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- 검색키워드
- 저자 : Ahmed M. Al-Abd (검색결과 12 건)
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Ahmed M. Abd El-Fattah,Hayder A. Rasheed,Ahmed H. Al-Rahmani 한국콘크리트학회 2017 International Journal of Concrete Structures and M Vol.11 No.1
The prediction of the actual ultimate capacity of confined concrete columns requires partial confinement utilization under eccentric loading. This is attributed to the reduction in compression zone compared to columns under pure axial compression. Modern codes and standards are introducing the need to perform extreme event analysis under static loads. There has been a number of studies that focused on the analysis and testing of concentric columns. On the other hand, the augmentation of compressive strength due to partial confinement has not been treated before. The higher eccentricity causes smaller confined concrete region in compression yielding smaller increase in strength of concrete. Accordingly, the ultimate eccentric confined strength is gradually reduced from the fully confined value fcc (at zero eccentricity) to the unconfined value f 0 c (at infinite eccentricity) as a function of the ratio of compression area to total area of each eccentricity. This approach is used to implement an adaptive Mander model for analyzing eccentrically loaded columns. Generalization of the 3D moment of area approach is implemented based on proportional loading, fiber model and the secant stiffness approach, in an incremental-iterative numerical procedure to achieve the equilibrium path of P–e and M–u response up to failure. This numerical analysis is adapted to assess the confining effect in rectangular columns confined with conventional lateral steel. This analysis is validated against experimental data found in the literature showing good correlation to the partial confinement model while rendering the full confinement treatment unsafe.
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Al-Abd, Ahmed M.,Hong, Ki-Yun,Song, Soo-Chang,Kuh, Hyo-Jeong Elsevier 2010 Journal of controlled release Vol.142 No.1
<P><B>Abstract</B></P><P>A novel, thermosensitive hydrogel, poly(organophosphazene), is an injectable drug delivery system that transforms from sol to gel at body temperature. Doxorubicin (DOX) is a cytotoxic drug used for the treatment of several solid tumors. Due to its acute cardiac toxicity, DOX is a good candidate for local chemo-drug delivery system. In this study, we evaluated the pharmacokinetics of DOX (30mg/kg) when given as an intratumoral injection using poly(organophosphazene) hydrogel in mice with human gastric tumor xenografts. DOX was formulated at 0.6% into a 10% hydrogel, and 40% and 90% of the dose was released in a sustained manner over 5weeks in vitro and in vivo, respectively. The hydrogel mass was well retained over 7weeks, and <I>T</I><SUB>1/2β, tumor</SUB> was 1.8-fold longer than that of the solution, but the 2.2-fold lower <I>C</I><SUB>max, tumor</SUB>, produced a similar AUC<SUB>tumor</SUB> and antitumor effect. However, solution caused a 2-fold higher systemic exposure (AUC<SUB>plasma</SUB>), which resulted in significant mortality due to acute cardiac toxicity. These data indicate that hydrogel formulation may have similar efficacy but lower systemic exposure than aqueous solution. In conclusion, poly(organophosphazene) showed adequate characteristics for local intratumoral delivery of DOX, including dose capacity, local retention, and minimal systemic spill-over. The safety and biocompatibility of poly(organophosphazene) should be further evaluated and its application should be extended to other anticancer agents.</P> <P><B>Graphical abstract</B></P><P><ce:figure></ce:figure></P>
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Abd El Fattah, Ahmed M.,Rasheed, Hayder A.,Al-Rahmani, Ahmed H. Korea Concrete Institute 2017 International Journal of Concrete Structures and M Vol.11 No.1
The prediction of the actual ultimate capacity of confined concrete columns requires partial confinement utilization under eccentric loading. This is attributed to the reduction in compression zone compared to columns under pure axial compression. Modern codes and standards are introducing the need to perform extreme event analysis under static loads. There has been a number of studies that focused on the analysis and testing of concentric columns. On the other hand, the augmentation of compressive strength due to partial confinement has not been treated before. The higher eccentricity causes smaller confined concrete region in compression yielding smaller increase in strength of concrete. Accordingly, the ultimate eccentric confined strength is gradually reduced from the fully confined value $f_{cc}$ (at zero eccentricity) to the unconfined value $f^{\prime}_c$ (at infinite eccentricity) as a function of the ratio of compression area to total area of each eccentricity. This approach is used to implement an adaptive Mander model for analyzing eccentrically loaded columns. Generalization of the 3D moment of area approach is implemented based on proportional loading, fiber model and the secant stiffness approach, in an incremental-iterative numerical procedure to achieve the equilibrium path of $P-{\varepsilon}$ and $M-{\varphi}$ response up to failure. This numerical analysis is adapted to assess the confining effect in rectangular columns confined with conventional lateral steel. This analysis is validated against experimental data found in the literature showing good correlation to the partial confinement model while rendering the full confinement treatment unsafe.
