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Work Ability Index: Psychometric Testing in Aeronautical Industry Workers
González-Domínguez María Eugenia,Fernández-García Elena,Paloma-Castro Olga,González-López Regina María,Rivas Pérez María Paz,López-Molina Luis,García-Jiménez Jesús,Romero-Sánchez José Manuel 한국산업안전보건공단 산업안전보건연구원 2024 Safety and health at work Vol.15 No.1
Background The Work Ability Index (WAI) is an instrument that measures work ability. The wide dispersion of the WAI internationally has led to its adaptation for use in different countries. This study aimed to evaluate the psychometric properties of the Spanish version of the WAI. Methods A methodological design was used over an opportunistic sample of 233 workers in the aeronautical industry in Spain. Reliability was evaluated through internal consistency. Factorial validity, known groups, and convergent validity were tested. Results The Cronbach's alpha and item-total correlation indicated an adequate internal consistency. The confirmatory factor analysis, performed to evaluate the factorial validity, found adequate fit indices for a two-factor solution with a high correlation between the factors. Factor 1, “Subjectively estimated work ability and resources”, was composed of 3 subscales and factor 2, “Ill-health-related”, of 2 subscales. Subscales 4 and 6 had loading in both factors. Workers under 45 years of age obtained higher significant scores than older ones. Convergent validity was also evidenced since WAI was highly correlated with self-assessment of health status. Conclusions The Spanish version of the WAI has shown evidence of reliability and validity in this study, supporting its use in individual and collective health surveillance by occupational health professionals. The factorial solution that was found has previously been reported in another international context. However, further research is needed to resolve the discrepancies detected in the role of some subscales between other national and international studies. Background The Work Ability Index (WAI) is an instrument that measures work ability. The wide dispersion of the WAI internationally has led to its adaptation for use in different countries. This study aimed to evaluate the psychometric properties of the Spanish version of the WAI. Methods A methodological design was used over an opportunistic sample of 233 workers in the aeronautical industry in Spain. Reliability was evaluated through internal consistency. Factorial validity, known groups, and convergent validity were tested. Results The Cronbach's alpha and item-total correlation indicated an adequate internal consistency. The confirmatory factor analysis, performed to evaluate the factorial validity, found adequate fit indices for a two-factor solution with a high correlation between the factors. Factor 1, “Subjectively estimated work ability and resources”, was composed of 3 subscales and factor 2, “Ill-health-related”, of 2 subscales. Subscales 4 and 6 had loading in both factors. Workers under 45 years of age obtained higher significant scores than older ones. Convergent validity was also evidenced since WAI was highly correlated with self-assessment of health status. Conclusions The Spanish version of the WAI has shown evidence of reliability and validity in this study, supporting its use in individual and collective health surveillance by occupational health professionals. The factorial solution that was found has previously been reported in another international context. However, further research is needed to resolve the discrepancies detected in the role of some subscales between other national and international studies.
Imaging Diagnosis of Perianal Leiomyoma: A Case Report
Enrique González-Díaz,Blanca García Cengotitabengoa,Ana Belen Dominguez Carbajo,Camino Fernández Fernández,A. Fernández Corona 대한대장항문학회 2021 Annals of Coloproctolgy Vol.37 No.S
A leiomyoma is a benign mesenchymal neoplasm that usually develops where smooth muscle is present. In this report, we present the case of a 75-year-old woman who sought medical attention due to pelvic organ prolapse and urinary incontinence, and without defecatory symptoms. Both pelvic floor ultrasound and magnetic resonance imaging (MRI) examination showed a well-defined mass in the ischioanal fossa, eventually diagnosed as a perianal leiomyoma. It is considered a rare entity because of its location involving the anal sphincter and clinical features. We describe the ultrasonographic and MRI findings of this perianal leiomyoma, together with differential diagnoses and immunohistochemical characterization.
