번에 관찰할 수 있는 기술로서 특정 질병의 유전학적 특성과 기전 연구를 더 광범위하게 연구 할 수 있는 기술이다. 본 연구에서는 전립선 암세포인 PC-3 세포에 pipernonaline을 처리하여 cDNA microarray를 실시하였다. 이후, DAVID database를 이용하여 gene ontology의 Biological Process를 분석하여 세포사멸과 세포주기, 세포성장 및 증식에 관련된 유전자들을 우선적으로 분석하였다. 그 결과, 세포주기관련 256개, 세포사멸관련 197개, 세포성장 및 증식관련에 154개의 유전자가 확인 되었다. 이러한 결과는 pipernonaline은 전립선 암세포 내에 존재하는 생물학적 신호전달체계에 관련된 유전자 발현을 조절함으로써 항암활성을 나타내 것을 알 수 있었고, 이후 이러한 microarray의 추가적인 분석은 암세포 내 새로운 유전자의 탐색 및 메커니즘을 규명하는데 유용하게 사용할 수 있을 것으로 사료된다. It has been reported that pipernonaline isolated from Piper longum Linn. has a wide biochemical and pharmacological effect, including antitumor activity in prostate cancer PC-3 cells. However, its mechanism and expression pattern of many genes involved in biological functions are not clearly understood. To perform the gene expression study in PC-3 cells treated with pipernonaline, a cDNA microarray chip composed of 44,000 human cDNA probes was used. As a result, cell cycle-related genes, apoptosis-related genes, and cell proliferation/growth-related genes have been identified in gene ontology of the DAVID database. These results suggest that pipernonaline has antitumor activity by regulating the expression pattern of genes involved in biological signaling pathway in prostate cancer PC-3 cells. Further, additional analysis of these microarray data can be a useful tool to identify the mechanism and discovery of novel genes in cancer therapy.
Ahn, Sung-Hun Korean Mathematical Society 1999 대한수학회논문집 Vol.14 No.1
In this paper, we improve some of results in [2] by showing that if I is a cnacellation ideal and if J is a regular ideal then $\alpha$(m), $\beta$(m) and $\delta$(m), behave nicely under localization. We prove that lim \ulcorner=0 if and only if $\alpha$(m) is eventually constant and that lim\ulcorner exists and is equal to or less than $\alpha$(1). Finally we give several conditions which are equivalent to $lim_{m{\rightarrow}{\infty}}{\frac{{\alpha}(m)}{m}}=0$.
SOME CONDITIONS FOR COMAXIMALITY OF IDEALS
Ahn, Sung Hun The Kangwon-Kyungki Mathematical Society 2000 한국수학논문집 Vol.8 No.1
In this paper, it is shown that if R is a commutative ring with identity and there exists a multiplicatively closed subset S of R such that $S{\cap}Z(R/(I_1I_2{{\cdots}I_n))={\emptyset}$ and $I_1R_s,I_2R_s{\cdots},I_nR_s$ are pairwise comaximal, then $I_1I_2{\cdots}I_n=I_1{\cap}I_2{\cap}{\cdots}{\cap}I_n={\cap}^n_{i=1}(I_i\;:_R\;I_1{\cdots}I_{i-1}I_{i+1}{\cdots}I_n)$.