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Ahmed H. Khalil,Atef S. Abd Al-Galil,Ahmed A. Sabek,Mohamed M. Zeineldin,Seham Y. Abo-Kora 대한수의학회 2019 Journal of Veterinary Science Vol.20 No.5
This study examined the sedative, analgesic, behavioral, and clinical effects of a combination of xylazine (XY) and nalbuphine-xylazine (NA-XY) in camels. A total of five adult camels were used in a prospective randomized cross-over design with a wash out period of two weeks. Camels were allocated randomly to two treatment groups: the XY group (xylazine, 1.1mL/100 kg IV) and the NA-XY group (xylazine, 1.1mL/100 kg IV and nalbuphine, 1 mg/kg IV). The sedative, analgesic, behavioral, and clinical effects of XY and NA-XY combination were evaluated prior to administration (baseline) and at 5, 15, 30, 45, 60, 75, 90, and 120 minutes post-administration. The results showed that the NA-XY combination accelerates the onset of sedation and analgesia and prolongs the durations of both sedation (p < 0.001) and analgesia (p < 0.01). The behavioral parameters showed higher scores with a NA-XY combination than xylazine alone. Although a XY injection resulted in a significant decline in the heart and respiratory rate, the NA-XY combination group revealed a non-significant change in both clinical parameters compared to the baseline. In conclusion, the use of a NA-XY combination in camels improved the sedative and analgesic onset and duration with an improved outcome in the behavioral scores, as well as in both the heart and respiratory rates compared to XY alone.
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A Simple HPLC Method for Doxorubicin in Plasma and Tissues of Nude Mice
Ahmed M. Al-Abd,Nam Ho Kim,구효정,송수창,이승진 대한약학회 2009 Archives of Pharmacal Research Vol.32 No.4
Doxorubicin is a cytotoxic anthracycline that has been used for the treatment of several malignancies. Several HPLC methods have been reported for the quantification of doxorubicin in biological samples. Tissue matrix effect and sample size requirements, however, have been remaining issues for simple and easy-to-adapt analytical methods in small animal experiments. The present study established a simple HPLC method for doxorubicin in plasma and tissues (tumor, heart, spleen, liver, gastrointestinal tract, brain, lung, and kidney) of nude mice. Our method required a small sample volume (100 μL plasma and 10 mg tissue), which made it possible to use each blank tissue for calibration curves. The limit of quantification was 25 ng/mL in plasma and 0.1 to 0.4 μg/mg in other tissues with recovery rates ranging from 52.4 to 95.2%. The linearity, accuracy and precision in all tissues, except astrointestinal tract (GIT), were found to be acceptable in the range of 25-2000 ng/mL plasma and 0.1-4 ng/mg tissue. This method was used successfully to determine the drug concentration in plasma and tissues of human tumor xenograft-bearing nude mice given intratumoral doxorubicin in a polymeric drug delivery system designed for sustained release. In conclusion, the present method may be useful as a simple and easy-to-adapt, yet, sensitive analytical method of doxorubicin for plasma and tissue pharmacokinetic studies in small animals such as nude mice.