Hb Murcia (β118(G19)His>Gln): A New Hemoglobin Variant Found in a Spanish Woman
Fernández Beatriz González,Campuzano José Bartolomé Nieto,Rocamora Dolores García,Nieto Jorge M,Fernández Fernando Ataúlfo González,Villegas Ana,Cuesta Celina Benavente,Ropero Paloma 대한진단검사의학회 2021 Annals of Laboratory Medicine Vol.41 No.5
A. Fernández-González,M.T. Mallada,J.L. Viesca,R. González,R. Badía,A. Hernández-Battez 한국공업화학회 2017 Journal of Industrial and Engineering Chemistry Vol.56 No.-
The corrosion behaviour and solubility of three bis(trifluoromethylsulfonyl)amide1 ([NTf2]) anion-basedionic liquids: 1-dodecyl-3-methylimidazolium bis(trifluoromethylsulfonyl)amide ([C12MIM][NTf2]),tributylmethylammonium bis(trifluoromethylsulfonyl)amide ([N4441][NTf2]), and methyltrioctylammo-nium bis(trifluoromethylsulfonyl)amide ([N1888][NTf2]), as a component in a mixture with different baseoils were analysed. Six polar oils suitable for use in lubrication were utilized as base oil. Solubility testswere performed by using turbidimetry, and corrosion was checked at 4 v/v% by examining the roughnessand chemical composition of the surface after 21 days. The results showed that long carbon chains in thecation improve the solubility greatly in diesters and slightly in polyolesters. Corrosion was not detected atthis concentration.
I Can Not Wear My Sunglasses: An Unusual Sarcoidosis Presentation
José Pablo Miramontes González,Virginia Velasco Tirado,Pablo González García,Marta Sánchez García,Ángeles Fidalgo Fernández 대한가정의학회 2017 Korean Journal of Family Medicine Vol.38 No.4
A 39-year-old Caucasian man was referred to University Hospital Salamanca from a primary care unit due to the presence of an erythematous violaceous nodule at the superior portion of his nose. Physical examination indicated that the firm, fixed erythematous violaceous nodule measured approximately 2 cm in diameter and was located in-ferior to a scar on the nasal bridge. Cutaneous involvement in sarcoidosis occurs in 25% of cases. A wide range of clinical presentations of cutaneous sarcoidosis is recognized. Skin lesions are classified as either non-specific, of which erythema nodosum is the most representative and specific, or as granulomatous, which includes maculo-papular nodules, plaques, infiltrated scars, lupus pernio, ulcerations, warty lesions and erythroderma. Scar sarcoid-osis is a type of cutaneous sarcoidosis.
A. Gil,A.M. García,M. Fernández,M.A. Vicente,B. González-Rodríguez,V. Rives,S.A. Korili 한국공업화학회 2017 Journal of Industrial and Engineering Chemistry Vol.53 No.-
Photocatalysts composed of titanium dioxide modified with B, F, N and P have been synthesized, characterized and applied to the degradation of caffeine, diclofenac, ibuprofen and salicylic acid. The modified TiO2 samples were prepared by the sol–gel technique starting from titanium(IV) isopropoxide and using H3BO3, NH4F, N(C2H5OH)3 and H3PO4 as precursors of the modifiers, with the content varying between 0 and 5 wt%. Structural characterization was based on nitrogen physisorption at 196 C, powder X-ray diffraction (PXRD), simultaneous thermogravimetric/differential thermal analysis (TG/ DTA) and X-ray photoelectron spectroscopy (XPS). The structural properties of the modified TiO2 solids were significantly different depending on the nature and amount of modifiers and the calcination temperature. TiO2 in the anatase phase was obtained in all cases and was stable upon calcination at 400 C. The photocatalytic degradation of caffeine, diclofenac, ibuprofen and salicylic acid by modified TiO2 was investigated under ultraviolet irradiation at 25 C. The photocatalytic degradation behavior followed the order: caffeine > diclofenac = ibuprofen > salicylic acid. B-doped TiO2 was the most efficient catalyst in the degradation of these selected emerging contaminants.
Paula Fernández-Palanca,Tania Payo-Serafín,Carolina Méndez-Blanco,Beatriz San-Miguel,María J. Tuñón,Javier González-Gallego,José L. Mauriz 대한간학회 2023 Clinical and Molecular Hepatology(대한간학회지) Vol.29 No.2
Hepatocellular carcinoma (HCC) is one of the most common and deadly cancers worldwide and is characterized by complex molecular carcinogenesis. Neuropilins (NRPs) NRP1 and NRP2 are the receptors of multiple proteins involved in key signaling pathways associated with tumor progression. We aimed to systematically review all the available findings on their role in HCC. We searched the Scopus, Web of Science (WOS), PubMed, Cochrane and Embase databases for articles evaluating NRPs in preclinical or clinical HCC models. This study was registered in PROSPERO (CRD42022349774) and include 49 studies. Multiple cellular and molecular processes have been associated with one or both NRPs, indicating that they are potential diagnostic and prognostic biomarkers in HCC patients. Mainly NRP1 has been shown to promote tumor cell survival and progression by modulating several signaling pathways. NRPs mainly regulate angiogenesis, invasion and migration and have shown to induce invasion and metastasis. They also regulate the immune response and tumor microenvironment, showing a crucial interplay with the hypoxia response and microRNAs in HCC. Altogether, NRP1 and NRP2 are potential biomarkers and therapeutic targets, providing novel insight into the clinical landscape of HCC patients.