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May Ahmed Al-Masoud,Mai M. Khalaf,Ibrahim M. A. Mohamed,K. Shalabi,Hany M Abd El-lateef 한국공업화학회 2022 Journal of Industrial and Engineering Chemistry Vol.112 No.-
Two novel nanocomposites based on polyaniline functionalized ZnO and ZnO-SiO2 nanoparticles(ZnO@PANi and ZnSiO@PANi) were synthesized, characterized, and evaluated as protective films for steelpipelines in the pickling process at 25–55 C. The prepared nanocomposites were described using differentspectroscopic characterization methods including UV–vis, FTIR, DLS, XPS methods, and other physicochemicaltechniques including XRD, FESEM, and HR-TEM. The novelty of these films is in the fact thatthe ZnO and ZnO-SiO2 nanoparticles are functionalized by polyaniline which is electrochemically stablein acidic solution and has high conductivity. Electrochemical systems such as open circuit potentials(OCP), electrochemical impedance spectroscopy (EIS), and potentiodynamic polarization (PDP) were utilizedto attain the kinetics and mechanistic findings of the corrosion protection route. The outcomes indicatethat the two fabricated ZnO@PANi and ZnSiO@PANi are efficient acidic corrosion inhibitors. Theprotection performance of ZnSiO@PANi (98.6%) was more pronounced at a dose (150 mg/L) thanZnO@PANi (92.3%) and individual PANi (83.4%) as achieved from PDP findings. The effect of temperatureand flowing conditions reinforces further the performance of both nanocomposites. Surface characterizationusing FESEM/EDS delivered more indication for the steel surface protection with the ZnO@PANi andZnSiO@PANi nanocomposites. Molecular modeling using DFT calculations and MC simulations supportedthe experimental findings. The binding energies of the compounds and Fe interface follow the order ofZnO@PANi > ZnSiO@PANi, which is in good agreement with the empirical results. An important suggestionof these results is the probability of substituting traditional toxic small molecules with cost-effectiveand non-toxic polymeric nanocomposites as protective films for use in the oil and gas industry.
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Nadia A. Khalil,Eman M. Ahmed,Hala B. El-Nassan,Osama K. Ahmed,Ahmed M. Al-Abd 대한약학회 2012 Archives of Pharmacal Research Vol.35 No.6
A series of novel 5-aryl-3-cyclopropyl-4,5-dihydropyrazole derivatives 2a-p were synthesized via cyclization of chalcones 1a-h with thiosemicarbazide or semicarbazide HCl and evaluated as anti-inflammatory/antioxidant agents. The structures were confirmed by elemental analyses and spectral data. The free radical scavenging activity toward superoxide was determined. Their effect on hepatocytes viability and nitric oxide (NO) production in LPS-stimulated macrophages was also determined. The results showed that compounds 2e and 2n demonstrated the highest free-radical scavenging and anti-inflammatory activities, thus can be useful in the prevention of oxidative stress and inflammation-related disorders.
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Trung, Tran-Quoc,Long, Pham-Hai,Al-Abd, Ahmed M,Ku, Hyo-Jeong,Lee, Ho-Yoon,Hwang, Sung-Joo,Kim, Kyeong-Ho 대한약학회 2007 Archives of Pharmacal Research Vol.30 No.7
A method was developed and fully validated for the determination of bevantolol, an adrenergic-receptor blocker, in human plasma. Bevantolol and betaxolol as internal standard (I.S) were extracted from 1mL of human plasma by solid phase extraction technique using Sep-pak silica cartridge. Chromatographic separation was accomplished under isocratic conditions using a reverse-phase $C_8$ analytical column and mixture of dibasic ammonium phosphate (pH 5.7; 50mM)-acetonitrile (75:25, v/v) as mobile phase, with a defection wavelength at 220 nm. The method was proved to be specific by testing six different human plasma sources. Linearity was established for the concentration ranges of 40-1600 ng/mL with correlation coefficent of 0.9995. The lower limit of quantification 40 ng/mL with precision of 10.9% as C.V%.
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Tran Quoc Trung,Pham Hai Long,Ahmed M Al-Abd,Hyo Jeong Kuh,Ho Yoon Lee,황성주,김경호 대한약학회 2007 Archives of Pharmacal Research Vol.30 No.7
A method was developed and fully validated for the determination of bevantolol, an adrenergicreceptor blocker, in human plasma. Bevantolol and betaxolol as internal standard (I.S) were extracted from 1mL of human plasma by solid phase extraction technique using Sep-pak silica cartridge. Chromatographic separation was accomplished under isocratic conditions using a reverse-phase C8 analytical column and mixture of dibasic ammonium phosphate (pH 5.7; 50mM)-acetonitrile (75:25, v/v) as mobile phase, with a detection wavelength at 220 nm. The method was proved to be specific by testing six different human plasma sources. Linearity was established for the concentration ranges of 40-1600 ng/mL with correlation coefficent of 0.9995. The lower limit of quantification 40 ng/mL with precision of 10.9% as C.V%.
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