Serum Sclerostin in Hepatitis C Virus Infected Patients
E. González-Reimers,Javier López-Prieto,Ricardo Pelazas-González,M.Remedios Alemán-Valls,María José de la Vega-Prieto,Carlos Jorge-Ripper,M. Carmen Durán-Castellón,F Santolaria-Fernández 대한골대사학회 2014 대한골대사학회지 Vol.21 No.1
Background: Sclerostin inhibits osteoblast functions, differentiations, and survival rates. As an endogenous inhibitor of the Wnt/β-catenin pathway, the sclerostin should be re-lated to decreased bone masses, although several studies indicate opposite results. Inaddition, it may be related to insulin resistances and carbohydrate metabolisms, a rela-tion shared with other markers of bone metabolisms, such as osteocalcin. Hepatitis C vi-rus (HCV) infected patients may present osteoporosis, and frequently show liver steato-sis, which is a consequence of insulin resistance. The behaviour of sclerostin in these pa-tients is yet unknown. The aim of this work is to analyse the relationships between se-rum sclerostin and osteocalcin levels and bone mineral density (BMD), liver functions,the intensity of liver steatosis and biochemical markers of bone homeostasis and insulinresistance in HCV-infected patients. Methods: Forty HCV patients with 20 years of ageand gender-matching controls were included in this study and underwent bone densi-tometry. Serum sclerostin, osteocalcin, collagen telopeptide, adiponectin, leptin, insulin,resistin, tumor necrosis factor (TNF)-α, and interleukin (IL)-6 were determined. Liver fatwas histomorphometrically assessed. Results: Sclerostin levels were slightly higher inpatients than in controls, and were directly related to BMD at different parts of the skele-ton, also to the serum telopeptide, and to the liver steatosis and TNF-α. On the contrary,osteocalcin showed a significant direct relationship with serum adiponectin, and an in-verse one with IL-6. Conclusions: Serum sclerostin levels were within the normal rangein HCV patients, and correlated directly with BMD and serum telopeptide. In addition,the relationships of sclerostin and osteocalcin with variables associated with insulin re-sistance suggested the role of bones for intermediary metabolisms.
Alfredo Hierro González,Julio César Fernández Travieso,Yoandy Hernández Casas,Susana Borges González,María de los Angeles Camacho Morales,Elena Ferrer Batallie,Anaisa Roja Carralera,Yenney Reyes Nuñez 대한내과학회 2024 The Korean Journal of Internal Medicine Vol.39 No.1
Background/Aims: Abexol is a mixture of primary aliphatic alcohols purified from beeswax (Apis mellifera), that produces anti-inflammatory, antioxidant and gastroprotective effects, as well as it is safe and well tolerated. To investigate and compare the efficacy and safety of Abexol (suspension versus tablets) in patients with gastrointestinal symptoms. Methods: Monocentric study, open-label, randomized design, with two parallel groups receiving Abexol tablets (150 mg/d) or Abexol suspension (75 mg/d) for 8 weeks. Primary efficacy variable (significant improvement in the total score of Gastrointestinal Symptom Rating Scale [GSRS]). Significant reduction in the intensity of the gastrointestinal-symptoms and the reduction in the consumption of antacids are considered secondary efficacy variable. Short form-36 (SF-36) quality of life questiongenonaire was evaluated as collateral variable. Data were analyzed as per intention to treat. Results: A significantly decrease in the overall score of the survey was observed with respect to the baseline level (p < 0.001) of 81.4% in the Abexol suspension group and 77.9% in the Abexol tablets group. At the end of the trial, most gastrointestinal- symptoms disappeared or reduced significantly. The frequency of consumption of neutralizing antacids was low. The significantly improvement in the perception of the state of health obtained in the Abexol is in correspondence with the improvement achieved in some of the components evaluate in the SF-36 questionnaire. Both treatments were safe and well tolerated. Conclusions: Abexol suspension showed efficacy and safety similar to Abexol tablets in patients with gastrointestinal symptoms, but using half the dose.